IMP: Integrative Multi-species Prediction

Drosophila melanogaster

95 known processes

brn (Dmel_CG4934)

brainiac

(Aliases: EG:EG0007.6,fs(1)107,fs(1)A107,Dmel\CG4934,l(1)6P6,CG4934,brc)

FLYBASE: FBgn0000221
Entrez: 31358
UniProtKB: Q24157

Process Predictions
Disease Predictions

brn biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
axonogenesis	GO:0007409	290	0.646
chemotaxis	GO:0006935	249	0.561
taxis	GO:0042330	304	0.484
neuron projection guidance	GO:0097485	241	0.469
axon development	GO:0061564	297	0.355
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.321
axon guidance	GO:0007411	233	0.280
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.264
positive regulation of gene expression	GO:0010628	290	0.249
positive regulation of cellular biosynthetic process	GO:0031328	316	0.232
regulation of cell differentiation	GO:0045595	302	0.157
intracellular signal transduction	GO:0035556	300	0.156
regulation of intracellular signal transduction	GO:1902531	236	0.154
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.154
positive regulation of response to stimulus	GO:0048584	323	0.143
positive regulation of macromolecule metabolic process	GO:0010604	405	0.119
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.115
regionalization	GO:0003002	416	0.111
regulation of cell morphogenesis	GO:0022604	163	0.105
regulation of phosphate metabolic process	GO:0019220	210	0.102
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.100
ovarian follicle cell development	GO:0030707	248	0.095
stem cell differentiation	GO:0048863	117	0.087
phosphorylation	GO:0016310	294	0.086
cellular protein modification process	GO:0006464	438	0.086
positive regulation of signal transduction	GO:0009967	223	0.086
positive regulation of biosynthetic process	GO:0009891	316	0.085
positive regulation of signaling	GO:0023056	243	0.085
regulation of multi organism process	GO:0043900	131	0.084
appendage morphogenesis	GO:0035107	397	0.084
regulation of cell cycle	GO:0051726	291	0.083
immune system process	GO:0002376	347	0.082
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.082
digestive tract morphogenesis	GO:0048546	127	0.082
central nervous system development	GO:0007417	201	0.078
transcription from rna polymerase ii promoter	GO:0006366	368	0.076
negative regulation of signaling	GO:0023057	219	0.076
regulation of notch signaling pathway	GO:0008593	100	0.073
appendage development	GO:0048736	401	0.072
cell migration	GO:0016477	238	0.072
wing disc morphogenesis	GO:0007472	344	0.072
camera type eye development	GO:0043010	4	0.071
notch signaling pathway	GO:0007219	120	0.068
embryonic morphogenesis	GO:0048598	206	0.067
positive regulation of rna metabolic process	GO:0051254	271	0.066
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.064
compound eye photoreceptor cell differentiation	GO:0001751	140	0.064
cell fate specification	GO:0001708	71	0.063
vesicle mediated transport	GO:0016192	381	0.062
protein phosphorylation	GO:0006468	169	0.061
protein modification process	GO:0036211	438	0.059
tube morphogenesis	GO:0035239	191	0.059
gland development	GO:0048732	191	0.057
epithelial cell development	GO:0002064	274	0.057
response to abiotic stimulus	GO:0009628	341	0.056
sensory organ morphogenesis	GO:0090596	260	0.056
intracellular transport	GO:0046907	228	0.055
positive regulation of cell communication	GO:0010647	250	0.055
regulation of immune system process	GO:0002682	176	0.054
regulation of cell development	GO:0060284	215	0.052
tube development	GO:0035295	244	0.052
body morphogenesis	GO:0010171	2	0.051
positive regulation of transcription dna templated	GO:0045893	266	0.049
epithelial cell differentiation	GO:0030855	322	0.049
response to other organism	GO:0051707	293	0.048
immune effector process	GO:0002252	98	0.048
negative regulation of gene expression	GO:0010629	387	0.048
reproductive behavior	GO:0019098	122	0.048
cuticle pattern formation	GO:0035017	27	0.048
regulation of multicellular organismal development	GO:2000026	414	0.047
morphogenesis of an epithelium	GO:0002009	276	0.047
cellular amine metabolic process	GO:0044106	12	0.046
regulation of cell cycle process	GO:0010564	181	0.046
single organism behavior	GO:0044708	391	0.046
regulation of localization	GO:0032879	275	0.045
cytoplasmic transport	GO:0016482	130	0.044
digestive tract development	GO:0048565	149	0.044
cell fate determination	GO:0001709	91	0.044
imaginal disc derived wing morphogenesis	GO:0007476	337	0.044
neurological system process	GO:0050877	358	0.044
negative regulation of phosphorus metabolic process	GO:0010563	45	0.044
regulation of cell projection organization	GO:0031344	92	0.043
cellular catabolic process	GO:0044248	372	0.043
nephron tubule development	GO:0072080	3	0.042
regulation of protein metabolic process	GO:0051246	256	0.042
regulation of phosphorus metabolic process	GO:0051174	210	0.042
cell projection assembly	GO:0030031	94	0.041
regulation of cellular amino acid metabolic process	GO:0006521	0	0.041
negative regulation of biosynthetic process	GO:0009890	277	0.040
organonitrogen compound metabolic process	GO:1901564	318	0.040
dna metabolic process	GO:0006259	227	0.039
imaginal disc derived appendage development	GO:0048737	399	0.039
meiotic cell cycle process	GO:1903046	132	0.039
negative regulation of phosphate metabolic process	GO:0045936	45	0.039
post embryonic appendage morphogenesis	GO:0035120	385	0.038
regulation of nervous system development	GO:0051960	248	0.038
dendrite morphogenesis	GO:0048813	199	0.038
asymmetric cell division	GO:0008356	37	0.038
cytokinesis	GO:0000910	90	0.037
blastoderm segmentation	GO:0007350	159	0.037
brain development	GO:0007420	120	0.037
protein complex biogenesis	GO:0070271	201	0.037
signal transduction by phosphorylation	GO:0023014	107	0.037
phagocytosis	GO:0006909	215	0.037
embryo development ending in birth or egg hatching	GO:0009792	152	0.036
regulation of cellular amine metabolic process	GO:0033238	3	0.036
cell proliferation	GO:0008283	299	0.036
amine metabolic process	GO:0009308	12	0.036
actin cytoskeleton organization	GO:0030036	206	0.036
organelle fission	GO:0048285	340	0.036
segmentation	GO:0035282	207	0.035
cellular amino acid metabolic process	GO:0006520	61	0.034
exocrine system development	GO:0035272	162	0.034
regulation of mapk cascade	GO:0043408	92	0.034
imaginal disc pattern formation	GO:0007447	91	0.033
cell division	GO:0051301	248	0.033
regulation of molecular function	GO:0065009	217	0.033
retina development in camera type eye	GO:0060041	4	0.033
multi organism behavior	GO:0051705	175	0.033
regulation of cell death	GO:0010941	173	0.033
eggshell chorion assembly	GO:0007306	66	0.032
regulation of anatomical structure size	GO:0090066	163	0.032
dendrite development	GO:0016358	204	0.032
embryonic development via the syncytial blastoderm	GO:0001700	148	0.031
mapk cascade	GO:0000165	107	0.031
renal system development	GO:0072001	72	0.031
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.031
mitotic nuclear division	GO:0007067	213	0.031
kidney development	GO:0001822	3	0.030
negative regulation of phosphorylation	GO:0042326	35	0.030
oxoacid metabolic process	GO:0043436	103	0.030
protein localization	GO:0008104	284	0.029
positive regulation of cell migration	GO:0030335	2	0.029
eye development	GO:0001654	323	0.028
neuron recognition	GO:0008038	101	0.028
negative regulation of cell communication	GO:0010648	223	0.028
negative regulation of cellular metabolic process	GO:0031324	382	0.028
regulation of reproductive process	GO:2000241	54	0.027
regulation of microtubule cytoskeleton organization	GO:0070507	41	0.027
lateral inhibition	GO:0046331	206	0.027
ameboidal type cell migration	GO:0001667	151	0.027
nucleus localization	GO:0051647	34	0.026
endodermal cell fate commitment	GO:0001711	3	0.026
sensory perception	GO:0007600	196	0.026
formation of organ boundary	GO:0010160	30	0.026
developmental programmed cell death	GO:0010623	138	0.026
response to organic substance	GO:0010033	284	0.026
regulation of cellular localization	GO:0060341	136	0.026
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.026
regulation of neurogenesis	GO:0050767	158	0.026
stem cell maintenance	GO:0019827	67	0.025
renal tubule morphogenesis	GO:0061333	44	0.025
negative regulation of organelle organization	GO:0010639	56	0.025
actin filament based process	GO:0030029	220	0.025
negative regulation of notch signaling pathway	GO:0045746	41	0.025
regulation of cellular component biogenesis	GO:0044087	201	0.025
cell adhesion	GO:0007155	136	0.025
negative regulation of multicellular organismal process	GO:0051241	142	0.025
negative regulation of rna biosynthetic process	GO:1902679	240	0.025
positive regulation of rna biosynthetic process	GO:1902680	266	0.025
multi multicellular organism process	GO:0044706	123	0.024
regulation of catalytic activity	GO:0050790	185	0.024
cellular lipid metabolic process	GO:0044255	83	0.024
cellular protein localization	GO:0034613	160	0.023
cell motility	GO:0048870	251	0.023
dorsal appendage formation	GO:0046843	47	0.023
response to biotic stimulus	GO:0009607	294	0.023
positive regulation of developmental process	GO:0051094	143	0.023
eye morphogenesis	GO:0048592	260	0.023
carboxylic acid metabolic process	GO:0019752	92	0.023
regulation of catabolic process	GO:0009894	170	0.023
wnt signaling pathway	GO:0016055	98	0.023
cell cycle arrest	GO:0007050	4	0.023
sex determination	GO:0007530	18	0.023
regulation of organelle organization	GO:0033043	196	0.022
regulation of phosphorylation	GO:0042325	147	0.022
peptidyl amino acid modification	GO:0018193	105	0.022
negative regulation of signal transduction	GO:0009968	206	0.022
regulation of organ morphogenesis	GO:2000027	78	0.022
regulation of microtubule polymerization or depolymerization	GO:0031110	27	0.022
regulation of neuron differentiation	GO:0045664	103	0.022
organic substance transport	GO:0071702	257	0.022
cellular macromolecule catabolic process	GO:0044265	136	0.022
negative regulation of rna metabolic process	GO:0051253	251	0.022
nuclear division	GO:0000280	332	0.022
phenol containing compound metabolic process	GO:0018958	57	0.022
defense response	GO:0006952	300	0.021
spindle organization	GO:0007051	253	0.021
regulation of microtubule based process	GO:0032886	49	0.021
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.021
eye photoreceptor cell development	GO:0042462	81	0.021
cellular ketone metabolic process	GO:0042180	24	0.021
ubiquitin dependent protein catabolic process	GO:0006511	78	0.021
negative regulation of response to stimulus	GO:0048585	258	0.021
dorsal ventral pattern formation	GO:0009953	133	0.021
small molecule metabolic process	GO:0044281	305	0.021
renal tubule development	GO:0061326	64	0.021
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.021
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.020
positive regulation of cell motility	GO:2000147	3	0.020
embryonic axis specification	GO:0000578	107	0.020
membrane organization	GO:0061024	112	0.020
mitotic spindle organization	GO:0007052	220	0.020
regulation of transport	GO:0051049	181	0.020
eye photoreceptor cell differentiation	GO:0001754	145	0.020
regulation of cellular ketone metabolic process	GO:0010565	3	0.020
salivary gland morphogenesis	GO:0007435	145	0.020
negative regulation of cellular component organization	GO:0051129	108	0.020
regulation of epithelial cell proliferation	GO:0050678	4	0.020
rna splicing	GO:0008380	83	0.019
leg disc development	GO:0035218	92	0.019
regulation of protein complex disassembly	GO:0043244	29	0.019
regulation of cell division	GO:0051302	72	0.019
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.019
posttranscriptional regulation of gene expression	GO:0010608	145	0.019
mesoderm development	GO:0007498	78	0.019
regulation of cellular catabolic process	GO:0031329	157	0.019
negative regulation of cellular protein metabolic process	GO:0032269	85	0.019
antimicrobial humoral response	GO:0019730	99	0.019
establishment of localization in cell	GO:0051649	402	0.019
rna processing	GO:0006396	147	0.019
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.019
microtubule based movement	GO:0007018	51	0.019
wing disc pattern formation	GO:0035222	66	0.019
cytoskeleton dependent intracellular transport	GO:0030705	44	0.019
cytoskeleton dependent cytokinesis	GO:0061640	81	0.019
endodermal cell differentiation	GO:0035987	3	0.019
humoral immune response	GO:0006959	117	0.018
catabolic process	GO:0009056	409	0.018
single organism catabolic process	GO:0044712	228	0.018
regulation of ras protein signal transduction	GO:0046578	93	0.018
negative regulation of protein metabolic process	GO:0051248	85	0.018
regulation of protein transport	GO:0051223	57	0.018
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.018
kidney epithelium development	GO:0072073	3	0.018
regulation of protein phosphorylation	GO:0001932	64	0.018
positive regulation of cell differentiation	GO:0045597	64	0.018
negative regulation of protein modification process	GO:0031400	29	0.018
negative regulation of cell cycle	GO:0045786	116	0.018
chorion containing eggshell formation	GO:0007304	105	0.017
hematopoietic progenitor cell differentiation	GO:0002244	1	0.017
negative regulation of developmental process	GO:0051093	201	0.017
establishment of organelle localization	GO:0051656	122	0.017
salivary gland development	GO:0007431	162	0.017
gastrulation	GO:0007369	70	0.017
nephron epithelium morphogenesis	GO:0072088	3	0.017
negative regulation of cytoskeleton organization	GO:0051494	30	0.017
positive regulation of catabolic process	GO:0009896	105	0.017
organelle localization	GO:0051640	148	0.017
immune response	GO:0006955	246	0.017
mesenchymal cell differentiation	GO:0048762	1	0.017
embryonic pattern specification	GO:0009880	174	0.017
small gtpase mediated signal transduction	GO:0007264	88	0.017
negative regulation of protein complex disassembly	GO:0043242	23	0.017
regulation of cellular protein metabolic process	GO:0032268	243	0.017
single organismal cell cell adhesion	GO:0016337	45	0.017
protein palmitoylation	GO:0018345	2	0.017
embryonic hindgut morphogenesis	GO:0048619	48	0.017
protein complex assembly	GO:0006461	200	0.017
nephron epithelium development	GO:0072009	3	0.016
negative regulation of cell cycle process	GO:0010948	109	0.016
defense response to other organism	GO:0098542	225	0.016
regulation of intracellular transport	GO:0032386	64	0.016
microtubule based transport	GO:0010970	42	0.016
negative regulation of microtubule depolymerization	GO:0007026	21	0.016
positive regulation of catalytic activity	GO:0043085	118	0.016
secretion	GO:0046903	109	0.016
regulation of protein complex assembly	GO:0043254	42	0.016
gliogenesis	GO:0042063	80	0.016
modification dependent protein catabolic process	GO:0019941	78	0.016
regulation of embryonic development	GO:0045995	68	0.016
photoreceptor cell development	GO:0042461	96	0.016
cellular nitrogen compound catabolic process	GO:0044270	165	0.016
endocytosis	GO:0006897	310	0.016
hematopoietic or lymphoid organ development	GO:0048534	57	0.016
digestive system development	GO:0055123	149	0.016
nephron development	GO:0072006	3	0.016
regulation of protein localization	GO:0032880	76	0.016
positive regulation of intracellular signal transduction	GO:1902533	116	0.016
regulation of mitotic cell cycle	GO:0007346	190	0.015
epithelial tube morphogenesis	GO:0060562	88	0.015
cellular response to chemical stimulus	GO:0070887	199	0.015
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.015
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.015
positive regulation of transport	GO:0051050	92	0.015
cellular response to dna damage stimulus	GO:0006974	223	0.015
organic acid metabolic process	GO:0006082	103	0.015
hindgut morphogenesis	GO:0007442	58	0.015
hemopoiesis	GO:0030097	46	0.015
anterior posterior pattern specification	GO:0009952	136	0.015
head development	GO:0060322	135	0.015
organic substance catabolic process	GO:1901575	308	0.015
regulation of immune response	GO:0050776	118	0.015
regulation of mitosis	GO:0007088	56	0.015
kidney morphogenesis	GO:0060993	3	0.015
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.015
positive regulation of i kappab kinase nf kappab signaling	GO:0043123	1	0.015
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.014
nucleotide metabolic process	GO:0009117	161	0.014
ras protein signal transduction	GO:0007265	88	0.014
cell fate commitment involved in formation of primary germ layer	GO:0060795	10	0.014
programmed cell death	GO:0012501	257	0.014
organic cyclic compound catabolic process	GO:1901361	168	0.014
positive regulation of cell death	GO:0010942	69	0.014
regulation of protein depolymerization	GO:1901879	27	0.014
positive regulation of cellular catabolic process	GO:0031331	95	0.014
death	GO:0016265	284	0.014
stem cell development	GO:0048864	79	0.014
protein heterooligomerization	GO:0051291	4	0.014
regulation of response to stress	GO:0080134	200	0.014
peripheral nervous system development	GO:0007422	52	0.014
negative regulation of protein depolymerization	GO:1901880	23	0.013
apoptotic process	GO:0006915	159	0.013
positive regulation of molecular function	GO:0044093	136	0.013
cell cycle phase transition	GO:0044770	140	0.013
response to organophosphorus	GO:0046683	2	0.013
actin filament organization	GO:0007015	126	0.013
mitotic cytokinesis	GO:0000281	50	0.013
regulation of pole plasm oskar mrna localization	GO:0007317	27	0.013
negative regulation of transcription dna templated	GO:0045892	237	0.013
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	18	0.013
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.013
wound healing	GO:0042060	75	0.013
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.013
dna templated transcription elongation	GO:0006354	18	0.013
cell death	GO:0008219	279	0.013
cuticle development	GO:0042335	86	0.013
nucleoside phosphate metabolic process	GO:0006753	162	0.013
female sex differentiation	GO:0046660	20	0.013
asymmetric protein localization	GO:0008105	33	0.013
establishment of nucleus localization	GO:0040023	26	0.013
locomotory behavior	GO:0007626	176	0.013
reproductive system development	GO:0061458	74	0.013
molting cycle	GO:0042303	56	0.012
immune response activating signal transduction	GO:0002757	2	0.012
negative regulation of cell proliferation	GO:0008285	69	0.012
purine ribonucleotide metabolic process	GO:0009150	145	0.012
gland morphogenesis	GO:0022612	145	0.012
protein complex disassembly	GO:0043241	36	0.012
nephron tubule morphogenesis	GO:0072078	3	0.012
regulation of production of molecular mediator of immune response	GO:0002700	44	0.012
oviposition	GO:0018991	19	0.012
response to oxygen containing compound	GO:1901700	200	0.012
gonad development	GO:0008406	50	0.012
regulation of cytoplasmic transport	GO:1903649	47	0.012
positive regulation of protein transport	GO:0051222	37	0.012
response to alcohol	GO:0097305	95	0.012
regulation of establishment of protein localization	GO:0070201	61	0.012
hindbrain development	GO:0030902	2	0.012
photoreceptor cell differentiation	GO:0046530	170	0.012
negative regulation of protein phosphorylation	GO:0001933	17	0.012
proteolysis	GO:0006508	192	0.012
protein localization to organelle	GO:0033365	82	0.012
regulation of wnt signaling pathway	GO:0030111	68	0.012
regulation of defense response	GO:0031347	102	0.012
imaginal disc derived leg morphogenesis	GO:0007480	80	0.012
sex differentiation	GO:0007548	81	0.012
protein import into nucleus	GO:0006606	51	0.011
protein localization to nucleus	GO:0034504	55	0.011
regulation of locomotion	GO:0040012	42	0.011
nephron morphogenesis	GO:0072028	3	0.011
innate immune response	GO:0045087	144	0.011
single organism cell adhesion	GO:0098602	47	0.011
meiosis i	GO:0007127	59	0.011
asymmetric stem cell division	GO:0098722	49	0.011
nucleobase containing compound catabolic process	GO:0034655	165	0.011
cellular component assembly involved in morphogenesis	GO:0010927	151	0.011
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.011
positive regulation of immune system process	GO:0002684	68	0.011
determination of adult lifespan	GO:0008340	137	0.011
anterior posterior axis specification embryo	GO:0008595	103	0.011
regulation of cyclin dependent protein serine threonine kinase activity	GO:0000079	3	0.011
camera type eye morphogenesis	GO:0048593	2	0.011
stress activated protein kinase signaling cascade	GO:0031098	55	0.011
open tracheal system development	GO:0007424	204	0.011
response to radiation	GO:0009314	155	0.011
neuroblast proliferation	GO:0007405	74	0.011
connective tissue development	GO:0061448	3	0.011
cell aging	GO:0007569	2	0.011
macromolecular complex assembly	GO:0065003	256	0.011
chromosome condensation	GO:0030261	41	0.011
nuclear transport	GO:0051169	72	0.011
negative regulation of cellular biosynthetic process	GO:0031327	277	0.011
larval development	GO:0002164	104	0.011
multi organism reproductive behavior	GO:0044705	121	0.011
regulation of antimicrobial peptide production	GO:0002784	44	0.011
chromosome segregation	GO:0007059	157	0.011
eggshell formation	GO:0030703	105	0.011
dna dependent dna replication	GO:0006261	17	0.011
peptidyl lysine modification	GO:0018205	57	0.011
axon target recognition	GO:0007412	16	0.011
mesenchymal cell development	GO:0014031	1	0.010
regulation of transferase activity	GO:0051338	58	0.010
regulation of protein secretion	GO:0050708	13	0.010
cellular macromolecular complex assembly	GO:0034622	153	0.010
regulation of protein polymerization	GO:0032271	28	0.010
positive regulation of protein metabolic process	GO:0051247	128	0.010
female germ line stem cell asymmetric division	GO:0048132	14	0.010
urogenital system development	GO:0001655	72	0.010
regulation of epithelial cell differentiation	GO:0030856	4	0.010
glial cell differentiation	GO:0010001	35	0.010
immune response regulating signaling pathway	GO:0002764	2	0.010
regulation of protein modification process	GO:0031399	112	0.010
nucleobase containing small molecule metabolic process	GO:0055086	174	0.010
tripartite regional subdivision	GO:0007351	103	0.010
positive regulation of immune response	GO:0050778	63	0.010
compound eye morphogenesis	GO:0001745	249	0.010
response to lipid	GO:0033993	38	0.010
positive regulation of phosphorus metabolic process	GO:0010562	139	0.010
negative regulation of chromosome segregation	GO:0051985	14	0.010
microtubule polymerization or depolymerization	GO:0031109	39	0.010

brn disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.036
organ system cancer	DOID:0050686	0.013
cancer	DOID:162	0.013
disease of cellular proliferation	DOID:14566	0.013
musculoskeletal system disease	DOID:17	0.012
bone disease	DOID:0080001	0.012
bone development disease	DOID:0080006	0.012
connective tissue disease	DOID:65	0.012

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