IMP: Integrative Multi-species Prediction

Drosophila melanogaster

86 known processes

inaC (Dmel_CG6518)

inactivation no afterpotential C

(Aliases: PKC 53E,Pkc2,Dmel\CG6518,ePKC,eye-PKC,dPKC53E(ey),CG6518,Dpkc2,INAC,PKC,pkc-2,eye PKC,dPKC53E,PKCi,InaC)

Entrez: 36897
FLYBASE: FBgn0004784
UniProtKB: P13677

Process Predictions
Disease Predictions

inaC biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cellular response to light stimulus	GO:0071482	37	0.997
detection of visible light	GO:0009584	38	0.997
rhodopsin mediated signaling pathway	GO:0016056	21	0.996
phototransduction visible light	GO:0007603	27	0.991
detection of light stimulus	GO:0009583	58	0.989
cellular response to radiation	GO:0071478	52	0.973
response to light stimulus	GO:0009416	124	0.971
phototransduction	GO:0007602	52	0.967
regulation of rhodopsin mediated signaling pathway	GO:0022400	17	0.962
deactivation of rhodopsin mediated signaling	GO:0016059	17	0.957
detection of external stimulus	GO:0009581	66	0.942
g protein coupled receptor signaling pathway	GO:0007186	136	0.925
single organism behavior	GO:0044708	391	0.915	Fly
detection of stimulus	GO:0051606	156	0.900
detection of abiotic stimulus	GO:0009582	66	0.892
light induced release of internally sequestered calcium ion	GO:0008377	1	0.846
response to abiotic stimulus	GO:0009628	341	0.801
response to radiation	GO:0009314	155	0.771
sensory perception of sound	GO:0007605	56	0.658
cellular response to abiotic stimulus	GO:0071214	58	0.644
optomotor response	GO:0071632	3	0.594
neurological system process	GO:0050877	358	0.498
adult behavior	GO:0030534	137	0.495
phospholipase c activating rhodopsin mediated signaling pathway	GO:0030265	1	0.464
purine nucleoside metabolic process	GO:0042278	127	0.462
heterocycle catabolic process	GO:0046700	166	0.447
phototransduction uv	GO:0007604	5	0.433
regulation of g protein coupled receptor protein signaling pathway	GO:0008277	23	0.416
negative regulation of homeostatic process	GO:0032845	2	0.400
detection of stimulus involved in sensory perception	GO:0050906	92	0.381
sensory perception	GO:0007600	196	0.356
cellular response to uv	GO:0034644	12	0.353
olfactory learning	GO:0008355	56	0.345
locomotory behavior	GO:0007626	176	0.318
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.308
peptidyl threonine phosphorylation	GO:0018107	2	0.290	Human
photoreceptor cell maintenance	GO:0045494	11	0.274
catabolic process	GO:0009056	409	0.248
ion transmembrane transport	GO:0034220	122	0.245	Mouse
regulation of sequestering of calcium ion	GO:0051282	3	0.239
response to organic substance	GO:0010033	284	0.232
organonitrogen compound catabolic process	GO:1901565	128	0.228
cgmp biosynthetic process	GO:0006182	8	0.221
light adaption	GO:0036367	3	0.203
metarhodopsin inactivation	GO:0016060	5	0.202
calcium ion transport	GO:0006816	24	0.201	Mouse
response to carbon dioxide	GO:0010037	4	0.196
anatomical structure homeostasis	GO:0060249	97	0.191
cellular catabolic process	GO:0044248	372	0.181
negative regulation of signal transduction	GO:0009968	206	0.180	Mouse
cellular protein modification process	GO:0006464	438	0.176	Human Mouse Worm Fly
purine ribonucleotide catabolic process	GO:0009154	109	0.175
asymmetric stem cell division	GO:0098722	49	0.173
transmembrane transport	GO:0055085	139	0.172	Mouse
cellular nitrogen compound catabolic process	GO:0044270	165	0.163
aromatic compound catabolic process	GO:0019439	166	0.156
sensory perception of smell	GO:0007608	80	0.153
purine ribonucleoside metabolic process	GO:0046128	127	0.152
chemosensory behavior	GO:0007635	106	0.150
cellular response to carbon dioxide	GO:0071244	2	0.148
behavioral response to ethanol	GO:0048149	49	0.146
purine nucleotide catabolic process	GO:0006195	109	0.145
nucleoside metabolic process	GO:0009116	127	0.144
regulation of cellular catabolic process	GO:0031329	157	0.143
single organism catabolic process	GO:0044712	228	0.140
ribonucleoside catabolic process	GO:0042454	112	0.138
cell division	GO:0051301	248	0.136
adult locomotory behavior	GO:0008344	76	0.134
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.130
glycosyl compound metabolic process	GO:1901657	127	0.130
organic cyclic compound catabolic process	GO:1901361	168	0.127
inorganic ion transmembrane transport	GO:0098660	73	0.124	Mouse
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.124
positive regulation of calcium ion transport	GO:0051928	4	0.123
multicellular organismal homeostasis	GO:0048871	41	0.119
cellular amine metabolic process	GO:0044106	12	0.119
nucleobase containing compound catabolic process	GO:0034655	165	0.119
stem cell division	GO:0017145	69	0.118
cell junction organization	GO:0034330	57	0.117	Human
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.115
homeostatic process	GO:0042592	199	0.114	Mouse
olfactory behavior	GO:0042048	97	0.113
organonitrogen compound metabolic process	GO:1901564	318	0.113
nucleotide catabolic process	GO:0009166	109	0.112
vesicle mediated transport	GO:0016192	381	0.108
cation transmembrane transport	GO:0098655	88	0.107	Mouse
phosphorylation	GO:0016310	294	0.104	Human Mouse Worm Fly
regulation of nucleotide catabolic process	GO:0030811	48	0.104
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.101
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.101
learning	GO:0007612	75	0.100
compound eye retinal cell programmed cell death	GO:0046667	23	0.098
negative regulation of cellular metabolic process	GO:0031324	382	0.098	Mouse
response to light intensity	GO:0009642	6	0.098
protein phosphorylation	GO:0006468	169	0.097	Human Mouse Worm Fly
dopamine receptor signaling pathway	GO:0007212	4	0.095
neuroblast proliferation	GO:0007405	74	0.095
cognition	GO:0050890	141	0.093	Fly
glycosyl compound catabolic process	GO:1901658	112	0.091
circadian rhythm	GO:0007623	105	0.091
regulation of response to external stimulus	GO:0032101	115	0.091
carbohydrate derivative catabolic process	GO:1901136	118	0.089
thermotaxis	GO:0043052	16	0.089
cation transport	GO:0006812	110	0.089	Mouse
regulation of cellular ketone metabolic process	GO:0010565	3	0.088
establishment or maintenance of polarity of follicular epithelium	GO:0016334	26	0.087
nucleoside triphosphate catabolic process	GO:0009143	108	0.087
purine ribonucleoside catabolic process	GO:0046130	112	0.087
endocytosis	GO:0006897	310	0.086
response to ethanol	GO:0045471	59	0.086
organic substance catabolic process	GO:1901575	308	0.086
carboxylic acid metabolic process	GO:0019752	92	0.083
purine ribonucleotide metabolic process	GO:0009150	145	0.082
regulation of system process	GO:0044057	36	0.081	Mouse
response to oxygen containing compound	GO:1901700	200	0.081
organic hydroxy compound metabolic process	GO:1901615	83	0.080
regionalization	GO:0003002	416	0.079	Fly
amine metabolic process	GO:0009308	12	0.076
negative regulation of retinal cell programmed cell death	GO:0046671	7	0.075
nucleoside catabolic process	GO:0009164	112	0.075
ion transport	GO:0006811	145	0.074	Mouse
cell projection assembly	GO:0030031	94	0.074
growth	GO:0040007	359	0.073
response to toxic substance	GO:0009636	22	0.073
detection of light stimulus involved in visual perception	GO:0050908	6	0.072
protein complex assembly	GO:0006461	200	0.071
nucleoside triphosphate metabolic process	GO:0009141	120	0.070
purine containing compound catabolic process	GO:0072523	112	0.067
organic acid metabolic process	GO:0006082	103	0.066
asymmetric neuroblast division	GO:0055059	33	0.066
macromolecule catabolic process	GO:0009057	161	0.066
detection of light stimulus involved in sensory perception	GO:0050962	9	0.065
positive regulation of response to stimulus	GO:0048584	323	0.065	Human Mouse
phagocytosis	GO:0006909	215	0.065
response to decreased oxygen levels	GO:0036293	58	0.064	Mouse
actin filament organization	GO:0007015	126	0.064
peptidyl amino acid modification	GO:0018193	105	0.062	Human Mouse Worm
response to uv	GO:0009411	24	0.062
sensory perception of mechanical stimulus	GO:0050954	72	0.061
metal ion transport	GO:0030001	74	0.061	Mouse
response to temperature stimulus	GO:0009266	106	0.061
protein modification process	GO:0036211	438	0.060	Human Mouse Worm Fly
gliogenesis	GO:0042063	80	0.059
regulation of hydrolase activity	GO:0051336	97	0.058
optokinetic behavior	GO:0007634	3	0.057
translation	GO:0006412	69	0.057
protein k48 linked ubiquitination	GO:0070936	3	0.056
purine nucleotide metabolic process	GO:0006163	146	0.056
macromolecular complex assembly	GO:0065003	256	0.056
regulation of ion homeostasis	GO:2000021	5	0.056
regulation of behavior	GO:0050795	75	0.055	Mouse
actin filament based process	GO:0030029	220	0.055
multicellular organismal aging	GO:0010259	140	0.055
purine nucleoside catabolic process	GO:0006152	112	0.053
rhythmic process	GO:0048511	106	0.053
cellular ketone metabolic process	GO:0042180	24	0.053
cuticle pigmentation	GO:0048067	22	0.053
central nervous system development	GO:0007417	201	0.053
regulation of epithelial cell differentiation	GO:0030856	4	0.051
positive regulation of biosynthetic process	GO:0009891	316	0.051
nucleobase containing small molecule metabolic process	GO:0055086	174	0.051
response to inorganic substance	GO:0010035	44	0.050
release of sequestered calcium ion into cytosol	GO:0051209	1	0.050
negative regulation of developmental process	GO:0051093	201	0.050
intracellular signal transduction	GO:0035556	300	0.050	Mouse Fly
response to hypoxia	GO:0001666	53	0.049	Mouse
regulation of phosphate metabolic process	GO:0019220	210	0.049	Mouse
neuroblast division	GO:0055057	35	0.048
proteolysis	GO:0006508	192	0.048
gtp metabolic process	GO:0046039	72	0.048
associative learning	GO:0008306	65	0.047
regulation of phosphorus metabolic process	GO:0051174	210	0.047	Mouse
circulatory system development	GO:0072359	82	0.047	Human Mouse
regulation of cell death	GO:0010941	173	0.047	Human
guanosine containing compound metabolic process	GO:1901068	74	0.047
ribonucleotide catabolic process	GO:0009261	109	0.047
morphogenesis of an epithelium	GO:0002009	276	0.046
regulation of cellular protein metabolic process	GO:0032268	243	0.044	Mouse
cell death	GO:0008219	279	0.044	Human Mouse
divalent metal ion transport	GO:0070838	26	0.044	Mouse
learning or memory	GO:0007611	141	0.043	Fly
establishment of glial blood brain barrier	GO:0060857	14	0.043
cell adhesion involved in heart morphogenesis	GO:0061343	12	0.043
chromosome organization	GO:0051276	360	0.042	Human
carbohydrate derivative metabolic process	GO:1901135	217	0.042
sensory perception of chemical stimulus	GO:0007606	116	0.042
organic substance transport	GO:0071702	257	0.042	Mouse
anion transport	GO:0006820	41	0.042
peptidyl threonine modification	GO:0018210	3	0.041	Human
ribose phosphate metabolic process	GO:0019693	145	0.041
somatic stem cell division	GO:0048103	37	0.041
organophosphate metabolic process	GO:0019637	195	0.041
regulation of cellular amino acid metabolic process	GO:0006521	0	0.040
light absorption	GO:0016037	2	0.040
positive regulation of signal transduction	GO:0009967	223	0.040	Human Mouse
positive regulation of molecular function	GO:0044093	136	0.040	Mouse
positive regulation of hydrolase activity	GO:0051345	78	0.039
regulation of nucleoside metabolic process	GO:0009118	50	0.039
axon development	GO:0061564	297	0.039
maintenance of location	GO:0051235	73	0.039
nucleoside phosphate catabolic process	GO:1901292	110	0.038
actin cytoskeleton organization	GO:0030036	206	0.037
rna localization	GO:0006403	115	0.037
regulation of protein metabolic process	GO:0051246	256	0.037	Mouse
catechol containing compound biosynthetic process	GO:0009713	3	0.037
nucleotide metabolic process	GO:0009117	161	0.036
positive regulation of macromolecule metabolic process	GO:0010604	405	0.036	Mouse
membrane organization	GO:0061024	112	0.036
calcium ion homeostasis	GO:0055074	23	0.036	Mouse
regulation of anatomical structure morphogenesis	GO:0022603	242	0.035	Human Mouse
cell cell junction organization	GO:0045216	55	0.035	Human
protein complex biogenesis	GO:0070271	201	0.035
regulation of tube size	GO:0035150	46	0.035
cuticle development	GO:0042335	86	0.034
cellular macromolecule catabolic process	GO:0044265	136	0.034
response to other organism	GO:0051707	293	0.034	Human
regulation of multicellular organismal development	GO:2000026	414	0.034	Human Mouse
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.034
ventral cord development	GO:0007419	16	0.034
regulation of cell cycle	GO:0051726	291	0.034	Human
ion homeostasis	GO:0050801	55	0.034	Mouse
developmental pigmentation	GO:0048066	68	0.034
regulation of cytoplasmic transport	GO:1903649	47	0.034
biological adhesion	GO:0022610	138	0.034	Human Mouse
positive regulation of cellular component biogenesis	GO:0044089	80	0.034	Mouse
chemotaxis	GO:0006935	249	0.033	Mouse
forebrain development	GO:0030900	2	0.033
regulation of filopodium assembly	GO:0051489	24	0.033
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.033
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.032
transcription from rna polymerase ii promoter	GO:0006366	368	0.032	Human
absorption of visible light	GO:0016038	1	0.032
chemical homeostasis	GO:0048878	92	0.030	Mouse
negative regulation of gene expression	GO:0010629	387	0.030
tissue morphogenesis	GO:0048729	297	0.030
establishment or maintenance of cell polarity	GO:0007163	167	0.030
tissue homeostasis	GO:0001894	36	0.030
regulation of nucleotide metabolic process	GO:0006140	62	0.030
heart process	GO:0003015	37	0.030	Mouse
response to extracellular stimulus	GO:0009991	116	0.030
response to organophosphorus	GO:0046683	2	0.029
regulation of gtpase activity	GO:0043087	44	0.029
germline stem cell asymmetric division	GO:0098728	15	0.029
developmental growth	GO:0048589	280	0.029
nucleoside phosphate metabolic process	GO:0006753	162	0.029
positive regulation of cell communication	GO:0010647	250	0.028	Human Mouse
atp metabolic process	GO:0046034	49	0.028
response to external biotic stimulus	GO:0043207	293	0.028	Human
purine ribonucleoside monophosphate catabolic process	GO:0009169	38	0.028
nucleoside monophosphate catabolic process	GO:0009125	39	0.028
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.027
regulation of growth	GO:0040008	233	0.027
regulation of membrane potential	GO:0042391	35	0.027
negative regulation of signaling	GO:0023057	219	0.027	Mouse
negative regulation of response to stimulus	GO:0048585	258	0.027	Mouse
filopodium assembly	GO:0046847	33	0.027
ubiquitin dependent protein catabolic process	GO:0006511	78	0.027
apoptotic process	GO:0006915	159	0.026	Human Mouse
mitochondrion organization	GO:0007005	65	0.026
protein catabolic process	GO:0030163	101	0.026
circadian behavior	GO:0048512	76	0.026
oxoacid metabolic process	GO:0043436	103	0.026
single organism biosynthetic process	GO:0044711	206	0.026
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.025
inorganic cation transmembrane transport	GO:0098662	61	0.025	Mouse
negative regulation of cell cycle	GO:0045786	116	0.025
negative regulation of multicellular organismal process	GO:0051241	142	0.025
modification dependent macromolecule catabolic process	GO:0043632	79	0.025
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.025
regulation of programmed cell death	GO:0043067	152	0.025	Human
ribonucleoside metabolic process	GO:0009119	127	0.025
glial cell differentiation	GO:0010001	35	0.025
nitrogen compound transport	GO:0071705	85	0.025
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.025	Human
gtp catabolic process	GO:0006184	72	0.024
guanosine containing compound catabolic process	GO:1901069	74	0.024
negative regulation of sequestering of calcium ion	GO:0051283	2	0.024
regulation of purine nucleotide metabolic process	GO:1900542	62	0.024
aging	GO:0007568	143	0.024
response to starvation	GO:0042594	97	0.024
protein maturation	GO:0051604	71	0.024
regulation of catabolic process	GO:0009894	170	0.023
regulation of anatomical structure size	GO:0090066	163	0.023
eye development	GO:0001654	323	0.023
anion homeostasis	GO:0055081	3	0.023
cortical cytoskeleton organization	GO:0030865	29	0.023
neuromuscular junction development	GO:0007528	149	0.023
small molecule metabolic process	GO:0044281	305	0.023
regulation of phospholipase activity	GO:0010517	2	0.023
cellular homeostasis	GO:0019725	80	0.023	Mouse
atp catabolic process	GO:0006200	38	0.022
positive regulation of cellular protein metabolic process	GO:0032270	118	0.022	Mouse
insecticide catabolic process	GO:0046701	1	0.022
energy taxis	GO:0009453	21	0.022
regulation of cyclic nucleotide metabolic process	GO:0030799	13	0.022
neuronal stem cell division	GO:0036445	35	0.021
negative regulation of catalytic activity	GO:0043086	42	0.021	Mouse
negative regulation of protein metabolic process	GO:0051248	85	0.021	Mouse
compound eye morphogenesis	GO:0001745	249	0.021
cellular cation homeostasis	GO:0030003	38	0.021	Mouse
protein ubiquitination	GO:0016567	70	0.021
response to nutrient levels	GO:0031667	114	0.021
eye photoreceptor cell differentiation	GO:0001754	145	0.021
calcium ion transport into cytosol	GO:0060402	2	0.021
protein localization	GO:0008104	284	0.021
photoreceptor cell differentiation	GO:0046530	170	0.021
dna metabolic process	GO:0006259	227	0.020
regulation of developmental growth	GO:0048638	174	0.020
regulation of circadian rhythm	GO:0042752	49	0.020
regulation of cellular component biogenesis	GO:0044087	201	0.020	Mouse
compound eye development	GO:0048749	307	0.020
posttranscriptional regulation of gene expression	GO:0010608	145	0.020
morphogenesis of follicular epithelium	GO:0016333	36	0.020
immune response	GO:0006955	246	0.020	Mouse
positive regulation of signaling	GO:0023056	243	0.020	Human Mouse
nucleoside monophosphate metabolic process	GO:0009123	52	0.020
cellular macromolecule localization	GO:0070727	220	0.020
adherens junction organization	GO:0034332	27	0.020
regulation of cellular amine metabolic process	GO:0033238	3	0.020
modification dependent protein catabolic process	GO:0019941	78	0.020
protein modification by small protein conjugation or removal	GO:0070647	106	0.020
pole plasm mrna localization	GO:0019094	49	0.020
positive regulation of cellular biosynthetic process	GO:0031328	316	0.020
regulation of gtp catabolic process	GO:0033124	44	0.019
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.019
positive regulation of catalytic activity	GO:0043085	118	0.019
cellular protein localization	GO:0034613	160	0.019
negative regulation of cellular biosynthetic process	GO:0031327	277	0.019
cardiovascular system development	GO:0072358	82	0.019	Human Mouse
morphogenesis of a polarized epithelium	GO:0001738	93	0.019
circadian sleep wake cycle process	GO:0022410	24	0.019
localization of cell	GO:0051674	257	0.019
intracellular transport	GO:0046907	228	0.019
establishment or maintenance of bipolar cell polarity	GO:0061245	34	0.019
single organism membrane organization	GO:0044802	93	0.018
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.018
cellular macromolecular complex assembly	GO:0034622	153	0.018
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.018	Mouse
intercellular transport	GO:0010496	2	0.018
circadian sleep wake cycle	GO:0042745	28	0.018
oocyte anterior posterior axis specification	GO:0007314	72	0.018
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.018
regulation of nervous system development	GO:0051960	248	0.018
regulation of hemocyte differentiation	GO:0045610	22	0.018
regulation of response to stress	GO:0080134	200	0.018	Human Mouse
feeding behavior	GO:0007631	50	0.017
chromatin organization	GO:0006325	207	0.017	Human
fat soluble vitamin biosynthetic process	GO:0042362	1	0.017
protein transport	GO:0015031	155	0.017
determination of adult lifespan	GO:0008340	137	0.017
response to oxygen levels	GO:0070482	59	0.017	Mouse
cellular divalent inorganic cation homeostasis	GO:0072503	23	0.017	Mouse
regulation of cell development	GO:0060284	215	0.017
cellular amino acid metabolic process	GO:0006520	61	0.017
regulation of molecular function	GO:0065009	217	0.017	Mouse
establishment of rna localization	GO:0051236	47	0.017
negative regulation of cellular component organization	GO:0051129	108	0.017
regulation of purine nucleotide catabolic process	GO:0033121	48	0.016
cell adhesion	GO:0007155	136	0.016	Human Mouse
sensory perception of light stimulus	GO:0050953	12	0.016
regulation of mitotic cell cycle	GO:0007346	190	0.016	Human
negative regulation of cell communication	GO:0010648	223	0.016	Mouse
organonitrogen compound biosynthetic process	GO:1901566	117	0.016
oocyte differentiation	GO:0009994	145	0.016
multi organism behavior	GO:0051705	175	0.016
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.016
absorption of uv light	GO:0016039	1	0.016
response to biotic stimulus	GO:0009607	294	0.016	Human
regulation of protein phosphorylation	GO:0001932	64	0.016	Mouse
adaptation of signaling pathway	GO:0023058	3	0.015
nucleobase containing compound transport	GO:0015931	56	0.015
regulation of synaptic transmission	GO:0050804	69	0.015
regulation of organelle organization	GO:0033043	196	0.015
cellular response to oxygen levels	GO:0071453	30	0.015
regulation of cell projection organization	GO:0031344	92	0.015
oocyte axis specification	GO:0007309	108	0.015
monocarboxylic acid transport	GO:0015718	3	0.015
regulation of cell cycle process	GO:0010564	181	0.015
response to alcohol	GO:0097305	95	0.015
response to lipopolysaccharide	GO:0032496	4	0.015	Human
positive regulation of transcription dna templated	GO:0045893	266	0.015
cortical actin cytoskeleton organization	GO:0030866	24	0.015
neural precursor cell proliferation	GO:0061351	75	0.015
camera type eye development	GO:0043010	4	0.014
response to organic cyclic compound	GO:0014070	89	0.014
rna transport	GO:0050658	46	0.014
dopamine biosynthetic process	GO:0042416	3	0.014
anion transmembrane transport	GO:0098656	26	0.014
establishment of tissue polarity	GO:0007164	87	0.014
eye morphogenesis	GO:0048592	260	0.014
regulation of organ morphogenesis	GO:2000027	78	0.014
pigmentation	GO:0043473	75	0.014
regulation of vesicle mediated transport	GO:0060627	59	0.014
axis specification	GO:0009798	167	0.014	Fly
cytosolic calcium ion transport	GO:0060401	2	0.014
sleep	GO:0030431	49	0.014
organophosphate catabolic process	GO:0046434	112	0.014
positive regulation of phosphorus metabolic process	GO:0010562	139	0.013	Mouse
cellular response to chemical stimulus	GO:0070887	199	0.013	Human Mouse
intracellular receptor signaling pathway	GO:0030522	19	0.013
positive regulation of cellular component organization	GO:0051130	156	0.013
positive regulation of protein metabolic process	GO:0051247	128	0.013	Mouse
regulation of protein ubiquitination	GO:0031396	22	0.013
taxis	GO:0042330	304	0.013	Mouse
positive regulation of protein phosphorylation	GO:0001934	34	0.013	Mouse
embryonic morphogenesis	GO:0048598	206	0.013
cellularization	GO:0007349	90	0.013
epithelial cell differentiation	GO:0030855	322	0.013
retina homeostasis	GO:0001895	13	0.013
regulation of cellular response to stress	GO:0080135	89	0.013
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.013
negative regulation of cell death	GO:0060548	81	0.013	Human
regulation of developmental pigmentation	GO:0048070	24	0.013
positive regulation of cellular amine metabolic process	GO:0033240	0	0.013
dorsal ventral pattern formation	GO:0009953	133	0.012	Fly
ovarian follicle cell development	GO:0030707	248	0.012
regulation of meiosis	GO:0040020	3	0.012
entrainment of circadian clock by photoperiod	GO:0043153	9	0.012
ribonucleoside monophosphate catabolic process	GO:0009158	39	0.012
skin development	GO:0043588	65	0.012
developmental maturation	GO:0021700	172	0.012
cellular response to dna damage stimulus	GO:0006974	223	0.012
apoptotic cell clearance	GO:0043277	14	0.012
male mating behavior	GO:0060179	70	0.012
positive regulation of gene expression	GO:0010628	290	0.012
cellular protein complex assembly	GO:0043623	71	0.012
purine containing compound metabolic process	GO:0072521	155	0.012
positive regulation of cell death	GO:0010942	69	0.012
response to endogenous stimulus	GO:0009719	119	0.012	Mouse
organ growth	GO:0035265	56	0.012
regulation of epithelial cell proliferation	GO:0050678	4	0.012	Human
cellular response to organic substance	GO:0071310	132	0.012	Human Mouse
calcium ion transmembrane transport	GO:0070588	17	0.012	Mouse
cellular response to decreased oxygen levels	GO:0036294	30	0.012
brain development	GO:0007420	120	0.012
protein polyubiquitination	GO:0000209	11	0.011
regulation of localization	GO:0032879	275	0.011	Human Mouse
columnar cuboidal epithelial cell development	GO:0002066	249	0.011
defense response	GO:0006952	300	0.011	Mouse
regulation of cell projection assembly	GO:0060491	30	0.011
compound eye photoreceptor cell differentiation	GO:0001751	140	0.011
negative regulation of transcription dna templated	GO:0045892	237	0.011
synaptic growth at neuromuscular junction	GO:0051124	119	0.011
limb development	GO:0060173	1	0.011
open tracheal system development	GO:0007424	204	0.011
regulation of embryonic cell shape	GO:0016476	30	0.011
positive regulation of protein modification process	GO:0031401	58	0.011	Mouse
cranial nerve development	GO:0021545	1	0.011
cellular chemical homeostasis	GO:0055082	40	0.011	Mouse
protein ubiquitination involved in ubiquitin dependent protein catabolic process	GO:0042787	14	0.011
negative regulation of programmed cell death	GO:0043069	72	0.011	Human
pole plasm assembly	GO:0007315	61	0.011
histone modification	GO:0016570	106	0.011	Human
establishment of blood brain barrier	GO:0060856	16	0.011
regulation of dna metabolic process	GO:0051052	34	0.011
spindle assembly	GO:0051225	80	0.011
cellular response to extracellular stimulus	GO:0031668	64	0.011
negative regulation of cell differentiation	GO:0045596	143	0.011
establishment of localization in cell	GO:0051649	402	0.011
mitotic cytokinesis	GO:0000281	50	0.011
cellular response to biotic stimulus	GO:0071216	4	0.011	Human
protein modification by small protein conjugation	GO:0032446	79	0.010
positive regulation of gtp catabolic process	GO:0033126	43	0.010
regulation of apoptotic process	GO:0042981	130	0.010	Human
positive regulation of cellular catabolic process	GO:0031331	95	0.010
cell proliferation	GO:0008283	299	0.010	Human Mouse Fly
rhythmic behavior	GO:0007622	76	0.010
glycerophospholipid metabolic process	GO:0006650	23	0.010
cellular ion homeostasis	GO:0006873	39	0.010	Mouse
male gamete generation	GO:0048232	201	0.010
mrna metabolic process	GO:0016071	124	0.010
sequestering of calcium ion	GO:0051208	5	0.010
signal transduction by phosphorylation	GO:0023014	107	0.010	Mouse
segmentation	GO:0035282	207	0.010
regulation of catalytic activity	GO:0050790	185	0.010	Mouse
phenol containing compound metabolic process	GO:0018958	57	0.010
morphogenesis of embryonic epithelium	GO:0016331	94	0.010
programmed cell death	GO:0012501	257	0.010	Human Mouse

inaC disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.134
vascular disease	DOID:178	0.081
cardiovascular system disease	DOID:1287	0.081
artery disease	DOID:0050828	0.037
cancer	DOID:162	0.030
disease of cellular proliferation	DOID:14566	0.030
nervous system disease	DOID:863	0.029
sensory system disease	DOID:0050155	0.023
auditory system disease	DOID:2742	0.023
nonsyndromic deafness	DOID:0050563	0.023
organ system cancer	DOID:0050686	0.016
autosomal dominant nonsyndromic deafness	DOID:0050564	0.016
neurodegenerative disease	DOID:1289	0.011
central nervous system disease	DOID:331	0.011

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