Drosophila melanogaster

0 known processes

Pdi (Dmel_CG6988)

Protein disulfide isomerase

(Aliases: CG6988,pdi,Dpdi,Dmel\CG6988,PDI,EP(3)1022,dpdi)

Pdi biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
proteolysisGO:00065081920.101
protein modification processGO:00362114380.091
Human
vesicle mediated transportGO:00161923810.090
regulation of gene expression epigeneticGO:00400291280.078
cellular protein modification processGO:00064644380.072
Human
regulation of localizationGO:00328792750.070
modification dependent protein catabolic processGO:0019941780.069
establishment of localization in cellGO:00516494020.069
negative regulation of cellular metabolic processGO:00313243820.068
anatomical structure homeostasisGO:0060249970.065
wing disc morphogenesisGO:00074723440.064
ion transmembrane transportGO:00342201220.063
protein catabolic processGO:00301631010.062
microtubule organizing center organizationGO:00310231680.057
intracellular transportGO:00469072280.057
positive regulation of response to stimulusGO:00485843230.057
male gamete generationGO:00482322010.056
Mouse
spermatogenesisGO:00072832000.055
Mouse
regulation of transportGO:00510491810.052
neurological system processGO:00508773580.052
catabolic processGO:00090564090.049
peptide metabolic processGO:0006518800.049
regulation of multicellular organismal developmentGO:20000264140.049
positive regulation of nitrogen compound metabolic processGO:00511733540.049
cellular catabolic processGO:00442483720.048
xenobiotic catabolic processGO:004217810.047
imaginal disc derived wing morphogenesisGO:00074763370.045
cellular protein catabolic processGO:0044257830.045
proteolysis involved in cellular protein catabolic processGO:0051603830.045
organic substance catabolic processGO:19015753080.044
negative regulation of rna metabolic processGO:00512532510.044
positive regulation of cellular component organizationGO:00511301560.043
negative regulation of cell cycleGO:00457861160.043
single organism behaviorGO:00447083910.043
protein localizationGO:00081042840.043
imaginal disc derived appendage developmentGO:00487373990.042
single organism intracellular transportGO:19025822070.041
proteasomal protein catabolic processGO:0010498590.041
regulation of cell differentiationGO:00455953020.041
mrna metabolic processGO:00160711240.041
endocytosisGO:00068973100.041
exocrine system developmentGO:00352721620.041
imaginal disc derived appendage morphogenesisGO:00351143950.040
cellular macromolecule catabolic processGO:00442651360.039
positive regulation of macromolecule metabolic processGO:00106044050.039
camera type eye developmentGO:004301040.039
transcription from rna polymerase ii promoterGO:00063663680.038
macromolecule catabolic processGO:00090571610.038
cytoplasmic transportGO:00164821300.037
regulation of molecular functionGO:00650092170.037
negative regulation of signalingGO:00230572190.037
single organism biosynthetic processGO:00447112060.036
peptidyl amino acid modificationGO:00181931050.036
Human
regulation of nervous system developmentGO:00519602480.036
response to organic substanceGO:00100332840.036
regulation of behaviorGO:0050795750.036
regionalizationGO:00030024160.036
negative regulation of cell cycle processGO:00109481090.035
negative regulation of gene expressionGO:00106293870.035
response to unfolded proteinGO:000698690.035
ubiquitin dependent protein catabolic processGO:0006511780.035
positive regulation of nucleobase containing compound metabolic processGO:00459353320.035
negative regulation of cell communicationGO:00106482230.035
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.034
cellular protein localizationGO:00346131600.033
negative regulation of nitrogen compound metabolic processGO:00511722650.033
cellular response to dna damage stimulusGO:00069742230.033
peptidyl proline hydroxylationGO:001951110.033
Human
aggressive behaviorGO:0002118630.033
negative regulation of nucleobase containing compound metabolic processGO:00459342610.033
phagocytosisGO:00069092150.032
immune system processGO:00023763470.032
negative regulation of nervous system developmentGO:0051961920.032
multicellular organismal reproductive behaviorGO:00330571100.032
organic substance transportGO:00717022570.032
regulation of cell cycleGO:00517262910.032
locomotory behaviorGO:00076261760.032
cellular response to chemical stimulusGO:00708871990.032
Human
forebrain developmentGO:003090020.031
sensory perception of mechanical stimulusGO:0050954720.031
lateral inhibitionGO:00463312060.031
regulation of imaginal disc derived wing sizeGO:0044719200.031
centrosome duplicationGO:00512981210.031
negative regulation of nucleic acid templated transcriptionGO:19035072400.031
endomembrane system organizationGO:00102561190.031
thioester metabolic processGO:003538330.030
regulation of anatomical structure morphogenesisGO:00226032420.030
dna conformation changeGO:00711031050.030
regulation of organelle organizationGO:00330431960.030
cellular response to unfolded proteinGO:003462090.029
regulation of intracellular signal transductionGO:19025312360.029
Human
negative regulation of rna biosynthetic processGO:19026792400.029
oocyte developmentGO:00485991240.029
cellular macromolecule localizationGO:00707272200.029
inorganic ion transmembrane transportGO:0098660730.029
centrosome cycleGO:00070981370.029
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161540.028
positive regulation of cell migrationGO:003033520.028
chromosome organizationGO:00512763600.028
negative regulation of signal transductionGO:00099682060.028
inter male aggressive behaviorGO:0002121600.028
developmental growthGO:00485892800.028
chaeta developmentGO:0022416970.027
negative regulation of transcription dna templatedGO:00458922370.027
salivary gland morphogenesisGO:00074351450.027
regulation of catalytic activityGO:00507901850.027
intracellular protein transportGO:00068861040.027
cell proliferationGO:00082832990.027
appendage morphogenesisGO:00351073970.026
cuticle developmentGO:0042335860.026
positive regulation of rna biosynthetic processGO:19026802660.026
dendrite morphogenesisGO:00488131990.026
vitamin biosynthetic processGO:000911010.026
positive regulation of signal transductionGO:00099672230.025
golgi organizationGO:0007030660.025
kidney developmentGO:000182230.025
positive regulation of biosynthetic processGO:00098913160.025
carbohydrate derivative metabolic processGO:19011352170.025
positive regulation of transcription dna templatedGO:00458932660.025
regulation of protein metabolic processGO:00512462560.024
agingGO:00075681430.024
regulation of cell developmentGO:00602842150.024
sensory perceptionGO:00076001960.024
gland developmentGO:00487321910.023
pigment metabolic process involved in pigmentationGO:0043474330.023
negative regulation of macromolecule biosynthetic processGO:00105582700.023
sister chromatid segregationGO:0000819920.023
carbohydrate metabolic processGO:0005975820.023
eye developmentGO:00016543230.023
appendage developmentGO:00487364010.023
axon developmentGO:00615642970.023
dna metabolic processGO:00062592270.023
centrosome organizationGO:00512971630.023
ion transportGO:00068111450.023
maintenance of locationGO:0051235730.022
synaptic transmissionGO:00072682880.022
post embryonic appendage morphogenesisGO:00351203850.022
regulation of chromatin silencingGO:0031935360.022
positive regulation of cellular biosynthetic processGO:00313283160.022
regulation of anatomical structure sizeGO:00900661630.022
multi organism behaviorGO:00517051750.022
sleepGO:0030431490.021
response to glucoseGO:000974920.021
negative regulation of cellular biosynthetic processGO:00313272770.021
organonitrogen compound metabolic processGO:19015643180.021
Human
positive regulation of cell communicationGO:00106472500.021
telencephalon developmentGO:002153720.021
regulation of cell proliferationGO:00421271630.021
embryo development ending in birth or egg hatchingGO:00097921520.021
modification dependent macromolecule catabolic processGO:0043632790.021
inorganic cation transmembrane transportGO:0098662610.021
positive regulation of gene expressionGO:00106282900.021
cell cycle arrestGO:000705040.020
chromosome segregationGO:00070591570.020
establishment of protein localizationGO:00451841630.020
regulation of catabolic processGO:00098941700.020
regulation of response to external stimulusGO:00321011150.020
oocyte differentiationGO:00099941450.020
single organism carbohydrate metabolic processGO:0044723720.020
chemotaxisGO:00069352490.020
gene silencingGO:00164581380.020
transmembrane transportGO:00550851390.020
dendrite developmentGO:00163582040.020
cellular ketone metabolic processGO:0042180240.020
chemosensory behaviorGO:00076351060.020
pigment metabolic process involved in developmental pigmentationGO:0043324330.020
cell agingGO:000756920.020
autophagyGO:00069141080.019
olfactory behaviorGO:0042048970.019
water soluble vitamin metabolic processGO:000676710.019
stem cell differentiationGO:00488631170.019
nuclear divisionGO:00002803320.019
detection of stimulus involved in sensory perceptionGO:0050906920.019
chromatin silencingGO:0006342760.019
sensory perception of soundGO:0007605560.019
multi multicellular organism processGO:00447061230.019
mitotic sister chromatid segregationGO:0000070870.019
salivary gland developmentGO:00074311620.019
cellular component assembly involved in morphogenesisGO:00109271510.019
regulation of transcription from rna polymerase ii promoterGO:00063573780.019
dorsal ventral pattern formationGO:00099531330.018
positive regulation of cell motilityGO:200014730.018
axis specificationGO:00097981670.018
regulation of notch signaling pathwayGO:00085931000.018
developmental programmed cell deathGO:00106231380.018
developmental pigmentationGO:0048066680.018
response to topologically incorrect proteinGO:0035966100.018
positive regulation of rna metabolic processGO:00512542710.018
negative regulation of gene expression epigeneticGO:0045814770.018
tissue deathGO:00162711020.017
small molecule metabolic processGO:00442813050.017
Human
sterol homeostasisGO:005509240.017
organic acid metabolic processGO:00060821030.017
Human
localization of cellGO:00516742570.017
Mouse
protein maturationGO:0051604710.017
carbohydrate derivative catabolic processGO:19011361180.017
striated muscle cell differentiationGO:0051146900.017
cell cycle phase transitionGO:00447701400.017
body morphogenesisGO:001017120.017
response to woundingGO:0009611940.017
regulation of cellular amine metabolic processGO:003323830.017
notch signaling pathwayGO:00072191200.017
regulation of response to stressGO:00801342000.017
Human
protein processingGO:0016485680.017
protein glycosylationGO:0006486320.016
regulation of multi organism processGO:00439001310.016
spindle organizationGO:00070512530.016
intracellular signal transductionGO:00355563000.016
Human
response to other organismGO:00517072930.016
vitamin metabolic processGO:000676620.016
positive regulation of macromolecule biosynthetic processGO:00105572830.016
reproductive behaviorGO:00190981220.016
central nervous system developmentGO:00074172010.016
negative regulation of cellular protein metabolic processGO:0032269850.016
regulation of gene silencingGO:0060968630.016
eye morphogenesisGO:00485922600.016
regulation of dna metabolic processGO:0051052340.016
response to abiotic stimulusGO:00096283410.016
Human
epithelial cell differentiationGO:00308553220.016
cellular response to organic substanceGO:00713101320.016
cellularizationGO:0007349900.016
small gtpase mediated signal transductionGO:0007264880.016
positive regulation of intracellular signal transductionGO:19025331160.016
negative regulation of response to stimulusGO:00485852580.016
response to monosaccharideGO:003428440.016
ras protein signal transductionGO:0007265880.016
cell cell signaling involved in cell fate commitmentGO:00451682100.016
glutathione metabolic processGO:0006749370.015
cation transmembrane transportGO:0098655880.015
regulation of organ morphogenesisGO:2000027780.015
response to hexoseGO:000974630.015
regulation of proteolysis involved in cellular protein catabolic processGO:1903050440.015
posttranscriptional regulation of gene expressionGO:00106081450.015
positive regulation of transportGO:0051050920.015
negative regulation of developmental processGO:00510932010.015
mating behaviorGO:00076171060.015
small molecule biosynthetic processGO:0044283370.015
digestive tract morphogenesisGO:00485461270.015
single organism membrane organizationGO:0044802930.015
positive regulation of signalingGO:00230562430.015
eye pigmentationGO:0048069430.015
chromatin organizationGO:00063252070.015
regulation of cell substrate adhesionGO:001081020.015
regulation of cell cycle phase transitionGO:19019871300.014
regulation of cellular protein metabolic processGO:00322682430.014
gland morphogenesisGO:00226121450.014
regulation of sequestering of calcium ionGO:005128230.014
growthGO:00400073590.014
substrate adhesion dependent cell spreadingGO:003444620.014
salivary gland histolysisGO:0035070880.014
lipid metabolic processGO:00066291210.014
regulation of mitotic cell cycle phase transitionGO:19019901300.014
retina development in camera type eyeGO:006004140.014
regulation of cellular catabolic processGO:00313291570.014
multi organism reproductive behaviorGO:00447051210.014
mitotic spindle organizationGO:00070522200.014
hindbrain developmentGO:003090220.014
regulation of cellular localizationGO:00603411360.014
protein secretionGO:0009306450.014
open tracheal system developmentGO:00074242040.014
regulation of immune system processGO:00026821760.014
tube morphogenesisGO:00352391910.014
intracellular protein transmembrane transportGO:006500240.014
regulation of neuron differentiationGO:00456641030.014
cellular lipid metabolic processGO:0044255830.014
muscle structure developmentGO:00610612240.013
androgen metabolic processGO:000820910.013
mitotic cell cycle phase transitionGO:00447721380.013
regulation of rna splicingGO:0043484690.013
regulation of synapse structure and activityGO:00508031280.013
mitotic cytokinesisGO:0000281500.013
regulation of intracellular transportGO:0032386640.013
homeostatic processGO:00425921990.013
regulation of autophagyGO:0010506620.013
carbohydrate derivative biosynthetic processGO:1901137850.013
response to mechanical stimulusGO:0009612280.013
programmed cell deathGO:00125012570.013
Human
cellular response to nutrient levelsGO:0031669620.013
polyol biosynthetic processGO:004617330.013
regulation of cytoplasmic transportGO:1903649470.013
mitotic nuclear divisionGO:00070672130.013
cognitionGO:00508901410.013
carboxylic acid metabolic processGO:0019752920.013
Human
drinking behaviorGO:004275620.013
regulation of mrna metabolic processGO:1903311720.013
protein transportGO:00150311550.013
regulation of proteolysisGO:0030162870.013
oocyte dorsal ventral axis specificationGO:0007310340.013
response to axon injuryGO:0048678120.013
positive regulation of behaviorGO:0048520190.013
steroid catabolic processGO:000670610.013
multicellular organismal agingGO:00102591400.013
carbohydrate biosynthetic processGO:0016051170.013
rna splicingGO:0008380830.013
regulation of i kappab kinase nf kappab signalingGO:004312220.013
immune responseGO:00069552460.013
regulation of steroid metabolic processGO:001921820.013
cardiocyte differentiationGO:0035051290.013
single organism cell adhesionGO:0098602470.013
mitotic spindle elongationGO:0000022810.013
lipid localizationGO:0010876540.012
response to organic cyclic compoundGO:0014070890.012
regulation of endocytosisGO:0030100370.012
negative regulation of catalytic activityGO:0043086420.012
meiotic nuclear divisionGO:00071261510.012
compound eye developmentGO:00487493070.012
urogenital system developmentGO:0001655720.012
negative regulation of translationGO:0017148280.012
axon guidanceGO:00074112330.012
vesicle organizationGO:0016050440.012
positive regulation of response to external stimulusGO:0032103440.012
endoplasmic reticulum organizationGO:0007029130.012
connective tissue developmentGO:006144830.012
neural retina developmentGO:000340740.012
negative regulation of protein metabolic processGO:0051248850.012
cytoskeleton dependent cytokinesisGO:0061640810.012
organic cyclic compound catabolic processGO:19013611680.012
oxoacid metabolic processGO:00434361030.012
Human
positive regulation of cell deathGO:0010942690.012
hematopoietic progenitor cell differentiationGO:000224410.012
cytosolic calcium ion transportGO:006040120.012
acetylcholine metabolic processGO:000829120.012
morphogenesis of follicular epitheliumGO:0016333360.012
cellular modified amino acid metabolic processGO:0006575450.012
Human
positive regulation of protein transportGO:0051222370.012
salivary gland cell autophagic cell deathGO:0035071830.012
circulatory system developmentGO:0072359820.012
regulation of cellular ketone metabolic processGO:001056530.012
sensory perception of painGO:001923340.012
positive regulation of reactive oxygen species metabolic processGO:200037900.012
metal ion transportGO:0030001740.012
positive regulation of cell developmentGO:0010720610.012
deathGO:00162652840.012
Human
meiotic cell cycleGO:00513211710.012
regulation of post mating ovipositionGO:0048042100.012
metaphase anaphase transition of cell cycleGO:0044784280.012
respiratory system developmentGO:00605412130.011
chromosome separationGO:0051304420.011
limb developmentGO:006017310.011
mitotic g2 dna damage checkpointGO:0007095690.011
developmental maturationGO:00217001720.011
response to decreased oxygen levelsGO:0036293580.011
Human
cellular homeostasisGO:0019725800.011
histolysisGO:00075591020.011
response to temperature stimulusGO:00092661060.011
neuron projection guidanceGO:00974852410.011
negative regulation of neurogenesisGO:0050768530.011
spindle elongationGO:0051231830.011
detection of mechanical stimulus involved in sensory perception of painGO:005096620.011
positive regulation of nucleic acid templated transcriptionGO:19035082660.011
positive regulation of molecular functionGO:00440931360.011
epithelial cell developmentGO:00020642740.011
mesenchymal cell developmentGO:001403110.011
translationGO:0006412690.011
pigment metabolic processGO:0042440840.011
amine metabolic processGO:0009308120.011
startle responseGO:0001964160.011
estrogen metabolic processGO:000821010.011
mapk cascadeGO:00001651070.011
negative regulation of transcription from rna polymerase ii promoterGO:00001221190.011
positive regulation of developmental processGO:00510941430.011
muscle organ developmentGO:00075171270.011
negative regulation of sequestering of calcium ionGO:005128320.011
regulation of small gtpase mediated signal transductionGO:0051056930.011
apoptotic cell clearanceGO:0043277140.011
morphogenesis of an epitheliumGO:00020092760.011
negative regulation of molecular functionGO:0044092510.011
release of sequestered calcium ion into cytosolGO:005120910.011
humoral immune responseGO:00069591170.011
regulation of cellular amino acid metabolic processGO:000652100.011
regulation of ras protein signal transductionGO:0046578930.011
taxisGO:00423303040.011
muscle cell differentiationGO:00426921030.011
mesenchymal cell differentiationGO:004876210.011
regulation of apoptotic processGO:00429811300.011
Human
er associated ubiquitin dependent protein catabolic processGO:003043330.011
pole plasm assemblyGO:0007315610.010
cellular amide metabolic processGO:0043603800.010
mitotic sister chromatid separationGO:0051306300.010
regulation of cyclin dependent protein serine threonine kinase activityGO:000007930.010
axon regenerationGO:003110380.010
digestive system developmentGO:00551231490.010
regulation of cell divisionGO:0051302720.010
response to oxygen containing compoundGO:19017002000.010
regulation of protein transportGO:0051223570.010
glycoprotein metabolic processGO:0009100410.010
single organism catabolic processGO:00447122280.010
renal system developmentGO:0072001720.010
ribonucleotide catabolic processGO:00092611090.010
response to biotic stimulusGO:00096072940.010
larval developmentGO:00021641040.010
l glutamate importGO:005193810.010
antimicrobial humoral responseGO:0019730990.010
cytokinesisGO:0000910900.010
protein localization to organelleGO:0033365820.010
response to lipopolysaccharideGO:003249640.010
cardiac muscle cell differentiationGO:005500740.010
protein complex assemblyGO:00064612000.010

Pdi disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.042
cancerDOID:16200.038
disease of cellular proliferationDOID:1456600.038
cardiovascular system diseaseDOID:128700.029
disease of metabolismDOID:001466700.029
lipid metabolism disorderDOID:314600.029
inherited metabolic disorderDOID:65500.029
muscular diseaseDOID:008000000.027
musculoskeletal system diseaseDOID:1700.027
organ system cancerDOID:005068600.021
urinary system diseaseDOID:1800.017
nervous system diseaseDOID:86300.013
kidney diseaseDOID:55700.012
renal tubular transport diseaseDOID:44700.012
muscle tissue diseaseDOID:6600.011
cardiomyopathyDOID:005070000.010
myopathyDOID:42300.010
heart diseaseDOID:11400.010
intrinsic cardiomyopathyDOID:006003600.010
lower respiratory tract diseaseDOID:005016100.010
respiratory system diseaseDOID:157900.010