IMP: Integrative Multi-species Prediction

Drosophila melanogaster

123 known processes

lin19 (Dmel_CG1877)

lin-19-like

(Aliases: Dmel\CG1877,cul-1,lin-19/cul-1,CUL1,cul1,lin19-like,dCul-1,Cullin1,l(2)k01207,l(2)02074,dCul1,Cul-1,Cul1,CG1877)

Entrez: 35742
FLYBASE: FBgn0015509
UniProtKB: Q24311

Process Predictions
Disease Predictions

lin19 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of intracellular signal transduction	GO:1902531	236	0.941
protein ubiquitination	GO:0016567	70	0.939	Human Mouse
protein modification by small protein conjugation or removal	GO:0070647	106	0.857	Human Mouse
axonogenesis	GO:0007409	290	0.839
mitotic cell cycle phase transition	GO:0044772	138	0.810
protein modification by small protein conjugation	GO:0032446	79	0.809	Human Mouse
protein modification process	GO:0036211	438	0.768	Human Mouse
growth	GO:0040007	359	0.763	Worm
catabolic process	GO:0009056	409	0.682
protein localization	GO:0008104	284	0.660
regulation of cell cycle phase transition	GO:1901987	130	0.637
cellular protein modification process	GO:0006464	438	0.598	Human Mouse
multicellular organismal reproductive behavior	GO:0033057	110	0.586
axon guidance	GO:0007411	233	0.584
reproductive behavior	GO:0019098	122	0.550
neuron remodeling	GO:0016322	29	0.544
cellular response to dna damage stimulus	GO:0006974	223	0.530
mitotic dna integrity checkpoint	GO:0044774	75	0.522
axon development	GO:0061564	297	0.508
regulation of cellular component biogenesis	GO:0044087	201	0.498
response to organic substance	GO:0010033	284	0.484
dendrite development	GO:0016358	204	0.483
mitotic g2 m transition checkpoint	GO:0044818	70	0.459
mitotic dna damage checkpoint	GO:0044773	74	0.458
nucleobase containing compound catabolic process	GO:0034655	165	0.442
regulation of cellular protein metabolic process	GO:0032268	243	0.436
cell cycle phase transition	GO:0044770	140	0.430
cell cycle checkpoint	GO:0000075	95	0.427
negative regulation of developmental process	GO:0051093	201	0.400
embryo development ending in birth or egg hatching	GO:0009792	152	0.396	Worm
cellular catabolic process	GO:0044248	372	0.387	Human Mouse
body morphogenesis	GO:0010171	2	0.380
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.374
regulation of nervous system development	GO:0051960	248	0.354
intracellular signal transduction	GO:0035556	300	0.347
ubiquitin dependent protein catabolic process	GO:0006511	78	0.337	Human Mouse
aromatic compound catabolic process	GO:0019439	166	0.327
multi organism reproductive behavior	GO:0044705	121	0.317
modification dependent protein catabolic process	GO:0019941	78	0.317	Human Mouse
negative regulation of neural precursor cell proliferation	GO:2000178	27	0.314
regulation of cellular catabolic process	GO:0031329	157	0.288
negative regulation of neuroblast proliferation	GO:0007406	27	0.285
ribonucleotide metabolic process	GO:0009259	145	0.278
taxis	GO:0042330	304	0.269
proteasomal protein catabolic process	GO:0010498	59	0.265	Human Mouse
regulation of molecular function	GO:0065009	217	0.265
modification dependent macromolecule catabolic process	GO:0043632	79	0.250	Human Mouse
regulation of multicellular organismal development	GO:2000026	414	0.247
neuron projection guidance	GO:0097485	241	0.245
response to biotic stimulus	GO:0009607	294	0.241	Worm
developmental growth	GO:0048589	280	0.238
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.236	Human Mouse
organic substance catabolic process	GO:1901575	308	0.230
synapse organization	GO:0050808	196	0.224
phosphorylation	GO:0016310	294	0.209
small molecule metabolic process	GO:0044281	305	0.208
protein catabolic process	GO:0030163	101	0.207
programmed cell death	GO:0012501	257	0.201
apoptotic process	GO:0006915	159	0.201
negative regulation of nervous system development	GO:0051961	92	0.193
establishment of localization in cell	GO:0051649	402	0.190
regulation of catabolic process	GO:0009894	170	0.180
regulation of cell development	GO:0060284	215	0.180
endocytosis	GO:0006897	310	0.174	Worm
regulation of response to stress	GO:0080134	200	0.173
positive regulation of cellular biosynthetic process	GO:0031328	316	0.170
positive regulation of cellular component organization	GO:0051130	156	0.164
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.158
cellular protein catabolic process	GO:0044257	83	0.157	Human Mouse
scf dependent proteasomal ubiquitin dependent protein catabolic process	GO:0031146	1	0.157	Human Mouse
regulation of growth	GO:0040008	233	0.153
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.151
negative regulation of multicellular organismal process	GO:0051241	142	0.148
positive regulation of protein metabolic process	GO:0051247	128	0.148
regulation of cellular amine metabolic process	GO:0033238	3	0.148
regulation of cell cycle process	GO:0010564	181	0.148
dna integrity checkpoint	GO:0031570	81	0.147
organic cyclic compound catabolic process	GO:1901361	168	0.143
lateral inhibition	GO:0046331	206	0.141
regulation of phosphorus metabolic process	GO:0051174	210	0.139
negative regulation of signaling	GO:0023057	219	0.138
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.133	Human Mouse
ribonucleoside catabolic process	GO:0042454	112	0.132
regulation of cell differentiation	GO:0045595	302	0.130
defense response to other organism	GO:0098542	225	0.127	Worm
regulation of cell morphogenesis	GO:0022604	163	0.127
cellular nitrogen compound catabolic process	GO:0044270	165	0.126
posttranscriptional regulation of gene expression	GO:0010608	145	0.125
synapse assembly	GO:0007416	143	0.125
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.124
regulation of anatomical structure morphogenesis	GO:0022603	242	0.121
protein complex biogenesis	GO:0070271	201	0.119
positive regulation of proteolysis	GO:0045862	52	0.119
organic acid metabolic process	GO:0006082	103	0.116
maintenance of location	GO:0051235	73	0.110
organophosphate metabolic process	GO:0019637	195	0.109
positive regulation of macromolecule metabolic process	GO:0010604	405	0.108
cellular macromolecule catabolic process	GO:0044265	136	0.107	Human Mouse
nuclear division	GO:0000280	332	0.105	Worm
positive regulation of cellular protein metabolic process	GO:0032270	118	0.104
regulation of organelle organization	GO:0033043	196	0.102
lipid localization	GO:0010876	54	0.102
amine metabolic process	GO:0009308	12	0.100
oxoacid metabolic process	GO:0043436	103	0.100
neurological system process	GO:0050877	358	0.099
regulation of translation	GO:0006417	56	0.099
macromolecule catabolic process	GO:0009057	161	0.098
photoreceptor cell differentiation	GO:0046530	170	0.097
multi multicellular organism process	GO:0044706	123	0.095
purine nucleoside metabolic process	GO:0042278	127	0.093
positive regulation of signal transduction	GO:0009967	223	0.092
purine ribonucleotide metabolic process	GO:0009150	145	0.092
macromolecular complex assembly	GO:0065003	256	0.091
synaptic growth at neuromuscular junction	GO:0051124	119	0.086
proteolysis	GO:0006508	192	0.083	Human Mouse
purine ribonucleotide catabolic process	GO:0009154	109	0.083
ribonucleotide catabolic process	GO:0009261	109	0.082
nucleoside phosphate metabolic process	GO:0006753	162	0.081
multicellular organismal aging	GO:0010259	140	0.079	Worm
negative regulation of stem cell proliferation	GO:2000647	30	0.078
larval midgut histolysis	GO:0035069	22	0.076
cell proliferation	GO:0008283	299	0.076	Mouse Worm
negative regulation of growth	GO:0045926	84	0.076
organonitrogen compound catabolic process	GO:1901565	128	0.076
organophosphate catabolic process	GO:0046434	112	0.075
glycosyl compound catabolic process	GO:1901658	112	0.074
intracellular transport	GO:0046907	228	0.072
regulation of endopeptidase activity	GO:0052548	36	0.072
regulation of protein modification process	GO:0031399	112	0.069
purine containing compound catabolic process	GO:0072523	112	0.068
necrotic cell death	GO:0070265	1	0.068
regulation of neurogenesis	GO:0050767	158	0.067
regulation of developmental growth	GO:0048638	174	0.066
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.065
regulation of phosphate metabolic process	GO:0019220	210	0.064
meiotic nuclear division	GO:0007126	151	0.064
organic substance transport	GO:0071702	257	0.063
heterocycle catabolic process	GO:0046700	166	0.062
cellularization	GO:0007349	90	0.060
establishment of protein localization	GO:0045184	163	0.059
regulation of cell cycle	GO:0051726	291	0.059
histone h2a ubiquitination	GO:0033522	2	0.058
oviposition	GO:0018991	19	0.057
response to wounding	GO:0009611	94	0.057
positive regulation of cellular catabolic process	GO:0031331	95	0.056
response to virus	GO:0009615	28	0.056	Worm
positive regulation of developmental growth	GO:0048639	62	0.055
nucleotide metabolic process	GO:0009117	161	0.054
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.053
purine containing compound metabolic process	GO:0072521	155	0.053
nucleoside triphosphate metabolic process	GO:0009141	120	0.052
dephosphorylation	GO:0016311	51	0.051
tube morphogenesis	GO:0035239	191	0.051
negative regulation of cell communication	GO:0010648	223	0.051
single organism intracellular transport	GO:1902582	207	0.051
negative regulation of cell differentiation	GO:0045596	143	0.050
eye morphogenesis	GO:0048592	260	0.050
nucleoside phosphate catabolic process	GO:1901292	110	0.049
nucleobase containing small molecule metabolic process	GO:0055086	174	0.048
regulation of nurse cell apoptotic process	GO:0045477	9	0.048
innate immune response	GO:0045087	144	0.047
regulation of multi organism process	GO:0043900	131	0.047
nf kappab import into nucleus	GO:0042348	1	0.047
cell maturation	GO:0048469	144	0.046
organelle fission	GO:0048285	340	0.046	Worm
regulation of cell growth	GO:0001558	43	0.046
regulation of neural precursor cell proliferation	GO:2000177	35	0.045
gene silencing by rna	GO:0031047	57	0.045
negative regulation of cellular component organization	GO:0051129	108	0.045
regulation of catalytic activity	GO:0050790	185	0.044
chemotaxis	GO:0006935	249	0.044
positive regulation of molecular function	GO:0044093	136	0.044
lipid storage	GO:0019915	38	0.043
organonitrogen compound metabolic process	GO:1901564	318	0.043
negative regulation of mitotic cell cycle	GO:0045930	109	0.043
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.042
protein acylation	GO:0043543	42	0.042
negative regulation of cell proliferation	GO:0008285	69	0.042	Worm
guanosine containing compound catabolic process	GO:1901069	74	0.041
ribose phosphate metabolic process	GO:0019693	145	0.041
regulation of nucleotide metabolic process	GO:0006140	62	0.040
positive regulation of peptidase activity	GO:0010952	29	0.039
negative regulation of neurogenesis	GO:0050768	53	0.039
regulation of cell death	GO:0010941	173	0.038
mitotic nuclear division	GO:0007067	213	0.037	Worm
negative regulation of developmental growth	GO:0048640	64	0.037
regulation of mitotic cell cycle	GO:0007346	190	0.036
tissue death	GO:0016271	102	0.036
positive regulation of response to stimulus	GO:0048584	323	0.036
negative regulation of intracellular signal transduction	GO:1902532	57	0.035
translation	GO:0006412	69	0.034
compound eye photoreceptor cell differentiation	GO:0001751	140	0.034
positive regulation of catabolic process	GO:0009896	105	0.034
protein phosphorylation	GO:0006468	169	0.033
response to dsrna	GO:0043331	15	0.032
protein polyubiquitination	GO:0000209	11	0.032
cell growth	GO:0016049	108	0.032
ovarian follicle cell development	GO:0030707	248	0.031
mitotic g2 dna damage checkpoint	GO:0007095	69	0.031
single organism catabolic process	GO:0044712	228	0.031
regulation of cell shape	GO:0008360	113	0.031
morphogenesis of a branching structure	GO:0001763	45	0.031
purine nucleoside catabolic process	GO:0006152	112	0.030
regulation of cell proliferation	GO:0042127	163	0.030	Worm
positive regulation of gene expression	GO:0010628	290	0.030
regulation of cellular response to stress	GO:0080135	89	0.030
organic hydroxy compound metabolic process	GO:1901615	83	0.029
response to external biotic stimulus	GO:0043207	293	0.029	Worm
production of molecular mediator of immune response	GO:0002440	46	0.028
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.028
protein complex assembly	GO:0006461	200	0.028
regulation of actin cytoskeleton organization	GO:0032956	42	0.028
protein transport	GO:0015031	155	0.028
cellular response to carbohydrate stimulus	GO:0071322	4	0.028
vesicle organization	GO:0016050	44	0.028
establishment or maintenance of cell polarity	GO:0007163	167	0.027
axon midline choice point recognition	GO:0016199	26	0.027
response to other organism	GO:0051707	293	0.026	Worm
regulation of ras protein signal transduction	GO:0046578	93	0.026
response to nitrogen compound	GO:1901698	90	0.026
regulation of protein localization to nucleus	GO:1900180	29	0.026
columnar cuboidal epithelial cell development	GO:0002066	249	0.025
cell death	GO:0008219	279	0.025
positive regulation of phosphate metabolic process	GO:0045937	139	0.025
purine ribonucleoside catabolic process	GO:0046130	112	0.025
cellular response to oxygen containing compound	GO:1901701	79	0.025
regulation of cellular ketone metabolic process	GO:0010565	3	0.025
regulation of stem cell proliferation	GO:0072091	40	0.024
cellular protein localization	GO:0034613	160	0.024
posttranscriptional gene silencing by rna	GO:0035194	45	0.024
larval development	GO:0002164	104	0.024	Worm
purine nucleotide catabolic process	GO:0006195	109	0.024
peptidyl amino acid modification	GO:0018193	105	0.024
cellular protein complex assembly	GO:0043623	71	0.024
dendrite morphogenesis	GO:0048813	199	0.024
cytoplasmic transport	GO:0016482	130	0.023
positive regulation of cysteine type endopeptidase activity	GO:2001056	24	0.023
peptide biosynthetic process	GO:0043043	42	0.023
regulation of synapse assembly	GO:0051963	94	0.023
cellular lipid metabolic process	GO:0044255	83	0.023
neural precursor cell proliferation	GO:0061351	75	0.023
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.023
homeostatic process	GO:0042592	199	0.022
regulation of protein targeting	GO:1903533	29	0.022
mitotic cell cycle checkpoint	GO:0007093	88	0.022
compound eye morphogenesis	GO:0001745	249	0.022
stem cell development	GO:0048864	79	0.022
regulation of hemocyte proliferation	GO:0035206	37	0.022
regulation of cellular component size	GO:0032535	98	0.022	Worm
mesenchymal cell differentiation	GO:0048762	1	0.021
positive regulation of programmed cell death	GO:0043068	62	0.021	Worm
regulation of synapse organization	GO:0050807	110	0.021
g2 dna damage checkpoint	GO:0031572	69	0.021
respiratory system development	GO:0060541	213	0.021
nucleoside catabolic process	GO:0009164	112	0.021
chromatin assembly or disassembly	GO:0006333	52	0.020
response to abiotic stimulus	GO:0009628	341	0.020
regulation of synapse structure and activity	GO:0050803	128	0.020
cognition	GO:0050890	141	0.020
male gamete generation	GO:0048232	201	0.020
positive regulation of biosynthetic process	GO:0009891	316	0.020
eye photoreceptor cell development	GO:0042462	81	0.020
larval midgut cell programmed cell death	GO:0035096	19	0.019
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	23	0.019
positive regulation of cellular amine metabolic process	GO:0033240	0	0.019
purine nucleotide metabolic process	GO:0006163	146	0.019
nucleoside metabolic process	GO:0009116	127	0.019
cellular amine metabolic process	GO:0044106	12	0.019
glycosyl compound metabolic process	GO:1901657	127	0.019
carboxylic acid metabolic process	GO:0019752	92	0.018
ribonucleoside metabolic process	GO:0009119	127	0.018
regulation of axonogenesis	GO:0050770	32	0.018
positive regulation of mitotic cell cycle	GO:0045931	34	0.018
endomembrane system organization	GO:0010256	119	0.018
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.018
lipid metabolic process	GO:0006629	121	0.018
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.018
cardiovascular system development	GO:0072358	82	0.018
determination of dorsal ventral asymmetry	GO:0048262	3	0.018
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	25	0.018
positive regulation of phosphorus metabolic process	GO:0010562	139	0.018
purine ribonucleoside metabolic process	GO:0046128	127	0.018
cellular response to chemical stimulus	GO:0070887	199	0.018
stem cell proliferation	GO:0072089	88	0.018
regulation of localization	GO:0032879	275	0.017
regulation of intracellular transport	GO:0032386	64	0.017
regulation of cysteine type endopeptidase activity	GO:2000116	27	0.017
regulation of protein stability	GO:0031647	43	0.017
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.017
positive regulation of cell communication	GO:0010647	250	0.017
meiotic cell cycle	GO:0051321	171	0.017
positive regulation of apoptotic process	GO:0043065	47	0.017	Worm
small gtpase mediated signal transduction	GO:0007264	88	0.017
signal transduction by phosphorylation	GO:0023014	107	0.017
regulation of mapk cascade	GO:0043408	92	0.017
vesicle mediated transport	GO:0016192	381	0.017	Worm
regulation of purine nucleotide catabolic process	GO:0033121	48	0.017
carbohydrate derivative catabolic process	GO:1901136	118	0.017
photoreceptor cell development	GO:0042461	96	0.017
regulation of nucleotide catabolic process	GO:0030811	48	0.016
regulation of cellular amino acid metabolic process	GO:0006521	0	0.016
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.016
dendrite guidance	GO:0070983	21	0.016
regulation of neuroblast proliferation	GO:1902692	34	0.016
phagocytosis	GO:0006909	215	0.016
positive regulation of cell cycle	GO:0045787	43	0.016
regulation of response to external stimulus	GO:0032101	115	0.016
positive regulation of growth	GO:0045927	75	0.016
death	GO:0016265	284	0.015
positive regulation of cellular component biogenesis	GO:0044089	80	0.015
cellular macromolecular complex assembly	GO:0034622	153	0.015
activation of cysteine type endopeptidase activity involved in apoptotic process	GO:0006919	16	0.015
stem cell differentiation	GO:0048863	117	0.015
positive regulation of translation	GO:0045727	12	0.015
regulation of programmed cell death	GO:0043067	152	0.015
reproductive structure development	GO:0048608	74	0.015	Worm
tissue morphogenesis	GO:0048729	297	0.015
response to radiation	GO:0009314	155	0.015
tube development	GO:0035295	244	0.015
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.015
negative regulation of cell cycle phase transition	GO:1901988	103	0.015
defense response	GO:0006952	300	0.015	Worm
apoptotic signaling pathway	GO:0097190	27	0.015
regulation of cytoskeleton organization	GO:0051493	89	0.015
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.014
positive regulation of i kappab kinase nf kappab signaling	GO:0043123	1	0.014
regulation of defense response to virus by host	GO:0050691	10	0.014
regulation of protein metabolic process	GO:0051246	256	0.014
immune response	GO:0006955	246	0.014
histone ubiquitination	GO:0016574	4	0.014
neuron maturation	GO:0042551	31	0.014
negative regulation of cell development	GO:0010721	62	0.014
multi organism behavior	GO:0051705	175	0.014
mitotic spindle organization	GO:0007052	220	0.013
regulation of nucleoside metabolic process	GO:0009118	50	0.013
regulation of response to biotic stimulus	GO:0002831	63	0.013
negative regulation of cellular metabolic process	GO:0031324	382	0.013
regulation of immune effector process	GO:0002697	52	0.013
dna damage checkpoint	GO:0000077	78	0.013
chromosome organization	GO:0051276	360	0.013
production of small rna involved in gene silencing by rna	GO:0070918	15	0.013
nitrogen compound transport	GO:0071705	85	0.013
glycerolipid metabolic process	GO:0046486	34	0.013
sensory organ morphogenesis	GO:0090596	260	0.013
regulation of phosphorylation	GO:0042325	147	0.013
cell motility	GO:0048870	251	0.012	Worm
purine ribonucleoside monophosphate catabolic process	GO:0009169	38	0.012
mrna splice site selection	GO:0006376	1	0.012
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.012
positive regulation of hydrolase activity	GO:0051345	78	0.012
response to glucose	GO:0009749	2	0.012
positive regulation of phosphorylation	GO:0042327	87	0.012
protein acetylation	GO:0006473	39	0.012
atp catabolic process	GO:0006200	38	0.012
morphogenesis of follicular epithelium	GO:0016333	36	0.012
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.012
regulation of hydrolase activity	GO:0051336	97	0.012
compound eye photoreceptor development	GO:0042051	78	0.012
regulation of neuron differentiation	GO:0045664	103	0.012
positive regulation of rna biosynthetic process	GO:1902680	266	0.012
nucleoside triphosphate catabolic process	GO:0009143	108	0.012
spindle organization	GO:0007051	253	0.011
regulation of response to gamma radiation	GO:2001228	4	0.011
cellular ketone metabolic process	GO:0042180	24	0.011
carbohydrate derivative metabolic process	GO:1901135	217	0.011
regulation of purine nucleotide metabolic process	GO:1900542	62	0.011
positive regulation of intracellular signal transduction	GO:1902533	116	0.011
defense response to gram negative bacterium	GO:0050829	94	0.011
guanosine containing compound metabolic process	GO:1901068	74	0.011
regulation of gtpase activity	GO:0043087	44	0.011
ras protein signal transduction	GO:0007265	88	0.011
negative regulation of cellular protein metabolic process	GO:0032269	85	0.010
histone h2a monoubiquitination	GO:0035518	1	0.010
chromatin modification	GO:0016568	147	0.010
regulation of nucleocytoplasmic transport	GO:0046822	35	0.010
cell migration	GO:0016477	238	0.010	Worm
regulation of protein ubiquitination	GO:0031396	22	0.010
execution phase of apoptosis	GO:0097194	7	0.010
learning or memory	GO:0007611	141	0.010
developmental growth involved in morphogenesis	GO:0060560	65	0.010
regulation of adult chitin containing cuticle pigmentation	GO:0048082	13	0.010
mapk cascade	GO:0000165	107	0.010
positive regulation of catalytic activity	GO:0043085	118	0.010
regulation of apoptotic process	GO:0042981	130	0.010
nucleosome assembly	GO:0006334	35	0.010
forebrain development	GO:0030900	2	0.010

lin19 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org

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