IMP: Integrative Multi-species Prediction

Drosophila melanogaster

40 known processes

eIF-1A (Dmel_CG8053)

Eukaryotic initiation factor 1A

(Aliases: CG8053,eIF1A,Group I,EP(3)0935,group I,EP935,anon-EST:Posey4,eIF-4c,anon-EST:Liang-2.3,clone 2.3,D-eIF4c,D-eIF1A,Dmel\CG8053)

Entrez: 44260
FLYBASE: FBgn0026250
UniProtKB: Q9VEA1

Process Predictions
Disease Predictions

eIF-1A biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
positive regulation of gene expression	GO:0010628	290	0.301
establishment of localization in cell	GO:0051649	402	0.251
intracellular transport	GO:0046907	228	0.182
positive regulation of macromolecule metabolic process	GO:0010604	405	0.161
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.157
posttranscriptional regulation of gene expression	GO:0010608	145	0.155
positive regulation of rna biosynthetic process	GO:1902680	266	0.153
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.145
positive regulation of cellular biosynthetic process	GO:0031328	316	0.141
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.136
dorsal ventral pattern formation	GO:0009953	133	0.133
cytoplasmic transport	GO:0016482	130	0.119
negative regulation of mitotic cell cycle	GO:0045930	109	0.117
modification dependent macromolecule catabolic process	GO:0043632	79	0.110
positive regulation of rna metabolic process	GO:0051254	271	0.105
positive regulation of transcription dna templated	GO:0045893	266	0.103
single organism intracellular transport	GO:1902582	207	0.101
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.097
regulation of gene expression epigenetic	GO:0040029	128	0.093
macromolecule catabolic process	GO:0009057	161	0.092
transcription from rna polymerase ii promoter	GO:0006366	368	0.085
immune system process	GO:0002376	347	0.084
response to biotic stimulus	GO:0009607	294	0.082
organic substance transport	GO:0071702	257	0.082
mitotic cell cycle phase transition	GO:0044772	138	0.079
positive regulation of biosynthetic process	GO:0009891	316	0.076
cellular macromolecule localization	GO:0070727	220	0.075
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.075
regulation of cell cycle phase transition	GO:1901987	130	0.074
homeostatic process	GO:0042592	199	0.072
stem cell differentiation	GO:0048863	117	0.072
protein catabolic process	GO:0030163	101	0.071
organic substance catabolic process	GO:1901575	308	0.071
chemical homeostasis	GO:0048878	92	0.070
mitotic dna damage checkpoint	GO:0044773	74	0.069
cell cycle phase transition	GO:0044770	140	0.069
male gamete generation	GO:0048232	201	0.068
cellular response to dna damage stimulus	GO:0006974	223	0.066
proteasomal protein catabolic process	GO:0010498	59	0.060
positive regulation of transport	GO:0051050	92	0.058
organonitrogen compound metabolic process	GO:1901564	318	0.057
dna repair	GO:0006281	54	0.057
gene silencing	GO:0016458	138	0.056
cell cycle checkpoint	GO:0000075	95	0.056
negative regulation of cell cycle process	GO:0010948	109	0.056
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.056
negative regulation of cellular metabolic process	GO:0031324	382	0.052
stem cell development	GO:0048864	79	0.052
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.051
post embryonic appendage morphogenesis	GO:0035120	385	0.050
imaginal disc derived wing morphogenesis	GO:0007476	337	0.050
regulation of localization	GO:0032879	275	0.049
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.049
negative regulation of cell cycle phase transition	GO:1901988	103	0.049
nucleocytoplasmic transport	GO:0006913	72	0.049
dna integrity checkpoint	GO:0031570	81	0.048
cellular component assembly involved in morphogenesis	GO:0010927	151	0.048
stem cell maintenance	GO:0019827	67	0.047
rna localization	GO:0006403	115	0.047
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.046
response to other organism	GO:0051707	293	0.046
aging	GO:0007568	143	0.046
catabolic process	GO:0009056	409	0.045
regulation of transport	GO:0051049	181	0.045
cellular macromolecule catabolic process	GO:0044265	136	0.045
cell division	GO:0051301	248	0.045
imaginal disc derived appendage development	GO:0048737	399	0.044
regulation of cell cycle	GO:0051726	291	0.044
response to bacterium	GO:0009617	198	0.044
eye development	GO:0001654	323	0.043
regulation of multicellular organismal development	GO:2000026	414	0.043
single organism biosynthetic process	GO:0044711	206	0.043
appendage development	GO:0048736	401	0.043
negative regulation of developmental process	GO:0051093	201	0.042
regulation of anatomical structure morphogenesis	GO:0022603	242	0.042
smoothened signaling pathway	GO:0007224	49	0.042
regulation of response to stress	GO:0080134	200	0.041
negative regulation of cell differentiation	GO:0045596	143	0.041
cell migration	GO:0016477	238	0.041
growth	GO:0040007	359	0.040
epithelial cell development	GO:0002064	274	0.040
proteolysis	GO:0006508	192	0.040
columnar cuboidal epithelial cell development	GO:0002066	249	0.040
negative regulation of cellular biosynthetic process	GO:0031327	277	0.039
rna processing	GO:0006396	147	0.039
epithelial cell differentiation	GO:0030855	322	0.039
secretion	GO:0046903	109	0.039
mitotic dna integrity checkpoint	GO:0044774	75	0.039
mitotic nuclear division	GO:0007067	213	0.038
embryo development ending in birth or egg hatching	GO:0009792	152	0.038
imaginal disc derived wing vein specification	GO:0007474	48	0.038
protein transport	GO:0015031	155	0.038
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.038
mrna metabolic process	GO:0016071	124	0.038
regulation of cell cycle process	GO:0010564	181	0.037
nitrogen compound transport	GO:0071705	85	0.037
mitotic cell cycle checkpoint	GO:0007093	88	0.036
translation	GO:0006412	69	0.036
cell proliferation	GO:0008283	299	0.035
appendage morphogenesis	GO:0035107	397	0.035
compound eye morphogenesis	GO:0001745	249	0.034
muscle structure development	GO:0061061	224	0.034
negative regulation of cell cycle	GO:0045786	116	0.034
body morphogenesis	GO:0010171	2	0.033
negative regulation of gene expression	GO:0010629	387	0.033
cellular catabolic process	GO:0044248	372	0.033
sensory organ morphogenesis	GO:0090596	260	0.033
regulation of mitotic cell cycle	GO:0007346	190	0.032
response to external biotic stimulus	GO:0043207	293	0.032
endocytosis	GO:0006897	310	0.032
compound eye development	GO:0048749	307	0.031
defense response to bacterium	GO:0042742	178	0.031
response to light stimulus	GO:0009416	124	0.031
protein modification process	GO:0036211	438	0.031
dendrite morphogenesis	GO:0048813	199	0.031
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.031
negative regulation of rna biosynthetic process	GO:1902679	240	0.031
imaginal disc derived leg morphogenesis	GO:0007480	80	0.030
ubiquitin dependent protein catabolic process	GO:0006511	78	0.030
dna damage checkpoint	GO:0000077	78	0.030
cation homeostasis	GO:0055080	51	0.030
dna metabolic process	GO:0006259	227	0.030
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.030
carbohydrate derivative metabolic process	GO:1901135	217	0.029
modification dependent protein catabolic process	GO:0019941	78	0.029
macromolecular complex disassembly	GO:0032984	37	0.029
ovarian follicle cell development	GO:0030707	248	0.029
dna conformation change	GO:0071103	105	0.029
organelle fission	GO:0048285	340	0.029
secretion by cell	GO:0032940	101	0.029
regulation of cellular response to stress	GO:0080135	89	0.028
jak stat cascade	GO:0007259	49	0.028
cellular protein modification process	GO:0006464	438	0.028
regulation of notch signaling pathway	GO:0008593	100	0.028
eggshell formation	GO:0030703	105	0.027
imaginal disc pattern formation	GO:0007447	91	0.027
single organism carbohydrate metabolic process	GO:0044723	72	0.027
leg disc morphogenesis	GO:0007478	80	0.027
regulation of epithelial cell proliferation	GO:0050678	4	0.027
chorion containing eggshell formation	GO:0007304	105	0.027
protein localization	GO:0008104	284	0.027
regionalization	GO:0003002	416	0.027
detection of stimulus	GO:0051606	156	0.026
chaeta morphogenesis	GO:0008407	42	0.026
regulation of developmental growth	GO:0048638	174	0.026
chromosome organization	GO:0051276	360	0.025
mitotic spindle elongation	GO:0000022	81	0.025
defense response	GO:0006952	300	0.025
nuclear division	GO:0000280	332	0.025
cellular protein complex disassembly	GO:0043624	35	0.024
protein modification by small protein conjugation	GO:0032446	79	0.024
biological adhesion	GO:0022610	138	0.023
cell motility	GO:0048870	251	0.023
eye morphogenesis	GO:0048592	260	0.023
multicellular organismal aging	GO:0010259	140	0.023
microtubule based movement	GO:0007018	51	0.023
cellular protein catabolic process	GO:0044257	83	0.023
spindle elongation	GO:0051231	83	0.022
negative regulation of biosynthetic process	GO:0009890	277	0.022
adult behavior	GO:0030534	137	0.022
carbohydrate metabolic process	GO:0005975	82	0.022
response to organic substance	GO:0010033	284	0.022
cell death	GO:0008219	279	0.022
organelle assembly	GO:0070925	198	0.022
negative regulation of cell cycle g1 s phase transition	GO:1902807	13	0.022
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.022
gland development	GO:0048732	191	0.022
rrna processing	GO:0006364	3	0.022
organonitrogen compound biosynthetic process	GO:1901566	117	0.021
regulation of cytoplasmic transport	GO:1903649	47	0.021
regulation of cellular localization	GO:0060341	136	0.021
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.021
regulation of immune system process	GO:0002682	176	0.021
intracellular protein transmembrane import	GO:0044743	4	0.021
oocyte development	GO:0048599	124	0.021
response to lipopolysaccharide	GO:0032496	4	0.021
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.021
mitotic g2 dna damage checkpoint	GO:0007095	69	0.021
single organism behavior	GO:0044708	391	0.021
intracellular signal transduction	GO:0035556	300	0.020
wing disc morphogenesis	GO:0007472	344	0.020
negative regulation of growth of symbiont involved in interaction with host	GO:0044146	9	0.020
phagocytosis	GO:0006909	215	0.020
spermatogenesis	GO:0007283	200	0.020
response to oxygen containing compound	GO:1901700	200	0.020
notch signaling pathway	GO:0007219	120	0.020
metal ion transport	GO:0030001	74	0.020
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.020
organophosphate metabolic process	GO:0019637	195	0.019
regulation of translation	GO:0006417	56	0.019
protein ubiquitination	GO:0016567	70	0.019
immune response	GO:0006955	246	0.019
regulation of cell cycle g1 s phase transition	GO:1902806	23	0.019
determination of adult lifespan	GO:0008340	137	0.019
cellular protein localization	GO:0034613	160	0.019
interspecies interaction between organisms	GO:0044419	16	0.019
embryonic development via the syncytial blastoderm	GO:0001700	148	0.019
rna transport	GO:0050658	46	0.019
positive regulation of molecular function	GO:0044093	136	0.019
cellular response to lipopolysaccharide	GO:0071222	3	0.019
protein glycosylation	GO:0006486	32	0.018
response to radiation	GO:0009314	155	0.018
cellular cation homeostasis	GO:0030003	38	0.018
cellular ion homeostasis	GO:0006873	39	0.018
eggshell chorion assembly	GO:0007306	66	0.018
cellular nitrogen compound catabolic process	GO:0044270	165	0.018
centrosome organization	GO:0051297	163	0.018
response to alcohol	GO:0097305	95	0.018
actin filament based process	GO:0030029	220	0.018
nucleobase containing compound transport	GO:0015931	56	0.018
regulation of intracellular transport	GO:0032386	64	0.018
purine nucleoside metabolic process	GO:0042278	127	0.017
vesicle mediated transport	GO:0016192	381	0.017
intracellular protein transmembrane transport	GO:0065002	4	0.017
striated muscle cell differentiation	GO:0051146	90	0.017
mitochondrion organization	GO:0007005	65	0.017
regulation of g1 s transition of mitotic cell cycle	GO:2000045	23	0.017
larval development	GO:0002164	104	0.017
intracellular protein transport	GO:0006886	104	0.017
negative regulation of transcription dna templated	GO:0045892	237	0.017
gliogenesis	GO:0042063	80	0.017
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.017
salivary gland histolysis	GO:0035070	88	0.017
regulation of epithelial cell differentiation	GO:0030856	4	0.017
regulation of catalytic activity	GO:0050790	185	0.017
lateral inhibition	GO:0046331	206	0.017
positive regulation of cell communication	GO:0010647	250	0.016
regulation of cellular protein metabolic process	GO:0032268	243	0.016
organic acid metabolic process	GO:0006082	103	0.016
wing disc pattern formation	GO:0035222	66	0.016
nucleoside triphosphate metabolic process	GO:0009141	120	0.016
positive regulation of cell cycle	GO:0045787	43	0.016
chemosensory behavior	GO:0007635	106	0.016
g1 s transition of mitotic cell cycle	GO:0000082	31	0.016
negative regulation of rna metabolic process	GO:0051253	251	0.016
membrane budding	GO:0006900	4	0.016
positive regulation of signal transduction	GO:0009967	223	0.016
ion homeostasis	GO:0050801	55	0.016
nuclear transport	GO:0051169	72	0.016
protein complex disassembly	GO:0043241	36	0.016
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.016
response to abiotic stimulus	GO:0009628	341	0.015
negative regulation of epithelial cell proliferation	GO:0050680	4	0.015
cell cycle g1 s phase transition	GO:0044843	31	0.015
g2 dna damage checkpoint	GO:0031572	69	0.015
compound eye photoreceptor development	GO:0042051	78	0.015
oocyte axis specification	GO:0007309	108	0.015
negative regulation of multicellular organismal process	GO:0051241	142	0.015
establishment of protein localization	GO:0045184	163	0.015
establishment of rna localization	GO:0051236	47	0.015
stress activated protein kinase signaling cascade	GO:0031098	55	0.015
nucleobase containing compound catabolic process	GO:0034655	165	0.015
single organism membrane budding	GO:1902591	2	0.015
hematopoietic or lymphoid organ development	GO:0048534	57	0.015
carbohydrate derivative biosynthetic process	GO:1901137	85	0.015
wing disc dorsal ventral pattern formation	GO:0048190	47	0.015
regulation of phosphate metabolic process	GO:0019220	210	0.015
defense response to other organism	GO:0098542	225	0.015
chromosome segregation	GO:0007059	157	0.014
developmental growth	GO:0048589	280	0.014
morphogenesis of an epithelium	GO:0002009	276	0.014
single organism cellular localization	GO:1902580	180	0.014
regulation of phosphorylation	GO:0042325	147	0.014
detection of abiotic stimulus	GO:0009582	66	0.014
cell junction assembly	GO:0034329	42	0.014
heterocycle catabolic process	GO:0046700	166	0.014
regulation of cell shape	GO:0008360	113	0.014
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.014
protein modification by small protein conjugation or removal	GO:0070647	106	0.014
mitotic cell cycle embryonic	GO:0045448	38	0.014
mrna polyadenylation	GO:0006378	11	0.014
regulation of organelle organization	GO:0033043	196	0.014
positive regulation of signaling	GO:0023056	243	0.014
mesenchymal cell differentiation	GO:0048762	1	0.014
negative regulation of protein metabolic process	GO:0051248	85	0.014
protein dna complex assembly	GO:0065004	63	0.014
developmental maturation	GO:0021700	172	0.014
single organism catabolic process	GO:0044712	228	0.014
dorsal ventral axis specification	GO:0009950	66	0.014
molting cycle	GO:0042303	56	0.014
er associated ubiquitin dependent protein catabolic process	GO:0030433	3	0.013
regulation of proteasomal protein catabolic process	GO:0061136	39	0.013
regulation of growth	GO:0040008	233	0.013
dendrite development	GO:0016358	204	0.013
negative regulation of gene expression epigenetic	GO:0045814	77	0.013
positive regulation of cell migration	GO:0030335	2	0.013
maintenance of location	GO:0051235	73	0.013
protein complex biogenesis	GO:0070271	201	0.013
mitotic sister chromatid segregation	GO:0000070	87	0.013
mesenchymal cell development	GO:0014031	1	0.013
nucleobase containing small molecule metabolic process	GO:0055086	174	0.013
endosome transport via multivesicular body sorting pathway	GO:0032509	12	0.013
nucleoside phosphate metabolic process	GO:0006753	162	0.013
regulation of protein metabolic process	GO:0051246	256	0.013
translational initiation	GO:0006413	11	0.013
camera type eye development	GO:0043010	4	0.013
salivary gland cell autophagic cell death	GO:0035071	83	0.012
negative regulation of immune system process	GO:0002683	50	0.012
regulation of cell proliferation	GO:0042127	163	0.012
mitotic spindle organization	GO:0007052	220	0.012
central nervous system development	GO:0007417	201	0.012
negative regulation of signal transduction	GO:0009968	206	0.012
death	GO:0016265	284	0.012
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.012
immune response activating signal transduction	GO:0002757	2	0.012
cell adhesion	GO:0007155	136	0.012
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.012
rna 3 end processing	GO:0031123	45	0.012
regulation of cellular ketone metabolic process	GO:0010565	3	0.012
chaeta development	GO:0022416	97	0.012
regulation of mrna 3 end processing	GO:0031440	7	0.012
protein complex assembly	GO:0006461	200	0.012
translational termination	GO:0006415	2	0.012
glial cell differentiation	GO:0010001	35	0.012
microtubule organizing center organization	GO:0031023	168	0.012
small molecule metabolic process	GO:0044281	305	0.012
regulation of proteolysis	GO:0030162	87	0.012
chromatin silencing	GO:0006342	76	0.012
mrna 3 end processing	GO:0031124	28	0.012
protein localization to organelle	GO:0033365	82	0.012
germarium derived egg chamber formation	GO:0007293	101	0.012
regulation of protein transport	GO:0051223	57	0.012
meiotic cell cycle	GO:0051321	171	0.012
dorsal appendage formation	GO:0046843	47	0.012
aromatic compound catabolic process	GO:0019439	166	0.011
protein import	GO:0017038	55	0.011
ribose phosphate metabolic process	GO:0019693	145	0.011
mesoderm development	GO:0007498	78	0.011
regulation of nucleocytoplasmic transport	GO:0046822	35	0.011
regulation of vesicle mediated transport	GO:0060627	59	0.011
embryonic pattern specification	GO:0009880	174	0.011
aggressive behavior	GO:0002118	63	0.011
posttranscriptional gene silencing	GO:0016441	46	0.011
pole plasm assembly	GO:0007315	61	0.011
neurological system process	GO:0050877	358	0.011
organic cyclic compound catabolic process	GO:1901361	168	0.011
posttranscriptional gene silencing by rna	GO:0035194	45	0.011
humoral immune response	GO:0006959	117	0.011
postreplication repair	GO:0006301	2	0.011
regulation of cell morphogenesis	GO:0022604	163	0.011
regulation of cellular catabolic process	GO:0031329	157	0.011
gland morphogenesis	GO:0022612	145	0.011
regulation of endocytosis	GO:0030100	37	0.011
muscle cell development	GO:0055001	50	0.011
positive regulation of proteolysis	GO:0045862	52	0.011
chromatin modification	GO:0016568	147	0.011
nucleotide metabolic process	GO:0009117	161	0.011
cell growth	GO:0016049	108	0.011
cellular homeostasis	GO:0019725	80	0.011
cell maturation	GO:0048469	144	0.011
protein targeting	GO:0006605	64	0.011
behavioral response to ethanol	GO:0048149	49	0.011
pigmentation	GO:0043473	75	0.011
nucleoside triphosphate catabolic process	GO:0009143	108	0.011
germarium derived oocyte differentiation	GO:0030706	29	0.011
antimicrobial humoral response	GO:0019730	99	0.011
immune system development	GO:0002520	57	0.011
dna templated transcription elongation	GO:0006354	18	0.011
protein k48 linked ubiquitination	GO:0070936	3	0.011
embryonic morphogenesis	GO:0048598	206	0.011
cytoplasm organization	GO:0007028	64	0.011
detection of external stimulus	GO:0009581	66	0.011
signal release	GO:0023061	49	0.011
oocyte differentiation	GO:0009994	145	0.011
negative regulation of cellular protein metabolic process	GO:0032269	85	0.011
spinal cord development	GO:0021510	1	0.011
positive regulation of multicellular organismal process	GO:0051240	143	0.010
covalent chromatin modification	GO:0016569	106	0.010
developmental programmed cell death	GO:0010623	138	0.010
compound eye photoreceptor cell differentiation	GO:0001751	140	0.010
developmental pigmentation	GO:0048066	68	0.010
histone ubiquitination	GO:0016574	4	0.010
positive regulation of intracellular transport	GO:0032388	42	0.010
regulation of pole plasm oskar mrna localization	GO:0007317	27	0.010
purine ribonucleoside catabolic process	GO:0046130	112	0.010
eye pigmentation	GO:0048069	43	0.010
negative regulation of neural precursor cell proliferation	GO:2000178	27	0.010
actin cytoskeleton organization	GO:0030036	206	0.010
hematopoietic progenitor cell differentiation	GO:0002244	1	0.010
cellular response to biotic stimulus	GO:0071216	4	0.010
ion transport	GO:0006811	145	0.010
pigment metabolic process	GO:0042440	84	0.010

eIF-1A disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.056
nervous system disease	DOID:863	0.019
organ system cancer	DOID:0050686	0.015
disease of cellular proliferation	DOID:14566	0.015
cancer	DOID:162	0.015

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