IMP: Integrative Multi-species Prediction

Drosophila melanogaster

35 known processes

pds5 (Dmel_CG17509)

CG17509 gene product from transcript CG17509-RA

(Aliases: l(2)k13312,Dmel\CG17509,CG17509,anon-WO0118547.183,dPds5,Pds5)

Entrez: 36286
FLYBASE: FBgn0260012
UniProtKB: A1Z8S6

Process Predictions
Disease Predictions

pds5 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
chromosome organization	GO:0051276	360	0.722
eggshell formation	GO:0030703	105	0.557
chromatin organization	GO:0006325	207	0.383
eggshell chorion assembly	GO:0007306	66	0.326
heterochromatin organization	GO:0070828	25	0.322
dna amplification	GO:0006277	11	0.249
nuclear body organization	GO:0030575	6	0.227
telomere capping	GO:0016233	11	0.211
chromosome segregation	GO:0007059	157	0.205
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.200
chromatin modification	GO:0016568	147	0.191
negative regulation of cellular metabolic process	GO:0031324	382	0.189
centrosome duplication	GO:0051298	121	0.182
regulation of reproductive process	GO:2000241	54	0.163
transcription from rna polymerase ii promoter	GO:0006366	368	0.154
regulation of nurse cell apoptotic process	GO:0045477	9	0.149
negative regulation of rna biosynthetic process	GO:1902679	240	0.144
dna endoreduplication	GO:0042023	22	0.141
negative regulation of cellular biosynthetic process	GO:0031327	277	0.140
aging	GO:0007568	143	0.126
muscle structure development	GO:0061061	224	0.126
regulation of cell cycle	GO:0051726	291	0.125
embryonic axis specification	GO:0000578	107	0.124
defense response to bacterium	GO:0042742	178	0.121
axon guidance	GO:0007411	233	0.121
defense response to other organism	GO:0098542	225	0.118
dna conformation change	GO:0071103	105	0.116
organic substance catabolic process	GO:1901575	308	0.115
organelle fission	GO:0048285	340	0.114
negative regulation of cell cycle	GO:0045786	116	0.114
negative regulation of cell cycle phase transition	GO:1901988	103	0.114
cell cycle checkpoint	GO:0000075	95	0.112
protein modification process	GO:0036211	438	0.108
establishment of organelle localization	GO:0051656	122	0.107
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.100
rna localization	GO:0006403	115	0.097
dendrite morphogenesis	GO:0048813	199	0.095
regulation of cell cycle process	GO:0010564	181	0.095
defense response	GO:0006952	300	0.095
immune response	GO:0006955	246	0.093
larval development	GO:0002164	104	0.088
dna metabolic process	GO:0006259	227	0.087
neuron projection guidance	GO:0097485	241	0.087
spindle organization	GO:0007051	253	0.087
multicellular organismal reproductive behavior	GO:0033057	110	0.084
negative regulation of gene expression	GO:0010629	387	0.084
axon cargo transport	GO:0008088	29	0.082
sex differentiation	GO:0007548	81	0.081
heterochromatin organization involved in chromatin silencing	GO:0070868	9	0.081
negative regulation of neuroblast proliferation	GO:0007406	27	0.080
regulation of mitotic cell cycle	GO:0007346	190	0.080
positive regulation of dna endoreduplication	GO:0032877	4	0.077
innate immune response	GO:0045087	144	0.075
forebrain development	GO:0030900	2	0.072
anterior posterior axis specification	GO:0009948	109	0.072
chorion containing eggshell formation	GO:0007304	105	0.072
immune system process	GO:0002376	347	0.071
organelle localization	GO:0051640	148	0.070
negative regulation of mitotic cell cycle	GO:0045930	109	0.070
regulation of multicellular organismal development	GO:2000026	414	0.067
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.066
epithelial cell development	GO:0002064	274	0.066
cellular protein modification process	GO:0006464	438	0.066
karyosome formation	GO:0030717	22	0.065
developmental growth	GO:0048589	280	0.062
microtubule based transport	GO:0010970	42	0.062
chromatin assembly or disassembly	GO:0006333	52	0.060
heterochromatin assembly	GO:0031507	13	0.059
establishment of localization in cell	GO:0051649	402	0.059
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.058
centrosome cycle	GO:0007098	137	0.058
response to bacterium	GO:0009617	198	0.056
mitotic sister chromatid segregation	GO:0000070	87	0.055
mitotic chromosome condensation	GO:0007076	22	0.055
cell cycle dna replication	GO:0044786	23	0.054
meiotic nuclear division	GO:0007126	151	0.053
negative regulation of neurogenesis	GO:0050768	53	0.052
catabolic process	GO:0009056	409	0.051
defense response to gram negative bacterium	GO:0050829	94	0.050
regulation of cell cycle phase transition	GO:1901987	130	0.050
negative regulation of cell cycle process	GO:0010948	109	0.049
regulation of heterochromatin assembly	GO:0031445	8	0.049
negative regulation of rna metabolic process	GO:0051253	251	0.048
chromatin remodeling	GO:0006338	72	0.048
meiotic cell cycle	GO:0051321	171	0.048
segmentation	GO:0035282	207	0.048
mitotic dna damage checkpoint	GO:0044773	74	0.047
eggshell chorion gene amplification	GO:0007307	9	0.047
sister chromatid segregation	GO:0000819	92	0.046
anterior posterior pattern specification	GO:0009952	136	0.046
regulation of protein metabolic process	GO:0051246	256	0.046
homeostatic process	GO:0042592	199	0.046
protein secretion	GO:0009306	45	0.046
dendrite development	GO:0016358	204	0.045
macromolecular complex assembly	GO:0065003	256	0.045
macromolecule catabolic process	GO:0009057	161	0.044
mitotic cell cycle checkpoint	GO:0007093	88	0.044
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.043
centrosome organization	GO:0051297	163	0.043
embryo development ending in birth or egg hatching	GO:0009792	152	0.042
cellular catabolic process	GO:0044248	372	0.041
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.040
negative regulation of developmental process	GO:0051093	201	0.040
locomotory behavior	GO:0007626	176	0.039
covalent chromatin modification	GO:0016569	106	0.039
chromatin silencing	GO:0006342	76	0.039
cell cycle phase transition	GO:0044770	140	0.039
tripartite regional subdivision	GO:0007351	103	0.039
positive regulation of cell projection organization	GO:0031346	29	0.038
oocyte dorsal ventral axis specification	GO:0007310	34	0.038
secretion	GO:0046903	109	0.038
mitotic spindle organization	GO:0007052	220	0.037
dna repair	GO:0006281	54	0.037
neuron maturation	GO:0042551	31	0.037
response to other organism	GO:0051707	293	0.037
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.037
mitotic cell cycle embryonic	GO:0045448	38	0.036
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.036
protein catabolic process	GO:0030163	101	0.035
nucleobase containing compound catabolic process	GO:0034655	165	0.035
chromatin assembly	GO:0031497	48	0.035
protein phosphorylation	GO:0006468	169	0.034
mitotic sister chromatid cohesion	GO:0007064	6	0.034
developmental maturation	GO:0021700	172	0.034
response to nutrient levels	GO:0031667	114	0.033
cellular homeostasis	GO:0019725	80	0.033
ovarian follicle cell development	GO:0030707	248	0.033
nucleosome mobilization	GO:0042766	9	0.033
cellular response to dna damage stimulus	GO:0006974	223	0.032
growth	GO:0040007	359	0.032
cation homeostasis	GO:0055080	51	0.032
positive regulation of response to stimulus	GO:0048584	323	0.031
regulation of phosphatase activity	GO:0010921	3	0.031
cellular nitrogen compound catabolic process	GO:0044270	165	0.030
lateral inhibition	GO:0046331	206	0.030
mitotic cell cycle phase transition	GO:0044772	138	0.030
histone h4 k20 methylation	GO:0034770	4	0.030
axonogenesis	GO:0007409	290	0.029
peptidyl lysine methylation	GO:0018022	16	0.029
dna packaging	GO:0006323	91	0.029
intracellular mrna localization	GO:0008298	66	0.029
synaptic transmission	GO:0007268	288	0.029
organophosphate metabolic process	GO:0019637	195	0.029
oocyte differentiation	GO:0009994	145	0.028
vesicle localization	GO:0051648	55	0.028
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.028
chromosome condensation	GO:0030261	41	0.027
rna processing	GO:0006396	147	0.027
peptidyl lysine trimethylation	GO:0018023	6	0.027
negative regulation of chromosome organization	GO:2001251	19	0.027
regulation of chromatin assembly	GO:0010847	9	0.026
mrna metabolic process	GO:0016071	124	0.026
germarium derived oocyte fate determination	GO:0007294	26	0.026
response to biotic stimulus	GO:0009607	294	0.026
cytoskeleton dependent intracellular transport	GO:0030705	44	0.025
establishment of mitochondrion localization	GO:0051654	7	0.025
neurological system process	GO:0050877	358	0.025
regulation of nervous system development	GO:0051960	248	0.025
cellular macromolecule catabolic process	GO:0044265	136	0.025
atp metabolic process	GO:0046034	49	0.024
reproductive behavior	GO:0019098	122	0.024
positive regulation of gene expression	GO:0010628	290	0.024
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.024
cell maturation	GO:0048469	144	0.024
muscle organ development	GO:0007517	127	0.023
response to external biotic stimulus	GO:0043207	293	0.023
regulation of innate immune response	GO:0045088	71	0.023
meiotic chromosome segregation	GO:0045132	59	0.023
nuclear migration	GO:0007097	20	0.023
neuroblast differentiation	GO:0014016	29	0.023
dna integrity checkpoint	GO:0031570	81	0.023
regulation of mrna metabolic process	GO:1903311	72	0.021
reproductive structure development	GO:0048608	74	0.021
stem cell differentiation	GO:0048863	117	0.021
methylation	GO:0032259	47	0.021
single organism behavior	GO:0044708	391	0.021
post embryonic appendage morphogenesis	GO:0035120	385	0.021
oocyte localization involved in germarium derived egg chamber formation	GO:0030720	12	0.020
establishment of spindle localization	GO:0051293	22	0.020
organic cyclic compound catabolic process	GO:1901361	168	0.020
regulation of multi organism process	GO:0043900	131	0.020
single organism biosynthetic process	GO:0044711	206	0.020
mrna catabolic process	GO:0006402	33	0.020
purine ribonucleotide catabolic process	GO:0009154	109	0.020
mitotic g2 dna damage checkpoint	GO:0007095	69	0.020
mitotic sister chromatid separation	GO:0051306	30	0.020
anterior posterior axis specification embryo	GO:0008595	103	0.020
stem cell proliferation	GO:0072089	88	0.019
positive regulation of biosynthetic process	GO:0009891	316	0.019
regulation of immune response	GO:0050776	118	0.019
heterocycle catabolic process	GO:0046700	166	0.019
taxis	GO:0042330	304	0.019
sensory organ precursor cell division	GO:0045035	10	0.019
positive regulation of heterochromatin assembly	GO:0031453	5	0.018
nuclear division	GO:0000280	332	0.018
torso signaling pathway	GO:0008293	21	0.018
negative regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032435	16	0.018
regulation of immune system process	GO:0002682	176	0.018
pole plasm mrna localization	GO:0019094	49	0.018
rhythmic process	GO:0048511	106	0.018
transition metal ion homeostasis	GO:0055076	17	0.017
columnar cuboidal epithelial cell development	GO:0002066	249	0.017
regulation of defense response	GO:0031347	102	0.017
response to abiotic stimulus	GO:0009628	341	0.017
regulation of protein catabolic process	GO:0042176	55	0.017
mitotic dna integrity checkpoint	GO:0044774	75	0.017
adult locomotory behavior	GO:0008344	76	0.017
cellular response to chemical stimulus	GO:0070887	199	0.017
negative regulation of gene expression epigenetic	GO:0045814	77	0.017
positive regulation of cell communication	GO:0010647	250	0.017
central nervous system development	GO:0007417	201	0.017
memory	GO:0007613	94	0.016
regulation of necrotic cell death	GO:0010939	1	0.016
imaginal disc derived wing vein specification	GO:0007474	48	0.016
multicellular organismal aging	GO:0010259	140	0.016
response to sterol	GO:0036314	34	0.016
female meiotic division	GO:0007143	70	0.016
response to ecdysone	GO:0035075	34	0.016
regulation of chromosome organization	GO:0033044	64	0.015
secretion by cell	GO:0032940	101	0.015
positive regulation of macromolecule metabolic process	GO:0010604	405	0.015
response to alcohol	GO:0097305	95	0.015
mitotic nuclear division	GO:0007067	213	0.015
single organism intracellular transport	GO:1902582	207	0.015
dorsal ventral pattern formation	GO:0009953	133	0.015
salivary gland histolysis	GO:0035070	88	0.015
gland development	GO:0048732	191	0.015
histone lysine methylation	GO:0034968	32	0.015
ncrna metabolic process	GO:0034660	43	0.015
multi organism behavior	GO:0051705	175	0.014
endomembrane system organization	GO:0010256	119	0.014
leucine import	GO:0060356	3	0.014
signal transduction in response to dna damage	GO:0042770	3	0.014
oviposition	GO:0018991	19	0.014
aromatic compound catabolic process	GO:0019439	166	0.014
regulation of mitotic sister chromatid segregation	GO:0033047	28	0.014
cellular response to organic cyclic compound	GO:0071407	32	0.014
negative regulation of multicellular organismal process	GO:0051241	142	0.014
histone methylation	GO:0016571	40	0.014
chromosome organization involved in meiosis	GO:0070192	10	0.014
nurse cell apoptotic process	GO:0045476	17	0.014
telomere maintenance	GO:0000723	21	0.014
histolysis	GO:0007559	102	0.014
death	GO:0016265	284	0.014
peptidyl amino acid modification	GO:0018193	105	0.014
positive regulation of multicellular organismal process	GO:0051240	143	0.014
regulation of cellular protein metabolic process	GO:0032268	243	0.013
response to extracellular stimulus	GO:0009991	116	0.013
eye photoreceptor cell fate commitment	GO:0042706	37	0.013
regulation of cell differentiation	GO:0045595	302	0.013
regulation of cell development	GO:0060284	215	0.013
regulation of neuron projection development	GO:0010975	69	0.013
stem cell development	GO:0048864	79	0.013
macromolecule methylation	GO:0043414	45	0.013
peptidyl lysine modification	GO:0018205	57	0.013
neural precursor cell proliferation	GO:0061351	75	0.013
cellular response to external stimulus	GO:0071496	66	0.013
positive regulation of axonogenesis	GO:0050772	2	0.013
regulation of cellular catabolic process	GO:0031329	157	0.013
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	11	0.013
metaphase anaphase transition of cell cycle	GO:0044784	28	0.012
nucleoside triphosphate catabolic process	GO:0009143	108	0.012
fusome organization	GO:0045478	13	0.012
chemical homeostasis	GO:0048878	92	0.012
cell proliferation	GO:0008283	299	0.012
regulation of response to stress	GO:0080134	200	0.012
phagocytosis	GO:0006909	215	0.012
sister chromatid cohesion	GO:0007062	18	0.012
metal ion homeostasis	GO:0055065	44	0.012
gene silencing	GO:0016458	138	0.012
positive regulation of cellular catabolic process	GO:0031331	95	0.012
ion homeostasis	GO:0050801	55	0.012
histone modification	GO:0016570	106	0.012
regulation of transcription by chromatin organization	GO:0034401	3	0.012
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	4	0.012
regulation of organelle organization	GO:0033043	196	0.012
single organism cellular localization	GO:1902580	180	0.012
positive regulation of cell death	GO:0010942	69	0.012
oxoacid metabolic process	GO:0043436	103	0.011
regulation of neurogenesis	GO:0050767	158	0.011
pirna metabolic process	GO:0034587	10	0.011
intracellular steroid hormone receptor signaling pathway	GO:0030518	12	0.011
vesicle mediated transport	GO:0016192	381	0.011
negative regulation of homeostatic process	GO:0032845	2	0.011
positive regulation of rna biosynthetic process	GO:1902680	266	0.011
semaphorin plexin signaling pathway	GO:0071526	4	0.011
body morphogenesis	GO:0010171	2	0.011
regulation of microtubule cytoskeleton organization	GO:0070507	41	0.011
nucleus localization	GO:0051647	34	0.011
response to monosaccharide	GO:0034284	4	0.011
purine nucleotide metabolic process	GO:0006163	146	0.011
establishment or maintenance of cell polarity	GO:0007163	167	0.011
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.011
anion transport	GO:0006820	41	0.011
pole plasm oskar mrna localization	GO:0045451	46	0.011
imaginal disc derived wing morphogenesis	GO:0007476	337	0.011
head development	GO:0060322	135	0.011
oxidation reduction process	GO:0055114	123	0.010
spindle assembly involved in meiosis	GO:0090306	20	0.010
immune system development	GO:0002520	57	0.010
proteolysis	GO:0006508	192	0.010
negative regulation of innate immune response	GO:0045824	30	0.010
regulation of centrosome cycle	GO:0046605	7	0.010
lymph gland development	GO:0048542	28	0.010
epithelial cell differentiation	GO:0030855	322	0.010
organonitrogen compound metabolic process	GO:1901564	318	0.010
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.010
intracellular mrna localization involved in anterior posterior axis specification	GO:0060811	53	0.010
axis specification	GO:0009798	167	0.010
regulation of catabolic process	GO:0009894	170	0.010
negative regulation of cell differentiation	GO:0045596	143	0.010
protein modification by small protein conjugation	GO:0032446	79	0.010
positive regulation of cellular protein metabolic process	GO:0032270	118	0.010
wing disc morphogenesis	GO:0007472	344	0.010
dendrite guidance	GO:0070983	21	0.010
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.010
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.010
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.010
sensory perception of sound	GO:0007605	56	0.010

pds5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	cardiovascular system disease	DOID:1287	0	0.014
	disease of anatomical entity	DOID:7	0	0.014

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