IMP: Integrative Multi-species Prediction

Drosophila melanogaster

29 known processes

tmod (Dmel_CG1539)

tropomodulin

(Aliases: E42,CG1539,CT41421,CG15540,1309/10,l(3)00848,Tmod,CT3919,spdo,l(3)S130910,CG11493,Dmel\CG1539)

Entrez: 43633
FLYBASE: FBgn0082582
UniProtKB: A8JRH3
UniProtKB: E1JJ21
UniProtKB: O46231
UniProtKB: C7LAH8
UniProtKB: Q9VA58
UniProtKB: Q9VA59
UniProtKB: Q9VA56

Process Predictions
Disease Predictions

tmod biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
myofibril assembly	GO:0030239	36	0.962	Mouse Worm
actomyosin structure organization	GO:0031032	56	0.912	Mouse Worm
sarcomere organization	GO:0045214	26	0.858	Worm
cellular component assembly involved in morphogenesis	GO:0010927	151	0.837	Mouse Worm
organelle assembly	GO:0070925	198	0.824	Mouse Worm
muscle cell differentiation	GO:0042692	103	0.796	Mouse Worm
actin filament based process	GO:0030029	220	0.790	Mouse Worm
striated muscle cell development	GO:0055002	50	0.765	Mouse Worm
muscle structure development	GO:0061061	224	0.763	Mouse Worm
adult somatic muscle development	GO:0007527	14	0.717
striated muscle cell differentiation	GO:0051146	90	0.640	Mouse Worm
actin cytoskeleton organization	GO:0030036	206	0.382	Mouse Worm
striated muscle myosin thick filament assembly	GO:0071688	3	0.301
regulation of localization	GO:0032879	275	0.258
regulation of cellular catabolic process	GO:0031329	157	0.168
establishment of localization in cell	GO:0051649	402	0.164
positive regulation of cellular component organization	GO:0051130	156	0.163
organonitrogen compound metabolic process	GO:1901564	318	0.143
actin filament organization	GO:0007015	126	0.141	Worm
tube morphogenesis	GO:0035239	191	0.131
somatic muscle development	GO:0007525	66	0.116
cellular macromolecule localization	GO:0070727	220	0.114
positive regulation of nucleotide catabolic process	GO:0030813	46	0.113
single organism cellular localization	GO:1902580	180	0.111
protein transport	GO:0015031	155	0.109
regionalization	GO:0003002	416	0.107
protein complex biogenesis	GO:0070271	201	0.104	Worm
regulation of cell development	GO:0060284	215	0.103
protein complex assembly	GO:0006461	200	0.103	Worm
developmental maturation	GO:0021700	172	0.101
regulation of defense response	GO:0031347	102	0.100
positive regulation of catabolic process	GO:0009896	105	0.100
positive regulation of cellular catabolic process	GO:0031331	95	0.099
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.099
cellular catabolic process	GO:0044248	372	0.086
sensory organ morphogenesis	GO:0090596	260	0.083
regulation of intracellular signal transduction	GO:1902531	236	0.082
regulation of catabolic process	GO:0009894	170	0.082
muscle cell development	GO:0055001	50	0.081	Mouse Worm
cellular macromolecular complex assembly	GO:0034622	153	0.081	Worm
catabolic process	GO:0009056	409	0.081	Worm
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.078
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.077
regulation of actin cytoskeleton organization	GO:0032956	42	0.077	Worm
cell division	GO:0051301	248	0.077
negative regulation of gene expression	GO:0010629	387	0.076
positive regulation of nucleoside metabolic process	GO:0045979	47	0.076
programmed cell death	GO:0012501	257	0.075
embryonic pattern specification	GO:0009880	174	0.075
multicellular organismal aging	GO:0010259	140	0.073
positive regulation of gtpase activity	GO:0043547	43	0.073
positive regulation of transcription dna templated	GO:0045893	266	0.073
endocytosis	GO:0006897	310	0.072
molting cycle	GO:0042303	56	0.071
macromolecular complex assembly	GO:0065003	256	0.071	Worm
respiratory system development	GO:0060541	213	0.070
organelle fission	GO:0048285	340	0.067
heterocycle catabolic process	GO:0046700	166	0.066
embryo development ending in birth or egg hatching	GO:0009792	152	0.065	Worm
nucleoside triphosphate catabolic process	GO:0009143	108	0.065
regulation of cell differentiation	GO:0045595	302	0.065
regulation of organelle organization	GO:0033043	196	0.064	Worm
aromatic compound catabolic process	GO:0019439	166	0.063
regulation of anatomical structure morphogenesis	GO:0022603	242	0.062
striated muscle tissue development	GO:0014706	27	0.062
purine containing compound catabolic process	GO:0072523	112	0.062
digestive tract morphogenesis	GO:0048546	127	0.061
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.059
nucleobase containing small molecule metabolic process	GO:0055086	174	0.059
intracellular protein transport	GO:0006886	104	0.059
immune system process	GO:0002376	347	0.058
anatomical structure homeostasis	GO:0060249	97	0.057
mesoderm development	GO:0007498	78	0.056
regulation of gtp catabolic process	GO:0033124	44	0.054
blastoderm segmentation	GO:0007350	159	0.054
regulation of cellular localization	GO:0060341	136	0.054
protein localization	GO:0008104	284	0.052
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.052
cellular homeostasis	GO:0019725	80	0.052
proteolysis	GO:0006508	192	0.052
aging	GO:0007568	143	0.050
embryonic morphogenesis	GO:0048598	206	0.050
positive regulation of multicellular organismal process	GO:0051240	143	0.049
organic substance catabolic process	GO:1901575	308	0.049	Worm
regulation of cell morphogenesis	GO:0022604	163	0.049
secretion	GO:0046903	109	0.049
organic cyclic compound catabolic process	GO:1901361	168	0.049
establishment of protein localization	GO:0045184	163	0.048
eye development	GO:0001654	323	0.047
positive regulation of phosphate metabolic process	GO:0045937	139	0.046
hair cell differentiation	GO:0035315	47	0.046
body morphogenesis	GO:0010171	2	0.045
tube development	GO:0035295	244	0.045
compound eye morphogenesis	GO:0001745	249	0.045
small molecule metabolic process	GO:0044281	305	0.045
positive regulation of hydrolase activity	GO:0051345	78	0.044
regulation of cellular component biogenesis	GO:0044087	201	0.044	Worm
cellular protein complex assembly	GO:0043623	71	0.044	Worm
myosin filament organization	GO:0031033	5	0.044
positive regulation of macromolecule metabolic process	GO:0010604	405	0.043
regulation of multicellular organismal development	GO:2000026	414	0.042
regulation of actin filament length	GO:0030832	27	0.042	Worm
anterior posterior pattern specification	GO:0009952	136	0.042
positive regulation of nucleotide metabolic process	GO:0045981	55	0.042
nucleobase containing compound catabolic process	GO:0034655	165	0.042
cell maturation	GO:0048469	144	0.041
negative regulation of actin filament depolymerization	GO:0030835	2	0.041	Worm
negative regulation of response to stimulus	GO:0048585	258	0.041
epidermis development	GO:0008544	65	0.040
nucleoside catabolic process	GO:0009164	112	0.040
regulation of actin filament depolymerization	GO:0030834	3	0.039	Worm
regulation of hydrolase activity	GO:0051336	97	0.039
positive regulation of gtp catabolic process	GO:0033126	43	0.039
regulation of vesicle mediated transport	GO:0060627	59	0.039
nucleotide catabolic process	GO:0009166	109	0.039
positive regulation of cell development	GO:0010720	61	0.038
mitotic cytokinesis	GO:0000281	50	0.038
neuron recognition	GO:0008038	101	0.037
actin filament bundle assembly	GO:0051017	26	0.037
regulation of protein transport	GO:0051223	57	0.037
vesicle mediated transport	GO:0016192	381	0.037
regulation of phosphorus metabolic process	GO:0051174	210	0.037
macromolecule catabolic process	GO:0009057	161	0.036	Worm
regulation of molecular function	GO:0065009	217	0.036
positive regulation of rna metabolic process	GO:0051254	271	0.036
regulation of cell maturation	GO:1903429	27	0.036
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.036
cytoplasmic transport	GO:0016482	130	0.036
purine nucleotide catabolic process	GO:0006195	109	0.036
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.036
establishment of nucleus localization	GO:0040023	26	0.035
cognition	GO:0050890	141	0.035
cytokinesis	GO:0000910	90	0.035
locomotory behavior	GO:0007626	176	0.035	Mouse
nucleotide metabolic process	GO:0009117	161	0.035
negative regulation of organelle organization	GO:0010639	56	0.034	Worm
nucleoside phosphate metabolic process	GO:0006753	162	0.034
regulation of rho protein signal transduction	GO:0035023	20	0.034
purine ribonucleoside metabolic process	GO:0046128	127	0.034
cellular protein localization	GO:0034613	160	0.033
defense response to other organism	GO:0098542	225	0.033
cellular protein complex disassembly	GO:0043624	35	0.033	Worm
single organism intracellular transport	GO:1902582	207	0.033
protein modification process	GO:0036211	438	0.032
retina development in camera type eye	GO:0060041	4	0.032
regulation of nucleotide catabolic process	GO:0030811	48	0.032
intracellular signal transduction	GO:0035556	300	0.032
regulation of immune response	GO:0050776	118	0.032
regulation of neuron projection development	GO:0010975	69	0.032
imaginal disc derived wing hair organization	GO:0035317	45	0.031
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.031
phagocytosis	GO:0006909	215	0.031
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.031
regulation of transport	GO:0051049	181	0.031
axis specification	GO:0009798	167	0.031
carbohydrate derivative metabolic process	GO:1901135	217	0.031
muscle tissue morphogenesis	GO:0060415	2	0.030
mitotic sister chromatid segregation	GO:0000070	87	0.030
regulation of programmed cell death	GO:0043067	152	0.030
defense response to bacterium	GO:0042742	178	0.030
protein depolymerization	GO:0051261	31	0.030	Worm
skeletal myofibril assembly	GO:0014866	6	0.030
oocyte development	GO:0048599	124	0.029
cell projection assembly	GO:0030031	94	0.029
purine ribonucleoside catabolic process	GO:0046130	112	0.029
stem cell differentiation	GO:0048863	117	0.029
ribonucleoside catabolic process	GO:0042454	112	0.029
spindle organization	GO:0007051	253	0.029
cytoskeleton dependent cytokinesis	GO:0061640	81	0.029
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.028
glycosyl compound catabolic process	GO:1901658	112	0.028
regulation of ras gtpase activity	GO:0032318	38	0.028
regulation of protein depolymerization	GO:1901879	27	0.028	Worm
actin filament depolymerization	GO:0030042	5	0.028	Worm
epithelial tube morphogenesis	GO:0060562	88	0.028
spiracle morphogenesis open tracheal system	GO:0035277	22	0.028
peptide metabolic process	GO:0006518	80	0.027
metal ion transport	GO:0030001	74	0.027
positive regulation of phosphorus metabolic process	GO:0010562	139	0.027
germarium derived female germ line cyst formation	GO:0030727	42	0.027
actin filament bundle organization	GO:0061572	28	0.027
positive regulation of actin filament polymerization	GO:0030838	11	0.027
purine ribonucleotide catabolic process	GO:0009154	109	0.026
regulation of protein polymerization	GO:0032271	28	0.026	Worm
heart development	GO:0007507	82	0.026
cell death	GO:0008219	279	0.026
regulation of cytoskeleton organization	GO:0051493	89	0.026	Worm
regulation of gtpase activity	GO:0043087	44	0.026
ribonucleotide catabolic process	GO:0009261	109	0.026
morphogenesis of an epithelium	GO:0002009	276	0.026
cell recognition	GO:0008037	102	0.025
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.025
cellularization	GO:0007349	90	0.025
protein catabolic process	GO:0030163	101	0.025	Worm
gastrulation involving germ band extension	GO:0010004	36	0.025
regulation of anatomical structure size	GO:0090066	163	0.025	Worm
regulation of dendrite development	GO:0050773	37	0.024
regulation of multi organism process	GO:0043900	131	0.024
sodium ion transport	GO:0006814	22	0.024
positive regulation of biosynthetic process	GO:0009891	316	0.024
positive regulation of molecular function	GO:0044093	136	0.024
cellular amino acid metabolic process	GO:0006520	61	0.024
regulation of endocytosis	GO:0030100	37	0.024
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.023
non sensory hair organization	GO:0035316	47	0.023
cell adhesion	GO:0007155	136	0.023
oocyte differentiation	GO:0009994	145	0.023
ribonucleoside metabolic process	GO:0009119	127	0.023
muscle organ development	GO:0007517	127	0.023
kidney development	GO:0001822	3	0.022
regulation of cell substrate adhesion	GO:0010810	2	0.022
regulation of apoptotic process	GO:0042981	130	0.022
negative regulation of cytoskeleton organization	GO:0051494	30	0.022	Worm
regulation of catalytic activity	GO:0050790	185	0.022
regulation of cell cycle	GO:0051726	291	0.022
convergent extension	GO:0060026	2	0.022
embryonic development via the syncytial blastoderm	GO:0001700	148	0.022
myosin filament assembly	GO:0031034	5	0.022
chromosome condensation	GO:0030261	41	0.022
positive regulation of signal transduction	GO:0009967	223	0.021
nucleoside triphosphate metabolic process	GO:0009141	120	0.021
glycosyl compound metabolic process	GO:1901657	127	0.021
ion transport	GO:0006811	145	0.021
nuclear division	GO:0000280	332	0.021
regulation of dendrite morphogenesis	GO:0048814	28	0.021
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.021
positive regulation of cellular component biogenesis	GO:0044089	80	0.020
compound eye development	GO:0048749	307	0.020
response to wounding	GO:0009611	94	0.020
biological adhesion	GO:0022610	138	0.020
response to other organism	GO:0051707	293	0.020
positive regulation of response to stimulus	GO:0048584	323	0.020
regulation of cell projection organization	GO:0031344	92	0.020
gastrulation with mouth forming first	GO:0001703	36	0.020
positive regulation of developmental process	GO:0051094	143	0.020
post embryonic appendage morphogenesis	GO:0035120	385	0.020
guanosine containing compound metabolic process	GO:1901068	74	0.020
cellular protein modification process	GO:0006464	438	0.020
epidermal cell differentiation	GO:0009913	51	0.020
negative regulation of protein complex disassembly	GO:0043242	23	0.019	Worm
intracellular transport	GO:0046907	228	0.019
intercellular bridge organization	GO:0043063	14	0.019
oligosaccharide biosynthetic process	GO:0009312	10	0.019
organophosphate catabolic process	GO:0046434	112	0.019
camera type eye development	GO:0043010	4	0.019
nucleoside phosphate catabolic process	GO:1901292	110	0.019
cellular component disassembly	GO:0022411	46	0.019	Worm
regulation of cell death	GO:0010941	173	0.019
carbohydrate derivative catabolic process	GO:1901136	118	0.019
dendrite morphogenesis	GO:0048813	199	0.019
gtp catabolic process	GO:0006184	72	0.019
germarium derived egg chamber formation	GO:0007293	101	0.018
tissue morphogenesis	GO:0048729	297	0.018
homeostatic process	GO:0042592	199	0.018
eye morphogenesis	GO:0048592	260	0.018
apoptotic process	GO:0006915	159	0.018
cytoplasmic transport nurse cell to oocyte	GO:0007303	12	0.018
gtp metabolic process	GO:0046039	72	0.018
regulation of cell shape	GO:0008360	113	0.018
neuron remodeling	GO:0016322	29	0.018
guanosine containing compound catabolic process	GO:1901069	74	0.018
germ line cyst formation	GO:0048134	44	0.018
determination of adult lifespan	GO:0008340	137	0.018
regulation of proteolysis	GO:0030162	87	0.018
skeletal muscle myosin thick filament assembly	GO:0030241	3	0.018
regulation of immune system process	GO:0002682	176	0.018
response to external biotic stimulus	GO:0043207	293	0.018
single organism catabolic process	GO:0044712	228	0.017
regulation of phosphate metabolic process	GO:0019220	210	0.017
rhabdomere development	GO:0042052	38	0.017
regulation of tube length open tracheal system	GO:0035159	24	0.017
chemical homeostasis	GO:0048878	92	0.017
digestive system development	GO:0055123	149	0.017
oocyte construction	GO:0007308	112	0.017
negative regulation of cellular metabolic process	GO:0031324	382	0.017
nucleoside metabolic process	GO:0009116	127	0.016
regulation of cell growth	GO:0001558	43	0.016
ras protein signal transduction	GO:0007265	88	0.016
positive regulation of protein polymerization	GO:0032273	14	0.016
epithelial cell differentiation	GO:0030855	322	0.016
organophosphate metabolic process	GO:0019637	195	0.016
positive regulation of catalytic activity	GO:0043085	118	0.016
regulation of protein localization	GO:0032880	76	0.016
extracellular structure organization	GO:0043062	46	0.016
cell cycle arrest	GO:0007050	4	0.016
cell proliferation	GO:0008283	299	0.016
dephosphorylation	GO:0016311	51	0.016
regulation of actin filament polymerization	GO:0030833	25	0.016	Worm
neuron projection guidance	GO:0097485	241	0.015
ribose phosphate metabolic process	GO:0019693	145	0.015
wound healing	GO:0042060	75	0.015
actin polymerization or depolymerization	GO:0008154	31	0.015	Worm
positive regulation of signaling	GO:0023056	243	0.015
regulation of neuron differentiation	GO:0045664	103	0.015
imaginal disc growth	GO:0007446	37	0.015
negative regulation of cell death	GO:0060548	81	0.015
regulation of purine nucleotide catabolic process	GO:0033121	48	0.015
glycoprotein biosynthetic process	GO:0009101	41	0.015
purine nucleotide metabolic process	GO:0006163	146	0.015
embryonic axis specification	GO:0000578	107	0.014
positive regulation of ras gtpase activity	GO:0032320	36	0.014
organonitrogen compound catabolic process	GO:1901565	128	0.014
mesenchymal cell differentiation	GO:0048762	1	0.014
intracellular mrna localization involved in anterior posterior axis specification	GO:0060811	53	0.014
protein targeting	GO:0006605	64	0.014
nuclear migration	GO:0007097	20	0.014
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.014
regulation of oocyte development	GO:0060281	27	0.014
oocyte fate determination	GO:0030716	27	0.014
negative regulation of protein depolymerization	GO:1901880	23	0.014	Worm
gene silencing	GO:0016458	138	0.014
morphogenesis of a branching epithelium	GO:0061138	45	0.013
skin development	GO:0043588	65	0.013
regulation of cytoplasmic transport	GO:1903649	47	0.013
tissue death	GO:0016271	102	0.013
defense response	GO:0006952	300	0.013
intracellular protein transmembrane transport	GO:0065002	4	0.013
positive regulation of cellular biosynthetic process	GO:0031328	316	0.013
nicotinamide nucleotide metabolic process	GO:0046496	2	0.013
response to biotic stimulus	GO:0009607	294	0.013
lamellipodium organization	GO:0097581	21	0.013
nucleus localization	GO:0051647	34	0.013
axon development	GO:0061564	297	0.013
camera type eye morphogenesis	GO:0048593	2	0.013
negative regulation of catalytic activity	GO:0043086	42	0.013
morphogenesis of embryonic epithelium	GO:0016331	94	0.012
wnt signaling pathway	GO:0016055	98	0.012
muscle thin filament assembly	GO:0071689	5	0.012	Worm
intracellular mrna localization involved in pattern specification process	GO:0060810	56	0.012
protein maturation	GO:0051604	71	0.012
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.012
positive regulation of cell death	GO:0010942	69	0.012
cellular amide metabolic process	GO:0043603	80	0.012
regulation of cellular amine metabolic process	GO:0033238	3	0.012
positive regulation of cytoskeleton organization	GO:0051495	21	0.012
protein import	GO:0017038	55	0.012
segmentation	GO:0035282	207	0.012
anterior posterior axis specification embryo	GO:0008595	103	0.012
tripartite regional subdivision	GO:0007351	103	0.012
mitotic nuclear division	GO:0007067	213	0.012
branching involved in open tracheal system development	GO:0060446	45	0.012
olfactory behavior	GO:0042048	97	0.012
female germ line cyst formation	GO:0048135	42	0.011
o glycan processing	GO:0016266	3	0.011
negative regulation of programmed cell death	GO:0043069	72	0.011
cytoskeleton dependent intracellular transport	GO:0030705	44	0.011
response to bacterium	GO:0009617	198	0.011
positive regulation of nervous system development	GO:0051962	69	0.011
actin mediated cell contraction	GO:0070252	21	0.011
microtubule polymerization or depolymerization	GO:0031109	39	0.011
maintenance of location	GO:0051235	73	0.011
regulation of establishment of protein localization	GO:0070201	61	0.011
positive regulation of rna biosynthetic process	GO:1902680	266	0.011
actin cytoskeleton reorganization	GO:0031532	22	0.011
cell motility	GO:0048870	251	0.011
cellular macromolecule catabolic process	GO:0044265	136	0.011
transcription from rna polymerase ii promoter	GO:0006366	368	0.011
dna metabolic process	GO:0006259	227	0.011
regulation of innate immune response	GO:0045088	71	0.011
negative regulation of cellular component organization	GO:0051129	108	0.011	Worm
purine nucleoside metabolic process	GO:0042278	127	0.011
developmental programmed cell death	GO:0010623	138	0.010
actin filament based movement	GO:0030048	26	0.010
meiotic nuclear division	GO:0007126	151	0.010
cellular chemical homeostasis	GO:0055082	40	0.010
production of small rna involved in gene silencing by rna	GO:0070918	15	0.010
regulation of reproductive process	GO:2000241	54	0.010
salivary gland development	GO:0007431	162	0.010
mrna processing	GO:0006397	104	0.010
negative regulation of apoptotic process	GO:0043066	63	0.010
peptide hormone processing	GO:0016486	2	0.010
organic substance transport	GO:0071702	257	0.010
cellular nitrogen compound catabolic process	GO:0044270	165	0.010

tmod disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.016
cardiovascular system disease	DOID:1287	0.016
nervous system disease	DOID:863	0.016
muscular disease	DOID:0080000	0.015
musculoskeletal system disease	DOID:17	0.015
connective tissue disease	DOID:65	0.014
disease of cellular proliferation	DOID:14566	0.014
muscle tissue disease	DOID:66	0.013
intrinsic cardiomyopathy	DOID:0060036	0.013
dilated cardiomyopathy	DOID:12930	0.013
cardiomyopathy	DOID:0050700	0.013
heart disease	DOID:114	0.013
myopathy	DOID:423	0.013
organ system cancer	DOID:0050686	0.011
cancer	DOID:162	0.011
urinary system disease	DOID:18	0.011
kidney disease	DOID:557	0.011

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