IMP: Integrative Multi-species Prediction

Drosophila melanogaster

89 known processes

Patj (Dmel_CG12021)

CG12021 gene product from transcript CG12021-RC

(Aliases: Dmel\CG12021,dlt:discs lost,PaTJ,BcDNA:LD22238,Dpatj,Dlt,dlt,DPatj,dPATJ,PatJ,Patj/Dlt,DPATJ,dPatj,DLT,D-Patj,PATJ,CG12021)

Entrez: 44100
FLYBASE: FBgn0067864
UniProtKB: Q9NB04
UniProtKB: A4V1B2

Process Predictions
Disease Predictions

Patj biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
asymmetric protein localization	GO:0008105	33	0.789
axis specification	GO:0009798	167	0.708
vesicle mediated transport	GO:0016192	381	0.668
tube development	GO:0035295	244	0.587
single organism cellular localization	GO:1902580	180	0.544
regulation of localization	GO:0032879	275	0.405
establishment of localization in cell	GO:0051649	402	0.376
extracellular structure organization	GO:0043062	46	0.349
epithelial cell development	GO:0002064	274	0.333
cellular protein localization	GO:0034613	160	0.299
tube morphogenesis	GO:0035239	191	0.278
morphogenesis of embryonic epithelium	GO:0016331	94	0.274
epithelial cell differentiation	GO:0030855	322	0.268
protein localization	GO:0008104	284	0.261
response to abiotic stimulus	GO:0009628	341	0.253	Fly
cell junction organization	GO:0034330	57	0.246
rna processing	GO:0006396	147	0.242
establishment or maintenance of cell polarity	GO:0007163	167	0.227
positive regulation of biosynthetic process	GO:0009891	316	0.226
positive regulation of transport	GO:0051050	92	0.211
homeostatic process	GO:0042592	199	0.208
positive regulation of cellular biosynthetic process	GO:0031328	316	0.197
growth	GO:0040007	359	0.191
morphogenesis of an epithelium	GO:0002009	276	0.188
regulation of notch signaling pathway	GO:0008593	100	0.182
regulation of transport	GO:0051049	181	0.160
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.160
cytokinesis	GO:0000910	90	0.149
compound eye morphogenesis	GO:0001745	249	0.148
anterior posterior axis specification	GO:0009948	109	0.144
localization of cell	GO:0051674	257	0.143
organonitrogen compound metabolic process	GO:1901564	318	0.136
oocyte development	GO:0048599	124	0.132
maternal determination of anterior posterior axis embryo	GO:0008358	74	0.128
embryo development ending in birth or egg hatching	GO:0009792	152	0.125
protein transport	GO:0015031	155	0.125
embryonic axis specification	GO:0000578	107	0.125
cellular macromolecule localization	GO:0070727	220	0.117
positive regulation of rna biosynthetic process	GO:1902680	266	0.116
cell division	GO:0051301	248	0.115
embryonic morphogenesis	GO:0048598	206	0.114
cell junction assembly	GO:0034329	42	0.111
appendage morphogenesis	GO:0035107	397	0.111
cellular catabolic process	GO:0044248	372	0.109
establishment of protein localization	GO:0045184	163	0.109
post embryonic appendage morphogenesis	GO:0035120	385	0.100
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.100
muscle structure development	GO:0061061	224	0.098
regionalization	GO:0003002	416	0.096
larval development	GO:0002164	104	0.094
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.094
intracellular mrna localization involved in anterior posterior axis specification	GO:0060811	53	0.092
oocyte construction	GO:0007308	112	0.091
ras protein signal transduction	GO:0007265	88	0.090
actin filament based process	GO:0030029	220	0.084
oocyte axis specification	GO:0007309	108	0.082
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.082
cellular protein modification process	GO:0006464	438	0.082
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.081
organic substance transport	GO:0071702	257	0.079
positive regulation of macromolecule metabolic process	GO:0010604	405	0.079
spindle organization	GO:0007051	253	0.079
macromolecular complex assembly	GO:0065003	256	0.078
protein targeting	GO:0006605	64	0.077
oocyte differentiation	GO:0009994	145	0.074
intracellular transport	GO:0046907	228	0.073
cytoskeleton dependent cytokinesis	GO:0061640	81	0.071
nucleotide metabolic process	GO:0009117	161	0.068
dna damage checkpoint	GO:0000077	78	0.066
mitotic g2 dna damage checkpoint	GO:0007095	69	0.066
digestive system development	GO:0055123	149	0.065
anterior posterior axis specification embryo	GO:0008595	103	0.064
regulation of cellular localization	GO:0060341	136	0.064
regulation of protein transport	GO:0051223	57	0.063
eye morphogenesis	GO:0048592	260	0.062
nephron tubule morphogenesis	GO:0072078	3	0.061
cellular macromolecular complex assembly	GO:0034622	153	0.061
detection of light stimulus	GO:0009583	58	0.060	Fly
cell cell junction organization	GO:0045216	55	0.059
response to light stimulus	GO:0009416	124	0.057	Fly
regulation of intracellular protein transport	GO:0033157	46	0.056
glycosyl compound metabolic process	GO:1901657	127	0.055
regulation of cell cycle	GO:0051726	291	0.054
pole plasm mrna localization	GO:0019094	49	0.054
blastoderm segmentation	GO:0007350	159	0.054
developmental growth	GO:0048589	280	0.053
regulation of catalytic activity	GO:0050790	185	0.053
male gamete generation	GO:0048232	201	0.052
regulation of multicellular organismal development	GO:2000026	414	0.051
cell proliferation	GO:0008283	299	0.050
cell migration	GO:0016477	238	0.050
intracellular protein transport	GO:0006886	104	0.050
regulation of cell shape	GO:0008360	113	0.049
mitotic cytokinesis	GO:0000281	50	0.048
ribose phosphate metabolic process	GO:0019693	145	0.048
proteolysis	GO:0006508	192	0.047
chromosome segregation	GO:0007059	157	0.047
regulation of protein metabolic process	GO:0051246	256	0.047
small gtpase mediated signal transduction	GO:0007264	88	0.046
kidney development	GO:0001822	3	0.045
embryonic development via the syncytial blastoderm	GO:0001700	148	0.045
negative regulation of gene expression	GO:0010629	387	0.044
epidermis development	GO:0008544	65	0.044
imaginal disc derived wing morphogenesis	GO:0007476	337	0.044
regulation of phosphate metabolic process	GO:0019220	210	0.043
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.042
establishment or maintenance of apical basal cell polarity	GO:0035088	34	0.042
nephron development	GO:0072006	3	0.042
ubiquitin dependent protein catabolic process	GO:0006511	78	0.041
regulation of synaptic transmission	GO:0050804	69	0.041
kidney morphogenesis	GO:0060993	3	0.041
cellular nitrogen compound catabolic process	GO:0044270	165	0.040
axon development	GO:0061564	297	0.039
extracellular matrix organization	GO:0030198	32	0.039
rna localization	GO:0006403	115	0.039
organic substance catabolic process	GO:1901575	308	0.038
response to biotic stimulus	GO:0009607	294	0.038
regulation of vesicle mediated transport	GO:0060627	59	0.038
apical junction assembly	GO:0043297	32	0.038
small molecule metabolic process	GO:0044281	305	0.037
nephron epithelium morphogenesis	GO:0072088	3	0.037
regulation of intracellular signal transduction	GO:1902531	236	0.037
developmental maturation	GO:0021700	172	0.036
ribonucleotide catabolic process	GO:0009261	109	0.035
actin cytoskeleton organization	GO:0030036	206	0.035
establishment of planar polarity	GO:0001736	87	0.035
organelle localization	GO:0051640	148	0.035
purine ribonucleoside catabolic process	GO:0046130	112	0.035
positive regulation of intracellular protein transport	GO:0090316	30	0.035
regulation of growth	GO:0040008	233	0.034
negative regulation of cell differentiation	GO:0045596	143	0.034
negative regulation of developmental growth	GO:0048640	64	0.034
regulation of immune system process	GO:0002682	176	0.034
wing disc morphogenesis	GO:0007472	344	0.034
single organism membrane organization	GO:0044802	93	0.033
regulation of cellular component biogenesis	GO:0044087	201	0.033
modification dependent macromolecule catabolic process	GO:0043632	79	0.033
purine nucleoside catabolic process	GO:0006152	112	0.032
regulation of developmental growth	GO:0048638	174	0.032
eye development	GO:0001654	323	0.032
response to organic substance	GO:0010033	284	0.032
anterior posterior pattern specification	GO:0009952	136	0.032
membrane organization	GO:0061024	112	0.032
negative regulation of cellular component organization	GO:0051129	108	0.031
germarium derived egg chamber formation	GO:0007293	101	0.031
regulation of molecular function	GO:0065009	217	0.031
ovarian follicle cell development	GO:0030707	248	0.030
hair cell differentiation	GO:0035315	47	0.030
germline ring canal formation	GO:0030725	13	0.030
cell cell junction assembly	GO:0007043	38	0.030
plasma membrane organization	GO:0007009	26	0.029
nucleoside triphosphate catabolic process	GO:0009143	108	0.029
protein modification process	GO:0036211	438	0.029
positive regulation of hydrolase activity	GO:0051345	78	0.029
organelle fission	GO:0048285	340	0.029
protein complex assembly	GO:0006461	200	0.029
single organism catabolic process	GO:0044712	228	0.029
regulation of protein localization	GO:0032880	76	0.028
positive regulation of catalytic activity	GO:0043085	118	0.028
regulation of intracellular transport	GO:0032386	64	0.028
positive regulation of phosphate metabolic process	GO:0045937	139	0.028
digestive tract morphogenesis	GO:0048546	127	0.028
positive regulation of phosphorus metabolic process	GO:0010562	139	0.028
negative regulation of multicellular organismal process	GO:0051241	142	0.028
ribonucleotide metabolic process	GO:0009259	145	0.027
mitotic g2 m transition checkpoint	GO:0044818	70	0.027
positive regulation of signaling	GO:0023056	243	0.027
purine nucleoside metabolic process	GO:0042278	127	0.026
positive regulation of rna metabolic process	GO:0051254	271	0.026
nucleoside phosphate catabolic process	GO:1901292	110	0.026
nucleotide catabolic process	GO:0009166	109	0.026
regulation of reproductive process	GO:2000241	54	0.026
oocyte anterior posterior axis specification	GO:0007314	72	0.026
gastrulation	GO:0007369	70	0.026
tissue morphogenesis	GO:0048729	297	0.025
columnar cuboidal epithelial cell development	GO:0002066	249	0.025
establishment of spindle localization	GO:0051293	22	0.025
axonogenesis	GO:0007409	290	0.025
sensory perception of mechanical stimulus	GO:0050954	72	0.025	Fly
cellular response to lipopolysaccharide	GO:0071222	3	0.025
organophosphate catabolic process	GO:0046434	112	0.025
cytoplasmic transport	GO:0016482	130	0.025
synapse organization	GO:0050808	196	0.024
ncrna processing	GO:0034470	30	0.024
establishment or maintenance of cytoskeleton polarity	GO:0030952	44	0.023
imaginal disc derived appendage development	GO:0048737	399	0.023
protein phosphorylation	GO:0006468	169	0.023
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.023
neurological system process	GO:0050877	358	0.023	Fly
regulation of immune response	GO:0050776	118	0.023
endocytosis	GO:0006897	310	0.023
cell maturation	GO:0048469	144	0.023
response to external biotic stimulus	GO:0043207	293	0.023
negative regulation of epithelial cell proliferation	GO:0050680	4	0.022
embryonic pattern specification	GO:0009880	174	0.022
negative regulation of response to stimulus	GO:0048585	258	0.022
tripartite regional subdivision	GO:0007351	103	0.021
appendage development	GO:0048736	401	0.021
organelle assembly	GO:0070925	198	0.021
nucleocytoplasmic transport	GO:0006913	72	0.021
apical constriction	GO:0003383	18	0.021
regulation of cellular protein metabolic process	GO:0032268	243	0.021
morphogenesis of a polarized epithelium	GO:0001738	93	0.021
positive regulation of developmental process	GO:0051094	143	0.021
sex differentiation	GO:0007548	81	0.021
adult behavior	GO:0030534	137	0.021
forebrain development	GO:0030900	2	0.021
mitotic cell cycle checkpoint	GO:0007093	88	0.020
body morphogenesis	GO:0010171	2	0.020
development of primary sexual characteristics	GO:0045137	50	0.020
regulation of endocytosis	GO:0030100	37	0.020
transcription from rna polymerase ii promoter	GO:0006366	368	0.020
circulatory system development	GO:0072359	82	0.020
regulation of cytoskeleton organization	GO:0051493	89	0.020
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	41	0.020
organic cyclic compound catabolic process	GO:1901361	168	0.020
positive regulation of transcription dna templated	GO:0045893	266	0.019
mitotic nuclear division	GO:0007067	213	0.019
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.019
ameboidal type cell migration	GO:0001667	151	0.019
cellular macromolecule catabolic process	GO:0044265	136	0.019
regulation of jnk cascade	GO:0046328	40	0.019
negative regulation of biosynthetic process	GO:0009890	277	0.018
guanosine containing compound metabolic process	GO:1901068	74	0.018
ion transport	GO:0006811	145	0.018
pole plasm assembly	GO:0007315	61	0.018
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	4	0.018
secondary metabolic process	GO:0019748	75	0.018
basement membrane organization	GO:0071711	10	0.018
establishment of protein localization to membrane	GO:0090150	11	0.018
regulation of ras protein signal transduction	GO:0046578	93	0.018
secretion	GO:0046903	109	0.018
establishment or maintenance of polarity of follicular epithelium	GO:0016334	26	0.018
notch signaling pathway	GO:0007219	120	0.018
instar larval development	GO:0002168	55	0.018
segmentation	GO:0035282	207	0.018
organonitrogen compound catabolic process	GO:1901565	128	0.018
nephron tubule development	GO:0072080	3	0.017
positive regulation of cellular component organization	GO:0051130	156	0.017
protein modification by small protein conjugation or removal	GO:0070647	106	0.017
regulation of cytoplasmic transport	GO:1903649	47	0.017
purine ribonucleotide metabolic process	GO:0009150	145	0.017
response to lipopolysaccharide	GO:0032496	4	0.017
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	73	0.017
camera type eye development	GO:0043010	4	0.017
rna splicing via transesterification reactions	GO:0000375	73	0.017
adherens junction organization	GO:0034332	27	0.017
ion homeostasis	GO:0050801	55	0.017
negative regulation of cell communication	GO:0010648	223	0.017
cellular response to dna damage stimulus	GO:0006974	223	0.017
purine containing compound catabolic process	GO:0072523	112	0.017
positive regulation of cellular catabolic process	GO:0031331	95	0.017
establishment or maintenance of epithelial cell apical basal polarity	GO:0045197	24	0.017
adherens junction assembly	GO:0034333	11	0.017
organophosphate metabolic process	GO:0019637	195	0.016
positive regulation of cellular amine metabolic process	GO:0033240	0	0.016
regulation of response to stress	GO:0080134	200	0.016
positive regulation of signal transduction	GO:0009967	223	0.016
negative regulation of developmental process	GO:0051093	201	0.016
purine ribonucleotide catabolic process	GO:0009154	109	0.016
regulation of cell morphogenesis	GO:0022604	163	0.016
neuromuscular junction development	GO:0007528	149	0.016
pronuclear migration	GO:0035046	4	0.016
positive regulation of molecular function	GO:0044093	136	0.016
gastrulation involving germ band extension	GO:0010004	36	0.015
regulation of hydrolase activity	GO:0051336	97	0.015
regulation of neuron apoptotic process	GO:0043523	16	0.015
detection of external stimulus	GO:0009581	66	0.015	Fly
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.015
chemotaxis	GO:0006935	249	0.015
nucleobase containing small molecule metabolic process	GO:0055086	174	0.015
regulation of secretion	GO:0051046	44	0.015
protein complex biogenesis	GO:0070271	201	0.015
nucleoside catabolic process	GO:0009164	112	0.015
axon guidance	GO:0007411	233	0.015
phototransduction	GO:0007602	52	0.015	Fly
antimicrobial peptide production	GO:0002775	46	0.015
eggshell formation	GO:0030703	105	0.015
single organism biosynthetic process	GO:0044711	206	0.015
purine nucleotide catabolic process	GO:0006195	109	0.015
immune system development	GO:0002520	57	0.015
phagocytosis	GO:0006909	215	0.015
vesicle organization	GO:0016050	44	0.014
molting cycle	GO:0042303	56	0.014
maintenance of protein location	GO:0045185	28	0.014
aging	GO:0007568	143	0.014
regulation of protein complex assembly	GO:0043254	42	0.014
establishment of protein localization to organelle	GO:0072594	62	0.014
oocyte microtubule cytoskeleton polarization	GO:0008103	22	0.014
response to other organism	GO:0051707	293	0.014
transmembrane transport	GO:0055085	139	0.014
nuclear import	GO:0051170	51	0.014
regulation of protein modification process	GO:0031399	112	0.014
single organism intracellular transport	GO:1902582	207	0.014
regulation of synapse structure and activity	GO:0050803	128	0.014
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.014
hematopoietic or lymphoid organ development	GO:0048534	57	0.014
positive regulation of protein metabolic process	GO:0051247	128	0.014
nucleoside phosphate metabolic process	GO:0006753	162	0.013
golgi vesicle transport	GO:0048193	27	0.013
protein localization to organelle	GO:0033365	82	0.013
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.013
regulation of neural precursor cell proliferation	GO:2000177	35	0.013
cellular response to chemical stimulus	GO:0070887	199	0.013
dorsal closure	GO:0007391	79	0.013
mating	GO:0007618	120	0.013
sensory organ morphogenesis	GO:0090596	260	0.013
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.013
intracellular protein transmembrane transport	GO:0065002	4	0.013
regulation of cell cycle process	GO:0010564	181	0.013
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.013
regulation of embryonic cell shape	GO:0016476	30	0.013
macromolecule methylation	GO:0043414	45	0.013
cellular ketone metabolic process	GO:0042180	24	0.013
purine nucleotide metabolic process	GO:0006163	146	0.012
response to radiation	GO:0009314	155	0.012	Fly
nuclear transport	GO:0051169	72	0.012
negative regulation of signal transduction	GO:0009968	206	0.012
regulation of microtubule cytoskeleton organization	GO:0070507	41	0.012
heterocycle catabolic process	GO:0046700	166	0.012
regulation of cell proliferation	GO:0042127	163	0.012
rrna processing	GO:0006364	3	0.012
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.012
nucleoside triphosphate metabolic process	GO:0009141	120	0.012
regulation of cellular catabolic process	GO:0031329	157	0.012
regulation of phosphorus metabolic process	GO:0051174	210	0.012
wnt signaling pathway	GO:0016055	98	0.012
purine containing compound metabolic process	GO:0072521	155	0.012
negative regulation of cellular metabolic process	GO:0031324	382	0.012
intracellular signal transduction	GO:0035556	300	0.012
gastrulation with mouth forming first	GO:0001703	36	0.012
regulation of mrna processing	GO:0050684	71	0.012
single organism behavior	GO:0044708	391	0.012
establishment of tissue polarity	GO:0007164	87	0.012
actin filament polymerization	GO:0030041	27	0.012
endoderm formation	GO:0001706	3	0.012
chaeta development	GO:0022416	97	0.012
endomembrane system organization	GO:0010256	119	0.012
retina morphogenesis in camera type eye	GO:0060042	2	0.012
actin filament based movement	GO:0030048	26	0.011
ribonucleoside catabolic process	GO:0042454	112	0.011
macromolecule catabolic process	GO:0009057	161	0.011
cellular response to carbon dioxide	GO:0071244	2	0.011
male meiosis cytokinesis	GO:0007112	26	0.011
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.011
female germline ring canal formation	GO:0007301	9	0.011
apical protein localization	GO:0045176	5	0.011
activation of jun kinase activity	GO:0007257	3	0.011
cellular ion homeostasis	GO:0006873	39	0.011
protein import into nucleus	GO:0006606	51	0.011
muscle organ development	GO:0007517	127	0.011
regulation of establishment of protein localization	GO:0070201	61	0.011
spindle localization	GO:0051653	22	0.011
positive regulation of response to stimulus	GO:0048584	323	0.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.011
morphogenesis of follicular epithelium	GO:0016333	36	0.010
mitotic cell cycle phase transition	GO:0044772	138	0.010
immune system process	GO:0002376	347	0.010
positive regulation of apoptotic cell clearance	GO:2000427	2	0.010
regulation of mrna 3 end processing	GO:0031440	7	0.010
cytoplasm organization	GO:0007028	64	0.010
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.010
gland development	GO:0048732	191	0.010
epithelial tube morphogenesis	GO:0060562	88	0.010
actin polymerization or depolymerization	GO:0008154	31	0.010
nuclear division	GO:0000280	332	0.010
cellular protein complex assembly	GO:0043623	71	0.010
catabolic process	GO:0009056	409	0.010

Patj disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.171
nervous system disease	DOID:863	0.019
disease of cellular proliferation	DOID:14566	0.014

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