IMP: Integrative Multi-species Prediction

Drosophila melanogaster

111 known processes

Timp (Dmel_CG6281)

Tissue inhibitor of metalloproteases

(Aliases: DTIMP,TIMP,CG6281,timp,Dmel\CG6281,Dtimp,dTIMP)

Entrez: 41248
FLYBASE: FBgn0025879
UniProtKB: A4V2N5
UniProtKB: Q9VH14

Process Predictions
Disease Predictions

Timp biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of tube length open tracheal system	GO:0035159	24	0.884
regulation of tube architecture open tracheal system	GO:0035152	68	0.778
regulation of defense response	GO:0031347	102	0.643
dorsal trunk growth open tracheal system	GO:0035001	7	0.625
cellular response to light stimulus	GO:0071482	37	0.581
regulation of immune system process	GO:0002682	176	0.504
regulation of tube size open tracheal system	GO:0035151	43	0.484
cellular response to abiotic stimulus	GO:0071214	58	0.453
open tracheal system development	GO:0007424	204	0.391
regulation of immune response	GO:0050776	118	0.282
cellular response to radiation	GO:0071478	52	0.280
immune effector process	GO:0002252	98	0.273
cell adhesion	GO:0007155	136	0.271
molting cycle chitin based cuticle	GO:0007591	56	0.268
extracellular matrix disassembly	GO:0022617	4	0.261
anatomical structure homeostasis	GO:0060249	97	0.251
response to fibroblast growth factor	GO:0071774	10	0.240
regulation of tube size	GO:0035150	46	0.240
extracellular structure organization	GO:0043062	46	0.227
tracheal outgrowth open tracheal system	GO:0007426	18	0.219
regulation of response to stress	GO:0080134	200	0.198
immune system process	GO:0002376	347	0.192
negative regulation of cell communication	GO:0010648	223	0.175
positive regulation of defense response	GO:0031349	59	0.171
cellular component disassembly	GO:0022411	46	0.165
catabolic process	GO:0009056	409	0.163	Human
positive regulation of response to stimulus	GO:0048584	323	0.162
activation of innate immune response	GO:0002218	4	0.158
negative regulation of signaling	GO:0023057	219	0.154
gland morphogenesis	GO:0022612	145	0.152
regeneration	GO:0031099	16	0.150
biological adhesion	GO:0022610	138	0.150
positive regulation of cellular biosynthetic process	GO:0031328	316	0.133
regulation of innate immune response	GO:0045088	71	0.132
positive regulation of immune response	GO:0050778	63	0.127
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.125
negative regulation of multicellular organismal process	GO:0051241	142	0.125	Human
response to light stimulus	GO:0009416	124	0.122
response to wounding	GO:0009611	94	0.108
respiratory system development	GO:0060541	213	0.107
growth	GO:0040007	359	0.104
molting cycle	GO:0042303	56	0.101
developmental growth	GO:0048589	280	0.096
positive regulation of immune system process	GO:0002684	68	0.086
defense response	GO:0006952	300	0.086
negative regulation of fibroblast growth factor receptor signaling pathway	GO:0040037	2	0.084
cellular metal ion homeostasis	GO:0006875	31	0.068
regulation of anatomical structure size	GO:0090066	163	0.067
cell recognition	GO:0008037	102	0.066
lateral inhibition	GO:0046331	206	0.066
negative regulation of signal transduction	GO:0009968	206	0.059
positive regulation of biosynthetic process	GO:0009891	316	0.059
homeostatic process	GO:0042592	199	0.056
regulation of cell differentiation	GO:0045595	302	0.054	Mouse
negative regulation of response to stimulus	GO:0048585	258	0.053
post embryonic appendage morphogenesis	GO:0035120	385	0.053
salivary gland development	GO:0007431	162	0.053
mapk cascade	GO:0000165	107	0.052	Mouse
positive regulation of developmental process	GO:0051094	143	0.052
melanin metabolic process	GO:0006582	47	0.050
cellular response to fibroblast growth factor stimulus	GO:0044344	10	0.049
substrate adhesion dependent cell spreading	GO:0034446	2	0.049
muscle cell development	GO:0055001	50	0.049
small molecule metabolic process	GO:0044281	305	0.049	Mouse
developmental growth involved in morphogenesis	GO:0060560	65	0.049
response to organic cyclic compound	GO:0014070	89	0.049
innate immune response	GO:0045087	144	0.048
salivary gland morphogenesis	GO:0007435	145	0.048
regulation of phosphorus metabolic process	GO:0051174	210	0.048	Mouse
sterol homeostasis	GO:0055092	4	0.048
immune response	GO:0006955	246	0.046
extracellular matrix organization	GO:0030198	32	0.045
positive regulation of immune effector process	GO:0002699	28	0.043
circadian sleep wake cycle process	GO:0022410	24	0.043
response to lipopolysaccharide	GO:0032496	4	0.043
regulation of epithelial cell migration open tracheal system	GO:2000274	11	0.042
histolysis	GO:0007559	102	0.042
response to high light intensity	GO:0009644	1	0.042
heart process	GO:0003015	37	0.041
proteolysis	GO:0006508	192	0.041
regulation of cell proliferation	GO:0042127	163	0.041	Human Mouse
positive regulation of phosphate metabolic process	GO:0045937	139	0.040
regulation of response to wounding	GO:1903034	19	0.040
organic cyclic compound catabolic process	GO:1901361	168	0.040
response to radiation	GO:0009314	155	0.039
cellular response to endogenous stimulus	GO:0071495	80	0.039
regulation of circadian rhythm	GO:0042752	49	0.039
regulation of proteolysis	GO:0030162	87	0.039
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.039
cellular response to light intensity	GO:0071484	1	0.039
regulation of phosphorylation	GO:0042325	147	0.038	Mouse
response to organic substance	GO:0010033	284	0.037	Mouse
instar larval development	GO:0002168	55	0.037
positive regulation of cell migration	GO:0030335	2	0.037
microtubule organizing center organization	GO:0031023	168	0.037
gland development	GO:0048732	191	0.036
exocrine system development	GO:0035272	162	0.036
carboxylic acid metabolic process	GO:0019752	92	0.035
death	GO:0016265	284	0.035
protein modification process	GO:0036211	438	0.035
cellular catabolic process	GO:0044248	372	0.035	Human
positive regulation of signaling	GO:0023056	243	0.035
regulation of mapk cascade	GO:0043408	92	0.034	Mouse
wing disc morphogenesis	GO:0007472	344	0.034
positive regulation of phosphorus metabolic process	GO:0010562	139	0.033
organelle assembly	GO:0070925	198	0.032
organic substance catabolic process	GO:1901575	308	0.032	Human
learning or memory	GO:0007611	141	0.032
catecholamine biosynthetic process	GO:0042423	3	0.032
cellular homeostasis	GO:0019725	80	0.031
imaginal disc derived appendage development	GO:0048737	399	0.031
centrosome organization	GO:0051297	163	0.030
dopamine biosynthetic process	GO:0042416	3	0.030
regulation of multicellular organismal development	GO:2000026	414	0.030	Human Mouse
kidney development	GO:0001822	3	0.030
regulation of response to external stimulus	GO:0032101	115	0.029
negative regulation of rna metabolic process	GO:0051253	251	0.029
endocytosis	GO:0006897	310	0.029
regulation of cellular protein metabolic process	GO:0032268	243	0.029
indole containing compound biosynthetic process	GO:0042435	4	0.028
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.028
tissue death	GO:0016271	102	0.028
connective tissue development	GO:0061448	3	0.027
single organism catabolic process	GO:0044712	228	0.026
centrosome duplication	GO:0051298	121	0.026
negative regulation of cellular metabolic process	GO:0031324	382	0.026
myotube cell development	GO:0014904	3	0.026
programmed cell death	GO:0012501	257	0.026
regulation of immune effector process	GO:0002697	52	0.025
establishment or maintenance of cell polarity	GO:0007163	167	0.025
cuticle pigmentation	GO:0048067	22	0.025
cellular response to high light intensity	GO:0071486	1	0.025
establishment of localization in cell	GO:0051649	402	0.025
cellular chemical homeostasis	GO:0055082	40	0.024
salivary gland cell autophagic cell death	GO:0035071	83	0.024
cellular response to growth factor stimulus	GO:0071363	30	0.024
positive regulation of innate immune response	GO:0045089	38	0.024
cellular response to organic substance	GO:0071310	132	0.024	Mouse
fluid transport	GO:0042044	19	0.023
rhythmic process	GO:0048511	106	0.023
aromatic compound catabolic process	GO:0019439	166	0.023
extrinsic apoptotic signaling pathway	GO:0097191	1	0.023
negative regulation of cell differentiation	GO:0045596	143	0.023
carbohydrate derivative biosynthetic process	GO:1901137	85	0.022
response to endogenous stimulus	GO:0009719	119	0.022
phosphorylation	GO:0016310	294	0.022	Mouse
cellular component assembly involved in morphogenesis	GO:0010927	151	0.022
pigment metabolic process	GO:0042440	84	0.022
positive regulation of protein metabolic process	GO:0051247	128	0.022
regulation of tube diameter open tracheal system	GO:0035158	11	0.022
regionalization	GO:0003002	416	0.022
cellular protein modification process	GO:0006464	438	0.022
muscle attachment	GO:0016203	36	0.022
cellular ion homeostasis	GO:0006873	39	0.021
protein phosphorylation	GO:0006468	169	0.021
positive regulation of cell communication	GO:0010647	250	0.021
production of molecular mediator of immune response	GO:0002440	46	0.021
purine nucleoside catabolic process	GO:0006152	112	0.021
negative regulation of cellular response to growth factor stimulus	GO:0090288	6	0.020
purine ribonucleotide metabolic process	GO:0009150	145	0.020	Mouse
imaginal disc growth	GO:0007446	37	0.020
protein transport	GO:0015031	155	0.020
vesicle mediated transport	GO:0016192	381	0.020
organic substance transport	GO:0071702	257	0.020
epiboly	GO:0090504	2	0.019
cation homeostasis	GO:0055080	51	0.019
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.019
single organism behavior	GO:0044708	391	0.019
body morphogenesis	GO:0010171	2	0.019
cell death	GO:0008219	279	0.019
cellular macromolecule catabolic process	GO:0044265	136	0.019
establishment of protein localization	GO:0045184	163	0.018
memory	GO:0007613	94	0.018
appendage morphogenesis	GO:0035107	397	0.018
phagocytosis	GO:0006909	215	0.018
regulation of multi organism process	GO:0043900	131	0.018	Human
aging	GO:0007568	143	0.018
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.018
gene silencing	GO:0016458	138	0.018
melanization defense response	GO:0035006	45	0.017
epithelial structure maintenance	GO:0010669	17	0.017
macromolecule catabolic process	GO:0009057	161	0.017	Human
regulation of wnt signaling pathway	GO:0030111	68	0.017
regulation of anatomical structure morphogenesis	GO:0022603	242	0.017
localization of cell	GO:0051674	257	0.017	Human
response to ecdysone	GO:0035075	34	0.017
nucleotide metabolic process	GO:0009117	161	0.017	Mouse
regulation of cell substrate adhesion	GO:0010810	2	0.017
oxoacid metabolic process	GO:0043436	103	0.017
imaginal disc eversion	GO:0007561	4	0.017
developmental programmed cell death	GO:0010623	138	0.017
cardiovascular system development	GO:0072358	82	0.017
steroid catabolic process	GO:0006706	1	0.017
positive regulation of signal transduction	GO:0009967	223	0.017
imaginal disc derived wing morphogenesis	GO:0007476	337	0.017
skeletal muscle organ development	GO:0060538	48	0.016
positive regulation of protein kinase activity	GO:0045860	25	0.016
organonitrogen compound metabolic process	GO:1901564	318	0.016	Mouse
response to abiotic stimulus	GO:0009628	341	0.016
terminal branching open tracheal system	GO:0007430	17	0.015
protein localization	GO:0008104	284	0.015
imaginal disc fusion	GO:0046528	19	0.015
regulation of protein modification process	GO:0031399	112	0.015
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.015
regulation of establishment of protein localization	GO:0070201	61	0.015
dephosphorylation	GO:0016311	51	0.015
cell aging	GO:0007569	2	0.015
organonitrogen compound biosynthetic process	GO:1901566	117	0.015
positive regulation of response to biotic stimulus	GO:0002833	31	0.014
response to bacterium	GO:0009617	198	0.014
positive regulation of antimicrobial peptide biosynthetic process	GO:0002807	26	0.014
cell proliferation	GO:0008283	299	0.014	Human Mouse
heterocycle catabolic process	GO:0046700	166	0.014
sensory perception	GO:0007600	196	0.014
sensory organ morphogenesis	GO:0090596	260	0.014
positive regulation of cell motility	GO:2000147	3	0.014
axis specification	GO:0009798	167	0.014
response to growth factor	GO:0070848	31	0.014
organic hydroxy compound metabolic process	GO:1901615	83	0.014
cellular amide metabolic process	GO:0043603	80	0.014
myofibril assembly	GO:0030239	36	0.014
positive regulation of growth	GO:0045927	75	0.014
mitochondrion organization	GO:0007005	65	0.014
rhythmic behavior	GO:0007622	76	0.014
cellular macromolecular complex assembly	GO:0034622	153	0.014
cellular response to organic cyclic compound	GO:0071407	32	0.013
wound healing	GO:0042060	75	0.013
establishment or maintenance of bipolar cell polarity	GO:0061245	34	0.013
ribose phosphate metabolic process	GO:0019693	145	0.013	Mouse
autophagic cell death	GO:0048102	83	0.013
camera type eye morphogenesis	GO:0048593	2	0.013
cellular ketone metabolic process	GO:0042180	24	0.013
cellular response to molecule of bacterial origin	GO:0071219	3	0.013
encapsulation of foreign target	GO:0035010	38	0.013
muscle tissue morphogenesis	GO:0060415	2	0.013
long term memory	GO:0007616	62	0.013
aromatic amino acid family metabolic process	GO:0009072	3	0.013
cellular response to dna damage stimulus	GO:0006974	223	0.013
embryonic development via the syncytial blastoderm	GO:0001700	148	0.013
regulation of synaptic transmission	GO:0050804	69	0.013
basement membrane organization	GO:0071711	10	0.013
organic acid metabolic process	GO:0006082	103	0.013
intracellular signal transduction	GO:0035556	300	0.013	Mouse
regulation of neural precursor cell proliferation	GO:2000177	35	0.013
ribonucleotide catabolic process	GO:0009261	109	0.013
regulation of localization	GO:0032879	275	0.012	Human
epithelial cell migration open tracheal system	GO:0007427	32	0.012
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.012
phenol containing compound metabolic process	GO:0018958	57	0.012
leg disc morphogenesis	GO:0007478	80	0.012
regulation of cell division	GO:0051302	72	0.012
mitotic cytokinesis	GO:0000281	50	0.012
immune response activating signal transduction	GO:0002757	2	0.012
regulation of hydrolase activity	GO:0051336	97	0.012
positive regulation of response to external stimulus	GO:0032103	44	0.012
tissue homeostasis	GO:0001894	36	0.012
epiboly involved in wound healing	GO:0090505	2	0.012
establishment or maintenance of cytoskeleton polarity	GO:0030952	44	0.012
negative regulation of cellular component organization	GO:0051129	108	0.012
hindbrain development	GO:0030902	2	0.012
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.012
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.012
positive regulation of rna biosynthetic process	GO:1902680	266	0.012
negative regulation of stem cell proliferation	GO:2000647	30	0.012
antifungal humoral response	GO:0019732	12	0.012
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.012
primary amino compound biosynthetic process	GO:1901162	2	0.011
neuron recognition	GO:0008038	101	0.011
regulation of cell death	GO:0010941	173	0.011
imaginal disc fusion thorax closure	GO:0046529	19	0.011
jnk cascade	GO:0007254	50	0.011
salivary gland histolysis	GO:0035070	88	0.011
positive regulation of phosphorylation	GO:0042327	87	0.011
peptide metabolic process	GO:0006518	80	0.011
regulation of response to biotic stimulus	GO:0002831	63	0.011
negative regulation of gene expression epigenetic	GO:0045814	77	0.011
muscle organ development	GO:0007517	127	0.011
fibroblast growth factor receptor signaling pathway	GO:0008543	10	0.011
larval development	GO:0002164	104	0.011
signal transduction by phosphorylation	GO:0023014	107	0.011	Mouse
serotonin metabolic process	GO:0042428	2	0.011
protein catabolic process	GO:0030163	101	0.011	Human
dorsal ventral pattern formation	GO:0009953	133	0.011
negative regulation of developmental process	GO:0051093	201	0.011	Human
positive regulation of cellular amine metabolic process	GO:0033240	0	0.011
skeletal muscle fiber development	GO:0048741	3	0.011
nucleoside phosphate metabolic process	GO:0006753	162	0.010	Mouse
regulation of nervous system development	GO:0051960	248	0.010	Mouse
cellular response to biotic stimulus	GO:0071216	4	0.010
positive regulation of protein serine threonine kinase activity	GO:0071902	15	0.010
neural precursor cell proliferation	GO:0061351	75	0.010
protein secretion	GO:0009306	45	0.010
segmentation	GO:0035282	207	0.010
cytoskeleton dependent cytokinesis	GO:0061640	81	0.010
striated muscle myosin thick filament assembly	GO:0071688	3	0.010
regulation of kinase activity	GO:0043549	53	0.010
regulation of protein metabolic process	GO:0051246	256	0.010
regulation of cell adhesion	GO:0030155	27	0.010

Timp disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.021
nervous system disease	DOID:863	0.017
bone disease	DOID:0080001	0.016
connective tissue disease	DOID:65	0.016
musculoskeletal system disease	DOID:17	0.016
vascular disease	DOID:178	0.011
artery disease	DOID:0050828	0.011
cardiovascular system disease	DOID:1287	0.011

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