IMP: Integrative Multi-species Prediction

Drosophila melanogaster

8 known processes

TORC (Dmel_CG6064)

CG6064 gene product from transcript CG6064-RA

(Aliases: Dmel\CG6064,CG6064,dTORC)

Entrez: 39970
FLYBASE: FBgn0036746
UniProtKB: M9PFU2
UniProtKB: Q9VVJ8

Process Predictions
Disease Predictions

TORC biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability
protein modification process	GO:0036211	438	0.295
regulation of cell death	GO:0010941	173	0.295
growth	GO:0040007	359	0.252
programmed cell death	GO:0012501	257	0.245
defense response	GO:0006952	300	0.242
regulation of cell differentiation	GO:0045595	302	0.234
lateral inhibition	GO:0046331	206	0.227
multi organism behavior	GO:0051705	175	0.217
regulation of response to stress	GO:0080134	200	0.210
regulation of cellular protein metabolic process	GO:0032268	243	0.179
negative regulation of signaling	GO:0023057	219	0.178
cellular protein modification process	GO:0006464	438	0.158
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.147
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.143
regulation of protein metabolic process	GO:0051246	256	0.143
photoreceptor cell differentiation	GO:0046530	170	0.141
cellular response to dna damage stimulus	GO:0006974	223	0.124
regulation of defense response	GO:0031347	102	0.121
wing disc morphogenesis	GO:0007472	344	0.119
taxis	GO:0042330	304	0.119
response to oxidative stress	GO:0006979	86	0.117
negative regulation of gene expression	GO:0010629	387	0.112
appendage morphogenesis	GO:0035107	397	0.110
compound eye photoreceptor development	GO:0042051	78	0.097
forebrain development	GO:0030900	2	0.093
phosphorylation	GO:0016310	294	0.093
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.085
positive regulation of macromolecule metabolic process	GO:0010604	405	0.085
eye development	GO:0001654	323	0.083
response to nutrient levels	GO:0031667	114	0.082
negative regulation of programmed cell death	GO:0043069	72	0.081
small molecule metabolic process	GO:0044281	305	0.080
regulation of gene expression epigenetic	GO:0040029	128	0.079
imaginal disc derived appendage development	GO:0048737	399	0.079
response to starvation	GO:0042594	97	0.078
response to radiation	GO:0009314	155	0.078
cell death	GO:0008219	279	0.077
negative regulation of cell communication	GO:0010648	223	0.076
dna metabolic process	GO:0006259	227	0.076
death	GO:0016265	284	0.075
peptidyl amino acid modification	GO:0018193	105	0.074
negative regulation of signal transduction	GO:0009968	206	0.073
regulation of catalytic activity	GO:0050790	185	0.072
chromosome organization	GO:0051276	360	0.072
gene silencing	GO:0016458	138	0.071
response to abiotic stimulus	GO:0009628	341	0.070
post embryonic appendage morphogenesis	GO:0035120	385	0.070
vesicle mediated transport	GO:0016192	381	0.066
compound eye photoreceptor cell differentiation	GO:0001751	140	0.066
imaginal disc fusion	GO:0046528	19	0.064
adult behavior	GO:0030534	137	0.064
regulation of intracellular signal transduction	GO:1902531	236	0.062
regulation of programmed cell death	GO:0043067	152	0.062
compound eye morphogenesis	GO:0001745	249	0.062
columnar cuboidal epithelial cell development	GO:0002066	249	0.060
chromatin remodeling	GO:0006338	72	0.060
response to biotic stimulus	GO:0009607	294	0.060
response to external biotic stimulus	GO:0043207	293	0.059
imaginal disc derived wing morphogenesis	GO:0007476	337	0.057
negative regulation of cellular metabolic process	GO:0031324	382	0.057
protein phosphorylation	GO:0006468	169	0.056
positive regulation of response to stimulus	GO:0048584	323	0.055
regulation of phosphorus metabolic process	GO:0051174	210	0.055
appendage development	GO:0048736	401	0.054
eye morphogenesis	GO:0048592	260	0.053
chromatin silencing	GO:0006342	76	0.052
telencephalon development	GO:0021537	2	0.052
regulation of molecular function	GO:0065009	217	0.052
regulation of cellular ketone metabolic process	GO:0010565	3	0.052
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.052
positive regulation of cellular protein metabolic process	GO:0032270	118	0.052
response to other organism	GO:0051707	293	0.051
chemical homeostasis	GO:0048878	92	0.051
negative regulation of cellular biosynthetic process	GO:0031327	277	0.050
response to wounding	GO:0009611	94	0.050
negative regulation of cell death	GO:0060548	81	0.049
establishment of localization in cell	GO:0051649	402	0.049
positive regulation of transcription dna templated	GO:0045893	266	0.049
regulation of cell development	GO:0060284	215	0.049
positive regulation of protein modification process	GO:0031401	58	0.049
negative regulation of apoptotic process	GO:0043066	63	0.049
regulation of cell morphogenesis	GO:0022604	163	0.048
cell growth	GO:0016049	108	0.048
regulation of cellular amino acid metabolic process	GO:0006521	0	0.047
purine nucleotide catabolic process	GO:0006195	109	0.047
brain development	GO:0007420	120	0.047
signal transduction by p53 class mediator	GO:0072331	6	0.047
protein modification by small protein conjugation or removal	GO:0070647	106	0.047
actin filament bundle organization	GO:0061572	28	0.047
regulation of protein modification process	GO:0031399	112	0.047
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.047
transcription from rna polymerase ii promoter	GO:0006366	368	0.046
negative regulation of response to stimulus	GO:0048585	258	0.046
cell migration	GO:0016477	238	0.046
regulation of cellular amine metabolic process	GO:0033238	3	0.045
regulation of cellular component biogenesis	GO:0044087	201	0.044
eye photoreceptor cell development	GO:0042462	81	0.044
macromolecular complex assembly	GO:0065003	256	0.044
regulation of phosphorylation	GO:0042325	147	0.043
positive regulation of signal transduction	GO:0009967	223	0.043
positive regulation of protein metabolic process	GO:0051247	128	0.043
intrinsic apoptotic signaling pathway	GO:0097193	16	0.042
positive regulation of phosphate metabolic process	GO:0045937	139	0.041
protein modification by small protein conjugation	GO:0032446	79	0.041
neutral lipid biosynthetic process	GO:0046460	2	0.041
regulation of nervous system development	GO:0051960	248	0.041
chemotaxis	GO:0006935	249	0.040
negative regulation of biosynthetic process	GO:0009890	277	0.040
regulation of transferase activity	GO:0051338	58	0.040
apoptotic process	GO:0006915	159	0.040
axon development	GO:0061564	297	0.039
regulation of localization	GO:0032879	275	0.039
regulation of multicellular organismal development	GO:2000026	414	0.038
synapse organization	GO:0050808	196	0.038
synaptic transmission	GO:0007268	288	0.038
negative regulation of developmental process	GO:0051093	201	0.037
regulation of immune system process	GO:0002682	176	0.037
defense response to bacterium	GO:0042742	178	0.037
heterocycle catabolic process	GO:0046700	166	0.037
amine metabolic process	GO:0009308	12	0.036
nuclear division	GO:0000280	332	0.036
central nervous system development	GO:0007417	201	0.036
negative regulation of rna metabolic process	GO:0051253	251	0.035
regulation of phosphate metabolic process	GO:0019220	210	0.035
aromatic compound catabolic process	GO:0019439	166	0.035
intracellular signal transduction	GO:0035556	300	0.035
single organism catabolic process	GO:0044712	228	0.034
regulation of protein phosphorylation	GO:0001932	64	0.034
peptidyl tyrosine phosphorylation	GO:0018108	24	0.034
negative regulation of rna biosynthetic process	GO:1902679	240	0.034
positive regulation of molecular function	GO:0044093	136	0.034
ovarian follicle cell development	GO:0030707	248	0.034
regulation of protein kinase activity	GO:0045859	51	0.033
cellular ketone metabolic process	GO:0042180	24	0.033
spermatogenesis	GO:0007283	200	0.033
organic acid metabolic process	GO:0006082	103	0.033
chromatin modification	GO:0016568	147	0.032
cellular response to chemical stimulus	GO:0070887	199	0.032
carbohydrate homeostasis	GO:0033500	12	0.032
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.032
organic substance catabolic process	GO:1901575	308	0.032
regulation of apoptotic process	GO:0042981	130	0.032
regulation of cellular response to stress	GO:0080135	89	0.032
intracellular transport	GO:0046907	228	0.031
homeostatic process	GO:0042592	199	0.031
single organism intracellular transport	GO:1902582	207	0.031
response to organic substance	GO:0010033	284	0.030
positive regulation of catabolic process	GO:0009896	105	0.030
organelle fission	GO:0048285	340	0.030
positive regulation of defense response	GO:0031349	59	0.030
regulation of anatomical structure size	GO:0090066	163	0.030
regulation of immune response	GO:0050776	118	0.029
negative regulation of intracellular signal transduction	GO:1902532	57	0.029
regulation of growth	GO:0040008	233	0.029
immune response	GO:0006955	246	0.029
cellular amine metabolic process	GO:0044106	12	0.029
neurological system process	GO:0050877	358	0.029
immune system process	GO:0002376	347	0.029
cellular catabolic process	GO:0044248	372	0.028
compound eye development	GO:0048749	307	0.028
ameboidal type cell migration	GO:0001667	151	0.028
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.028
phagocytosis	GO:0006909	215	0.028
response to extracellular stimulus	GO:0009991	116	0.028
positive regulation of gene expression	GO:0010628	290	0.028
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.028
positive regulation of cellular amine metabolic process	GO:0033240	0	0.028
positive regulation of catalytic activity	GO:0043085	118	0.028
regulation of cell cycle	GO:0051726	291	0.028
oxoacid metabolic process	GO:0043436	103	0.028
localization of cell	GO:0051674	257	0.028
cellular amino acid metabolic process	GO:0006520	61	0.027
purine nucleotide metabolic process	GO:0006163	146	0.026
triglyceride biosynthetic process	GO:0019432	2	0.026
positive regulation of signaling	GO:0023056	243	0.026
imaginal disc derived wing vein specification	GO:0007474	48	0.026
positive regulation of autophagy	GO:0010508	21	0.025
extracellular structure organization	GO:0043062	46	0.025
regulation of catabolic process	GO:0009894	170	0.025
negative regulation of cellular component organization	GO:0051129	108	0.025
response to oxygen containing compound	GO:1901700	200	0.025
imaginal disc fusion thorax closure	GO:0046529	19	0.025
spermatid differentiation	GO:0048515	114	0.025
regulation of response to dna damage stimulus	GO:2001020	23	0.024
positive regulation of cellular biosynthetic process	GO:0031328	316	0.024
organonitrogen compound metabolic process	GO:1901564	318	0.024
posttranscriptional gene silencing	GO:0016441	46	0.024
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.024
defense response to other organism	GO:0098542	225	0.024
peptidyl lysine modification	GO:0018205	57	0.023
jnk cascade	GO:0007254	50	0.023
negative regulation of cell differentiation	GO:0045596	143	0.023
developmental growth	GO:0048589	280	0.023
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.023
tissue migration	GO:0090130	155	0.023
actin filament bundle assembly	GO:0051017	26	0.023
lipid metabolic process	GO:0006629	121	0.023
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.023
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.023
locomotory behavior	GO:0007626	176	0.022
spermatid development	GO:0007286	98	0.022
tissue death	GO:0016271	102	0.022
cellular carbohydrate metabolic process	GO:0044262	22	0.022
nucleobase containing small molecule metabolic process	GO:0055086	174	0.021
eye photoreceptor cell differentiation	GO:0001754	145	0.021
positive regulation of immune system process	GO:0002684	68	0.021
organic substance transport	GO:0071702	257	0.021
respiratory system development	GO:0060541	213	0.021
store operated calcium entry	GO:0002115	3	0.021
regulation of peptidyl tyrosine phosphorylation	GO:0050730	10	0.021
regulation of kinase activity	GO:0043549	53	0.021
ribonucleoside catabolic process	GO:0042454	112	0.021
chromatin organization	GO:0006325	207	0.021
catabolic process	GO:0009056	409	0.020
regulation of phosphatase activity	GO:0010921	3	0.020
regulation of organelle organization	GO:0033043	196	0.020
ribose phosphate metabolic process	GO:0019693	145	0.020
regulation of mitotic cell cycle	GO:0007346	190	0.020
positive regulation of immune response	GO:0050778	63	0.019
jak stat cascade	GO:0007259	49	0.019
signal transduction in response to dna damage	GO:0042770	3	0.019
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.019
single organism cellular localization	GO:1902580	180	0.019
photoreceptor cell development	GO:0042461	96	0.019
regulation of hydrolase activity	GO:0051336	97	0.019
developmental maturation	GO:0021700	172	0.019
positive regulation of cell death	GO:0010942	69	0.019
purine ribonucleoside catabolic process	GO:0046130	112	0.019
negative regulation of cell cycle process	GO:0010948	109	0.018
signal transduction by phosphorylation	GO:0023014	107	0.018
aging	GO:0007568	143	0.018
response to heat	GO:0009408	63	0.018
carboxylic acid metabolic process	GO:0019752	92	0.018
positive regulation of phosphorus metabolic process	GO:0010562	139	0.018
purine containing compound metabolic process	GO:0072521	155	0.018
maintenance of location	GO:0051235	73	0.018
positive regulation of endopeptidase activity	GO:0010950	26	0.018
purine ribonucleotide metabolic process	GO:0009150	145	0.018
mitotic spindle organization	GO:0007052	220	0.018
regulation of synapse organization	GO:0050807	110	0.018
purine ribonucleotide catabolic process	GO:0009154	109	0.018
regulation of cellular catabolic process	GO:0031329	157	0.018
negative regulation of multicellular organismal process	GO:0051241	142	0.018
stress activated protein kinase signaling cascade	GO:0031098	55	0.018
nucleoside catabolic process	GO:0009164	112	0.018
negative regulation of molecular function	GO:0044092	51	0.018
glycerolipid metabolic process	GO:0046486	34	0.018
carbohydrate derivative metabolic process	GO:1901135	217	0.017
microtubule based transport	GO:0010970	42	0.017
neuron projection guidance	GO:0097485	241	0.017
mitotic nuclear division	GO:0007067	213	0.017
negative regulation of phosphorylation	GO:0042326	35	0.017
organophosphate metabolic process	GO:0019637	195	0.017
negative regulation of cellular protein metabolic process	GO:0032269	85	0.017
triglyceride metabolic process	GO:0006641	12	0.017
somatic muscle development	GO:0007525	66	0.017
regulation of anatomical structure morphogenesis	GO:0022603	242	0.017
regulation of gene silencing	GO:0060968	63	0.017
endocytosis	GO:0006897	310	0.017
regulation of synapse structure and activity	GO:0050803	128	0.017
filtration diaphragm assembly	GO:0036058	4	0.017
regulation of response to external stimulus	GO:0032101	115	0.017
positive regulation of cell communication	GO:0010647	250	0.017
ribonucleoside metabolic process	GO:0009119	127	0.017
multi organism reproductive behavior	GO:0044705	121	0.017
secretion	GO:0046903	109	0.017
negative regulation of transcription dna templated	GO:0045892	237	0.017
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.017
intrinsic apoptotic signaling pathway by p53 class mediator	GO:0072332	5	0.016
notch signaling pathway	GO:0007219	120	0.016
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.016
rna processing	GO:0006396	147	0.016
chaeta development	GO:0022416	97	0.016
purine containing compound catabolic process	GO:0072523	112	0.016
peptidyl tyrosine modification	GO:0018212	24	0.016
microtubule based movement	GO:0007018	51	0.016
antimicrobial humoral response	GO:0019730	99	0.016
negative regulation of kinase activity	GO:0033673	16	0.016
negative regulation of protein metabolic process	GO:0051248	85	0.016
mapk cascade	GO:0000165	107	0.016
humoral immune response	GO:0006959	117	0.016
cellular macromolecule localization	GO:0070727	220	0.015
regulation of mapk cascade	GO:0043408	92	0.015
generation of precursor metabolites and energy	GO:0006091	42	0.015
sensory organ morphogenesis	GO:0090596	260	0.015
ras protein signal transduction	GO:0007265	88	0.015
cytoskeleton dependent intracellular transport	GO:0030705	44	0.015
cellular response to nutrient levels	GO:0031669	62	0.015
cellular response to oxygen containing compound	GO:1901701	79	0.015
internal peptidyl lysine acetylation	GO:0018393	38	0.015
positive regulation of rna metabolic process	GO:0051254	271	0.015
negative regulation of catalytic activity	GO:0043086	42	0.015
axon guidance	GO:0007411	233	0.015
posttranscriptional gene silencing by rna	GO:0035194	45	0.015
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.015
response to temperature stimulus	GO:0009266	106	0.015
carbohydrate derivative catabolic process	GO:1901136	118	0.015
response to peptide	GO:1901652	29	0.014
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.014
epithelial cell differentiation	GO:0030855	322	0.014
cellular response to organic substance	GO:0071310	132	0.014
muscle tissue development	GO:0060537	30	0.014
determination of adult lifespan	GO:0008340	137	0.014
nucleotide catabolic process	GO:0009166	109	0.014
cell proliferation	GO:0008283	299	0.014
regulation of lipid metabolic process	GO:0019216	15	0.014
actin cytoskeleton organization	GO:0030036	206	0.014
single organism biosynthetic process	GO:0044711	206	0.014
regulation of neuron differentiation	GO:0045664	103	0.014
positive regulation of apoptotic process	GO:0043065	47	0.014
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.014
axon cargo transport	GO:0008088	29	0.014
positive regulation of protein phosphorylation	GO:0001934	34	0.014
muscle organ development	GO:0007517	127	0.013
positive regulation of jun kinase activity	GO:0043507	4	0.013
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.013
ribosomal large subunit biogenesis	GO:0042273	1	0.013
neuron death	GO:0070997	27	0.013
protein complex biogenesis	GO:0070271	201	0.013
positive regulation of multicellular organismal process	GO:0051240	143	0.013
r7 cell differentiation	GO:0045466	43	0.013
protein ubiquitination	GO:0016567	70	0.013
ribonucleotide catabolic process	GO:0009261	109	0.013
organelle localization	GO:0051640	148	0.013
nucleobase containing compound catabolic process	GO:0034655	165	0.013
positive regulation of cell motility	GO:2000147	3	0.013
wound healing	GO:0042060	75	0.013
regulation of peptidase activity	GO:0052547	39	0.013
nucleoside triphosphate catabolic process	GO:0009143	108	0.013
meiotic cell cycle	GO:0051321	171	0.013
posttranscriptional regulation of gene expression	GO:0010608	145	0.013
purine ribonucleoside metabolic process	GO:0046128	127	0.013
skeletal muscle fiber development	GO:0048741	3	0.013
regulation of actin cytoskeleton organization	GO:0032956	42	0.013
response to endogenous stimulus	GO:0009719	119	0.013
negative regulation of protein phosphorylation	GO:0001933	17	0.013
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.013
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.013
positive regulation of lipid metabolic process	GO:0045834	4	0.013
negative regulation of response to external stimulus	GO:0032102	22	0.013
germarium derived egg chamber formation	GO:0007293	101	0.013
regulation of response to nutrient levels	GO:0032107	18	0.012
cellular nitrogen compound catabolic process	GO:0044270	165	0.012
cytoplasmic transport	GO:0016482	130	0.012
positive regulation of phosphorylation	GO:0042327	87	0.012
regulation of cellular component size	GO:0032535	98	0.012
regulation of transport	GO:0051049	181	0.012
tube development	GO:0035295	244	0.012
spindle organization	GO:0007051	253	0.012
regulation of cell size	GO:0008361	63	0.012
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.012
cell type specific apoptotic process	GO:0097285	38	0.012
multicellular organismal aging	GO:0010259	140	0.012
chemosensory behavior	GO:0007635	106	0.012
regulation of developmental growth	GO:0048638	174	0.012
germ line stem cell maintenance	GO:0030718	50	0.012
regulation of neuron death	GO:1901214	26	0.012
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.012
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.012
cell motility	GO:0048870	251	0.012
positive regulation of intracellular signal transduction	GO:1902533	116	0.012
positive regulation of peptidase activity	GO:0010952	29	0.012
ribonucleoprotein complex subunit organization	GO:0071826	28	0.011
gtp catabolic process	GO:0006184	72	0.011
positive regulation of transferase activity	GO:0051347	26	0.011
negative regulation of mitotic cell cycle	GO:0045930	109	0.011
protein localization	GO:0008104	284	0.011
mitotic dna damage checkpoint	GO:0044773	74	0.011
circadian rhythm	GO:0007623	105	0.011
response to ionizing radiation	GO:0010212	32	0.011
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	23	0.011
central nervous system neuron differentiation	GO:0021953	8	0.011
embryonic morphogenesis	GO:0048598	206	0.011
regulation of cytoskeleton organization	GO:0051493	89	0.011
actin filament based process	GO:0030029	220	0.011
response to hexose	GO:0009746	3	0.011
compound eye cone cell differentiation	GO:0042675	13	0.011
regulation of multi organism process	GO:0043900	131	0.011
cellular response to starvation	GO:0009267	61	0.011
neutral lipid metabolic process	GO:0006638	12	0.011
proteolysis	GO:0006508	192	0.011
cardiac cell fate specification	GO:0060912	10	0.011
polyol biosynthetic process	GO:0046173	3	0.011
negative regulation of protein modification process	GO:0031400	29	0.011
protein complex assembly	GO:0006461	200	0.011
axonogenesis	GO:0007409	290	0.011
negative regulation of neurogenesis	GO:0050768	53	0.011
cellular response to endogenous stimulus	GO:0071495	80	0.010
positive regulation of innate immune response	GO:0045089	38	0.010
activation of innate immune response	GO:0002218	4	0.010
nucleotide metabolic process	GO:0009117	161	0.010
connective tissue development	GO:0061448	3	0.010
embryonic hemopoiesis	GO:0035162	26	0.010
embryo development ending in birth or egg hatching	GO:0009792	152	0.010
oxidation reduction process	GO:0055114	123	0.010
developmental programmed cell death	GO:0010623	138	0.010
regulation of stress activated mapk cascade	GO:0032872	41	0.010
regulation of neurogenesis	GO:0050767	158	0.010
innate immune response	GO:0045087	144	0.010

TORC disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.017
disease of anatomical entity	DOID:7	0.016
type 2 diabetes mellitus	DOID:9352	0.014
glucose metabolism disease	DOID:4194	0.014
carbohydrate metabolism disease	DOID:0050013	0.014
acquired metabolic disease	DOID:0060158	0.014
diabetes mellitus	DOID:9351	0.014
nervous system disease	DOID:863	0.011

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