IMP: Integrative Multi-species Prediction

Drosophila melanogaster

69 known processes

Sas-4 (Dmel_CG10061)

CG10061 gene product from transcript CG10061-RA

(Aliases: SAS4,DSas4,SAS-4,Dmel\CG10061,Sas4,dsas-4,l(3)S2214,D-Sas4,l(3)s2214,DSas-4,CG10061,DSAS-4,sas-4)

Entrez: 40859
FLYBASE: FBgn0011020
UniProtKB: Q9VI72

Process Predictions
Disease Predictions

Sas-4 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
centrosome organization	GO:0051297	163	0.997
organelle fission	GO:0048285	340	0.993
centrosome duplication	GO:0051298	121	0.991
microtubule organizing center organization	GO:0031023	168	0.990
centrosome cycle	GO:0007098	137	0.986
male gamete generation	GO:0048232	201	0.982
mitotic spindle organization	GO:0007052	220	0.982
nuclear division	GO:0000280	332	0.979
centriole centriole cohesion	GO:0010457	5	0.971
centrosome separation	GO:0051299	20	0.969
neuroblast division	GO:0055057	35	0.955
neuronal stem cell division	GO:0036445	35	0.932
asymmetric neuroblast division	GO:0055059	33	0.929
spermatogenesis	GO:0007283	200	0.927
centriole assembly	GO:0098534	24	0.924
asymmetric stem cell division	GO:0098722	49	0.860
somatic stem cell division	GO:0048103	37	0.860
regulation of cell cycle	GO:0051726	291	0.860
spermatid differentiation	GO:0048515	114	0.852
cell division	GO:0051301	248	0.817
neural precursor cell proliferation	GO:0061351	75	0.791
regulation of cell cycle process	GO:0010564	181	0.789
cell cycle comprising mitosis without cytokinesis	GO:0033301	25	0.758
meiotic nuclear division	GO:0007126	151	0.732
cilium organization	GO:0044782	41	0.665
meiotic cell cycle process	GO:1903046	132	0.658
microtubule bundle formation	GO:0001578	27	0.647
organelle assembly	GO:0070925	198	0.629
neuroblast proliferation	GO:0007405	74	0.626
negative regulation of cell cycle	GO:0045786	116	0.592
centriole replication	GO:0007099	24	0.588
mitotic nuclear division	GO:0007067	213	0.578
spermatid development	GO:0007286	98	0.574
stem cell division	GO:0017145	69	0.538
mitotic sister chromatid segregation	GO:0000070	87	0.521
establishment of localization in cell	GO:0051649	402	0.505
cell proliferation	GO:0008283	299	0.476
dna metabolic process	GO:0006259	227	0.454
negative regulation of cellular metabolic process	GO:0031324	382	0.426
negative regulation of cell cycle process	GO:0010948	109	0.405
spindle organization	GO:0007051	253	0.385
mitotic centrosome separation	GO:0007100	8	0.334
spindle assembly involved in mitosis	GO:0090307	50	0.324
chromosome segregation	GO:0007059	157	0.306
cellular macromolecule localization	GO:0070727	220	0.302
protein complex assembly	GO:0006461	200	0.290
regulation of microtubule based process	GO:0032886	49	0.268
cellular protein localization	GO:0034613	160	0.263
protein localization	GO:0008104	284	0.259
single organism cellular localization	GO:1902580	180	0.255
organelle localization	GO:0051640	148	0.241
negative regulation of rna biosynthetic process	GO:1902679	240	0.236
gland development	GO:0048732	191	0.229
microtubule cytoskeleton organization involved in mitosis	GO:1902850	52	0.223
mitotic cell cycle checkpoint	GO:0007093	88	0.218
negative regulation of cell cycle phase transition	GO:1901988	103	0.204
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.204
embryo development ending in birth or egg hatching	GO:0009792	152	0.201
regulation of catalytic activity	GO:0050790	185	0.199
mitotic cell cycle phase transition	GO:0044772	138	0.195
establishment of cell polarity	GO:0030010	40	0.195
cytoskeleton dependent cytokinesis	GO:0061640	81	0.192
asymmetric cell division	GO:0008356	37	0.189
protein localization to organelle	GO:0033365	82	0.174
positive regulation of macromolecule metabolic process	GO:0010604	405	0.164
male meiosis cytokinesis	GO:0007112	26	0.163
regulation of cell division	GO:0051302	72	0.153
dna conformation change	GO:0071103	105	0.153
regulation of mitotic cell cycle	GO:0007346	190	0.148
sister chromatid segregation	GO:0000819	92	0.147
regulation of organelle organization	GO:0033043	196	0.146
cell projection assembly	GO:0030031	94	0.144
developmental maturation	GO:0021700	172	0.140
regulation of microtubule cytoskeleton organization	GO:0070507	41	0.139
male meiosis	GO:0007140	52	0.133
protein dna complex assembly	GO:0065004	63	0.128
g2 dna damage checkpoint	GO:0031572	69	0.125
maintenance of protein location	GO:0045185	28	0.124
regulation of epithelial cell proliferation	GO:0050678	4	0.123
axoneme assembly	GO:0035082	18	0.121
negative regulation of protein complex disassembly	GO:0043242	23	0.117
negative regulation of response to stimulus	GO:0048585	258	0.116
cilium morphogenesis	GO:0060271	39	0.116
snrna metabolic process	GO:0016073	14	0.112
negative regulation of microtubule polymerization or depolymerization	GO:0031111	21	0.111
development of primary sexual characteristics	GO:0045137	50	0.108
mitotic g2 m transition checkpoint	GO:0044818	70	0.106
nucleobase containing small molecule metabolic process	GO:0055086	174	0.105
nonmotile primary cilium assembly	GO:0035058	8	0.102
negative regulation of transcription dna templated	GO:0045892	237	0.102
cellular component disassembly	GO:0022411	46	0.099
snrna processing	GO:0016180	14	0.098
nucleus localization	GO:0051647	34	0.098
reproductive system development	GO:0061458	74	0.097
anatomical structure homeostasis	GO:0060249	97	0.095
microtubule based movement	GO:0007018	51	0.093
sex differentiation	GO:0007548	81	0.091
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.083
negative regulation of mitotic cell cycle	GO:0045930	109	0.083
gland morphogenesis	GO:0022612	145	0.083
organonitrogen compound metabolic process	GO:1901564	318	0.081
growth	GO:0040007	359	0.081
establishment of spindle orientation	GO:0051294	18	0.080
protein maturation	GO:0051604	71	0.080
regulation of cellular response to stress	GO:0080135	89	0.078
positive regulation of catalytic activity	GO:0043085	118	0.077
purine ribonucleotide metabolic process	GO:0009150	145	0.075
macromolecular complex disassembly	GO:0032984	37	0.073
phosphorylation	GO:0016310	294	0.073
meiotic chromosome segregation	GO:0045132	59	0.072
sensory perception	GO:0007600	196	0.072
negative regulation of cellular component organization	GO:0051129	108	0.071
regulation of molecular function	GO:0065009	217	0.070
gonad development	GO:0008406	50	0.070
purine containing compound catabolic process	GO:0072523	112	0.070
positive regulation of signaling	GO:0023056	243	0.068
regulation of dendrite development	GO:0050773	37	0.067
regulation of microtubule depolymerization	GO:0031114	24	0.067
stem cell proliferation	GO:0072089	88	0.066
microtubule anchoring	GO:0034453	11	0.065
spindle assembly	GO:0051225	80	0.064
programmed cell death	GO:0012501	257	0.062
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.060
meiosis i	GO:0007127	59	0.060
negative regulation of protein depolymerization	GO:1901880	23	0.060
negative regulation of organelle organization	GO:0010639	56	0.059
regulation of protein depolymerization	GO:1901879	27	0.059
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.057
nucleus organization	GO:0006997	45	0.057
macromolecular complex assembly	GO:0065003	256	0.057
peptidyl tyrosine phosphorylation	GO:0018108	24	0.056
cell maturation	GO:0048469	144	0.056
regulation of phosphorylation	GO:0042325	147	0.055
mitotic chromosome condensation	GO:0007076	22	0.055
cell motility	GO:0048870	251	0.053
cytokinesis	GO:0000910	90	0.051
small molecule metabolic process	GO:0044281	305	0.051
establishment or maintenance of cell polarity	GO:0007163	167	0.051
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.051
negative regulation of rna metabolic process	GO:0051253	251	0.050
exocrine system development	GO:0035272	162	0.050
regulation of cell cycle phase transition	GO:1901987	130	0.049
cilium assembly	GO:0042384	38	0.049
protein targeting	GO:0006605	64	0.048
eye development	GO:0001654	323	0.048
positive regulation of signal transduction	GO:0009967	223	0.048
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.047
cellular protein modification process	GO:0006464	438	0.046
single organism biosynthetic process	GO:0044711	206	0.046
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.045
response to abiotic stimulus	GO:0009628	341	0.044
cell adhesion	GO:0007155	136	0.044
single organism cell adhesion	GO:0098602	47	0.044
mitotic sister chromatid separation	GO:0051306	30	0.043
attachment of spindle microtubules to kinetochore	GO:0008608	5	0.042
developmental growth	GO:0048589	280	0.042
larval development	GO:0002164	104	0.041
response to oxidative stress	GO:0006979	86	0.041
cell fate determination	GO:0001709	91	0.041
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.040
purine containing compound metabolic process	GO:0072521	155	0.040
regulation of mitosis	GO:0007088	56	0.040
chromosome condensation	GO:0030261	41	0.039
cell cycle phase transition	GO:0044770	140	0.039
single organism intracellular transport	GO:1902582	207	0.039
regionalization	GO:0003002	416	0.039
regulation of nuclear division	GO:0051783	58	0.038
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.037
microtubule based transport	GO:0010970	42	0.036
cellular component assembly involved in morphogenesis	GO:0010927	151	0.032
cellular response to dna damage stimulus	GO:0006974	223	0.032
ribonucleotide metabolic process	GO:0009259	145	0.032
endomembrane system organization	GO:0010256	119	0.031
organonitrogen compound catabolic process	GO:1901565	128	0.031
regulation of protein complex disassembly	GO:0043244	29	0.031
reproductive structure development	GO:0048608	74	0.031
purine ribonucleotide catabolic process	GO:0009154	109	0.031
double strand break repair	GO:0006302	26	0.031
neurological system process	GO:0050877	358	0.030
regulation of embryonic development	GO:0045995	68	0.030
embryonic morphogenesis	GO:0048598	206	0.029
protein phosphorylation	GO:0006468	169	0.029
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.029
maintenance of protein location in cell	GO:0032507	26	0.029
negative regulation of epithelial cell proliferation	GO:0050680	4	0.029
ribose phosphate metabolic process	GO:0019693	145	0.029
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.028
salivary gland development	GO:0007431	162	0.028
digestive tract development	GO:0048565	149	0.028
spindle localization	GO:0051653	22	0.027
positive regulation of phosphorus metabolic process	GO:0010562	139	0.027
single organismal cell cell adhesion	GO:0016337	45	0.027
maintenance of location	GO:0051235	73	0.027
mitotic g2 dna damage checkpoint	GO:0007095	69	0.027
localization of cell	GO:0051674	257	0.027
apoptotic process	GO:0006915	159	0.027
regulation of phosphate metabolic process	GO:0019220	210	0.027
salivary gland morphogenesis	GO:0007435	145	0.026
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.026
cellular response to chemical stimulus	GO:0070887	199	0.026
regulation of hydrolase activity	GO:0051336	97	0.025
protein complex biogenesis	GO:0070271	201	0.025
regulation of ras protein signal transduction	GO:0046578	93	0.025
glycosyl compound metabolic process	GO:1901657	127	0.025
mitotic dna integrity checkpoint	GO:0044774	75	0.025
pole cell formation	GO:0007279	19	0.025
protein polymerization	GO:0051258	42	0.024
regulation of response to stress	GO:0080134	200	0.024
cystoblast division	GO:0007282	10	0.024
female meiosis i	GO:0007144	8	0.024
nucleoside phosphate metabolic process	GO:0006753	162	0.024
purine nucleotide metabolic process	GO:0006163	146	0.024
positive regulation of rna metabolic process	GO:0051254	271	0.024
chromosome organization	GO:0051276	360	0.024
regulation of apoptotic process	GO:0042981	130	0.024
dna packaging	GO:0006323	91	0.024
regulation of immune system process	GO:0002682	176	0.024
axonogenesis	GO:0007409	290	0.024
response to organic substance	GO:0010033	284	0.023
catabolic process	GO:0009056	409	0.023
dendrite development	GO:0016358	204	0.023
regulation of cell death	GO:0010941	173	0.023
regulation of protein modification process	GO:0031399	112	0.023
single organism nuclear import	GO:1902593	51	0.023
protein complex disassembly	GO:0043241	36	0.023
cellular catabolic process	GO:0044248	372	0.023
positive regulation of cell communication	GO:0010647	250	0.022
mitotic spindle stabilization	GO:0043148	6	0.022
golgi organization	GO:0007030	66	0.022
establishment of spindle localization	GO:0051293	22	0.022
cell cycle checkpoint	GO:0000075	95	0.022
regulation of cell proliferation	GO:0042127	163	0.022
reciprocal meiotic recombination	GO:0007131	19	0.022
positive regulation of response to stimulus	GO:0048584	323	0.022
purine nucleoside catabolic process	GO:0006152	112	0.022
female meiotic division	GO:0007143	70	0.021
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.021
germ line stem cell maintenance	GO:0030718	50	0.021
dna damage checkpoint	GO:0000077	78	0.021
establishment of protein localization	GO:0045184	163	0.021
negative regulation of apoptotic process	GO:0043066	63	0.020
small gtpase mediated signal transduction	GO:0007264	88	0.020
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.020
protein modification process	GO:0036211	438	0.020
regulation of cytoskeleton organization	GO:0051493	89	0.020
asymmetric protein localization involved in cell fate determination	GO:0045167	9	0.020
positive regulation of cell cycle process	GO:0090068	28	0.020
regulation of cellular protein metabolic process	GO:0032268	243	0.020
positive regulation of protein deacetylation	GO:0090312	2	0.019
protein import	GO:0017038	55	0.019
ras protein signal transduction	GO:0007265	88	0.019
intracellular signal transduction	GO:0035556	300	0.019
positive regulation of phosphate metabolic process	GO:0045937	139	0.019
purine ribonucleoside metabolic process	GO:0046128	127	0.019
positive regulation of biosynthetic process	GO:0009891	316	0.019
negative regulation of cell proliferation	GO:0008285	69	0.019
oocyte dorsal ventral axis specification	GO:0007310	34	0.019
protein transport	GO:0015031	155	0.018
negative regulation of cytoskeleton organization	GO:0051494	30	0.018
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.018
heterocycle catabolic process	GO:0046700	166	0.018
tube development	GO:0035295	244	0.018
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.018
maintenance of location in cell	GO:0051651	28	0.018
negative regulation of multicellular organismal process	GO:0051241	142	0.018
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.018
regulation of mitotic spindle organization	GO:0060236	9	0.018
epithelial cell development	GO:0002064	274	0.018
digestive tract morphogenesis	GO:0048546	127	0.017
nucleoside triphosphate metabolic process	GO:0009141	120	0.017
nucleoside catabolic process	GO:0009164	112	0.017
regulation of anatomical structure morphogenesis	GO:0022603	242	0.017
mitotic cell cycle embryonic	GO:0045448	38	0.017
purine ribonucleoside catabolic process	GO:0046130	112	0.017
multicellular organismal aging	GO:0010259	140	0.017
gastrulation	GO:0007369	70	0.017
developmental programmed cell death	GO:0010623	138	0.016
death	GO:0016265	284	0.016
genitalia development	GO:0048806	26	0.016
regulation of protein metabolic process	GO:0051246	256	0.016
oocyte nucleus localization involved in oocyte dorsal ventral axis specification	GO:0051663	12	0.016
protein import into nucleus	GO:0006606	51	0.016
oocyte axis specification	GO:0007309	108	0.015
cellular protein complex disassembly	GO:0043624	35	0.015
nucleoside metabolic process	GO:0009116	127	0.015
embryonic pattern specification	GO:0009880	174	0.015
protein modification by small protein conjugation or removal	GO:0070647	106	0.015
nucleotide metabolic process	GO:0009117	161	0.015
positive regulation of rna biosynthetic process	GO:1902680	266	0.015
cellular protein complex assembly	GO:0043623	71	0.015
modification dependent macromolecule catabolic process	GO:0043632	79	0.015
regulation of protein localization to nucleus	GO:1900180	29	0.015
single organism membrane organization	GO:0044802	93	0.015
ribonucleoside catabolic process	GO:0042454	112	0.015
positive regulation of cell cycle	GO:0045787	43	0.014
aromatic compound catabolic process	GO:0019439	166	0.014
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.014
embryonic development via the syncytial blastoderm	GO:0001700	148	0.014
proteolysis	GO:0006508	192	0.014
cellular response to endogenous stimulus	GO:0071495	80	0.014
regulation of cytokinesis	GO:0032465	3	0.014
regulation of localization	GO:0032879	275	0.014
chromatin silencing	GO:0006342	76	0.014
locomotory behavior	GO:0007626	176	0.014
organic substance catabolic process	GO:1901575	308	0.014
negative regulation of developmental process	GO:0051093	201	0.014
peptidyl threonine modification	GO:0018210	3	0.013
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.013
nucleoside phosphate catabolic process	GO:1901292	110	0.013
cell cycle arrest	GO:0007050	4	0.013
mitotic dna damage checkpoint	GO:0044773	74	0.013
signal transduction by phosphorylation	GO:0023014	107	0.013
asymmetric protein localization	GO:0008105	33	0.013
dna recombination	GO:0006310	32	0.013
negative regulation of nervous system development	GO:0051961	92	0.012
positive regulation of molecular function	GO:0044093	136	0.012
negative regulation of gene expression	GO:0010629	387	0.012
proteasomal protein catabolic process	GO:0010498	59	0.012
dna endoreduplication	GO:0042023	22	0.012
mitotic spindle midzone assembly	GO:0051256	1	0.012
protein depolymerization	GO:0051261	31	0.012
dna repair	GO:0006281	54	0.012
negative regulation of microtubule depolymerization	GO:0007026	21	0.012
regulation of hemocyte proliferation	GO:0035206	37	0.012
cytoskeleton dependent intracellular transport	GO:0030705	44	0.012
organic cyclic compound catabolic process	GO:1901361	168	0.011
response to growth factor	GO:0070848	31	0.011
carbohydrate derivative metabolic process	GO:1901135	217	0.011
metaphase anaphase transition of cell cycle	GO:0044784	28	0.011
single organism catabolic process	GO:0044712	228	0.011
tissue morphogenesis	GO:0048729	297	0.011
positive regulation of protein modification process	GO:0031401	58	0.011
regulation of protein processing	GO:0070613	32	0.011
establishment of organelle localization	GO:0051656	122	0.011
membrane organization	GO:0061024	112	0.011
negative regulation of phosphorus metabolic process	GO:0010563	45	0.011
regulation of protein targeting	GO:1903533	29	0.011
sperm axoneme assembly	GO:0007288	13	0.011
nuclear migration	GO:0007097	20	0.011
regulation of cellular amino acid metabolic process	GO:0006521	0	0.011
establishment of mitotic spindle orientation	GO:0000132	13	0.011
negative regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032435	16	0.011
organophosphate catabolic process	GO:0046434	112	0.010
cellular nitrogen compound catabolic process	GO:0044270	165	0.010
chemosensory behavior	GO:0007635	106	0.010
negative regulation of small gtpase mediated signal transduction	GO:0051058	13	0.010
positive regulation of gtpase activity	GO:0043547	43	0.010
anterior posterior axis specification embryo	GO:0008595	103	0.010
nucleotide catabolic process	GO:0009166	109	0.010
digestive system development	GO:0055123	149	0.010

Sas-4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
cancer	DOID:162	0.049
disease of cellular proliferation	DOID:14566	0.049
organ system cancer	DOID:0050686	0.031
disease of anatomical entity	DOID:7	0.012
congenital nervous system abnormality	DOID:2490	0.010
physical disorder	DOID:0080015	0.010

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