IMP: Integrative Multi-species Prediction

Drosophila melanogaster

170 known processes

tsr (Dmel_CG4254)

twinstar

(Aliases: Adf,T8,l(2)k03101,Tsr,cofilin/actin depolymerizing factor homolog,D-cof,l(2)k05633,ADF,l(2)03101,CG4254,Cadf,cofilin/ADF,12/8,cofilin,ADF/cofilin,D61,l(2)k13409,Dmel\CG4254,ntf)

FLYBASE: FBgn0011726
Entrez: 37841
UniProtKB: P45594

Process Predictions
Disease Predictions

tsr biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
meiotic cytokinesis	GO:0033206	33	0.990
ovarian follicle cell migration	GO:0007297	121	0.986
regulation of cell differentiation	GO:0045595	302	0.984
actin filament based process	GO:0030029	220	0.983
regulation of neurogenesis	GO:0050767	158	0.978
regulation of cell development	GO:0060284	215	0.966
regulation of multicellular organismal development	GO:2000026	414	0.964
regulation of nervous system development	GO:0051960	248	0.964
gland development	GO:0048732	191	0.954
positive regulation of multicellular organismal process	GO:0051240	143	0.953
male gamete generation	GO:0048232	201	0.949
cell migration	GO:0016477	238	0.943
spermatid development	GO:0007286	98	0.925
regulation of cellular component biogenesis	GO:0044087	201	0.921
negative regulation of gene expression	GO:0010629	387	0.906
axon development	GO:0061564	297	0.894
macromolecular complex assembly	GO:0065003	256	0.885
regulation of cell projection organization	GO:0031344	92	0.871
protein complex assembly	GO:0006461	200	0.871
cell death	GO:0008219	279	0.865
dendrite development	GO:0016358	204	0.850
compound eye photoreceptor cell differentiation	GO:0001751	140	0.848
muscle cell differentiation	GO:0042692	103	0.843	Worm
embryo development ending in birth or egg hatching	GO:0009792	152	0.830	Worm
hematopoietic or lymphoid organ development	GO:0048534	57	0.821
regulation of anatomical structure morphogenesis	GO:0022603	242	0.783
regulation of neuron differentiation	GO:0045664	103	0.748
ovarian follicle cell development	GO:0030707	248	0.747
regulation of programmed cell death	GO:0043067	152	0.747
actomyosin structure organization	GO:0031032	56	0.743	Worm
cytoskeleton dependent cytokinesis	GO:0061640	81	0.739
actin cytoskeleton organization	GO:0030036	206	0.734
epithelial cell differentiation	GO:0030855	322	0.731
apoptotic process	GO:0006915	159	0.710
regulation of response to stress	GO:0080134	200	0.710
macromolecule catabolic process	GO:0009057	161	0.688	Worm
spermatogenesis	GO:0007283	200	0.685
catabolic process	GO:0009056	409	0.667	Worm
protein complex biogenesis	GO:0070271	201	0.665
regulation of apoptotic process	GO:0042981	130	0.648
regulation of protein metabolic process	GO:0051246	256	0.637
protein modification by small protein conjugation or removal	GO:0070647	106	0.627
purine ribonucleotide catabolic process	GO:0009154	109	0.624
positive regulation of developmental process	GO:0051094	143	0.620
head development	GO:0060322	135	0.587
programmed cell death	GO:0012501	257	0.568
negative regulation of multicellular organismal process	GO:0051241	142	0.560
cytokinesis	GO:0000910	90	0.544
determination of adult lifespan	GO:0008340	137	0.537	Worm
spermatid differentiation	GO:0048515	114	0.524
organonitrogen compound metabolic process	GO:1901564	318	0.519
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.510
organonitrogen compound catabolic process	GO:1901565	128	0.505
regulation of cell morphogenesis	GO:0022604	163	0.501
purine containing compound catabolic process	GO:0072523	112	0.498
cellular catabolic process	GO:0044248	372	0.495
cuticle development	GO:0042335	86	0.478
organic substance catabolic process	GO:1901575	308	0.458	Worm
eye photoreceptor cell development	GO:0042462	81	0.453
positive regulation of programmed cell death	GO:0043068	62	0.452
organophosphate catabolic process	GO:0046434	112	0.450
border follicle cell migration	GO:0007298	113	0.449
establishment of planar polarity	GO:0001736	87	0.449
positive regulation of molecular function	GO:0044093	136	0.427
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.423
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.413
compound eye photoreceptor development	GO:0042051	78	0.405
brain development	GO:0007420	120	0.404
nucleoside phosphate metabolic process	GO:0006753	162	0.398
male meiosis cytokinesis	GO:0007112	26	0.396
purine nucleotide catabolic process	GO:0006195	109	0.383
axonogenesis	GO:0007409	290	0.383
central nervous system development	GO:0007417	201	0.379
dendrite morphogenesis	GO:0048813	199	0.378
proteolysis	GO:0006508	192	0.371
nucleoside catabolic process	GO:0009164	112	0.356
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.353
striated muscle cell differentiation	GO:0051146	90	0.346	Worm
nucleoside triphosphate catabolic process	GO:0009143	108	0.342
regulation of proteolysis	GO:0030162	87	0.342
regulation of cell death	GO:0010941	173	0.337
negative regulation of rna metabolic process	GO:0051253	251	0.335
protein modification process	GO:0036211	438	0.333
death	GO:0016265	284	0.325
regulation of cytoskeleton organization	GO:0051493	89	0.318	Worm
ras protein signal transduction	GO:0007265	88	0.318
negative regulation of transcription dna templated	GO:0045892	237	0.298
ribonucleotide catabolic process	GO:0009261	109	0.295
immune system process	GO:0002376	347	0.294
regulation of response to external stimulus	GO:0032101	115	0.289
negative regulation of developmental process	GO:0051093	201	0.285
cell division	GO:0051301	248	0.278
compound eye development	GO:0048749	307	0.275
regulation of neuron projection development	GO:0010975	69	0.269
purine ribonucleoside metabolic process	GO:0046128	127	0.267
morphogenesis of an epithelium	GO:0002009	276	0.265
positive regulation of nervous system development	GO:0051962	69	0.264
oocyte microtubule cytoskeleton polarization	GO:0008103	22	0.263
cellular macromolecular complex assembly	GO:0034622	153	0.261
negative regulation of cellular component organization	GO:0051129	108	0.251
nucleoside triphosphate metabolic process	GO:0009141	120	0.247
cellular nitrogen compound catabolic process	GO:0044270	165	0.245
regulation of catalytic activity	GO:0050790	185	0.240
negative regulation of cellular metabolic process	GO:0031324	382	0.239
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.239
glycosyl compound catabolic process	GO:1901658	112	0.235
columnar cuboidal epithelial cell development	GO:0002066	249	0.225
muscle structure development	GO:0061061	224	0.214	Worm
cell maturation	GO:0048469	144	0.212
eye photoreceptor cell differentiation	GO:0001754	145	0.209
ribose phosphate metabolic process	GO:0019693	145	0.208
immune system development	GO:0002520	57	0.208
endocytosis	GO:0006897	310	0.203
growth	GO:0040007	359	0.202	Worm
compound eye morphogenesis	GO:0001745	249	0.201
hemopoiesis	GO:0030097	46	0.199
single organism intracellular transport	GO:1902582	207	0.198
regulation of molecular function	GO:0065009	217	0.193
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.192
positive regulation of macromolecule metabolic process	GO:0010604	405	0.192
cellular protein modification process	GO:0006464	438	0.192
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.191
neuron projection guidance	GO:0097485	241	0.190
negative regulation of response to stimulus	GO:0048585	258	0.189
regulation of behavior	GO:0050795	75	0.189
purine ribonucleoside catabolic process	GO:0046130	112	0.189
organophosphate metabolic process	GO:0019637	195	0.187
spermatocyte division	GO:0048137	13	0.184
regulation of cell cycle process	GO:0010564	181	0.182
nuclear migration	GO:0007097	20	0.181
positive regulation of rna biosynthetic process	GO:1902680	266	0.180
protein ubiquitination	GO:0016567	70	0.178
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.178
hemocyte differentiation	GO:0042386	38	0.173
muscle cell development	GO:0055001	50	0.172	Worm
regulation of catabolic process	GO:0009894	170	0.172
small molecule metabolic process	GO:0044281	305	0.170
regulation of gene expression epigenetic	GO:0040029	128	0.169
intracellular signal transduction	GO:0035556	300	0.168
gonad development	GO:0008406	50	0.167
regulation of actin filament based process	GO:0032970	42	0.166	Worm
cell proliferation	GO:0008283	299	0.164
regulation of intracellular signal transduction	GO:1902531	236	0.162
nucleotide metabolic process	GO:0009117	161	0.161
regulation of wnt signaling pathway	GO:0030111	68	0.160
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.160
positive regulation of cell development	GO:0010720	61	0.160
instar larval development	GO:0002168	55	0.159
gliogenesis	GO:0042063	80	0.158
positive regulation of cell death	GO:0010942	69	0.158
negative regulation of cell communication	GO:0010648	223	0.154
nucleus localization	GO:0051647	34	0.153
positive regulation of nucleoside metabolic process	GO:0045979	47	0.152
ribonucleotide metabolic process	GO:0009259	145	0.149
purine nucleotide metabolic process	GO:0006163	146	0.146
chemotaxis	GO:0006935	249	0.146
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.146
localization of cell	GO:0051674	257	0.144
regulation of organelle organization	GO:0033043	196	0.143	Worm
larval development	GO:0002164	104	0.142	Worm
ribonucleoside metabolic process	GO:0009119	127	0.142
purine containing compound metabolic process	GO:0072521	155	0.137
carbohydrate derivative catabolic process	GO:1901136	118	0.136
tissue migration	GO:0090130	155	0.135
receptor mediated endocytosis	GO:0006898	21	0.133
purine nucleoside metabolic process	GO:0042278	127	0.133
positive regulation of neurogenesis	GO:0050769	41	0.132
transcription from rna polymerase ii promoter	GO:0006366	368	0.132
positive regulation of gene expression	GO:0010628	290	0.131
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.130
developmental growth	GO:0048589	280	0.129
nucleobase containing compound catabolic process	GO:0034655	165	0.126
response to wounding	GO:0009611	94	0.125
cellular macromolecule localization	GO:0070727	220	0.124
protein transport	GO:0015031	155	0.123
negative regulation of catabolic process	GO:0009895	36	0.122
circadian rhythm	GO:0007623	105	0.121
appendage morphogenesis	GO:0035107	397	0.120
protein maturation	GO:0051604	71	0.119
protein modification by small protein conjugation	GO:0032446	79	0.119
eye development	GO:0001654	323	0.119
cell growth	GO:0016049	108	0.118
histone modification	GO:0016570	106	0.117
modification dependent macromolecule catabolic process	GO:0043632	79	0.117
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.116
positive regulation of rna metabolic process	GO:0051254	271	0.116
actin filament organization	GO:0007015	126	0.113
positive regulation of response to stimulus	GO:0048584	323	0.112
regulation of axonogenesis	GO:0050770	32	0.107
germ line cyst formation	GO:0048134	44	0.107
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.105
cell motility	GO:0048870	251	0.105
tissue morphogenesis	GO:0048729	297	0.104
regulation of organ morphogenesis	GO:2000027	78	0.103
regulation of cellular protein metabolic process	GO:0032268	243	0.103
mitotic cell cycle phase transition	GO:0044772	138	0.101
nucleoside phosphate catabolic process	GO:1901292	110	0.100
negative regulation of cell cycle	GO:0045786	116	0.099
regulation of response to wounding	GO:1903034	19	0.094
meiotic nuclear division	GO:0007126	151	0.094
carbohydrate derivative metabolic process	GO:1901135	217	0.093
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.093
microtubule organizing center organization	GO:0031023	168	0.088
cell cycle phase transition	GO:0044770	140	0.088
negative regulation of gene expression epigenetic	GO:0045814	77	0.088
negative regulation of signal transduction	GO:0009968	206	0.087
regulation of cell projection assembly	GO:0060491	30	0.086
regulation of cell cycle phase transition	GO:1901987	130	0.085
regulation of cellular component size	GO:0032535	98	0.084	Worm
salivary gland morphogenesis	GO:0007435	145	0.084
positive regulation of cell differentiation	GO:0045597	64	0.083
eye morphogenesis	GO:0048592	260	0.083
positive regulation of signaling	GO:0023056	243	0.082
multicellular organismal reproductive behavior	GO:0033057	110	0.082
regulation of protein modification process	GO:0031399	112	0.081
protein localization	GO:0008104	284	0.081
guanosine containing compound metabolic process	GO:1901068	74	0.080
salivary gland development	GO:0007431	162	0.079
regulation of developmental growth	GO:0048638	174	0.079
negative regulation of cellular catabolic process	GO:0031330	34	0.078
rna interference	GO:0016246	27	0.077
regulation of protein catabolic process	GO:0042176	55	0.076
sensory organ morphogenesis	GO:0090596	260	0.075
negative regulation of cell differentiation	GO:0045596	143	0.074
regulation of actin polymerization or depolymerization	GO:0008064	27	0.074	Worm
glycosyl compound metabolic process	GO:1901657	127	0.073
reproductive structure development	GO:0048608	74	0.073
establishment or maintenance of cell polarity	GO:0007163	167	0.072
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.070
reproductive system development	GO:0061458	74	0.070
regulation of defense response to virus by host	GO:0050691	10	0.070
guanosine containing compound catabolic process	GO:1901069	74	0.068
tube development	GO:0035295	244	0.068
protein targeting	GO:0006605	64	0.066
negative regulation of nervous system development	GO:0051961	92	0.066
pronuclear migration	GO:0035046	4	0.065
nucleoside metabolic process	GO:0009116	127	0.064
cell projection assembly	GO:0030031	94	0.064
establishment of organelle localization	GO:0051656	122	0.064
developmental programmed cell death	GO:0010623	138	0.063
organic cyclic compound catabolic process	GO:1901361	168	0.063
neuromuscular junction development	GO:0007528	149	0.063
ubiquitin dependent protein catabolic process	GO:0006511	78	0.063
regulation of locomotion	GO:0040012	42	0.063
ameboidal type cell migration	GO:0001667	151	0.063
establishment of nucleus localization	GO:0040023	26	0.061
protein catabolic process	GO:0030163	101	0.061	Worm
circulatory system development	GO:0072359	82	0.060
protein import	GO:0017038	55	0.059
cell cycle checkpoint	GO:0000075	95	0.058
cellularization	GO:0007349	90	0.058
regulation of actin filament polymerization	GO:0030833	25	0.058	Worm
meiotic cell cycle process	GO:1903046	132	0.058
regulation of actin cytoskeleton organization	GO:0032956	42	0.057	Worm
response to virus	GO:0009615	28	0.057
regulation of actin filament length	GO:0030832	27	0.056	Worm
regulation of hydrolase activity	GO:0051336	97	0.056
ribonucleoprotein complex subunit organization	GO:0071826	28	0.056
positive regulation of cell projection organization	GO:0031346	29	0.056
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.056
positive regulation of signal transduction	GO:0009967	223	0.055
covalent chromatin modification	GO:0016569	106	0.055
regulation of cell proliferation	GO:0042127	163	0.054
single organism behavior	GO:0044708	391	0.054
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.054
humoral immune response	GO:0006959	117	0.053
negative regulation of organelle organization	GO:0010639	56	0.053
regulation of endopeptidase activity	GO:0052548	36	0.051
regulation of proteasomal protein catabolic process	GO:0061136	39	0.050
germarium derived female germ line cyst formation	GO:0030727	42	0.050
organelle fission	GO:0048285	340	0.050
negative regulation of wnt signaling pathway	GO:0030178	28	0.049
epidermis development	GO:0008544	65	0.049
taxis	GO:0042330	304	0.049
histone acetylation	GO:0016573	38	0.049
regulation of growth	GO:0040008	233	0.049
regulation of cellular response to stress	GO:0080135	89	0.049
regulation of chromosome organization	GO:0033044	64	0.048
positive regulation of neuron differentiation	GO:0045666	26	0.048
negative regulation of neurotransmitter secretion	GO:0046929	2	0.048
negative regulation of apoptotic process	GO:0043066	63	0.047
regulation of establishment of protein localization	GO:0070201	61	0.047
nuclear import	GO:0051170	51	0.047
negative regulation of programmed cell death	GO:0043069	72	0.047
centrosome organization	GO:0051297	163	0.047
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.045
negative regulation of signaling	GO:0023057	219	0.045
regulation of nucleotide catabolic process	GO:0030811	48	0.045
heterocycle catabolic process	GO:0046700	166	0.045
negative regulation of cell development	GO:0010721	62	0.044
mitotic dna damage checkpoint	GO:0044773	74	0.044
epithelial cell development	GO:0002064	274	0.044
regulation of phosphorylation	GO:0042325	147	0.044
genitalia development	GO:0048806	26	0.044	Worm
purine nucleoside catabolic process	GO:0006152	112	0.044
regulation of gtpase activity	GO:0043087	44	0.043
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.043
female germ line cyst formation	GO:0048135	42	0.042
positive regulation of phosphorus metabolic process	GO:0010562	139	0.042
neuron remodeling	GO:0016322	29	0.042
positive regulation of catabolic process	GO:0009896	105	0.042
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.042
histone h4 acetylation	GO:0043967	13	0.041
cellular macromolecule catabolic process	GO:0044265	136	0.041
modification dependent protein catabolic process	GO:0019941	78	0.041
actin filament depolymerization	GO:0030042	5	0.041	Worm
regionalization	GO:0003002	416	0.041
lateral inhibition	GO:0046331	206	0.041
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.040
regulation of dendrite development	GO:0050773	37	0.040
protein targeting to nucleus	GO:0044744	51	0.040
nucleobase containing small molecule metabolic process	GO:0055086	174	0.040
positive regulation of nucleotide metabolic process	GO:0045981	55	0.040
single organism catabolic process	GO:0044712	228	0.039
cellular protein localization	GO:0034613	160	0.039
epithelium migration	GO:0090132	148	0.039
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.039
body morphogenesis	GO:0010171	2	0.039
non sensory hair organization	GO:0035316	47	0.038
negative regulation of cell cycle process	GO:0010948	109	0.038
skin development	GO:0043588	65	0.038
regulation of phosphate metabolic process	GO:0019220	210	0.038
histone deubiquitination	GO:0016578	8	0.036
ribonucleoside catabolic process	GO:0042454	112	0.036
positive regulation of proteolysis	GO:0045862	52	0.036
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.036
eggshell formation	GO:0030703	105	0.036
gland morphogenesis	GO:0022612	145	0.036
protein processing	GO:0016485	68	0.036
negative regulation of mitotic cell cycle	GO:0045930	109	0.035
positive regulation of cellular component biogenesis	GO:0044089	80	0.035	Worm
peptidyl lysine modification	GO:0018205	57	0.035
negative regulation of cell death	GO:0060548	81	0.035
protein import into nucleus	GO:0006606	51	0.034
development of primary sexual characteristics	GO:0045137	50	0.034
regulation of cell cycle	GO:0051726	291	0.034
defense response	GO:0006952	300	0.034
regulation of cellular protein catabolic process	GO:1903362	44	0.034
wing disc morphogenesis	GO:0007472	344	0.033
establishment of oocyte nucleus localization involved in oocyte dorsal ventral axis specification	GO:0030722	6	0.033
establishment of localization in cell	GO:0051649	402	0.033
positive regulation of hydrolase activity	GO:0051345	78	0.033
cognition	GO:0050890	141	0.033
positive regulation of cellular catabolic process	GO:0031331	95	0.033
negative regulation of cellular biosynthetic process	GO:0031327	277	0.032
neurological system process	GO:0050877	358	0.032
epidermal cell differentiation	GO:0009913	51	0.031
gene silencing	GO:0016458	138	0.031
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.030
purine ribonucleotide metabolic process	GO:0009150	145	0.030
establishment of spindle orientation	GO:0051294	18	0.030
meiotic cell cycle	GO:0051321	171	0.030
mitotic cytokinesis	GO:0000281	50	0.030
positive regulation of cytoskeleton organization	GO:0051495	21	0.030	Worm
positive regulation of intracellular signal transduction	GO:1902533	116	0.030
positive regulation of multi organism process	GO:0043902	40	0.030
regulation of peptidase activity	GO:0052547	39	0.029
ncrna metabolic process	GO:0034660	43	0.029
oviposition	GO:0018991	19	0.029
proteasomal protein catabolic process	GO:0010498	59	0.029
regulation of canonical wnt signaling pathway	GO:0060828	15	0.029
regulation of localization	GO:0032879	275	0.028
positive regulation of protein metabolic process	GO:0051247	128	0.028
multi organism behavior	GO:0051705	175	0.028
regulation of gtp catabolic process	GO:0033124	44	0.028
positive regulation of defense response to virus by host	GO:0002230	10	0.028
positive regulation of ribosome biogenesis	GO:0090070	3	0.027
positive regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032436	19	0.027
positive regulation of cell cycle	GO:0045787	43	0.026
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.026
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	12	0.026
protein localization to plasma membrane	GO:0072659	13	0.026
antimicrobial humoral response	GO:0019730	99	0.026
establishment or maintenance of apical basal cell polarity	GO:0035088	34	0.026
positive regulation of transcription dna templated	GO:0045893	266	0.026
negative regulation of protein processing	GO:0010955	31	0.026
regulation of r7 cell differentiation	GO:0045676	15	0.026
cellular protein catabolic process	GO:0044257	83	0.026
regulation of purine nucleotide metabolic process	GO:1900542	62	0.024
positive regulation of catalytic activity	GO:0043085	118	0.024
vesicle mediated transport	GO:0016192	381	0.024
positive regulation of biosynthetic process	GO:0009891	316	0.024
membrane organization	GO:0061024	112	0.024
regulation of phosphorus metabolic process	GO:0051174	210	0.024
exocrine system development	GO:0035272	162	0.024
regulation of anatomical structure size	GO:0090066	163	0.024	Worm
rna processing	GO:0006396	147	0.024
nucleotide catabolic process	GO:0009166	109	0.024
negative regulation of catalytic activity	GO:0043086	42	0.024
small gtpase mediated signal transduction	GO:0007264	88	0.023
morphogenesis of a branching structure	GO:0001763	45	0.023
regulation of cellular component movement	GO:0051270	42	0.023
neuron maturation	GO:0042551	31	0.023
regulation of dendrite morphogenesis	GO:0048814	28	0.022
oocyte construction	GO:0007308	112	0.022
regulation of cysteine type endopeptidase activity	GO:2000116	27	0.022
lipid storage	GO:0019915	38	0.022
sex differentiation	GO:0007548	81	0.022
axon guidance	GO:0007411	233	0.022
striated muscle myosin thick filament assembly	GO:0071688	3	0.022
organic substance transport	GO:0071702	257	0.021
rna splicing	GO:0008380	83	0.021
chromatin organization	GO:0006325	207	0.021
appendage development	GO:0048736	401	0.021
posttranscriptional gene silencing	GO:0016441	46	0.021
dephosphorylation	GO:0016311	51	0.021
response to oxygen containing compound	GO:1901700	200	0.021
imaginal disc derived wing hair organization	GO:0035317	45	0.021
regulation of sister chromatid cohesion	GO:0007063	2	0.020
positive regulation of peptidase activity	GO:0010952	29	0.020
positive regulation of protein import into nucleus translocation	GO:0033160	2	0.020
regulation of cell migration	GO:0030334	22	0.019
glial cell migration	GO:0008347	31	0.019
secretion	GO:0046903	109	0.019
positive regulation of cell communication	GO:0010647	250	0.019
negative regulation of protein metabolic process	GO:0051248	85	0.019
response to starvation	GO:0042594	97	0.018
positive regulation of apoptotic process	GO:0043065	47	0.018
response to extracellular stimulus	GO:0009991	116	0.018
response to nutrient levels	GO:0031667	114	0.018
autophagy	GO:0006914	108	0.018
regulation of protein phosphorylation	GO:0001932	64	0.018
negative regulation of cell proliferation	GO:0008285	69	0.018
regulation of jnk cascade	GO:0046328	40	0.018
regulation of protein processing	GO:0070613	32	0.018
regulation of protein localization	GO:0032880	76	0.017
regulation of cellular localization	GO:0060341	136	0.017
regulation of immune system process	GO:0002682	176	0.017
synaptic growth at neuromuscular junction	GO:0051124	119	0.017
regulation of cellular ketone metabolic process	GO:0010565	3	0.017
positive regulation of organelle organization	GO:0010638	65	0.017	Worm
protein phosphorylation	GO:0006468	169	0.017
regulation of cellular amino acid metabolic process	GO:0006521	0	0.017
positive regulation of response to external stimulus	GO:0032103	44	0.017
wnt signaling pathway	GO:0016055	98	0.017
regulation of protein maturation	GO:1903317	32	0.017
establishment or maintenance of bipolar cell polarity	GO:0061245	34	0.017
regulation of mapk cascade	GO:0043408	92	0.017
organic acid metabolic process	GO:0006082	103	0.017
gene silencing by rna	GO:0031047	57	0.017
epithelial cell migration	GO:0010631	148	0.016
positive regulation of cell cycle process	GO:0090068	28	0.016
secretion by cell	GO:0032940	101	0.016
cellular component disassembly	GO:0022411	46	0.016	Worm
morphogenesis of a branching epithelium	GO:0061138	45	0.016
regulation of cellular amine metabolic process	GO:0033238	3	0.016
single organism nuclear import	GO:1902593	51	0.016
phagocytosis	GO:0006909	215	0.016
regulation of compound eye retinal cell programmed cell death	GO:0046669	18	0.015
establishment or maintenance of monopolar cell polarity	GO:0061339	15	0.015
negative regulation of phosphatase activity	GO:0010923	3	0.015
stem cell proliferation	GO:0072089	88	0.015
protein polymerization	GO:0051258	42	0.015
cellular protein complex assembly	GO:0043623	71	0.015
cellular response to sterol depletion	GO:0071501	3	0.015
establishment of monopolar cell polarity	GO:0061162	15	0.015
phosphorylation	GO:0016310	294	0.015
peptide metabolic process	GO:0006518	80	0.014
establishment or maintenance of cytoskeleton polarity	GO:0030952	44	0.014
intracellular transport	GO:0046907	228	0.014
cell cycle arrest	GO:0007050	4	0.014
dorsal appendage formation	GO:0046843	47	0.014
mitotic spindle organization	GO:0007052	220	0.014
tube morphogenesis	GO:0035239	191	0.014
locomotory behavior	GO:0007626	176	0.013
aromatic compound catabolic process	GO:0019439	166	0.013
regulation of epithelial cell differentiation	GO:0030856	4	0.013
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.013
stem cell differentiation	GO:0048863	117	0.013
developmental cell growth	GO:0048588	52	0.013
myofibril assembly	GO:0030239	36	0.013	Worm
eggshell chorion assembly	GO:0007306	66	0.013
tube formation	GO:0035148	21	0.013
organelle assembly	GO:0070925	198	0.013	Worm
regulation of hemocyte proliferation	GO:0035206	37	0.013
regulation of nuclear division	GO:0051783	58	0.013

tsr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.030
cancer	DOID:162	0.028
disease of cellular proliferation	DOID:14566	0.028
central nervous system cancer	DOID:3620	0.028
familial meningioma	DOID:4586	0.028
meningioma	DOID:3565	0.028
nervous system cancer	DOID:3093	0.028
organ system cancer	DOID:0050686	0.028
nervous system disease	DOID:863	0.024
muscular disease	DOID:0080000	0.017
musculoskeletal system disease	DOID:17	0.017
cardiovascular system disease	DOID:1287	0.017
myopathy	DOID:423	0.017
heart disease	DOID:114	0.017
cardiomyopathy	DOID:0050700	0.017
muscle tissue disease	DOID:66	0.017
dilated cardiomyopathy	DOID:12930	0.013
intrinsic cardiomyopathy	DOID:0060036	0.013
ovarian disease	DOID:1100	0.013
female reproductive system disease	DOID:229	0.013
reproductive system disease	DOID:15	0.013

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