IMP: Integrative Multi-species Prediction

Drosophila melanogaster

155 known processes

mor (Dmel_CG18740)

moira

(Aliases: Dmel\CG18740,dmMOIRA,CG18740,MOR,Moira,MOR/BAP155,Swi3D,E(E2F)3B,BAP155,l(3)89B1,Mor,CG4275)

Entrez: 41942
FLYBASE: FBgn0002783
UniProtKB: Q9VF03

Process Predictions
Disease Predictions

mor biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
positive regulation of transcription dna templated	GO:0045893	266	0.995
positive regulation of rna metabolic process	GO:0051254	271	0.992
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.980	Mouse
negative regulation of rna biosynthetic process	GO:1902679	240	0.975	Human Mouse
positive regulation of gene expression	GO:0010628	290	0.973
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.971	Human Mouse
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.971	Mouse
positive regulation of cellular biosynthetic process	GO:0031328	316	0.970
negative regulation of gene expression	GO:0010629	387	0.969	Human Mouse
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.969
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.950
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.947
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.933	Human Mouse
reproductive system development	GO:0061458	74	0.933	Worm
negative regulation of cellular biosynthetic process	GO:0031327	277	0.914	Human Mouse
positive regulation of rna biosynthetic process	GO:1902680	266	0.909
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.886	Human Mouse
axon development	GO:0061564	297	0.882
embryo development ending in birth or egg hatching	GO:0009792	152	0.880	Worm
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.862
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.816	Human Mouse
regionalization	GO:0003002	416	0.815
positive regulation of biosynthetic process	GO:0009891	316	0.797
imaginal disc derived appendage development	GO:0048737	399	0.776
negative regulation of transcription dna templated	GO:0045892	237	0.762	Human Mouse
regulation of cell differentiation	GO:0045595	302	0.759
post embryonic appendage morphogenesis	GO:0035120	385	0.743
appendage morphogenesis	GO:0035107	397	0.707
stem cell maintenance	GO:0019827	67	0.702
transcription from rna polymerase ii promoter	GO:0006366	368	0.671	Mouse
chromosome organization	GO:0051276	360	0.643	Human
positive regulation of macromolecule metabolic process	GO:0010604	405	0.641
sex differentiation	GO:0007548	81	0.621	Worm
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.601	Human Mouse
gonad development	GO:0008406	50	0.568	Worm
negative regulation of cellular metabolic process	GO:0031324	382	0.553	Human Mouse
development of primary sexual characteristics	GO:0045137	50	0.512	Worm
segmentation	GO:0035282	207	0.464
appendage development	GO:0048736	401	0.458
body morphogenesis	GO:0010171	2	0.446
protein dna complex subunit organization	GO:0071824	86	0.436	Human
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.412
embryonic pattern specification	GO:0009880	174	0.392
protein modification process	GO:0036211	438	0.388
regulation of rna splicing	GO:0043484	69	0.377
neuron projection guidance	GO:0097485	241	0.362
negative regulation of neuroblast proliferation	GO:0007406	27	0.356
regulation of intracellular signal transduction	GO:1902531	236	0.354
axonogenesis	GO:0007409	290	0.342
negative regulation of biosynthetic process	GO:0009890	277	0.341	Human Mouse
sensory organ morphogenesis	GO:0090596	260	0.329
reproductive structure development	GO:0048608	74	0.309	Worm
anterior posterior pattern specification	GO:0009952	136	0.299
axon guidance	GO:0007411	233	0.298
eye photoreceptor cell differentiation	GO:0001754	145	0.287
stem cell differentiation	GO:0048863	117	0.283
cellular response to organic substance	GO:0071310	132	0.282	Mouse
chromatin modification	GO:0016568	147	0.276	Human
negative regulation of rna metabolic process	GO:0051253	251	0.269	Human Mouse
regulation of mrna metabolic process	GO:1903311	72	0.260
chromatin silencing	GO:0006342	76	0.255
response to organic substance	GO:0010033	284	0.250	Mouse
rna splicing via transesterification reactions	GO:0000375	73	0.245
axis specification	GO:0009798	167	0.243
regulation of multi organism process	GO:0043900	131	0.242	Worm
tube development	GO:0035295	244	0.239
muscle structure development	GO:0061061	224	0.236
intracellular signal transduction	GO:0035556	300	0.231
cellular response to dna damage stimulus	GO:0006974	223	0.226
mrna metabolic process	GO:0016071	124	0.222
dna templated transcription elongation	GO:0006354	18	0.212
internal protein amino acid acetylation	GO:0006475	38	0.210
oocyte development	GO:0048599	124	0.209
negative regulation of cell proliferation	GO:0008285	69	0.206
blastoderm segmentation	GO:0007350	159	0.195
atp dependent chromatin remodeling	GO:0043044	22	0.192	Human
regulation of alternative mrna splicing via spliceosome	GO:0000381	60	0.188
photoreceptor cell differentiation	GO:0046530	170	0.186
eye development	GO:0001654	323	0.185
nucleosome mobilization	GO:0042766	9	0.173
peptidyl amino acid modification	GO:0018193	105	0.173
cellular component assembly involved in morphogenesis	GO:0010927	151	0.171
dendrite development	GO:0016358	204	0.159
mrna processing	GO:0006397	104	0.157
imaginal disc derived wing morphogenesis	GO:0007476	337	0.152
regulation of response to stress	GO:0080134	200	0.150
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	73	0.150
compound eye development	GO:0048749	307	0.130
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.129	Mouse
digestive system development	GO:0055123	149	0.129
multicellular organismal reproductive behavior	GO:0033057	110	0.129	Worm
death	GO:0016265	284	0.128
cell migration	GO:0016477	238	0.125
peptidyl lysine acetylation	GO:0018394	39	0.125
cell proliferation	GO:0008283	299	0.120
histone lysine methylation	GO:0034968	32	0.116
covalent chromatin modification	GO:0016569	106	0.116
regulation of apoptotic process	GO:0042981	130	0.115
posttranscriptional regulation of gene expression	GO:0010608	145	0.114
regulation of mrna processing	GO:0050684	71	0.113
response to oxygen containing compound	GO:1901700	200	0.111	Mouse
embryonic axis specification	GO:0000578	107	0.110
nucleosome organization	GO:0034728	59	0.109	Human
genitalia development	GO:0048806	26	0.109	Worm
regulation of neurogenesis	GO:0050767	158	0.107
regulation of molecular function	GO:0065009	217	0.105
stem cell development	GO:0048864	79	0.104
growth	GO:0040007	359	0.101	Worm
organelle assembly	GO:0070925	198	0.101
macromolecular complex assembly	GO:0065003	256	0.099
dendrite morphogenesis	GO:0048813	199	0.098
chromatin organization	GO:0006325	207	0.096	Human
methylation	GO:0032259	47	0.096
cell fate determination	GO:0001709	91	0.096
ras protein signal transduction	GO:0007265	88	0.095
male gamete generation	GO:0048232	201	0.094
regulation of localization	GO:0032879	275	0.093
regulation of cell development	GO:0060284	215	0.092
peptidyl lysine trimethylation	GO:0018023	6	0.090
regulation of dna templated transcription elongation	GO:0032784	17	0.090
larval development	GO:0002164	104	0.087	Worm
cellular macromolecular complex assembly	GO:0034622	153	0.086
regulation of cell proliferation	GO:0042127	163	0.085
meiotic cell cycle	GO:0051321	171	0.084
negative regulation of mitotic cell cycle	GO:0045930	109	0.083
meiotic nuclear division	GO:0007126	151	0.081
oocyte differentiation	GO:0009994	145	0.081
mrna splicing via spliceosome	GO:0000398	73	0.080
wing disc morphogenesis	GO:0007472	344	0.080
rna localization	GO:0006403	115	0.078
cell death	GO:0008219	279	0.076
organonitrogen compound metabolic process	GO:1901564	318	0.074
transcription elongation from rna polymerase ii promoter	GO:0006368	18	0.074
regulation of gene silencing	GO:0060968	63	0.073
regulation of dna templated transcription in response to stress	GO:0043620	4	0.070
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.067
histone h3 k4 methylation	GO:0051568	16	0.066
small gtpase mediated signal transduction	GO:0007264	88	0.066
developmental growth	GO:0048589	280	0.063	Worm
rna splicing	GO:0008380	83	0.063
regulation of growth	GO:0040008	233	0.063	Worm
protein acylation	GO:0043543	42	0.062
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.062
dorsal ventral pattern formation	GO:0009953	133	0.061
multi organism reproductive behavior	GO:0044705	121	0.061	Worm
pole plasm mrna localization	GO:0019094	49	0.060
anterior posterior axis specification	GO:0009948	109	0.059
regulation of phosphorus metabolic process	GO:0051174	210	0.057
rna processing	GO:0006396	147	0.056
negative regulation of developmental process	GO:0051093	201	0.055
cellular response to chemical stimulus	GO:0070887	199	0.055	Mouse
oviposition	GO:0018991	19	0.054	Worm
leg disc morphogenesis	GO:0007478	80	0.053
dna metabolic process	GO:0006259	227	0.053
regulation of neuroblast proliferation	GO:1902692	34	0.053
dna templated transcription initiation	GO:0006352	25	0.053
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.052	Mouse
cellular component disassembly	GO:0022411	46	0.052	Human
programmed cell death	GO:0012501	257	0.052
regulation of mrna splicing via spliceosome	GO:0048024	64	0.052
regulation of protein metabolic process	GO:0051246	256	0.052	Mouse
epithelial cell differentiation	GO:0030855	322	0.051
digestive tract development	GO:0048565	149	0.051
cellular protein modification process	GO:0006464	438	0.051
negative regulation of organelle organization	GO:0010639	56	0.050
regulation of cell cycle process	GO:0010564	181	0.050
imaginal disc derived leg morphogenesis	GO:0007480	80	0.050
regulation of cellular response to stress	GO:0080135	89	0.049
camera type eye development	GO:0043010	4	0.049
protein alkylation	GO:0008213	43	0.047
positive regulation of response to stimulus	GO:0048584	323	0.045
positive regulation of cell proliferation	GO:0008284	47	0.045
regulation of cellular amine metabolic process	GO:0033238	3	0.045
alternative mrna splicing via spliceosome	GO:0000380	60	0.044
morphogenesis of an epithelium	GO:0002009	276	0.044	Worm
oocyte axis specification	GO:0007309	108	0.043
regulation of cellular ketone metabolic process	GO:0010565	3	0.043
regulation of cellular amino acid metabolic process	GO:0006521	0	0.043
tripartite regional subdivision	GO:0007351	103	0.043
prostaglandin biosynthetic process	GO:0001516	1	0.042
regulation of reproductive process	GO:2000241	54	0.041	Worm
response to alcohol	GO:0097305	95	0.041
regulation of nervous system development	GO:0051960	248	0.040
histone methylation	GO:0016571	40	0.040
peptidyl lysine modification	GO:0018205	57	0.038
neuron recognition	GO:0008038	101	0.038
cell division	GO:0051301	248	0.038
protein localization to chromatin	GO:0071168	3	0.037
forebrain development	GO:0030900	2	0.036	Mouse
positive regulation of phosphate metabolic process	GO:0045937	139	0.036
intracellular steroid hormone receptor signaling pathway	GO:0030518	12	0.035
compound eye photoreceptor cell differentiation	GO:0001751	140	0.035
regulation of chromatin modification	GO:1903308	28	0.034
immune system process	GO:0002376	347	0.034
myofibril assembly	GO:0030239	36	0.034
negative regulation of nucleoside metabolic process	GO:0045978	1	0.033
dorsal ventral axis specification	GO:0009950	66	0.032
regulation of cell death	GO:0010941	173	0.031
cell cycle checkpoint	GO:0000075	95	0.031
wnt signaling pathway	GO:0016055	98	0.030
regulation of phosphate metabolic process	GO:0019220	210	0.029
regulation of protein modification process	GO:0031399	112	0.029
dna packaging	GO:0006323	91	0.029
response to abiotic stimulus	GO:0009628	341	0.028
regulation of organelle organization	GO:0033043	196	0.028
cellular response to endogenous stimulus	GO:0071495	80	0.027	Mouse
purine ribonucleoside catabolic process	GO:0046130	112	0.027
oocyte construction	GO:0007308	112	0.027
response to external biotic stimulus	GO:0043207	293	0.027
negative regulation of cell cycle	GO:0045786	116	0.027
cellular response to oxygen containing compound	GO:1901701	79	0.027	Mouse
cellular ketone metabolic process	GO:0042180	24	0.027
mitotic cell cycle phase transition	GO:0044772	138	0.026
eye morphogenesis	GO:0048592	260	0.025
amine metabolic process	GO:0009308	12	0.025
symbiosis encompassing mutualism through parasitism	GO:0044403	16	0.025
chromosome segregation	GO:0007059	157	0.025
embryonic morphogenesis	GO:0048598	206	0.025
protein acetylation	GO:0006473	39	0.025
multicellular organism growth	GO:0035264	46	0.025	Worm
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	4	0.025
gland development	GO:0048732	191	0.025
glial cell fate determination	GO:0007403	3	0.024
zygotic determination of anterior posterior axis embryo	GO:0007354	27	0.024
spermatogenesis	GO:0007283	200	0.024
mitotic g2 m transition checkpoint	GO:0044818	70	0.024
developmental programmed cell death	GO:0010623	138	0.023
localization of cell	GO:0051674	257	0.023
regulation of phosphorylation	GO:0042325	147	0.023
positive regulation of signal transduction	GO:0009967	223	0.023
eggshell chorion assembly	GO:0007306	66	0.023
macromolecule methylation	GO:0043414	45	0.022
dendrite guidance	GO:0070983	21	0.022
g2 dna damage checkpoint	GO:0031572	69	0.022
regulation of meiosis	GO:0040020	3	0.022
chromatin remodeling	GO:0006338	72	0.022	Human
cellular response to lipid	GO:0071396	20	0.021
negative regulation of cell cycle process	GO:0010948	109	0.021
negative regulation of neural precursor cell proliferation	GO:2000178	27	0.021
response to endogenous stimulus	GO:0009719	119	0.021	Mouse
positive regulation of growth	GO:0045927	75	0.020	Worm
spliceosomal complex assembly	GO:0000245	1	0.020
regulation of mitotic cell cycle	GO:0007346	190	0.020
embryonic organ development	GO:0048568	50	0.020
intermediate filament based process	GO:0045103	1	0.020
regulation of response to gamma radiation	GO:2001228	4	0.019
regulation of programmed cell death	GO:0043067	152	0.019
positive regulation of cellular amine metabolic process	GO:0033240	0	0.019
neuron fate commitment	GO:0048663	50	0.019	Mouse
chemotaxis	GO:0006935	249	0.018
cellular macromolecule localization	GO:0070727	220	0.018
dna integrity checkpoint	GO:0031570	81	0.018
negative regulation of cell differentiation	GO:0045596	143	0.018
apoptotic process	GO:0006915	159	0.018
gene silencing	GO:0016458	138	0.018
reproductive behavior	GO:0019098	122	0.018	Worm
head development	GO:0060322	135	0.018	Mouse
leg disc development	GO:0035218	92	0.017
negative regulation of programmed cell death	GO:0043069	72	0.017
intracellular mrna localization involved in pattern specification process	GO:0060810	56	0.017
response to lipid	GO:0033993	38	0.017
positive regulation of transport	GO:0051050	92	0.017
histone acetylation	GO:0016573	38	0.017
positive regulation of phosphorus metabolic process	GO:0010562	139	0.017
gland morphogenesis	GO:0022612	145	0.017
histone modification	GO:0016570	106	0.017
cellular amine metabolic process	GO:0044106	12	0.017
columnar cuboidal epithelial cell development	GO:0002066	249	0.017
phagocytosis	GO:0006909	215	0.016
ameboidal type cell migration	GO:0001667	151	0.016
positive regulation of protein metabolic process	GO:0051247	128	0.016
regulation of sister chromatid cohesion	GO:0007063	2	0.016
tube morphogenesis	GO:0035239	191	0.016
negative regulation of cell cycle phase transition	GO:1901988	103	0.016
small molecule metabolic process	GO:0044281	305	0.016
multi organism behavior	GO:0051705	175	0.016	Worm
eggshell formation	GO:0030703	105	0.015
positive regulation of signaling	GO:0023056	243	0.015
mitotic g2 dna damage checkpoint	GO:0007095	69	0.015
extrinsic apoptotic signaling pathway	GO:0097191	1	0.015
eye photoreceptor cell development	GO:0042462	81	0.015
organic acid metabolic process	GO:0006082	103	0.015
cell adhesion	GO:0007155	136	0.015
cell type specific apoptotic process	GO:0097285	38	0.015
negative regulation of apoptotic process	GO:0043066	63	0.015
cellular response to hormone stimulus	GO:0032870	44	0.015	Mouse
regulation of cell cycle	GO:0051726	291	0.015
positive regulation of ras protein signal transduction	GO:0046579	43	0.015
regulation of hemocyte proliferation	GO:0035206	37	0.014
convergent extension	GO:0060026	2	0.014
protein localization	GO:0008104	284	0.014
endocytosis	GO:0006897	310	0.014
salivary gland development	GO:0007431	162	0.014
meiotic nuclear envelope disassembly	GO:0051078	2	0.014
regulation of wnt signaling pathway	GO:0030111	68	0.014
stress granule disassembly	GO:0035617	1	0.014
negative regulation of nucleotide metabolic process	GO:0045980	4	0.014
spermatid differentiation	GO:0048515	114	0.014
negative regulation of gene expression epigenetic	GO:0045814	77	0.014
positive regulation of neuron projection regeneration	GO:0070572	3	0.014
dna methylation	GO:0006306	4	0.014
embryonic development via the syncytial blastoderm	GO:0001700	148	0.014
positive regulation of nucleocytoplasmic transport	GO:0046824	24	0.014
camera type eye morphogenesis	GO:0048593	2	0.014
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	9	0.014
regulation of neuron differentiation	GO:0045664	103	0.013
compound eye morphogenesis	GO:0001745	249	0.013
mitochondrial membrane organization	GO:0007006	3	0.013
positive regulation of molecular function	GO:0044093	136	0.013
regulation of transcription elongation from rna polymerase ii promoter	GO:0034243	15	0.013
regulation of chromatin silencing	GO:0031935	36	0.013
cellular protein localization	GO:0034613	160	0.013
positive regulation of protein modification process	GO:0031401	58	0.013
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.012	Mouse
organic cyclic compound catabolic process	GO:1901361	168	0.012
posttranscriptional gene silencing	GO:0016441	46	0.012
histolysis	GO:0007559	102	0.012
formation of a compartment boundary	GO:0060288	4	0.012
photoreceptor cell fate commitment	GO:0046552	41	0.012
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.012
negative regulation of purine nucleotide catabolic process	GO:0033122	1	0.012
epithelial cell development	GO:0002064	274	0.012
internal peptidyl lysine acetylation	GO:0018393	38	0.012
retina development in camera type eye	GO:0060041	4	0.012
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.012
cellular respiration	GO:0045333	26	0.011
ovarian follicle cell development	GO:0030707	248	0.011
salivary gland histolysis	GO:0035070	88	0.011
regulation of response to dna damage stimulus	GO:2001020	23	0.011
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	1	0.011
regulation of cell shape	GO:0008360	113	0.011
organelle fission	GO:0048285	340	0.011
digestive tract morphogenesis	GO:0048546	127	0.011
photoreceptor cell development	GO:0042461	96	0.011
disaccharide metabolic process	GO:0005984	4	0.011
muscle organ development	GO:0007517	127	0.011
regulation of catalytic activity	GO:0050790	185	0.011
icosanoid biosynthetic process	GO:0046456	1	0.011
hindbrain development	GO:0030902	2	0.011
negative regulation of gtp catabolic process	GO:0033125	1	0.011
limb morphogenesis	GO:0035108	1	0.010
regulation of ras protein signal transduction	GO:0046578	93	0.010
positive regulation of ruffle assembly	GO:1900029	1	0.010
autophagic cell death	GO:0048102	83	0.010
dna damage checkpoint	GO:0000077	78	0.010
negative regulation of cell death	GO:0060548	81	0.010
striated muscle cell development	GO:0055002	50	0.010
nucleobase containing compound catabolic process	GO:0034655	165	0.010
negative regulation of transcription factor import into nucleus	GO:0042992	4	0.010
intracellular receptor signaling pathway	GO:0030522	19	0.010
cell maturation	GO:0048469	144	0.010

mor disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.024
nervous system disease	DOID:863	0.020
musculoskeletal system disease	DOID:17	0.010

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