Drosophila melanogaster

165 known processes

mle (Dmel_CG11680)

maleless

(Aliases: MLE,mll,Dmel\CG11680,mls,nap,CG11680,mak,nap[ts])

mle biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
adult behaviorGO:00305341370.975
neuromuscular junction developmentGO:00075281490.943
synaptic transmissionGO:00072682880.913
regulation of synaptic growth at neuromuscular junctionGO:0008582890.888
synapse organizationGO:00508081960.845
establishment of synaptic vesicle localizationGO:0097480500.611
synapse assemblyGO:00074161430.571
cellular protein modification processGO:00064644380.528
synaptic vesicle transportGO:0048489500.525
regulation of synaptic transmissionGO:0050804690.507
synaptic vesicle recyclingGO:0036465280.434
regulation of synapse structure and activityGO:00508031280.417
histone h4 acetylationGO:0043967130.413
covalent chromatin modificationGO:00165691060.376
synaptic growth at neuromuscular junctionGO:00511241190.367
establishment of vesicle localizationGO:0051650510.305
histone modificationGO:00165701060.297
regulation of synapse assemblyGO:0051963940.261
single organism behaviorGO:00447083910.251
negative regulation of cellular metabolic processGO:00313243820.248
male mating behaviorGO:0060179700.232
metal ion homeostasisGO:0055065440.232
peptidyl lysine modificationGO:0018205570.219
positive regulation of synaptic growth at neuromuscular junctionGO:0045887260.194
columnar cuboidal epithelial cell developmentGO:00020662490.188
vesicle localizationGO:0051648550.183
chromosome organizationGO:00512763600.180
regulation of cellular component biogenesisGO:00440872010.179
cell divisionGO:00513012480.163
response to organic substanceGO:00100332840.161
response to ethanolGO:0045471590.156
locomotory behaviorGO:00076261760.155
negative regulation of cell communicationGO:00106482230.153
divalent inorganic cation homeostasisGO:0072507290.153
response to temperature stimulusGO:00092661060.143
Mouse
synaptic vesicle endocytosisGO:0048488280.140
positive regulation of growthGO:0045927750.138
protein modification processGO:00362114380.136
protein modification by small protein conjugationGO:0032446790.135
negative regulation of signalingGO:00230572190.130
positive regulation of developmental processGO:00510941430.130
regionalizationGO:00030024160.120
establishment of organelle localizationGO:00516561220.119
chromosome segregationGO:00070591570.115
phosphorylationGO:00163102940.113
regulation of cell cycle processGO:00105641810.113
establishment of localization in cellGO:00516494020.112
ion transmembrane transportGO:00342201220.109
cellular homeostasisGO:0019725800.108
apoptotic processGO:00069151590.108
cation transmembrane transportGO:0098655880.105
regulation of localizationGO:00328792750.102
protein modification by small protein conjugation or removalGO:00706471060.100
g protein coupled receptor signaling pathwayGO:00071861360.098
positive regulation of multicellular organismal processGO:00512401430.095
organelle fissionGO:00482853400.093
chromatin modificationGO:00165681470.093
regulation of developmental growthGO:00486381740.092
cell proliferationGO:00082832990.090
metal ion transportGO:0030001740.089
cellular catabolic processGO:00442483720.088
synaptic vesicle exocytosisGO:0016079160.087
central nervous system developmentGO:00074172010.086
negative regulation of signal transductionGO:00099682060.086
adult locomotory behaviorGO:0008344760.080
cell cycle checkpointGO:0000075950.080
multi organism reproductive behaviorGO:00447051210.078
regulation of neurotransmitter levelsGO:0001505380.078
positive regulation of programmed cell deathGO:0043068620.077
regulation of transportGO:00510491810.076
macromolecular complex assemblyGO:00650032560.075
positive regulation of cellular component biogenesisGO:0044089800.071
positive regulation of nucleobase containing compound metabolic processGO:00459353320.071
cellular protein localizationGO:00346131600.070
positive regulation of cellular component organizationGO:00511301560.070
catabolic processGO:00090564090.069
organelle localizationGO:00516401480.069
regulation of apoptotic processGO:00429811300.069
regulation of cell cycleGO:00517262910.068
positive regulation of macromolecule metabolic processGO:00106044050.068
positive regulation of cell communicationGO:00106472500.068
positive regulation of response to stimulusGO:00485843230.067
regulation of neuron projection developmentGO:0010975690.067
regulation of response to stressGO:00801342000.067
cellular macromolecule catabolic processGO:00442651360.066
cellular divalent inorganic cation homeostasisGO:0072503230.066
macromolecule catabolic processGO:00090571610.065
endocytosisGO:00068973100.064
positive regulation of signal transductionGO:00099672230.063
organonitrogen compound metabolic processGO:19015643180.062
taxisGO:00423303040.062
negative regulation of cellular component organizationGO:00511291080.062
protein catabolic processGO:00301631010.060
regulation of cell deathGO:00109411730.060
programmed cell deathGO:00125012570.060
peptidyl lysine methylationGO:0018022160.059
synaptic vesicle localizationGO:0097479530.059
regulation of blood circulationGO:1903522210.058
regulation of dendrite morphogenesisGO:0048814280.058
axon guidanceGO:00074112330.056
regulation of phosphorus metabolic processGO:00511742100.055
modification dependent protein catabolic processGO:0019941780.055
regulation of growthGO:00400082330.055
growthGO:00400073590.054
intracellular transportGO:00469072280.054
chemical homeostasisGO:0048878920.053
regulation of nervous system developmentGO:00519602480.053
neuron projection guidanceGO:00974852410.052
response to radiationGO:00093141550.050
axonogenesisGO:00074092900.050
regulation of gene expression epigeneticGO:00400291280.050
meiotic cell cycleGO:00513211710.050
membrane depolarizationGO:005189940.050
ion homeostasisGO:0050801550.049
vesicle mediated transportGO:00161923810.049
regulation of notch signaling pathwayGO:00085931000.048
response to starvationGO:0042594970.048
response to abiotic stimulusGO:00096283410.048
Mouse
regulation of intracellular signal transductionGO:19025312360.047
cell motilityGO:00488702510.047
neuromuscular synaptic transmissionGO:0007274670.047
negative regulation of cell cycle phase transitionGO:19019881030.047
stem cell proliferationGO:0072089880.046
cellular macromolecular complex assemblyGO:00346221530.046
neurotransmitter secretionGO:0007269350.045
modification dependent macromolecule catabolic processGO:0043632790.045
protein ubiquitinationGO:0016567700.045
meiotic cell cycle processGO:19030461320.045
single organism membrane organizationGO:0044802930.044
regulation of mitotic cell cycleGO:00073461900.044
intracellular signal transductionGO:00355563000.043
positive regulation of cellular catabolic processGO:0031331950.043
regulation of response to dna damage stimulusGO:2001020230.043
cation homeostasisGO:0055080510.041
negative regulation of nitrogen compound metabolic processGO:00511722650.041
actin cytoskeleton organizationGO:00300362060.041
actomyosin structure organizationGO:0031032560.041
single organism intracellular transportGO:19025822070.041
regulation of synapse organizationGO:00508071100.040
histone h4 k16 acetylationGO:004398440.040
positive regulation of developmental growthGO:0048639620.040
protein phosphorylationGO:00064681690.039
regulation of membrane potentialGO:0042391350.039
histone acetylationGO:0016573380.039
brain developmentGO:00074201200.039
calcium ion homeostasisGO:0055074230.038
positive regulation of biosynthetic processGO:00098913160.038
inorganic ion transmembrane transportGO:0098660730.038
positive regulation of signalingGO:00230562430.038
oocyte differentiationGO:00099941450.038
regulation of catalytic activityGO:00507901850.038
heterocycle catabolic processGO:00467001660.038
response to decreased oxygen levelsGO:0036293580.038
response to extracellular stimulusGO:00099911160.038
developmental growthGO:00485892800.037
protein localizationGO:00081042840.037
multicellular organismal reproductive behaviorGO:00330571100.035
courtship behaviorGO:0007619680.035
regulation of short term neuronal synaptic plasticityGO:004817250.035
transmission of nerve impulseGO:0019226120.035
positive regulation of synapse assemblyGO:0051965290.035
negative regulation of neuron apoptotic processGO:0043524140.035
cellular macromolecule localizationGO:00707272200.034
sperm individualizationGO:0007291480.034
proteolysisGO:00065081920.034
learning or memoryGO:00076111410.034
regulation of response to external stimulusGO:00321011150.034
neuroblast proliferationGO:0007405740.033
meiotic nuclear divisionGO:00071261510.033
single organism cellular localizationGO:19025801800.033
axis specificationGO:00097981670.032
cellular cation homeostasisGO:0030003380.032
single organism biosynthetic processGO:00447112060.032
regulation of protein kinase activityGO:0045859510.031
nuclear divisionGO:00002803320.031
negative regulation of response to stimulusGO:00485852580.031
neurotransmitter transportGO:0006836370.031
rna processingGO:00063961470.031
developmental maturationGO:00217001720.031
regulation of cellular localizationGO:00603411360.030
meiotic chromosome segregationGO:0045132590.030
secretion by cellGO:00329401010.030
regulation of cellular amino acid metabolic processGO:000652100.030
negative regulation of chromatin silencingGO:003193690.029
regulation of programmed cell deathGO:00430671520.029
positive regulation of nitrogen compound metabolic processGO:00511733540.029
negative regulation of molecular functionGO:0044092510.028
response to nutrient levelsGO:00316671140.028
regulation of cell divisionGO:0051302720.028
cellular response to starvationGO:0009267610.028
cytoplasmic transportGO:00164821300.027
small molecule metabolic processGO:00442813050.027
positive regulation of apoptotic processGO:0043065470.027
positive regulation of rna metabolic processGO:00512542710.027
dendrite morphogenesisGO:00488131990.027
anterograde axon cargo transportGO:000808960.026
negative regulation of cell cycle processGO:00109481090.026
actin filament based processGO:00300292200.026
mitotic cell cycle checkpointGO:0007093880.025
dendrite developmentGO:00163582040.025
response to heatGO:0009408630.025
Mouse
regulation of cellular response to stressGO:0080135890.025
response to organic cyclic compoundGO:0014070890.025
deathGO:00162652840.025
regulation of nuclear divisionGO:0051783580.025
vesicle organizationGO:0016050440.025
ovarian follicle cell developmentGO:00307072480.024
response to oxidative stressGO:0006979860.024
cellular metal ion homeostasisGO:0006875310.024
organic substance transportGO:00717022570.024
response to endogenous stimulusGO:00097191190.023
regulation of protein metabolic processGO:00512462560.023
cell deathGO:00082192790.023
organic substance catabolic processGO:19015753080.023
regulation of neurotransmitter secretionGO:0046928140.023
cellular calcium ion homeostasisGO:0006874210.022
establishment of protein localizationGO:00451841630.022
positive regulation of apoptotic signaling pathwayGO:200123540.022
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161540.022
organic cyclic compound catabolic processGO:19013611680.022
spermatid differentiationGO:00485151140.022
response to oxygen levelsGO:0070482590.022
microtubule based transportGO:0010970420.021
cell cycle phase transitionGO:00447701400.021
synaptic transmission cholinergicGO:000727190.021
regulation of cellular protein metabolic processGO:00322682430.021
signal transduction in response to dna damageGO:004277030.021
regulation of cellular amine metabolic processGO:003323830.021
agingGO:00075681430.021
defense response to other organismGO:00985422250.020
peptidyl lysine acetylationGO:0018394390.020
cytoplasmic microtubule organizationGO:0031122220.020
anterior posterior axis specificationGO:00099481090.020
negative regulation of nervous system developmentGO:0051961920.020
wound healingGO:0042060750.020
peripheral nervous system developmentGO:0007422520.020
cellular ketone metabolic processGO:0042180240.019
short term memoryGO:0007614190.019
regulation of transferase activityGO:0051338580.019
ribonucleotide metabolic processGO:00092591450.018
anterior posterior axis specification embryoGO:00085951030.018
neuronal action potentialGO:0019228100.018
phagocytosisGO:00069092150.018
nucleobase containing small molecule metabolic processGO:00550861740.018
mitotic sister chromatid separationGO:0051306300.018
exocytosisGO:0006887280.018
negative regulation of gene expressionGO:00106293870.017
Worm
cellularizationGO:0007349900.017
regulation of cell developmentGO:00602842150.017
homeostatic processGO:00425921990.017
regulation of cell proliferationGO:00421271630.017
carboxylic acid metabolic processGO:0019752920.017
regulation of mapk cascadeGO:0043408920.017
ubiquitin dependent protein catabolic processGO:0006511780.017
purine ribonucleoside monophosphate catabolic processGO:0009169380.017
spermatogenesisGO:00072832000.016
regulation of organelle organizationGO:00330431960.016
mitotic dna integrity checkpointGO:0044774750.016
regulation of cellular catabolic processGO:00313291570.016
reproductive behaviorGO:00190981220.016
response to hypoxiaGO:0001666530.016
regulation of multicellular organismal developmentGO:20000264140.016
gene silencing by rnaGO:0031047570.016
forebrain developmentGO:003090020.016
axon cargo transportGO:0008088290.016
nucleoside phosphate metabolic processGO:00067531620.016
positive regulation of nervous system developmentGO:0051962690.016
regulation of synaptic vesicle exocytosisGO:200030030.016
positive regulation of proteolysisGO:0045862520.016
cellular response to dna damage stimulusGO:00069742230.015
purine ribonucleotide metabolic processGO:00091501450.015
regulation of meiosisGO:004002030.015
bmp signaling pathwayGO:0030509270.015
mrna metabolic processGO:00160711240.015
multicellular organismal signalingGO:0035637120.015
positive regulation of catalytic activityGO:00430851180.015
organophosphate metabolic processGO:00196371950.015
neuron neuron synaptic transmissionGO:0007270140.015
regulation of synaptic plasticityGO:0048167140.015
chemotaxisGO:00069352490.015
regulation of immune system processGO:00026821760.015
nucleoside catabolic processGO:00091641120.015
gliogenesisGO:0042063800.015
maternal determination of anterior posterior axis embryoGO:0008358740.015
secretionGO:00469031090.015
negative regulation of rna biosynthetic processGO:19026792400.015
positive regulation of cell deathGO:0010942690.014
regulation of secretion by cellGO:1903530390.014
terminal button organizationGO:0072553190.014
negative regulation of programmed cell deathGO:0043069720.014
positive regulation of intracellular signal transductionGO:19025331160.014
determination of adult lifespanGO:00083401370.014
regulation of phosphatase activityGO:001092130.014
segmentationGO:00352822070.014
positive regulation of catabolic processGO:00098961050.014
negative regulation of stem cell proliferationGO:2000647300.014
purine ribonucleoside monophosphate metabolic processGO:0009167500.014
peptidyl amino acid modificationGO:00181931050.014
regulation of cell cycle phase transitionGO:19019871300.013
mitotic chromosome condensationGO:0007076220.013
positive regulation of transcription dna templatedGO:00458932660.013
negative regulation of organelle organizationGO:0010639560.013
single organism catabolic processGO:00447122280.013
chromatin organizationGO:00063252070.013
learningGO:0007612750.013
negative regulation of response to oxidative stressGO:190288310.013
mitotic cytokinesisGO:0000281500.013
camera type eye developmentGO:004301040.013
regulation of terminal button organizationGO:2000331110.013
internal peptidyl lysine acetylationGO:0018393380.013
receptor recyclingGO:000188120.013
negative regulation of neuron deathGO:1901215180.013
spinal cord developmentGO:002151010.013
ribonucleoside triphosphate metabolic processGO:00091991190.013
epithelial cell developmentGO:00020642740.013
regulation of neurogenesisGO:00507671580.013
purine containing compound metabolic processGO:00725211550.013
membrane organizationGO:00610241120.013
regulation of cellular response to oxidative stressGO:190040740.013
lipid metabolic processGO:00066291210.012
regulation of neuronal synaptic plasticityGO:004816880.012
chromosome separationGO:0051304420.012
cellular nitrogen compound catabolic processGO:00442701650.012
protein localization to organelleGO:0033365820.012
morphogenesis of an epitheliumGO:00020092760.012
purine ribonucleoside metabolic processGO:00461281270.012
negative regulation of apoptotic processGO:0043066630.012
cellular response to external stimulusGO:0071496660.012
regulation of behaviorGO:0050795750.012
neural precursor cell proliferationGO:0061351750.012
spindle checkpointGO:0031577110.012
aromatic compound catabolic processGO:00194391660.012
negative regulation of catalytic activityGO:0043086420.012
signal releaseGO:0023061490.012
apoptotic signaling pathwayGO:0097190270.011
regulation of protein localizationGO:0032880760.011
autophagic vacuole assemblyGO:000004520.011
mitotic g2 dna damage checkpointGO:0007095690.011
neuroblast divisionGO:0055057350.011
regulation of multi organism processGO:00439001310.011
ribonucleoprotein complex subunit organizationGO:0071826280.011
organic acid metabolic processGO:00060821030.011
regulation of protein catabolic processGO:0042176550.011
g1 s transition of mitotic cell cycleGO:0000082310.011
regulation of mitotic cell cycle phase transitionGO:19019901300.011
cellular amino acid metabolic processGO:0006520610.011
ribonucleoprotein complex biogenesisGO:0022613310.011
regulation of anatomical structure sizeGO:00900661630.011
male gamete generationGO:00482322010.011
posttranscriptional regulation of gene expressionGO:00106081450.011
Human
protein transportGO:00150311550.011
nucleoside triphosphate metabolic processGO:00091411200.010
negative regulation of synapse assemblyGO:0051964390.010
nucleotide metabolic processGO:00091171610.010
negative regulation of nucleic acid templated transcriptionGO:19035072400.010
action potentialGO:0001508130.010
cellular response to chemical stimulusGO:00708871990.010
proteasomal protein catabolic processGO:0010498590.010
nucleobase containing compound catabolic processGO:00346551650.010
nucleoside triphosphate catabolic processGO:00091431080.010
nucleoside phosphate catabolic processGO:19012921100.010
synaptic vesicle fusion to presynaptic membraneGO:003162970.010
positive regulation of notch signaling pathwayGO:0045747340.010
mitotic nuclear divisionGO:00070672130.010

mle disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.027
nervous system diseaseDOID:86300.017
disease of cellular proliferationDOID:1456600.013
central nervous system diseaseDOID:33100.011