IMP: Integrative Multi-species Prediction

Drosophila melanogaster

37 known processes

Pros54 (Dmel_CG7619)

Proteasome 54kD subunit

(Aliases: 7619,S5A,Rpn10/p54,CG7619,DmS5a,S5a,Dmel\CG7619,dRpn10,p54,Rpn10,mu-54)

FLYBASE: FBgn0015283
Entrez: 40388
UniProtKB: M9PIG8
UniProtKB: P55035

Process Predictions
Disease Predictions

Pros54 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
mitotic spindle organization	GO:0007052	220	0.976
spindle assembly	GO:0051225	80	0.906
proteolysis	GO:0006508	192	0.900
spindle assembly involved in mitosis	GO:0090307	50	0.809
modification dependent protein catabolic process	GO:0019941	78	0.650	Yeast Worm
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.624
mitotic spindle elongation	GO:0000022	81	0.621
cellular protein complex assembly	GO:0043623	71	0.610
mitotic nuclear division	GO:0007067	213	0.608
spindle elongation	GO:0051231	83	0.566
regulation of molecular function	GO:0065009	217	0.496
modification dependent macromolecule catabolic process	GO:0043632	79	0.474	Yeast Worm
microtubule cytoskeleton organization involved in mitosis	GO:1902850	52	0.474
catabolic process	GO:0009056	409	0.461	Yeast Worm
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.433	Yeast Worm
ubiquitin dependent protein catabolic process	GO:0006511	78	0.413	Yeast Worm
proteasomal protein catabolic process	GO:0010498	59	0.384
cellular catabolic process	GO:0044248	372	0.347	Yeast Worm
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.336
spindle organization	GO:0007051	253	0.323
organelle assembly	GO:0070925	198	0.313
chromosome segregation	GO:0007059	157	0.312
protein complex assembly	GO:0006461	200	0.304
negative regulation of biosynthetic process	GO:0009890	277	0.297
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.288
negative regulation of cellular biosynthetic process	GO:0031327	277	0.283
protein complex biogenesis	GO:0070271	201	0.280
regulation of catabolic process	GO:0009894	170	0.272
taxis	GO:0042330	304	0.255
positive regulation of molecular function	GO:0044093	136	0.247
negative regulation of cellular metabolic process	GO:0031324	382	0.245
protein modification by small protein conjugation	GO:0032446	79	0.204
protein catabolic process	GO:0030163	101	0.196	Yeast Worm
epithelial cell development	GO:0002064	274	0.194
negative regulation of signaling	GO:0023057	219	0.188
chromosome organization	GO:0051276	360	0.174
dna repair	GO:0006281	54	0.167
organic substance catabolic process	GO:1901575	308	0.166	Yeast Worm
nucleotide metabolic process	GO:0009117	161	0.165
organelle fission	GO:0048285	340	0.164
protein modification process	GO:0036211	438	0.159
mitotic sister chromatid segregation	GO:0000070	87	0.152
response to light stimulus	GO:0009416	124	0.151
regulation of endopeptidase activity	GO:0052548	36	0.140
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.138
nuclear division	GO:0000280	332	0.137
heterocycle catabolic process	GO:0046700	166	0.133
ribose phosphate metabolic process	GO:0019693	145	0.132
defense response	GO:0006952	300	0.131
nucleoside triphosphate metabolic process	GO:0009141	120	0.131
regulation of proteolysis	GO:0030162	87	0.130
nucleobase containing small molecule metabolic process	GO:0055086	174	0.127
positive regulation of hydrolase activity	GO:0051345	78	0.124
purine ribonucleotide catabolic process	GO:0009154	109	0.124
positive regulation of macromolecule metabolic process	GO:0010604	405	0.117
small molecule metabolic process	GO:0044281	305	0.115
protein ubiquitination	GO:0016567	70	0.113
hematopoietic or lymphoid organ development	GO:0048534	57	0.112
purine containing compound catabolic process	GO:0072523	112	0.110
organophosphate catabolic process	GO:0046434	112	0.109
protein modification by small protein conjugation or removal	GO:0070647	106	0.109
cell migration	GO:0016477	238	0.108
nucleotide catabolic process	GO:0009166	109	0.108
regulation of cellular protein metabolic process	GO:0032268	243	0.108
nucleobase containing compound catabolic process	GO:0034655	165	0.107
cell proliferation	GO:0008283	299	0.106
nuclear envelope organization	GO:0006998	7	0.105
positive regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032436	19	0.103
regulation of cellular catabolic process	GO:0031329	157	0.103
regulation of hydrolase activity	GO:0051336	97	0.098
centrosome cycle	GO:0007098	137	0.096
cellular protein modification process	GO:0006464	438	0.096
cellular macromolecule catabolic process	GO:0044265	136	0.096	Yeast Worm
columnar cuboidal epithelial cell development	GO:0002066	249	0.093
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.090
negative regulation of phosphorus metabolic process	GO:0010563	45	0.090
negative regulation of catalytic activity	GO:0043086	42	0.090
transcription from rna polymerase ii promoter	GO:0006366	368	0.088
regulation of mitotic cell cycle	GO:0007346	190	0.087
dna templated transcription elongation	GO:0006354	18	0.085
purine ribonucleotide metabolic process	GO:0009150	145	0.084
determination of adult lifespan	GO:0008340	137	0.083	Worm
macromolecule catabolic process	GO:0009057	161	0.083	Yeast Worm
ribonucleoside metabolic process	GO:0009119	127	0.083
positive regulation of proteasomal protein catabolic process	GO:1901800	20	0.082
response to radiation	GO:0009314	155	0.082
regulation of catalytic activity	GO:0050790	185	0.082
er associated ubiquitin dependent protein catabolic process	GO:0030433	3	0.080
centrosome organization	GO:0051297	163	0.080
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.078
regulation of proteasomal protein catabolic process	GO:0061136	39	0.077
cellular response to dna damage stimulus	GO:0006974	223	0.075
negative regulation of multicellular organismal process	GO:0051241	142	0.075	Worm
multicellular organismal aging	GO:0010259	140	0.075	Worm
organic cyclic compound catabolic process	GO:1901361	168	0.074
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.073
positive regulation of catabolic process	GO:0009896	105	0.072
cell cycle comprising mitosis without cytokinesis	GO:0033301	25	0.072
negative regulation of molecular function	GO:0044092	51	0.072
sister chromatid segregation	GO:0000819	92	0.070
negative regulation of signal transduction	GO:0009968	206	0.070
response to inorganic substance	GO:0010035	44	0.070
secretion by cell	GO:0032940	101	0.069
larval development	GO:0002164	104	0.069	Worm
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.069
regulation of mitosis	GO:0007088	56	0.069
negative regulation of gene expression	GO:0010629	387	0.067	Worm
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.065
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.062
neurological system process	GO:0050877	358	0.061
microtubule based transport	GO:0010970	42	0.061
cellular protein catabolic process	GO:0044257	83	0.061	Yeast Worm
anterior posterior pattern specification	GO:0009952	136	0.061
regulation of protein metabolic process	GO:0051246	256	0.059
purine ribonucleoside catabolic process	GO:0046130	112	0.059
establishment of cell polarity	GO:0030010	40	0.059
organonitrogen compound metabolic process	GO:1901564	318	0.059
neuron projection guidance	GO:0097485	241	0.059
epithelial cell differentiation	GO:0030855	322	0.059
wnt signaling pathway	GO:0016055	98	0.057
cellular macromolecular complex assembly	GO:0034622	153	0.056
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	24	0.055
purine nucleotide catabolic process	GO:0006195	109	0.054
cell death	GO:0008219	279	0.054
regulation of mitotic sister chromatid segregation	GO:0033047	28	0.054
response to organic substance	GO:0010033	284	0.053
nucleoside phosphate catabolic process	GO:1901292	110	0.053
negative regulation of cellular protein metabolic process	GO:0032269	85	0.053
embryo development ending in birth or egg hatching	GO:0009792	152	0.052
lymph gland development	GO:0048542	28	0.052
positive regulation of gene expression	GO:0010628	290	0.051
ribonucleotide catabolic process	GO:0009261	109	0.050
purine nucleoside catabolic process	GO:0006152	112	0.049
ribonucleoside catabolic process	GO:0042454	112	0.049
carbohydrate derivative catabolic process	GO:1901136	118	0.049
immune response	GO:0006955	246	0.049
nucleoside metabolic process	GO:0009116	127	0.048
cellular nitrogen compound catabolic process	GO:0044270	165	0.047
regulation of nucleoside metabolic process	GO:0009118	50	0.045
ribonucleotide metabolic process	GO:0009259	145	0.044
negative regulation of response to stimulus	GO:0048585	258	0.043
regulation of protein modification process	GO:0031399	112	0.043
single organism catabolic process	GO:0044712	228	0.043
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.042
lateral inhibition	GO:0046331	206	0.042
nucleoside phosphate metabolic process	GO:0006753	162	0.042
cellular response to chemical stimulus	GO:0070887	199	0.042
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.042
head development	GO:0060322	135	0.041
regulation of gtpase activity	GO:0043087	44	0.041
multi organism behavior	GO:0051705	175	0.041
regulation of peptidase activity	GO:0052547	39	0.041
mitotic cell cycle phase transition	GO:0044772	138	0.040
purine nucleoside metabolic process	GO:0042278	127	0.040
organonitrogen compound catabolic process	GO:1901565	128	0.039
organophosphate metabolic process	GO:0019637	195	0.039
cell type specific apoptotic process	GO:0097285	38	0.038
regulation of response to stress	GO:0080134	200	0.038
establishment of spindle localization	GO:0051293	22	0.038
central nervous system development	GO:0007417	201	0.037
glycosyl compound catabolic process	GO:1901658	112	0.037
wing disc morphogenesis	GO:0007472	344	0.037
aromatic compound catabolic process	GO:0019439	166	0.036
locomotory behavior	GO:0007626	176	0.035
dna packaging	GO:0006323	91	0.035
growth	GO:0040007	359	0.035
synaptic vesicle recycling	GO:0036465	28	0.035
sensory organ morphogenesis	GO:0090596	260	0.034
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.034
positive regulation of proteolysis	GO:0045862	52	0.033
purine ribonucleoside metabolic process	GO:0046128	127	0.033
regulation of multicellular organismal development	GO:2000026	414	0.032	Worm
gene silencing	GO:0016458	138	0.032	Worm
regulation of cell cycle	GO:0051726	291	0.032
positive regulation of transcription dna templated	GO:0045893	266	0.032
positive regulation of cellular catabolic process	GO:0031331	95	0.031
regulation of cellular component biogenesis	GO:0044087	201	0.031
gtp metabolic process	GO:0046039	72	0.031
detection of stimulus	GO:0051606	156	0.031
developmental growth	GO:0048589	280	0.030
anterior posterior axis specification	GO:0009948	109	0.030
transcription elongation from rna polymerase ii promoter	GO:0006368	18	0.029
regulation of synapse assembly	GO:0051963	94	0.029
neuromuscular synaptic transmission	GO:0007274	67	0.029
cellular component assembly involved in morphogenesis	GO:0010927	151	0.029
regulation of protein complex assembly	GO:0043254	42	0.028
regulation of phosphate metabolic process	GO:0019220	210	0.028
body morphogenesis	GO:0010171	2	0.028
purine nucleotide metabolic process	GO:0006163	146	0.027
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.026
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.026
regulation of protein catabolic process	GO:0042176	55	0.026
aging	GO:0007568	143	0.026	Worm
nucleoside catabolic process	GO:0009164	112	0.026
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.026
regulation of organ morphogenesis	GO:2000027	78	0.026
ovarian follicle cell development	GO:0030707	248	0.026
response to peptide	GO:1901652	29	0.025
blastoderm segmentation	GO:0007350	159	0.025
chemotaxis	GO:0006935	249	0.025
positive regulation of endopeptidase activity	GO:0010950	26	0.025
negative regulation of phosphate metabolic process	GO:0045936	45	0.024
double strand break repair	GO:0006302	26	0.024
nucleoside triphosphate catabolic process	GO:0009143	108	0.024
axon cargo transport	GO:0008088	29	0.024
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.024
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.024
guanosine containing compound catabolic process	GO:1901069	74	0.024
negative regulation of rna biosynthetic process	GO:1902679	240	0.023
positive regulation of nucleoside metabolic process	GO:0045979	47	0.023
cellular response to endogenous stimulus	GO:0071495	80	0.023
positive regulation of protein metabolic process	GO:0051247	128	0.023
regulation of phosphorus metabolic process	GO:0051174	210	0.023
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.023
dna metabolic process	GO:0006259	227	0.023
positive regulation of cellular protein metabolic process	GO:0032270	118	0.023
regulation of gtp catabolic process	GO:0033124	44	0.022
embryonic axis specification	GO:0000578	107	0.022
regulation of apoptotic process	GO:0042981	130	0.022
telencephalon development	GO:0021537	2	0.022
negative regulation of developmental growth	GO:0048640	64	0.022
fertilization	GO:0009566	26	0.022
death	GO:0016265	284	0.022
positive regulation of biosynthetic process	GO:0009891	316	0.021
programmed cell death	GO:0012501	257	0.021
negative regulation of cell communication	GO:0010648	223	0.021
chaperone mediated protein folding	GO:0061077	2	0.021
vesicle mediated transport	GO:0016192	381	0.021
protein deubiquitination	GO:0016579	17	0.021
appendage morphogenesis	GO:0035107	397	0.021
positive regulation of catalytic activity	GO:0043085	118	0.021
regulation of purine nucleotide catabolic process	GO:0033121	48	0.021
protein maturation	GO:0051604	71	0.020
axon guidance	GO:0007411	233	0.020
cell motility	GO:0048870	251	0.020
positive regulation of protein catabolic process	GO:0045732	34	0.020
eye development	GO:0001654	323	0.020
protein processing	GO:0016485	68	0.019
tripartite regional subdivision	GO:0007351	103	0.019
anterior posterior axis specification embryo	GO:0008595	103	0.019
response to peptide hormone	GO:0043434	29	0.019
positive regulation of phosphorus metabolic process	GO:0010562	139	0.019
mitotic g2 dna damage checkpoint	GO:0007095	69	0.018
regulation of nucleotide metabolic process	GO:0006140	62	0.018
lipid localization	GO:0010876	54	0.018
glycosyl compound metabolic process	GO:1901657	127	0.018
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.018
mitotic sister chromatid separation	GO:0051306	30	0.017
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.017
regulation of growth	GO:0040008	233	0.016
organelle localization	GO:0051640	148	0.016
negative regulation of protein metabolic process	GO:0051248	85	0.016
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.016
negative regulation of cell proliferation	GO:0008285	69	0.016
endocytosis	GO:0006897	310	0.016
chromosome separation	GO:0051304	42	0.016
protein neddylation	GO:0045116	5	0.016
regulation of innate immune response	GO:0045088	71	0.016
detection of stimulus involved in sensory perception	GO:0050906	92	0.016
protein transport	GO:0015031	155	0.016
regulation of wnt signaling pathway	GO:0030111	68	0.015
positive regulation of peptidase activity	GO:0010952	29	0.015
photoreceptor cell differentiation	GO:0046530	170	0.015
small gtpase mediated signal transduction	GO:0007264	88	0.015
positive regulation of cell death	GO:0010942	69	0.015
axon development	GO:0061564	297	0.015
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.015
microtubule organizing center organization	GO:0031023	168	0.015
striated muscle cell differentiation	GO:0051146	90	0.015
regulation of mitotic sister chromatid separation	GO:0010965	28	0.015
ras protein signal transduction	GO:0007265	88	0.015
larval behavior	GO:0030537	42	0.015
regulation of ras protein signal transduction	GO:0046578	93	0.015
cellular response to nitrogen compound	GO:1901699	51	0.015
axis specification	GO:0009798	167	0.015
protein phosphorylation	GO:0006468	169	0.015
macromolecular complex assembly	GO:0065003	256	0.015
imaginal disc derived appendage development	GO:0048737	399	0.014
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process	GO:0031145	30	0.014
maternal determination of anterior posterior axis embryo	GO:0008358	74	0.014
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	4	0.014
metaphase anaphase transition of cell cycle	GO:0044784	28	0.014
centriole assembly	GO:0098534	24	0.014
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.014
positive regulation of nucleotide metabolic process	GO:0045981	55	0.014
male gamete generation	GO:0048232	201	0.013	Worm
positive regulation of cellular biosynthetic process	GO:0031328	316	0.013
eye morphogenesis	GO:0048592	260	0.013
organic substance transport	GO:0071702	257	0.013
response to endogenous stimulus	GO:0009719	119	0.013
compound eye development	GO:0048749	307	0.013
establishment of protein localization	GO:0045184	163	0.013
regulation of programmed cell death	GO:0043067	152	0.013
chromatin organization	GO:0006325	207	0.013
transition metal ion transport	GO:0000041	16	0.013
positive regulation of rna metabolic process	GO:0051254	271	0.013
establishment or maintenance of apical basal cell polarity	GO:0035088	34	0.013
compound eye morphogenesis	GO:0001745	249	0.013
protein modification by small protein removal	GO:0070646	28	0.013
regulation of chromosome organization	GO:0033044	64	0.013
positive regulation of gtp catabolic process	GO:0033126	43	0.013
sex differentiation	GO:0007548	81	0.012
regionalization	GO:0003002	416	0.012
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.012
brain development	GO:0007420	120	0.012
positive regulation of cellular component biogenesis	GO:0044089	80	0.012
rna polymerase ii transcriptional preinitiation complex assembly	GO:0051123	20	0.012
positive regulation of rna biosynthetic process	GO:1902680	266	0.012
guanosine containing compound metabolic process	GO:1901068	74	0.012
innate immune response	GO:0045087	144	0.012
axonogenesis	GO:0007409	290	0.012
reproductive system development	GO:0061458	74	0.012
cell maturation	GO:0048469	144	0.012
tube development	GO:0035295	244	0.012
regulation of striated muscle contraction	GO:0006942	2	0.012
negative regulation of cell death	GO:0060548	81	0.012
regulation of developmental growth	GO:0048638	174	0.012
protein alkylation	GO:0008213	43	0.012
forebrain development	GO:0030900	2	0.011
rhabdomere development	GO:0042052	38	0.011
tube morphogenesis	GO:0035239	191	0.011
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.011
cellular response to organic substance	GO:0071310	132	0.011
negative regulation of protein phosphorylation	GO:0001933	17	0.011
protein secretion	GO:0009306	45	0.011
cell division	GO:0051301	248	0.011
negative regulation of defense response	GO:0031348	35	0.011
negative regulation of gene expression epigenetic	GO:0045814	77	0.011
cellular component maintenance	GO:0043954	23	0.011
protein polymerization	GO:0051258	42	0.011
ion transport	GO:0006811	145	0.011
imaginal disc derived wing morphogenesis	GO:0007476	337	0.011
centriole replication	GO:0007099	24	0.011
positive regulation of gtpase activity	GO:0043547	43	0.011
dephosphorylation	GO:0016311	51	0.011
establishment of organelle localization	GO:0051656	122	0.011
protein localization	GO:0008104	284	0.011
histone lysine methylation	GO:0034968	32	0.011
apoptotic process involved in morphogenesis	GO:0060561	3	0.010
regulation of organelle organization	GO:0033043	196	0.010
establishment of localization in cell	GO:0051649	402	0.010
purine nucleoside monophosphate catabolic process	GO:0009128	38	0.010
regulation of immune response	GO:0050776	118	0.010

Pros54 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org

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