IMP: Integrative Multi-species Prediction

Drosophila melanogaster

29 known processes

Ilp3 (Dmel_CG14167)

Insulin-like peptide 3

(Aliases: Ilp-3,dILP-3,dilp3,ilp3,Dilp-3,dilp,DILP3,dilp-3,DILP,Dmel\CG14167,Dilp 3,Ilp,CG14167,Dilp3,Dilp,dILP3)

Entrez: 39151
FLYBASE: FBgn0044050
UniProtKB: E7BBS2
UniProtKB: Q9VT52

Process Predictions
Disease Predictions

Ilp3 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
carbohydrate utilization	GO:0009758	1	0.938	Fly
mating behavior	GO:0007617	106	0.628
neuropeptide signaling pathway	GO:0007218	45	0.500
multi organism behavior	GO:0051705	175	0.461
larval feeding behavior	GO:0030536	15	0.443	Fly
circadian rhythm	GO:0007623	105	0.433
locomotor rhythm	GO:0045475	56	0.430
mating	GO:0007618	120	0.268
reproductive behavior	GO:0019098	122	0.265
anatomical structure homeostasis	GO:0060249	97	0.252	Fly
multi organism reproductive behavior	GO:0044705	121	0.244
female mating behavior	GO:0060180	30	0.240
regulation of cellular component size	GO:0032535	98	0.235	Fly
positive regulation of multicellular organism growth	GO:0040018	21	0.230	Fly
multi multicellular organism process	GO:0044706	123	0.228
regulation of organ growth	GO:0046620	42	0.200	Fly
regulation of multicellular organism growth	GO:0040014	40	0.190	Fly
g protein coupled receptor signaling pathway	GO:0007186	136	0.183
multicellular organismal reproductive behavior	GO:0033057	110	0.177
regulation of growth	GO:0040008	233	0.175	Fly
positive regulation of growth	GO:0045927	75	0.168	Fly
cellular response to peptide	GO:1901653	28	0.163	Fly
regulation of anatomical structure size	GO:0090066	163	0.153	Fly
multicellular organism growth	GO:0035264	46	0.151	Fly
larval behavior	GO:0030537	42	0.150	Fly
cyclic nucleotide metabolic process	GO:0009187	28	0.150
purine ribonucleotide metabolic process	GO:0009150	145	0.147
feeding behavior	GO:0007631	50	0.146	Fly
positive regulation of cell growth	GO:0030307	19	0.144	Fly
cellular response to peptide hormone stimulus	GO:0071375	28	0.138	Fly
rhythmic behavior	GO:0007622	76	0.133
insulin receptor signaling pathway	GO:0008286	25	0.126	Fly
cellular response to insulin stimulus	GO:0032869	28	0.122	Fly
regulation of developmental growth	GO:0048638	174	0.113	Fly
regulation of cell size	GO:0008361	63	0.113	Fly
developmental growth	GO:0048589	280	0.111	Fly
sensory perception	GO:0007600	196	0.110
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.105	Fly
response to oxygen containing compound	GO:1901700	200	0.104	Fly
regulation of behavior	GO:0050795	75	0.099	Fly
locomotory behavior	GO:0007626	176	0.098
homeostatic process	GO:0042592	199	0.097	Fly
organ growth	GO:0035265	56	0.095	Fly
positive regulation of developmental growth	GO:0048639	62	0.088	Fly
positive regulation of developmental process	GO:0051094	143	0.088	Fly
positive regulation of multicellular organismal process	GO:0051240	143	0.085	Fly
growth	GO:0040007	359	0.083	Fly
response to insulin	GO:0032868	29	0.082	Fly
cellular response to chemical stimulus	GO:0070887	199	0.081	Fly
insecticide catabolic process	GO:0046701	1	0.079
response to peptide hormone	GO:0043434	29	0.078	Fly
cellular response to organic substance	GO:0071310	132	0.076	Fly
response to abiotic stimulus	GO:0009628	341	0.076
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.075	Fly
circadian behavior	GO:0048512	76	0.074
cell growth	GO:0016049	108	0.073	Fly
negative regulation of response to stimulus	GO:0048585	258	0.072	Fly
positive regulation of adenylate cyclase activity involved in g protein coupled receptor signaling pathway	GO:0010579	7	0.069
regulation of cell growth	GO:0001558	43	0.067	Fly
regulation of adenylate cyclase activity involved in g protein coupled receptor signaling pathway	GO:0010578	8	0.067
nucleoside phosphate metabolic process	GO:0006753	162	0.064
hormone metabolic process	GO:0042445	33	0.064
organonitrogen compound metabolic process	GO:1901564	318	0.062
ribose phosphate metabolic process	GO:0019693	145	0.060
detection of stimulus	GO:0051606	156	0.059
secondary metabolite catabolic process	GO:0090487	1	0.057
response to organic substance	GO:0010033	284	0.057	Fly
adenylate cyclase modulating g protein coupled receptor signaling pathway	GO:0007188	17	0.057
cellular response to endogenous stimulus	GO:0071495	80	0.056	Fly
positive regulation of camp biosynthetic process	GO:0030819	8	0.055
response to organonitrogen compound	GO:0010243	75	0.052	Fly
steroid catabolic process	GO:0006706	1	0.051
response to endogenous stimulus	GO:0009719	119	0.051	Fly
compound eye development	GO:0048749	307	0.049
positive regulation of cell proliferation	GO:0008284	47	0.047	Fly
cellular response to oxygen containing compound	GO:1901701	79	0.046	Fly
fat soluble vitamin biosynthetic process	GO:0042362	1	0.046
taxis	GO:0042330	304	0.045
xenobiotic catabolic process	GO:0042178	1	0.044
response to nitrogen compound	GO:1901698	90	0.044	Fly
intracellular signal transduction	GO:0035556	300	0.044
triglyceride homeostasis	GO:0070328	18	0.043	Fly
positive regulation of signal transduction	GO:0009967	223	0.043
organophosphate metabolic process	GO:0019637	195	0.040
nucleotide metabolic process	GO:0009117	161	0.040
single organism behavior	GO:0044708	391	0.040
purine containing compound metabolic process	GO:0072521	155	0.040
response to light stimulus	GO:0009416	124	0.039
small molecule metabolic process	GO:0044281	305	0.039
regulation of anatomical structure morphogenesis	GO:0022603	242	0.039
lipid homeostasis	GO:0055088	33	0.039	Fly
multicellular organismal aging	GO:0010259	140	0.038	Fly
cation transport	GO:0006812	110	0.038
nucleobase containing small molecule metabolic process	GO:0055086	174	0.037
positive regulation of cell communication	GO:0010647	250	0.037
regulation of feeding behavior	GO:0060259	16	0.036	Fly
detection of abiotic stimulus	GO:0009582	66	0.035
detection of external stimulus	GO:0009581	66	0.035
chemical homeostasis	GO:0048878	92	0.034	Fly
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.032
negative regulation of cellular metabolic process	GO:0031324	382	0.031
detection of stimulus involved in sensory perception	GO:0050906	92	0.031
neurological system process	GO:0050877	358	0.031
vitamin biosynthetic process	GO:0009110	1	0.031
phototaxis	GO:0042331	21	0.031
carboxylic acid metabolic process	GO:0019752	92	0.030
purine nucleotide metabolic process	GO:0006163	146	0.030
regulation of phosphorus metabolic process	GO:0051174	210	0.029
oxoacid metabolic process	GO:0043436	103	0.029
axon development	GO:0061564	297	0.029
neuron projection guidance	GO:0097485	241	0.029
regionalization	GO:0003002	416	0.029
positive regulation of phosphorus metabolic process	GO:0010562	139	0.029
cellular response to hormone stimulus	GO:0032870	44	0.029	Fly
regulation of mapk cascade	GO:0043408	92	0.028
response to pain	GO:0048265	3	0.028
cell proliferation	GO:0008283	299	0.028	Fly
positive regulation of signaling	GO:0023056	243	0.027
organic acid metabolic process	GO:0006082	103	0.027
response to organophosphorus	GO:0046683	2	0.027
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger	GO:0007187	17	0.027
sensory perception of chemical stimulus	GO:0007606	116	0.027
organic substance catabolic process	GO:1901575	308	0.027
response to external biotic stimulus	GO:0043207	293	0.026
organic cyclic compound catabolic process	GO:1901361	168	0.026
secondary metabolic process	GO:0019748	75	0.025
entrainment of circadian clock	GO:0009649	16	0.025
cellular response to nitrogen compound	GO:1901699	51	0.025	Fly
cell division	GO:0051301	248	0.025
transcription from rna polymerase ii promoter	GO:0006366	368	0.024
axonogenesis	GO:0007409	290	0.024
compound eye morphogenesis	GO:0001745	249	0.024
detection of light stimulus	GO:0009583	58	0.023
endocytosis	GO:0006897	310	0.023
epithelial cell differentiation	GO:0030855	322	0.023
regulation of growth rate	GO:0040009	3	0.023	Fly
positive regulation of rna biosynthetic process	GO:1902680	266	0.023
rhythmic process	GO:0048511	106	0.023
male courtship behavior veined wing extension	GO:0048065	22	0.022
positive regulation of phosphate metabolic process	GO:0045937	139	0.022
aging	GO:0007568	143	0.022	Fly
response to organic cyclic compound	GO:0014070	89	0.022
regulation of immune system process	GO:0002682	176	0.022
germ line stem cell niche homeostasis	GO:0060250	5	0.022	Fly
protein heterooligomerization	GO:0051291	4	0.022
toxin metabolic process	GO:0009404	2	0.022
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.022
regulation of localization	GO:0032879	275	0.022
mapk cascade	GO:0000165	107	0.022
organic substance transport	GO:0071702	257	0.021
response to other organism	GO:0051707	293	0.021
positive regulation of cellular biosynthetic process	GO:0031328	316	0.021
positive regulation of biosynthetic process	GO:0009891	316	0.021
appendage development	GO:0048736	401	0.021
chemotaxis	GO:0006935	249	0.021
macromolecular complex assembly	GO:0065003	256	0.021
positive regulation of response to stimulus	GO:0048584	323	0.020
catabolic process	GO:0009056	409	0.020
dendrite morphogenesis	GO:0048813	199	0.020
carbohydrate derivative metabolic process	GO:1901135	217	0.020
signal transduction by phosphorylation	GO:0023014	107	0.020
positive regulation of phosphorylation	GO:0042327	87	0.020
carbohydrate derivative biosynthetic process	GO:1901137	85	0.020
establishment of localization in cell	GO:0051649	402	0.020
wing disc morphogenesis	GO:0007472	344	0.020
response to radiation	GO:0009314	155	0.020
single organism biosynthetic process	GO:0044711	206	0.019
erk1 and erk2 cascade	GO:0070371	39	0.019
open tracheal system development	GO:0007424	204	0.019
positive regulation of nucleotide biosynthetic process	GO:0030810	10	0.019
regulation of response to stress	GO:0080134	200	0.019
camera type eye development	GO:0043010	4	0.019
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.019
tissue morphogenesis	GO:0048729	297	0.019
vesicle mediated transport	GO:0016192	381	0.018
eye development	GO:0001654	323	0.018
response to bacterium	GO:0009617	198	0.018
imaginal disc derived wing morphogenesis	GO:0007476	337	0.018
positive regulation of lyase activity	GO:0051349	10	0.018
male courtship behavior	GO:0008049	63	0.018
regulation of phosphate metabolic process	GO:0019220	210	0.018
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.018
dorsal ventral pattern formation	GO:0009953	133	0.018
regulation of cell morphogenesis	GO:0022604	163	0.018
cellular amino acid metabolic process	GO:0006520	61	0.018
cellular nitrogen compound catabolic process	GO:0044270	165	0.018
negative regulation of behavior	GO:0048521	8	0.018	Fly
neuromuscular junction development	GO:0007528	149	0.018
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.018
regulation of multicellular organismal development	GO:2000026	414	0.018
defense response to other organism	GO:0098542	225	0.018
regulation of cellular component biogenesis	GO:0044087	201	0.018
inorganic ion transmembrane transport	GO:0098660	73	0.018
phagocytosis	GO:0006909	215	0.018
vitamin metabolic process	GO:0006766	2	0.017
protein modification process	GO:0036211	438	0.017
heterocycle catabolic process	GO:0046700	166	0.017
regulation of molecular function	GO:0065009	217	0.017
response to alcohol	GO:0097305	95	0.017
phosphorylation	GO:0016310	294	0.017
positive regulation of intracellular signal transduction	GO:1902533	116	0.017
cell death	GO:0008219	279	0.017
ribonucleotide metabolic process	GO:0009259	145	0.017
regulation of intracellular signal transduction	GO:1902531	236	0.017
single organism carbohydrate metabolic process	GO:0044723	72	0.017
protein localization	GO:0008104	284	0.017
cellular ion homeostasis	GO:0006873	39	0.016
developmental maturation	GO:0021700	172	0.016
regulation of cellular amino acid metabolic process	GO:0006521	0	0.016
kidney development	GO:0001822	3	0.016
cyclic purine nucleotide metabolic process	GO:0052652	25	0.016
response to monosaccharide	GO:0034284	4	0.016
single organism catabolic process	GO:0044712	228	0.016
cellular protein modification process	GO:0006464	438	0.016
body morphogenesis	GO:0010171	2	0.016
cgmp metabolic process	GO:0046068	11	0.016
aromatic compound catabolic process	GO:0019439	166	0.016
limb development	GO:0060173	1	0.016
secondary metabolite biosynthetic process	GO:0044550	24	0.016
neurotransmitter metabolic process	GO:0042133	2	0.016
organonitrogen compound biosynthetic process	GO:1901566	117	0.016
cellular lipid metabolic process	GO:0044255	83	0.016
ras protein signal transduction	GO:0007265	88	0.016
response to extracellular stimulus	GO:0009991	116	0.016
mesenchymal cell development	GO:0014031	1	0.016
single organism intracellular transport	GO:1902582	207	0.015
regulation of cell proliferation	GO:0042127	163	0.015	Fly
immune system process	GO:0002376	347	0.015
regulation of camp biosynthetic process	GO:0030817	12	0.015
kidney morphogenesis	GO:0060993	3	0.015
defense response to bacterium	GO:0042742	178	0.015
inter male aggressive behavior	GO:0002121	60	0.015
regulation of protein metabolic process	GO:0051246	256	0.015
cellular response to ethanol	GO:0071361	4	0.015
epithelial cell development	GO:0002064	274	0.015
response to hormone	GO:0009725	45	0.015	Fly
protein complex biogenesis	GO:0070271	201	0.015
defense response to gram negative bacterium	GO:0050829	94	0.015
sensory perception of smell	GO:0007608	80	0.015
positive regulation of catalytic activity	GO:0043085	118	0.015
connective tissue development	GO:0061448	3	0.015
embryonic development via the syncytial blastoderm	GO:0001700	148	0.014
positive regulation of cyclic nucleotide biosynthetic process	GO:0030804	9	0.014
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.014
salt aversion	GO:0035199	3	0.014
sleep	GO:0030431	49	0.014
ribose phosphate biosynthetic process	GO:0046390	28	0.014
response to ketone	GO:1901654	34	0.014
eye photoreceptor cell fate commitment	GO:0042706	37	0.014
response to glucose	GO:0009749	2	0.014
regulation of camp metabolic process	GO:0030814	12	0.014
cell maturation	GO:0048469	144	0.014
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.014
immune response	GO:0006955	246	0.014
compound eye photoreceptor cell differentiation	GO:0001751	140	0.014
cellular catabolic process	GO:0044248	372	0.014
regulation of cyclic nucleotide biosynthetic process	GO:0030802	13	0.014
positive regulation of mapk cascade	GO:0043410	63	0.014
immune response regulating signaling pathway	GO:0002764	2	0.014
androgen metabolic process	GO:0008209	1	0.014
protein transport	GO:0015031	155	0.014
sensory perception of pain	GO:0019233	4	0.014
kidney epithelium development	GO:0072073	3	0.013
regulation of apoptotic process	GO:0042981	130	0.013
regulation of cellular localization	GO:0060341	136	0.013
response to biotic stimulus	GO:0009607	294	0.013
defense response	GO:0006952	300	0.013
appendage morphogenesis	GO:0035107	397	0.013
response to alkaloid	GO:0043279	26	0.013
synapse assembly	GO:0007416	143	0.013
forebrain development	GO:0030900	2	0.013
sensory organ morphogenesis	GO:0090596	260	0.013
hormone catabolic process	GO:0042447	3	0.013
hindbrain development	GO:0030902	2	0.013
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.013
toxin catabolic process	GO:0009407	1	0.013
regulation of cellular protein metabolic process	GO:0032268	243	0.013
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.013
nuclear division	GO:0000280	332	0.013
acylglycerol homeostasis	GO:0055090	19	0.013	Fly
positive regulation of gene expression	GO:0010628	290	0.013
imaginal disc derived appendage development	GO:0048737	399	0.013
respiratory system development	GO:0060541	213	0.013
inorganic cation transmembrane transport	GO:0098662	61	0.013
nucleobase containing compound catabolic process	GO:0034655	165	0.012
blastoderm segmentation	GO:0007350	159	0.012
ribonucleotide biosynthetic process	GO:0009260	28	0.012
regulation of cell cycle	GO:0051726	291	0.012
organonitrogen compound catabolic process	GO:1901565	128	0.012
photoreceptor cell differentiation	GO:0046530	170	0.012
chemosensory behavior	GO:0007635	106	0.012
localization of cell	GO:0051674	257	0.012
regulation of protein localization	GO:0032880	76	0.012
innate immune response	GO:0045087	144	0.012
rna processing	GO:0006396	147	0.012
glutathione metabolic process	GO:0006749	37	0.012
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.012
small gtpase mediated signal transduction	GO:0007264	88	0.012
determination of adult lifespan	GO:0008340	137	0.012	Fly
death	GO:0016265	284	0.012
benzene containing compound metabolic process	GO:0042537	3	0.012
regulation of erk1 and erk2 cascade	GO:0070372	39	0.012
regulation of transport	GO:0051049	181	0.012
cellular macromolecule localization	GO:0070727	220	0.012
sensory perception of taste	GO:0050909	25	0.012
intracellular transport	GO:0046907	228	0.012
positive regulation of cell migration	GO:0030335	2	0.012
embryo development ending in birth or egg hatching	GO:0009792	152	0.012
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.012
nephron morphogenesis	GO:0072028	3	0.012
programmed cell death	GO:0012501	257	0.012
positive regulation of macromolecule metabolic process	GO:0010604	405	0.012
regulation of nervous system development	GO:0051960	248	0.011
response to lipopolysaccharide	GO:0032496	4	0.011
regulation of adenylate cyclase activity	GO:0045761	12	0.011
cellular protein localization	GO:0034613	160	0.011
regulation of catalytic activity	GO:0050790	185	0.011
developmental programmed cell death	GO:0010623	138	0.011
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.011
nucleoside triphosphate catabolic process	GO:0009143	108	0.011
nucleoside metabolic process	GO:0009116	127	0.011
axis specification	GO:0009798	167	0.011
camera type eye morphogenesis	GO:0048593	2	0.011
cellular response to dna damage stimulus	GO:0006974	223	0.011
eye photoreceptor cell differentiation	GO:0001754	145	0.011
response to hexose	GO:0009746	3	0.011
columnar cuboidal epithelial cell development	GO:0002066	249	0.011
neuromuscular synaptic transmission	GO:0007274	67	0.011
exocrine system development	GO:0035272	162	0.011
post embryonic appendage morphogenesis	GO:0035120	385	0.011
negative regulation of cellular biosynthetic process	GO:0031327	277	0.011
cellular amine metabolic process	GO:0044106	12	0.011
organelle assembly	GO:0070925	198	0.011
pattern recognition receptor signaling pathway	GO:0002221	2	0.011
retina morphogenesis in camera type eye	GO:0060042	2	0.011
estrogen metabolic process	GO:0008210	1	0.011
spindle organization	GO:0007051	253	0.011
nephron development	GO:0072006	3	0.011
cell motility	GO:0048870	251	0.011
adenylate cyclase activating g protein coupled receptor signaling pathway	GO:0007189	9	0.011
mesenchymal cell differentiation	GO:0048762	1	0.011
regulation of circadian sleep wake cycle	GO:0042749	25	0.011
single organism cellular localization	GO:1902580	180	0.011
nephron tubule development	GO:0072080	3	0.011
positive regulation of transcription dna templated	GO:0045893	266	0.011
establishment of protein localization	GO:0045184	163	0.011
carbohydrate metabolic process	GO:0005975	82	0.011
nephron epithelium development	GO:0072009	3	0.011
lipid metabolic process	GO:0006629	121	0.011
regulation of mitotic cell cycle	GO:0007346	190	0.011
cellular response to carbohydrate stimulus	GO:0071322	4	0.011
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.011
telencephalon development	GO:0021537	2	0.011
negative regulation of cellular protein metabolic process	GO:0032269	85	0.010
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.010
medium chain fatty acid metabolic process	GO:0051791	1	0.010
regulation of cellular ketone metabolic process	GO:0010565	3	0.010
positive regulation of nucleotide metabolic process	GO:0045981	55	0.010
anion homeostasis	GO:0055081	3	0.010
secretion	GO:0046903	109	0.010
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.010
negative regulation of biosynthetic process	GO:0009890	277	0.010
nucleoside phosphate catabolic process	GO:1901292	110	0.010
transmembrane transport	GO:0055085	139	0.010
retina development in camera type eye	GO:0060041	4	0.010
regulation of cellular amine metabolic process	GO:0033238	3	0.010
regulation of phosphorylation	GO:0042325	147	0.010
regulation of innate immune response	GO:0045088	71	0.010
positive regulation of cellular catabolic process	GO:0031331	95	0.010
adult behavior	GO:0030534	137	0.010
metal ion transport	GO:0030001	74	0.010
adult locomotory behavior	GO:0008344	76	0.010
smoothened signaling pathway	GO:0007224	49	0.010
very long chain fatty acid metabolic process	GO:0000038	4	0.010

Ilp3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.051
cardiovascular system disease	DOID:1287	0.025
artery disease	DOID:0050828	0.025
vascular disease	DOID:178	0.025
hypertension	DOID:10763	0.025
nervous system disease	DOID:863	0.018
musculoskeletal system disease	DOID:17	0.012
urinary system disease	DOID:18	0.011
sensory system disease	DOID:0050155	0.011

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