Drosophila melanogaster

42 known processes

Megalin (Dmel_CG42611)

CG42611 gene product from transcript CG42611-RA

(Aliases: Dmel\CG42611,CG42611,CG34352,CG12654,Dmel_CG12654,CG12139,Dmel_CG34352,LDLR,CG15316,CT7830,Dmel_CG34339,SOSIE,Dmel_CG12139,anon-WO0140519.108,CG34339)

Megalin biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cuticle developmentGO:0042335860.468
chitin based cuticle developmentGO:0040003490.356
respiratory system developmentGO:00605412130.318
taxisGO:00423303040.276
open tracheal system developmentGO:00074242040.226
cellular protein modification processGO:00064644380.160
wing disc morphogenesisGO:00074723440.159
chemotaxisGO:00069352490.139
positive regulation of macromolecule metabolic processGO:00106044050.138
transcription from rna polymerase ii promoterGO:00063663680.128
negative regulation of signalingGO:00230572190.122
epithelium migrationGO:00901321480.120
post embryonic appendage morphogenesisGO:00351203850.113
regulation of multicellular organismal developmentGO:20000264140.111
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.109
negative regulation of response to stimulusGO:00485852580.107
regulation of protein metabolic processGO:00512462560.099
negative regulation of cellular metabolic processGO:00313243820.094
imaginal disc derived wing morphogenesisGO:00074763370.086
endomembrane system organizationGO:00102561190.086
biological adhesionGO:00226101380.084
negative regulation of cell communicationGO:00106482230.080
tissue migrationGO:00901301550.078
appendage developmentGO:00487364010.077
appendage morphogenesisGO:00351073970.076
protein modification processGO:00362114380.076
negative regulation of signal transductionGO:00099682060.075
branching involved in open tracheal system developmentGO:0060446450.075
adult chitin containing cuticle pigmentationGO:0048085160.074
mapk cascadeGO:00001651070.073
imaginal disc derived appendage developmentGO:00487373990.070
positive regulation of cell migrationGO:003033520.069
regulation of molecular functionGO:00650092170.069
regulation of hydrolase activityGO:0051336970.068
positive regulation of molecular functionGO:00440931360.068
regulation of cell differentiationGO:00455953020.065
regulation of developmental pigmentationGO:0048070240.065
negative regulation of growthGO:0045926840.065
regulation of cell cycleGO:00517262910.063
organonitrogen compound metabolic processGO:19015643180.063
regulation of response to stressGO:00801342000.061
imaginal disc derived appendage morphogenesisGO:00351143950.060
lipopolysaccharide mediated signaling pathwayGO:003166310.060
regulation of cellular amine metabolic processGO:003323830.058
carbohydrate derivative metabolic processGO:19011352170.057
histoblast morphogenesisGO:000748890.057
regulation of multi organism processGO:00439001310.056
regulation of cellular protein metabolic processGO:00322682430.056
enzyme linked receptor protein signaling pathwayGO:00071671790.055
o glycan processingGO:001626630.054
regulation of response to external stimulusGO:00321011150.053
regulation of cuticle pigmentationGO:0048079160.053
response to organic substanceGO:00100332840.053
cell adhesionGO:00071551360.052
immune response regulating signaling pathwayGO:000276420.052
negative regulation of biosynthetic processGO:00098902770.052
localization of cellGO:00516742570.050
regulation of catalytic activityGO:00507901850.050
small molecule metabolic processGO:00442813050.049
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.049
positive regulation of cell motilityGO:200014730.049
neuron projection guidanceGO:00974852410.048
muscle organ developmentGO:00075171270.048
catabolic processGO:00090564090.047
regulation of localizationGO:00328792750.047
organic substance transportGO:00717022570.046
axonogenesisGO:00074092900.045
regulation of transcription from rna polymerase ii promoterGO:00063573780.045
regulation of phosphate metabolic processGO:00192202100.044
oxoacid metabolic processGO:00434361030.044
cuticle pigmentationGO:0048067220.042
amine metabolic processGO:0009308120.042
chromatin modificationGO:00165681470.042
positive regulation of multi organism processGO:0043902400.042
positive regulation of protein metabolic processGO:00512471280.042
cell migrationGO:00164772380.041
cell motilityGO:00488702510.041
positive regulation of catalytic activityGO:00430851180.040
tube developmentGO:00352952440.040
negative regulation of gene expressionGO:00106293870.040
positive regulation of peptidase activityGO:0010952290.039
response to abiotic stimulusGO:00096283410.039
regulation of proteolysisGO:0030162870.039
regulation of cellular component movementGO:0051270420.039
embryonic development via the syncytial blastodermGO:00017001480.038
macromolecule catabolic processGO:00090571610.038
proteolysisGO:00065081920.037
regulation of cellular response to stressGO:0080135890.037
regulation of rna splicingGO:0043484690.037
phagocytosisGO:00069092150.037
regulation of cellular ketone metabolic processGO:001056530.037
intracellular signal transductionGO:00355563000.036
positive regulation of cellular protein metabolic processGO:00322701180.036
epithelial cell migrationGO:00106311480.035
negative regulation of catalytic activityGO:0043086420.035
single organismal cell cell adhesionGO:0016337450.034
positive regulation of phosphate metabolic processGO:00459371390.034
dendrite morphogenesisGO:00488131990.034
regulation of response to biotic stimulusGO:0002831630.034
regulation of endopeptidase activityGO:0052548360.034
regulation of phosphorus metabolic processGO:00511742100.034
ameboidal type cell migrationGO:00016671510.033
chitin based cuticle sclerotizationGO:0007593190.033
organic substance catabolic processGO:19015753080.033
cell divisionGO:00513012480.033
embryonic morphogenesisGO:00485982060.032
instar larval developmentGO:0002168550.032
inter male aggressive behaviorGO:0002121600.032
cellular macromolecule localizationGO:00707272200.031
cellular ketone metabolic processGO:0042180240.031
regulation of sterol transportGO:003237110.031
positive regulation of response to stimulusGO:00485843230.031
actin cytoskeleton organizationGO:00300362060.031
g protein coupled receptor signaling pathwayGO:00071861360.031
positive regulation of hydrolase activityGO:0051345780.031
regulation of epidermal growth factor receptor signaling pathwayGO:0042058420.030
neurological system processGO:00508773580.030
regulation of peptidase activityGO:0052547390.030
ribonucleoside catabolic processGO:00424541120.029
axis specificationGO:00097981670.029
small gtpase mediated signal transductionGO:0007264880.029
response to light stimulusGO:00094161240.029
axon developmentGO:00615642970.028
intracellular transportGO:00469072280.028
growthGO:00400073590.028
single organism biosynthetic processGO:00447112060.028
negative regulation of erbb signaling pathwayGO:1901185290.028
regionalizationGO:00030024160.028
dorsal closureGO:0007391790.028
head developmentGO:00603221350.027
glycoprotein biosynthetic processGO:0009101410.027
aggressive behaviorGO:0002118630.027
regulation of cellular component biogenesisGO:00440872010.027
single organism cell adhesionGO:0098602470.027
morphogenesis of an epitheliumGO:00020092760.027
regulation of cell motilityGO:2000145230.027
embryo development ending in birth or egg hatchingGO:00097921520.026
connective tissue developmentGO:006144830.026
dorsal ventral axis specificationGO:0009950660.026
endocytosisGO:00068973100.026
cell cell junction organizationGO:0045216550.025
carboxylic acid metabolic processGO:0019752920.025
response to toxic substanceGO:0009636220.025
cell junction organizationGO:0034330570.025
vesicle mediated transportGO:00161923810.025
positive regulation of purine nucleotide catabolic processGO:0033123460.025
negative regulation of intracellular signal transductionGO:1902532570.025
cellular macromolecule catabolic processGO:00442651360.025
regulation of mapk cascadeGO:0043408920.025
regulation of cell migrationGO:0030334220.025
regulation of mitotic cell cycleGO:00073461900.025
protein catabolic processGO:00301631010.025
cellular component assembly involved in morphogenesisGO:00109271510.025
positive regulation of signal transductionGO:00099672230.024
negative regulation of epidermal growth factor receptor signaling pathwayGO:0042059290.024
glycoprotein metabolic processGO:0009100410.024
response to woundingGO:0009611940.024
extracellular matrix constituent secretionGO:007027840.024
regulation of cellular amino acid metabolic processGO:000652100.024
wound healingGO:0042060750.024
dendrite developmentGO:00163582040.024
tube morphogenesisGO:00352391910.024
epidermal growth factor receptor signaling pathwayGO:0007173580.023
single organism intracellular transportGO:19025822070.023
response to alcoholGO:0097305950.023
developmental growthGO:00485892800.023
regulation of tube architecture open tracheal systemGO:0035152680.023
regulation of anatomical structure morphogenesisGO:00226032420.023
cellular amino acid metabolic processGO:0006520610.023
cuticle pattern formationGO:0035017270.023
regulation of phosphorylationGO:00423251470.023
compound eye developmentGO:00487493070.022
columnar cuboidal epithelial cell developmentGO:00020662490.022
single organism cellular localizationGO:19025801800.022
morphogenesis of a branching structureGO:0001763450.022
chromosome organizationGO:00512763600.021
establishment of protein localizationGO:00451841630.021
positive regulation of proteolysisGO:0045862520.021
actin filament organizationGO:00070151260.021
rna processingGO:00063961470.021
deathGO:00162652840.021
regulation of g protein coupled receptor protein signaling pathwayGO:0008277230.021
spindle organizationGO:00070512530.021
protein phosphorylationGO:00064681690.021
positive regulation of response to external stimulusGO:0032103440.021
detection of visible lightGO:0009584380.021
glycosyl compound catabolic processGO:19016581120.021
regulation of intracellular signal transductionGO:19025312360.020
chromosome segregationGO:00070591570.020
regulation of protein localizationGO:0032880760.020
memoryGO:0007613940.020
digestive system developmentGO:00551231490.020
immune response activating signal transductionGO:000275720.020
modification dependent macromolecule catabolic processGO:0043632790.020
molting cycle chitin based cuticleGO:0007591560.019
gene silencingGO:00164581380.019
response to biotic stimulusGO:00096072940.019
cell cell adhesion via plasma membrane adhesion moleculesGO:0098742260.019
regulation of neurogenesisGO:00507671580.019
negative regulation of nitrogen compound metabolic processGO:00511722650.019
learning or memoryGO:00076111410.019
regulation of locomotionGO:0040012420.019
negative regulation of protein metabolic processGO:0051248850.019
negative regulation of endopeptidase activityGO:0010951110.019
compound eye photoreceptor developmentGO:0042051780.019
chromatin organizationGO:00063252070.019
intracellular protein transportGO:00068861040.019
cellular amine metabolic processGO:0044106120.019
deactivation of rhodopsin mediated signalingGO:0016059170.019
actin filament bundle assemblyGO:0051017260.019
response to ethanolGO:0045471590.019
sensory perception of smellGO:0007608800.019
regulation of anatomical structure sizeGO:00900661630.019
reproductive system developmentGO:0061458740.019
protein transportGO:00150311550.019
response to lipopolysaccharideGO:003249640.019
leg disc developmentGO:0035218920.018
regulation of cytoskeleton organizationGO:0051493890.018
telencephalon developmentGO:002153720.018
cytoplasmic transportGO:00164821300.018
positive regulation of cellular biosynthetic processGO:00313283160.018
negative regulation of cellular biosynthetic processGO:00313272770.018
mitotic spindle organizationGO:00070522200.018
positive regulation of gtp catabolic processGO:0033126430.018
detection of stimulus involved in sensory perceptionGO:0050906920.018
negative regulation of molecular functionGO:0044092510.018
molting cycleGO:0042303560.018
rna splicingGO:0008380830.018
regulation of protein modification processGO:00313991120.018
regulation of small gtpase mediated signal transductionGO:0051056930.018
central nervous system developmentGO:00074172010.018
regulation of cell adhesionGO:0030155270.017
cell cell adhesionGO:0098609260.017
morphogenesis of embryonic epitheliumGO:0016331940.017
cellular response to carbohydrate stimulusGO:007132240.017
apoptotic processGO:00069151590.017
regulation of transferase activityGO:0051338580.017
regulation of cell proliferationGO:00421271630.017
single organism behaviorGO:00447083910.017
cellular response to molecule of bacterial originGO:007121930.017
regulation of tube length open tracheal systemGO:0035159240.017
carbohydrate derivative biosynthetic processGO:1901137850.017
mitotic nuclear divisionGO:00070672130.017
cytoskeleton dependent cytokinesisGO:0061640810.017
gtp metabolic processGO:0046039720.017
adult behaviorGO:00305341370.017
nucleoside catabolic processGO:00091641120.017
positive regulation of nucleic acid templated transcriptionGO:19035082660.016
golgi vesicle transportGO:0048193270.016
nucleoside phosphate catabolic processGO:19012921100.016
sensory perceptionGO:00076001960.016
tissue morphogenesisGO:00487292970.016
epithelial cell differentiationGO:00308553220.016
regulation of nucleoside metabolic processGO:0009118500.016
spermatid differentiationGO:00485151140.016
regulation of intracellular transportGO:0032386640.016
cell fate determinationGO:0001709910.016
smoothened signaling pathwayGO:0007224490.016
regulation of cell shapeGO:00083601130.016
cell cell junction assemblyGO:0007043380.016
secretionGO:00469031090.016
response to endogenous stimulusGO:00097191190.016
peptidyl amino acid modificationGO:00181931050.016
regulation of smoothened signaling pathwayGO:0008589280.016
positive regulation of intracellular signal transductionGO:19025331160.015
nucleobase containing compound catabolic processGO:00346551650.015
protein modification by small protein conjugationGO:0032446790.015
ubiquitin dependent protein catabolic processGO:0006511780.015
negative regulation of phosphorus metabolic processGO:0010563450.015
regulation of protein kinase activityGO:0045859510.015
membrane depolarizationGO:005189940.015
positive regulation of cell proliferationGO:0008284470.015
regulation of notch signaling pathwayGO:00085931000.015
regulation of behaviorGO:0050795750.015
negative regulation of developmental growthGO:0048640640.015
adult locomotory behaviorGO:0008344760.015
spermatid developmentGO:0007286980.015
regulation of reproductive processGO:2000241540.015
ion transportGO:00068111450.015
negative regulation of organ growthGO:0046621150.015
dorsal ventral pattern formationGO:00099531330.015
regulation of response to woundingGO:1903034190.015
cellular response to organic substanceGO:00713101320.015
epithelial tube morphogenesisGO:0060562880.015
cellular protein catabolic processGO:0044257830.015
organic acid metabolic processGO:00060821030.015
striated muscle tissue developmentGO:0014706270.015
posttranscriptional gene silencing by rnaGO:0035194450.015
branch fusion open tracheal systemGO:0035147170.015
regulation of mrna processingGO:0050684710.015
sensory organ morphogenesisGO:00905962600.015
regulation of growthGO:00400082330.014
male gamete generationGO:00482322010.014
purine ribonucleoside triphosphate catabolic processGO:00092071080.014
golgi organizationGO:0007030660.014
metal ion transportGO:0030001740.014
protein maturationGO:0051604710.014
phosphorylationGO:00163102940.014
regulation of cytoplasmic transportGO:1903649470.014
positive regulation of gene expressionGO:00106282900.014
cellular response to light stimulusGO:0071482370.014
negative regulation of cellular protein metabolic processGO:0032269850.014
regulation of organelle organizationGO:00330431960.014
regulation of transportGO:00510491810.014
larval developmentGO:00021641040.014
regulation of apoptotic processGO:00429811300.014
eye pigmentationGO:0048069430.014
transmembrane transportGO:00550851390.014
regulation of cysteine type endopeptidase activityGO:2000116270.014
adherens junction organizationGO:0034332270.014
negative regulation of transcription dna templatedGO:00458922370.014
protein ubiquitinationGO:0016567700.014
single organism catabolic processGO:00447122280.014
sperm individualizationGO:0007291480.014
cellular response to biotic stimulusGO:007121640.014
cell growthGO:00160491080.014
pattern recognition receptor signaling pathwayGO:000222120.014
heterocycle catabolic processGO:00467001660.014
negative regulation of programmed cell deathGO:0043069720.014
forebrain developmentGO:003090020.014
nuclear divisionGO:00002803320.014
positive regulation of nucleobase containing compound metabolic processGO:00459353320.014
positive regulation of signalingGO:00230562430.014
nucleoside triphosphate catabolic processGO:00091431080.014
organonitrogen compound biosynthetic processGO:19015661170.014
regulation of epithelial cell proliferationGO:005067840.013
purine nucleoside catabolic processGO:00061521120.013
regulation of immune system processGO:00026821760.013
regulation of programmed cell deathGO:00430671520.013
circulatory system developmentGO:0072359820.013
regulation of stress activated protein kinase signaling cascadeGO:0070302420.013
sensory perception of chemical stimulusGO:00076061160.013
positive regulation of phosphorylationGO:0042327870.013
ribonucleoside triphosphate catabolic processGO:00092031080.013
response to radiationGO:00093141550.013
epithelial cell developmentGO:00020642740.013
cell proliferationGO:00082832990.013
regulation of cell developmentGO:00602842150.013
protein localizationGO:00081042840.013
programmed cell deathGO:00125012570.013
ovarian follicle cell developmentGO:00307072480.013
positive regulation of protein modification processGO:0031401580.013
regulation of chitin based cuticle tanningGO:0007564140.013
organelle assemblyGO:00709251980.013
establishment of localization in cellGO:00516494020.013
organic cyclic compound catabolic processGO:19013611680.013
peptidyl threonine modificationGO:001821030.013
lateral inhibitionGO:00463312060.013
cell junction assemblyGO:0034329420.013
regulation of i kappab kinase nf kappab signalingGO:004312220.013
actin filament based processGO:00300292200.013
regulation of adult chitin containing cuticle pigmentationGO:0048082130.013
cellular nitrogen compound catabolic processGO:00442701650.013
regulation of catabolic processGO:00098941700.013
morphogenesis of a branching epitheliumGO:0061138450.013
signal transduction by phosphorylationGO:00230141070.012
chorion containing eggshell formationGO:00073041050.012
muscle structure developmentGO:00610612240.012
purine nucleoside triphosphate catabolic processGO:00091461080.012
regulation of cell fate specificationGO:0042659270.012
positive regulation of phosphorus metabolic processGO:00105621390.012
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.012
positive regulation of i kappab kinase nf kappab signalingGO:004312310.012
regulation of actin filament based processGO:0032970420.012
pigmentationGO:0043473750.012
genital disc developmentGO:0035215440.012
positive regulation of macromolecule biosynthetic processGO:00105572830.012
nucleotide metabolic processGO:00091171610.012
positive regulation of nitrogen compound metabolic processGO:00511733540.012
purine nucleotide catabolic processGO:00061951090.012
detection of light stimulusGO:0009583580.012
convergent extensionGO:006002620.012
nucleus organizationGO:0006997450.012
membrane organizationGO:00610241120.012
single organism carbohydrate metabolic processGO:0044723720.012
branching morphogenesis of an epithelial tubeGO:0048754450.012
aminoglycan metabolic processGO:0006022180.012
regulation of protein transportGO:0051223570.012
cellular response to lipopolysaccharideGO:007122230.012
protein processingGO:0016485680.012
divalent inorganic cation transportGO:0072511300.012
developmental maturationGO:00217001720.012
regulation of cholesterol transportGO:003237410.012
developmental cell growthGO:0048588520.012
spinal cord developmentGO:002151010.012
positive regulation of cell communicationGO:00106472500.012
single organism nuclear importGO:1902593510.012
anterior posterior axis specification embryoGO:00085951030.012
peptidyl tyrosine phosphorylationGO:0018108240.012
establishment or maintenance of cell polarityGO:00071631670.012
negative regulation of protein tyrosine kinase activityGO:006109950.012
catecholamine biosynthetic processGO:004242330.012
regulation of heart contractionGO:0008016210.012
cellular response to chemical stimulusGO:00708871990.012
eye developmentGO:00016543230.012
regulation of nervous system developmentGO:00519602480.011
hippo signalingGO:0035329200.011
endoderm formationGO:000170630.011
oocyte developmentGO:00485991240.011
chromatin remodelingGO:0006338720.011
stress activated mapk cascadeGO:0051403520.011
cellular protein localizationGO:00346131600.011
macromolecular complex assemblyGO:00650032560.011
negative regulation of cell differentiationGO:00455961430.011
mrna metabolic processGO:00160711240.011
regulation of epithelial cell migrationGO:0010632120.011
gastrulationGO:0007369700.011
modification dependent protein catabolic processGO:0019941780.011
positive regulation of protein transportGO:0051222370.011
development of primary female sexual characteristicsGO:0046545120.011
negative regulation of cell cycleGO:00457861160.011
positive regulation of cell cycleGO:0045787430.011
guanosine containing compound metabolic processGO:1901068740.011
response to oxygen levelsGO:0070482590.011
regulation of defense responseGO:00313471020.011
positive regulation of rna biosynthetic processGO:19026802660.011
regulation of oocyte developmentGO:0060281270.011
intercellular bridge organizationGO:0043063140.011
agingGO:00075681430.011
organophosphate metabolic processGO:00196371950.011
determination of adult lifespanGO:00083401370.011
cell cell signaling involved in cell fate commitmentGO:00451682100.011
homophilic cell adhesion via plasma membrane adhesion moleculesGO:0007156180.011
multi organism behaviorGO:00517051750.011
regulation of cell substrate adhesionGO:001081020.011
negative regulation of wnt signaling pathwayGO:0030178280.011
ribonucleotide catabolic processGO:00092611090.011
nucleotide catabolic processGO:00091661090.011
ras protein signal transductionGO:0007265880.011
intracellular mrna localization involved in pattern specification processGO:0060810560.011
regulation of stress activated mapk cascadeGO:0032872410.011
cell recognitionGO:00080371020.011
regulation of nucleotide catabolic processGO:0030811480.011
cognitionGO:00508901410.011
cellular homeostasisGO:0019725800.011
epithelial cell migration open tracheal systemGO:0007427320.011
regulation of developmental growthGO:00486381740.011
protein targetingGO:0006605640.011
regulation of kinase activityGO:0043549530.011
proteasomal protein catabolic processGO:0010498590.011
positive regulation of catabolic processGO:00098961050.011
proteolysis involved in cellular protein catabolic processGO:0051603830.010
dna metabolic processGO:00062592270.010
cellular catabolic processGO:00442483720.010
carbohydrate metabolic processGO:0005975820.010
developmental pigmentationGO:0048066680.010
muscle cell differentiationGO:00426921030.010
nucleoside triphosphate metabolic processGO:00091411200.010
regulation of nucleotide metabolic processGO:0006140620.010
aromatic compound catabolic processGO:00194391660.010
germline ring canal formationGO:0030725130.010
lipid metabolic processGO:00066291210.010
macromolecule glycosylationGO:0043413320.010
positive regulation of cellular catabolic processGO:0031331950.010
negative regulation of transferase activityGO:0051348180.010
detection of stimulusGO:00516061560.010
negative regulation of nucleic acid templated transcriptionGO:19035072400.010
purine nucleoside triphosphate metabolic processGO:00091441190.010
malpighian tubule developmentGO:0072002640.010

Megalin disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.013
cardiovascular system diseaseDOID:128700.013
integumentary system diseaseDOID:1600.012