IMP: Integrative Multi-species Prediction

Drosophila melanogaster

22 known processes

GstE7 (Dmel_CG17531)

Glutathione S transferase E7

(Aliases: Dmel\CG17531,DmGSTE7,CG17531,GSTE7)

Entrez: 37112
FLYBASE: FBgn0063493
UniProtKB: A1ZB72

Process Predictions
Disease Predictions

GstE7 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cellular modified amino acid metabolic process	GO:0006575	45	0.996
glutathione metabolic process	GO:0006749	37	0.990
sulfur compound metabolic process	GO:0006790	59	0.963
cellular amide metabolic process	GO:0043603	80	0.911
peptide metabolic process	GO:0006518	80	0.908
response to heat	GO:0009408	63	0.811	Fly
response to temperature stimulus	GO:0009266	106	0.723	Fly
cellular amino acid metabolic process	GO:0006520	61	0.461
oxoacid metabolic process	GO:0043436	103	0.385
carboxylic acid metabolic process	GO:0019752	92	0.359
organonitrogen compound metabolic process	GO:1901564	318	0.289
organic acid metabolic process	GO:0006082	103	0.282
response to abiotic stimulus	GO:0009628	341	0.192	Fly
small molecule metabolic process	GO:0044281	305	0.187
polyol biosynthetic process	GO:0046173	3	0.069
death	GO:0016265	284	0.052
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.044
appendage morphogenesis	GO:0035107	397	0.042
cell death	GO:0008219	279	0.042
appendage development	GO:0048736	401	0.041
protein modification process	GO:0036211	438	0.041
post embryonic appendage morphogenesis	GO:0035120	385	0.041
response to biotic stimulus	GO:0009607	294	0.040
xenobiotic catabolic process	GO:0042178	1	0.036
response to other organism	GO:0051707	293	0.036
wing disc morphogenesis	GO:0007472	344	0.035
imaginal disc derived wing morphogenesis	GO:0007476	337	0.035
regulation of multicellular organismal development	GO:2000026	414	0.032
positive regulation of cellular biosynthetic process	GO:0031328	316	0.031
immune system process	GO:0002376	347	0.030
cellular protein modification process	GO:0006464	438	0.030
response to organic substance	GO:0010033	284	0.030
positive regulation of macromolecule metabolic process	GO:0010604	405	0.029
response to oxygen containing compound	GO:1901700	200	0.029
programmed cell death	GO:0012501	257	0.028
response to external biotic stimulus	GO:0043207	293	0.028
response to bacterium	GO:0009617	198	0.028
imaginal disc derived appendage development	GO:0048737	399	0.027
regionalization	GO:0003002	416	0.027
defense response	GO:0006952	300	0.027
regulation of programmed cell death	GO:0043067	152	0.026
transcription from rna polymerase ii promoter	GO:0006366	368	0.026
multicellular organismal aging	GO:0010259	140	0.025
chemotaxis	GO:0006935	249	0.025
cellular catabolic process	GO:0044248	372	0.025
taxis	GO:0042330	304	0.025
organic hydroxy compound metabolic process	GO:1901615	83	0.024
neuron projection guidance	GO:0097485	241	0.024
regulation of cell death	GO:0010941	173	0.023
regulation of cell proliferation	GO:0042127	163	0.023
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.023
positive regulation of rna biosynthetic process	GO:1902680	266	0.023
axon guidance	GO:0007411	233	0.023
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.023
cellular response to ethanol	GO:0071361	4	0.022
nuclear division	GO:0000280	332	0.022
organophosphate metabolic process	GO:0019637	195	0.022
homeostatic process	GO:0042592	199	0.022
organelle fission	GO:0048285	340	0.021
response to monosaccharide	GO:0034284	4	0.021
aggressive behavior	GO:0002118	63	0.021
immune response	GO:0006955	246	0.021
axon development	GO:0061564	297	0.021
positive regulation of gene expression	GO:0010628	290	0.021
response to starvation	GO:0042594	97	0.021
chaeta development	GO:0022416	97	0.021
apoptotic process	GO:0006915	159	0.020
single organism behavior	GO:0044708	391	0.020
defense response to bacterium	GO:0042742	178	0.020
response to hexose	GO:0009746	3	0.020
phosphorylation	GO:0016310	294	0.020
positive regulation of biosynthetic process	GO:0009891	316	0.020
forebrain development	GO:0030900	2	0.020
cellular amine metabolic process	GO:0044106	12	0.020
ethanolamine containing compound metabolic process	GO:0042439	4	0.020
camera type eye development	GO:0043010	4	0.020
negative regulation of cell communication	GO:0010648	223	0.019
single organism biosynthetic process	GO:0044711	206	0.019
establishment of localization in cell	GO:0051649	402	0.019
connective tissue development	GO:0061448	3	0.019
dna metabolic process	GO:0006259	227	0.019
mrna processing	GO:0006397	104	0.019
negative regulation of cellular metabolic process	GO:0031324	382	0.019
negative regulation of gene expression	GO:0010629	387	0.019
benzene containing compound metabolic process	GO:0042537	3	0.018
aromatic compound catabolic process	GO:0019439	166	0.018
positive regulation of rna metabolic process	GO:0051254	271	0.018
sterol homeostasis	GO:0055092	4	0.018
eye pigment metabolic process	GO:0042441	33	0.018
body morphogenesis	GO:0010171	2	0.018
regulation of cellular protein metabolic process	GO:0032268	243	0.018
epithelial cell differentiation	GO:0030855	322	0.018
axonogenesis	GO:0007409	290	0.018
kidney development	GO:0001822	3	0.018
macromolecular complex assembly	GO:0065003	256	0.018
response to lipopolysaccharide	GO:0032496	4	0.018
regulation of cellular ketone metabolic process	GO:0010565	3	0.018
defense response to other organism	GO:0098542	225	0.017
protein localization	GO:0008104	284	0.017
response to extracellular stimulus	GO:0009991	116	0.017
positive regulation of response to stimulus	GO:0048584	323	0.017
cellular response to radiation	GO:0071478	52	0.017
rna processing	GO:0006396	147	0.017
catabolic process	GO:0009056	409	0.017
amine metabolic process	GO:0009308	12	0.017
cellular nitrogen compound catabolic process	GO:0044270	165	0.017
intracellular signal transduction	GO:0035556	300	0.017
melanin metabolic process	GO:0006582	47	0.017
positive regulation of transcription dna templated	GO:0045893	266	0.017
defense response to gram negative bacterium	GO:0050829	94	0.017
vitamin metabolic process	GO:0006766	2	0.017
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.017
regulation of molecular function	GO:0065009	217	0.017
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.016
chemical homeostasis	GO:0048878	92	0.016
localization of cell	GO:0051674	257	0.016
eye development	GO:0001654	323	0.016
positive regulation of cell communication	GO:0010647	250	0.016
regulation of catabolic process	GO:0009894	170	0.016
positive regulation of signaling	GO:0023056	243	0.016
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.016
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.016
compound eye development	GO:0048749	307	0.016
negative regulation of cellular biosynthetic process	GO:0031327	277	0.016
phenol containing compound metabolic process	GO:0018958	57	0.016
hormone catabolic process	GO:0042447	3	0.016
defense response to fungus	GO:0050832	48	0.016
mrna metabolic process	GO:0016071	124	0.016
cellular ketone metabolic process	GO:0042180	24	0.016
response to glucose	GO:0009749	2	0.016
wound healing spreading of epidermal cells	GO:0035313	1	0.016
regulation of humoral immune response	GO:0002920	51	0.016
male gamete generation	GO:0048232	201	0.016
regulation of phosphorus metabolic process	GO:0051174	210	0.015
embryonic development via the syncytial blastoderm	GO:0001700	148	0.015
nucleocytoplasmic transport	GO:0006913	72	0.015
neuron recognition	GO:0008038	101	0.015
organic cyclic compound catabolic process	GO:1901361	168	0.015
protein phosphorylation	GO:0006468	169	0.015
gland development	GO:0048732	191	0.015
cellular lipid metabolic process	GO:0044255	83	0.015
telencephalon development	GO:0021537	2	0.015
determination of adult lifespan	GO:0008340	137	0.015
regulation of cell differentiation	GO:0045595	302	0.015
antimicrobial humoral response	GO:0019730	99	0.015
regulation of cell cycle	GO:0051726	291	0.015
developmental maturation	GO:0021700	172	0.015
regulation of multi organism process	GO:0043900	131	0.014
carbohydrate derivative metabolic process	GO:1901135	217	0.014
heterocycle catabolic process	GO:0046700	166	0.014
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.014
positive regulation of signal transduction	GO:0009967	223	0.014
positive regulation of programmed cell death	GO:0043068	62	0.014
regulation of localization	GO:0032879	275	0.014
regulation of cellular catabolic process	GO:0031329	157	0.014
cell proliferation	GO:0008283	299	0.014
negative regulation of signaling	GO:0023057	219	0.014
negative regulation of signal transduction	GO:0009968	206	0.014
carbohydrate metabolic process	GO:0005975	82	0.014
ameboidal type cell migration	GO:0001667	151	0.014
cellular response to dna damage stimulus	GO:0006974	223	0.014
single organism cellular localization	GO:1902580	180	0.014
regulation of transport	GO:0051049	181	0.014
cholesterol homeostasis	GO:0042632	3	0.014
response to light stimulus	GO:0009416	124	0.014
dephosphorylation	GO:0016311	51	0.014
stress activated protein kinase signaling cascade	GO:0031098	55	0.014
regulation of anatomical structure morphogenesis	GO:0022603	242	0.014
developmental programmed cell death	GO:0010623	138	0.014
negative regulation of cell death	GO:0060548	81	0.014
fat soluble vitamin metabolic process	GO:0006775	1	0.013
organic substance transport	GO:0071702	257	0.013
regulation of cell development	GO:0060284	215	0.013
chromosome organization	GO:0051276	360	0.013
cellular protein localization	GO:0034613	160	0.013
negative regulation of biosynthetic process	GO:0009890	277	0.013
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.013
small molecule biosynthetic process	GO:0044283	37	0.013
regulation of intracellular signal transduction	GO:1902531	236	0.013
vesicle mediated transport	GO:0016192	381	0.013
intracellular transport	GO:0046907	228	0.013
response to organophosphorus	GO:0046683	2	0.013
tube development	GO:0035295	244	0.013
eye morphogenesis	GO:0048592	260	0.013
cellular macromolecule localization	GO:0070727	220	0.013
glycosyl compound metabolic process	GO:1901657	127	0.013
regulation of mrna metabolic process	GO:1903311	72	0.013
regulation of cellular localization	GO:0060341	136	0.013
cellular biogenic amine catabolic process	GO:0042402	1	0.013
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.013
proteolysis	GO:0006508	192	0.013
positive regulation of cell death	GO:0010942	69	0.013
chorion containing eggshell formation	GO:0007304	105	0.013
regulation of response to stress	GO:0080134	200	0.013
triglyceride biosynthetic process	GO:0019432	2	0.013
negative regulation of response to stimulus	GO:0048585	258	0.013
regulation of response to external stimulus	GO:0032101	115	0.013
meiotic cell cycle	GO:0051321	171	0.013
epithelial cell development	GO:0002064	274	0.013
compound eye morphogenesis	GO:0001745	249	0.013
organic hydroxy compound catabolic process	GO:1901616	4	0.013
neutral lipid biosynthetic process	GO:0046460	2	0.012
negative regulation of rna biosynthetic process	GO:1902679	240	0.012
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.012
cellular response to lipopolysaccharide	GO:0071222	3	0.012
purine ribonucleoside metabolic process	GO:0046128	127	0.012
cell motility	GO:0048870	251	0.012
regulation of immune system process	GO:0002682	176	0.012
protein transport	GO:0015031	155	0.012
lipopolysaccharide mediated signaling pathway	GO:0031663	1	0.012
segmentation	GO:0035282	207	0.012
cytoplasmic transport	GO:0016482	130	0.012
lipid metabolic process	GO:0006629	121	0.012
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.012
salivary gland development	GO:0007431	162	0.012
small gtpase mediated signal transduction	GO:0007264	88	0.012
synaptic target recognition	GO:0008039	45	0.012
regulation of rna splicing	GO:0043484	69	0.012
regulation of protein metabolic process	GO:0051246	256	0.012
response to organic cyclic compound	GO:0014070	89	0.012
negative regulation of rna metabolic process	GO:0051253	251	0.012
regulation of cellular amine metabolic process	GO:0033238	3	0.012
organic substance catabolic process	GO:1901575	308	0.012
regulation of cell cycle process	GO:0010564	181	0.012
neurological system process	GO:0050877	358	0.012
adult behavior	GO:0030534	137	0.012
intracellular protein transport	GO:0006886	104	0.012
ovarian follicle cell development	GO:0030707	248	0.012
negative regulation of cell cycle	GO:0045786	116	0.012
regulation of steroid metabolic process	GO:0019218	2	0.012
regulation of catalytic activity	GO:0050790	185	0.012
chemosensory behavior	GO:0007635	106	0.012
regulation of mrna processing	GO:0050684	71	0.012
regulation of phosphorylation	GO:0042325	147	0.012
nucleoside phosphate metabolic process	GO:0006753	162	0.012
regulation of immune response	GO:0050776	118	0.012
response to radiation	GO:0009314	155	0.012
mushroom body development	GO:0016319	70	0.012
response to oxidative stress	GO:0006979	86	0.012
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.012
epithelium migration	GO:0090132	148	0.012
negative regulation of developmental process	GO:0051093	201	0.011
positive regulation of cell migration	GO:0030335	2	0.011
secondary metabolic process	GO:0019748	75	0.011
positive regulation of lipid metabolic process	GO:0045834	4	0.011
lipid homeostasis	GO:0055088	33	0.011
positive regulation of multicellular organismal process	GO:0051240	143	0.011
intracellular protein transmembrane import	GO:0044743	4	0.011
generation of precursor metabolites and energy	GO:0006091	42	0.011
nucleobase containing small molecule metabolic process	GO:0055086	174	0.011
estrogen metabolic process	GO:0008210	1	0.011
cellular response to molecule of bacterial origin	GO:0071219	3	0.011
insecticide metabolic process	GO:0017143	2	0.011
protein complex biogenesis	GO:0070271	201	0.011
protein complex assembly	GO:0006461	200	0.011
protein targeting to nucleus	GO:0044744	51	0.011
positive regulation of cell motility	GO:2000147	3	0.011
sensory organ morphogenesis	GO:0090596	260	0.011
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.011
response to nitrogen compound	GO:1901698	90	0.011
choline metabolic process	GO:0019695	1	0.011
insecticide catabolic process	GO:0046701	1	0.011
protein localization to nucleus	GO:0034504	55	0.011
transmembrane transport	GO:0055085	139	0.011
limb development	GO:0060173	1	0.011
regulation of autophagy	GO:0010506	62	0.011
positive regulation of catabolic process	GO:0009896	105	0.011
tube morphogenesis	GO:0035239	191	0.011
motor neuron axon guidance	GO:0008045	58	0.011
head development	GO:0060322	135	0.011
response to ethanol	GO:0045471	59	0.011
metal ion homeostasis	GO:0055065	44	0.011
nucleotide metabolic process	GO:0009117	161	0.011
cell recognition	GO:0008037	102	0.011
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.011
wnt signaling pathway	GO:0016055	98	0.011
amine catabolic process	GO:0009310	1	0.011
ion homeostasis	GO:0050801	55	0.011
nuclear transport	GO:0051169	72	0.011
mitotic nuclear division	GO:0007067	213	0.011
cellular macromolecular complex assembly	GO:0034622	153	0.010
single organism intracellular transport	GO:1902582	207	0.010
columnar cuboidal epithelial cell development	GO:0002066	249	0.010
behavioral response to ethanol	GO:0048149	49	0.010
defense response to gram positive bacterium	GO:0050830	41	0.010
cell aging	GO:0007569	2	0.010
sensory perception	GO:0007600	196	0.010
humoral immune response	GO:0006959	117	0.010
positive regulation of developmental process	GO:0051094	143	0.010
regulation of synapse organization	GO:0050807	110	0.010
protein transmembrane transport	GO:0071806	4	0.010
regulation of cellular amino acid metabolic process	GO:0006521	0	0.010
response to organonitrogen compound	GO:0010243	75	0.010
regulation of cellular response to stress	GO:0080135	89	0.010
positive regulation of cellular protein metabolic process	GO:0032270	118	0.010
skeletal muscle fiber development	GO:0048741	3	0.010
regulation of apoptotic process	GO:0042981	130	0.010
spindle organization	GO:0007051	253	0.010
myotube cell development	GO:0014904	3	0.010
organonitrogen compound biosynthetic process	GO:1901566	117	0.010
regulation of anatomical structure size	GO:0090066	163	0.010
phagocytosis	GO:0006909	215	0.010
ribonucleoside metabolic process	GO:0009119	127	0.010
nuclear import	GO:0051170	51	0.010

GstE7 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.030
nervous system disease	DOID:863	0.019
cardiovascular system disease	DOID:1287	0.014
inherited metabolic disorder	DOID:655	0.014
disease of metabolism	DOID:0014667	0.014
central nervous system disease	DOID:331	0.013
hypertension	DOID:10763	0.011
vascular disease	DOID:178	0.011
artery disease	DOID:0050828	0.011
lipid metabolism disorder	DOID:3146	0.011
disease of cellular proliferation	DOID:14566	0.011
organ system cancer	DOID:0050686	0.011
cancer	DOID:162	0.011
musculoskeletal system disease	DOID:17	0.010

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