IMP: Integrative Multi-species Prediction

Drosophila melanogaster

0 known processes

Mcr (Dmel_CG7586)

Macroglobulin complement-related

(Aliases: Dmel\CG7586,CG7586,anon-28DE,alpha-2-Mrp)

Entrez: 44071
FLYBASE: FBgn0020240
UniProtKB: Q9VLT3

Process Predictions
Disease Predictions

Mcr biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
cell junction assembly	GO:0034329	42	0.998
regulation of tube architecture open tracheal system	GO:0035152	68	0.998
cell cell junction organization	GO:0045216	55	0.997
establishment of blood brain barrier	GO:0060856	16	0.995
apical junction assembly	GO:0043297	32	0.995
open tracheal system development	GO:0007424	204	0.994
cell junction organization	GO:0034330	57	0.992
respiratory system development	GO:0060541	213	0.992
cell cell junction assembly	GO:0007043	38	0.989
tissue morphogenesis	GO:0048729	297	0.981
embryonic morphogenesis	GO:0048598	206	0.948
regulation of tube size open tracheal system	GO:0035151	43	0.937
morphogenesis of an epithelium	GO:0002009	276	0.930
regulation of tube size	GO:0035150	46	0.910
axon development	GO:0061564	297	0.890
septate junction assembly	GO:0019991	26	0.886
dorsal closure	GO:0007391	79	0.881
neuron projection guidance	GO:0097485	241	0.819
tube morphogenesis	GO:0035239	191	0.817
morphogenesis of embryonic epithelium	GO:0016331	94	0.807
extracellular matrix organization	GO:0030198	32	0.804
axonogenesis	GO:0007409	290	0.778
cell motility	GO:0048870	251	0.770
biological adhesion	GO:0022610	138	0.761
developmental growth involved in morphogenesis	GO:0060560	65	0.728
regulation of anatomical structure morphogenesis	GO:0022603	242	0.709
gliogenesis	GO:0042063	80	0.708
cell adhesion	GO:0007155	136	0.668
glial cell differentiation	GO:0010001	35	0.638
immune response	GO:0006955	246	0.630	Fly
cell migration	GO:0016477	238	0.606
establishment of glial blood brain barrier	GO:0060857	14	0.539
axon guidance	GO:0007411	233	0.509
epithelial cell differentiation	GO:0030855	322	0.502	Mouse
central nervous system development	GO:0007417	201	0.494
protein modification process	GO:0036211	438	0.489	Mouse
regulation of tube length open tracheal system	GO:0035159	24	0.458
regulation of cell differentiation	GO:0045595	302	0.446	Mouse
localization of cell	GO:0051674	257	0.415
response to biotic stimulus	GO:0009607	294	0.399	Fly
defense response	GO:0006952	300	0.395	Fly
presynaptic membrane organization	GO:0097090	4	0.381
innate immune response	GO:0045087	144	0.375
response to organic substance	GO:0010033	284	0.344
negative regulation of cell differentiation	GO:0045596	143	0.340
regulation of multicellular organismal development	GO:2000026	414	0.319	Mouse
maintenance of location	GO:0051235	73	0.315
immune system process	GO:0002376	347	0.313	Mouse Fly
protein localization	GO:0008104	284	0.311
response to other organism	GO:0051707	293	0.308	Fly
extracellular structure organization	GO:0043062	46	0.294
regulation of cell morphogenesis	GO:0022604	163	0.293
tube development	GO:0035295	244	0.281
head involution	GO:0008258	35	0.277
ameboidal type cell migration	GO:0001667	151	0.274
intracellular signal transduction	GO:0035556	300	0.257
positive regulation of protein metabolic process	GO:0051247	128	0.255
neuron projection extension	GO:1990138	32	0.249
glial cell development	GO:0021782	27	0.243
ion transport	GO:0006811	145	0.235
regulation of anatomical structure size	GO:0090066	163	0.234
positive regulation of developmental process	GO:0051094	143	0.233
embryonic development via the syncytial blastoderm	GO:0001700	148	0.230
protein complex biogenesis	GO:0070271	201	0.224
developmental maturation	GO:0021700	172	0.223
cellular protein modification process	GO:0006464	438	0.222	Mouse
response to wounding	GO:0009611	94	0.220
germ cell migration	GO:0008354	43	0.220
branching involved in open tracheal system development	GO:0060446	45	0.209
meiotic cell cycle	GO:0051321	171	0.208
single organism carbohydrate metabolic process	GO:0044723	72	0.191
cellular macromolecule localization	GO:0070727	220	0.189
regulation of response to external stimulus	GO:0032101	115	0.186
striated muscle cell development	GO:0055002	50	0.179
chemotaxis	GO:0006935	249	0.179
cellular response to oxygen containing compound	GO:1901701	79	0.173
trachea development	GO:0060438	29	0.168
digestive system development	GO:0055123	149	0.165
response to organophosphorus	GO:0046683	2	0.164
cell recognition	GO:0008037	102	0.163
regulation of defense response	GO:0031347	102	0.157
digestive tract development	GO:0048565	149	0.155
cation transport	GO:0006812	110	0.153
camera type eye development	GO:0043010	4	0.148
carbohydrate derivative metabolic process	GO:1901135	217	0.144
single organism cellular localization	GO:1902580	180	0.143
metal ion transport	GO:0030001	74	0.140
ovarian follicle cell development	GO:0030707	248	0.136
taxis	GO:0042330	304	0.130
ion transmembrane transport	GO:0034220	122	0.129
epithelial cell migration	GO:0010631	148	0.128
regulation of cellular localization	GO:0060341	136	0.126
response to radiation	GO:0009314	155	0.125
carbohydrate derivative biosynthetic process	GO:1901137	85	0.124
positive regulation of signal transduction	GO:0009967	223	0.123
regionalization	GO:0003002	416	0.122
regulation of cell development	GO:0060284	215	0.121
regulation of cell shape	GO:0008360	113	0.121
meiotic cell cycle process	GO:1903046	132	0.119
cellular response to chemical stimulus	GO:0070887	199	0.118
regulation of immune system process	GO:0002682	176	0.116
epithelial cell development	GO:0002064	274	0.114
cellular protein localization	GO:0034613	160	0.114
striated muscle cell differentiation	GO:0051146	90	0.111
response to oxygen containing compound	GO:1901700	200	0.108
telencephalon development	GO:0021537	2	0.104
cell maturation	GO:0048469	144	0.102
single organism behavior	GO:0044708	391	0.100
homeostatic process	GO:0042592	199	0.100
cellular catabolic process	GO:0044248	372	0.097
defense response to other organism	GO:0098542	225	0.090	Fly
immune response regulating signaling pathway	GO:0002764	2	0.090
skin development	GO:0043588	65	0.089	Mouse
protein transport	GO:0015031	155	0.088
protein complex assembly	GO:0006461	200	0.088
response to organonitrogen compound	GO:0010243	75	0.088
regulation of catalytic activity	GO:0050790	185	0.087
cellular component disassembly	GO:0022411	46	0.086
response to external biotic stimulus	GO:0043207	293	0.086	Fly
axis specification	GO:0009798	167	0.086
regulation of response to stress	GO:0080134	200	0.084
positive regulation of cellular component organization	GO:0051130	156	0.084
protein localization to organelle	GO:0033365	82	0.083
regulation of cell cell adhesion	GO:0022407	21	0.081
protein complex disassembly	GO:0043241	36	0.080
positive regulation of defense response	GO:0031349	59	0.080
positive regulation of multicellular organismal process	GO:0051240	143	0.080
cell adhesion involved in heart morphogenesis	GO:0061343	12	0.079
single organismal cell cell adhesion	GO:0016337	45	0.079
endocytosis	GO:0006897	310	0.078	Fly
positive regulation of signaling	GO:0023056	243	0.077
ensheathment of neurons	GO:0007272	10	0.077
body morphogenesis	GO:0010171	2	0.076
protein import	GO:0017038	55	0.075
cell substrate adhesion	GO:0031589	10	0.074
single organism nuclear import	GO:1902593	51	0.073
neurological system process	GO:0050877	358	0.073
regulation of innate immune response	GO:0045088	71	0.071
organophosphate metabolic process	GO:0019637	195	0.070
imaginal disc derived wing morphogenesis	GO:0007476	337	0.069
muscle cell differentiation	GO:0042692	103	0.069
response to hormone	GO:0009725	45	0.068
regulation of cell adhesion	GO:0030155	27	0.066
regulation of axonogenesis	GO:0050770	32	0.066
organelle fission	GO:0048285	340	0.065
synaptic transmission	GO:0007268	288	0.065
response to lipopolysaccharide	GO:0032496	4	0.065
cell migration involved in gastrulation	GO:0042074	9	0.063
developmental growth	GO:0048589	280	0.063
innate immune response in mucosa	GO:0002227	2	0.063
branching morphogenesis of an epithelial tube	GO:0048754	45	0.063
heart morphogenesis	GO:0003007	32	0.062
regulation of actin cytoskeleton organization	GO:0032956	42	0.061
positive regulation of phosphate metabolic process	GO:0045937	139	0.058
cellular response to organic substance	GO:0071310	132	0.058
detection of stimulus involved in sensory perception	GO:0050906	92	0.058
response to endogenous stimulus	GO:0009719	119	0.058
mesodermal cell migration	GO:0008078	7	0.057
cellular response to endogenous stimulus	GO:0071495	80	0.057
cell activation	GO:0001775	9	0.055
single organism biosynthetic process	GO:0044711	206	0.055
regulation of immune response	GO:0050776	118	0.055
negative regulation of cell adhesion	GO:0007162	9	0.054
morphogenesis of a branching structure	GO:0001763	45	0.053
embryo development ending in birth or egg hatching	GO:0009792	152	0.053
carbohydrate metabolic process	GO:0005975	82	0.053
regulation of transport	GO:0051049	181	0.052
cellular component assembly involved in morphogenesis	GO:0010927	151	0.052
regulation of protein metabolic process	GO:0051246	256	0.052	Mouse
regulation of cellular response to stress	GO:0080135	89	0.052
negative regulation of multicellular organismal process	GO:0051241	142	0.051
brain development	GO:0007420	120	0.051
forebrain development	GO:0030900	2	0.051
response to abiotic stimulus	GO:0009628	341	0.051
adult locomotory behavior	GO:0008344	76	0.050
wing disc morphogenesis	GO:0007472	344	0.050
columnar cuboidal epithelial cell development	GO:0002066	249	0.049
protein modification by small protein conjugation or removal	GO:0070647	106	0.049
transmembrane transport	GO:0055085	139	0.049
gastrulation	GO:0007369	70	0.048
epithelial cell morphogenesis involved in gastrulation	GO:0003381	7	0.048
nuclear transport	GO:0051169	72	0.048
axonal fasciculation	GO:0007413	12	0.048
axon ensheathment	GO:0008366	10	0.048
negative regulation of developmental growth	GO:0048640	64	0.047
lipopolysaccharide mediated signaling pathway	GO:0031663	1	0.046
response to organic cyclic compound	GO:0014070	89	0.046
post embryonic appendage morphogenesis	GO:0035120	385	0.045
learning	GO:0007612	75	0.044
cation homeostasis	GO:0055080	51	0.044
protein localization to nucleus	GO:0034504	55	0.044
establishment of protein localization	GO:0045184	163	0.044
cellular response to hormone stimulus	GO:0032870	44	0.042
wound healing	GO:0042060	75	0.042
positive regulation of immune response	GO:0050778	63	0.042
oocyte axis specification	GO:0007309	108	0.041
regulation of mapk cascade	GO:0043408	92	0.041
positive regulation of transport	GO:0051050	92	0.041
regulation of transferase activity	GO:0051338	58	0.040
negative regulation of signal transduction	GO:0009968	206	0.040
cellular response to peptide	GO:1901653	28	0.039
negative regulation of cell development	GO:0010721	62	0.039
tissue migration	GO:0090130	155	0.037
wnt signaling pathway	GO:0016055	98	0.036
positive regulation of developmental growth	GO:0048639	62	0.036
protein targeting to nucleus	GO:0044744	51	0.036
synaptic target recognition	GO:0008039	45	0.036
protein phosphorylation	GO:0006468	169	0.035	Mouse
epidermis development	GO:0008544	65	0.035	Mouse
circulatory system development	GO:0072359	82	0.035
negative regulation of response to stimulus	GO:0048585	258	0.035
epithelium migration	GO:0090132	148	0.034
regulation of tube diameter	GO:0035296	14	0.034
actin cytoskeleton organization	GO:0030036	206	0.033
lateral inhibition	GO:0046331	206	0.033
positive regulation of cell communication	GO:0010647	250	0.033
regulation of localization	GO:0032879	275	0.033
response to nitrogen compound	GO:1901698	90	0.033
response to light stimulus	GO:0009416	124	0.033
negative regulation of developmental process	GO:0051093	201	0.033
regulation of cell projection organization	GO:0031344	92	0.033
reproductive system development	GO:0061458	74	0.033
regulation of nervous system development	GO:0051960	248	0.032
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.032
morphogenesis of a branching epithelium	GO:0061138	45	0.032
retinal ganglion cell axon guidance	GO:0031290	12	0.031
heart development	GO:0007507	82	0.031
regulation of cell size	GO:0008361	63	0.031
gland development	GO:0048732	191	0.031
establishment of protein localization to organelle	GO:0072594	62	0.030
cellular response to organonitrogen compound	GO:0071417	36	0.030
phosphorylation	GO:0016310	294	0.030	Mouse
golgi organization	GO:0007030	66	0.030
positive regulation of molecular function	GO:0044093	136	0.030
negative regulation of cellular component organization	GO:0051129	108	0.030
mesoderm development	GO:0007498	78	0.030
single organism cell adhesion	GO:0098602	47	0.029
positive regulation of response to stimulus	GO:0048584	323	0.029
cellular protein complex disassembly	GO:0043624	35	0.029
regulation of multi organism process	GO:0043900	131	0.029
gastrulation with mouth forming first	GO:0001703	36	0.028
cuticle development	GO:0042335	86	0.028
hemopoiesis	GO:0030097	46	0.027	Mouse
nucleotide metabolic process	GO:0009117	161	0.027
establishment or maintenance of polarity of follicular epithelium	GO:0016334	26	0.027
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.027
glycoprotein biosynthetic process	GO:0009101	41	0.026
appendage development	GO:0048736	401	0.026
digestive tract morphogenesis	GO:0048546	127	0.026
retina development in camera type eye	GO:0060041	4	0.026
positive regulation of innate immune response	GO:0045089	38	0.025
growth	GO:0040007	359	0.025
regulation of intracellular protein transport	GO:0033157	46	0.025
genitalia morphogenesis	GO:0035112	16	0.025
larval development	GO:0002164	104	0.025
regulation of intracellular signal transduction	GO:1902531	236	0.025
positive regulation of catalytic activity	GO:0043085	118	0.025
mapk cascade	GO:0000165	107	0.024
endodermal cell differentiation	GO:0035987	3	0.024
macromolecular complex assembly	GO:0065003	256	0.024
regulation of response to biotic stimulus	GO:0002831	63	0.024
oocyte development	GO:0048599	124	0.023
endodermal cell fate commitment	GO:0001711	3	0.023
innate immune response activating signal transduction	GO:0002758	2	0.023
regulation of molecular function	GO:0065009	217	0.023
neuron recognition	GO:0008038	101	0.022
carbohydrate derivative catabolic process	GO:1901136	118	0.022
apical constriction	GO:0003383	18	0.022
signal transduction by phosphorylation	GO:0023014	107	0.022
zinc ion transport	GO:0006829	5	0.021
regulation of phosphorylation	GO:0042325	147	0.021	Mouse
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.021
membrane organization	GO:0061024	112	0.021
sensory perception of mechanical stimulus	GO:0050954	72	0.021
imaginal disc derived appendage development	GO:0048737	399	0.021
regulation of protein modification process	GO:0031399	112	0.021	Mouse
positive regulation of immune system process	GO:0002684	68	0.021
photoreceptor cell development	GO:0042461	96	0.021
transmission of nerve impulse	GO:0019226	12	0.020
heparan sulfate proteoglycan biosynthetic process	GO:0015012	10	0.020
nuclear import	GO:0051170	51	0.020
negative regulation of multi organism process	GO:0043901	29	0.020
interspecies interaction between organisms	GO:0044419	16	0.020
establishment of cell polarity	GO:0030010	40	0.020
regulation of symbiosis encompassing mutualism through parasitism	GO:0043903	15	0.020
protein modification by small protein conjugation	GO:0032446	79	0.020
organic substance transport	GO:0071702	257	0.019
cell growth	GO:0016049	108	0.018
exocrine system development	GO:0035272	162	0.018
cell adhesion mediated by integrin	GO:0033627	12	0.018
membrane biogenesis	GO:0044091	8	0.018
adult behavior	GO:0030534	137	0.018
hindbrain development	GO:0030902	2	0.018
response to virus	GO:0009615	28	0.018
molting cycle	GO:0042303	56	0.018	Mouse
determination of adult lifespan	GO:0008340	137	0.018
positive regulation of cell differentiation	GO:0045597	64	0.018
positive regulation of axon extension	GO:0045773	2	0.018
intracellular transport	GO:0046907	228	0.018
action potential	GO:0001508	13	0.017
lipid localization	GO:0010876	54	0.017
mesenchymal cell development	GO:0014031	1	0.017
axon extension	GO:0048675	32	0.017
regulation of neuron projection development	GO:0010975	69	0.017
regulation of phosphorus metabolic process	GO:0051174	210	0.017	Mouse
positive regulation of protein localization to nucleus	GO:1900182	21	0.017
instar larval development	GO:0002168	55	0.017
organic hydroxy compound metabolic process	GO:1901615	83	0.017
regulation of dendrite morphogenesis	GO:0048814	28	0.016
cellular response to lipopolysaccharide	GO:0071222	3	0.016
detection of light stimulus	GO:0009583	58	0.016
neuronal action potential	GO:0019228	10	0.016
catabolic process	GO:0009056	409	0.016
regulation of tube diameter open tracheal system	GO:0035158	11	0.016
regulation of hydrolase activity	GO:0051336	97	0.016
inorganic ion transmembrane transport	GO:0098660	73	0.016
adherens junction organization	GO:0034332	27	0.016
detection of stimulus	GO:0051606	156	0.016
immune response activating signal transduction	GO:0002757	2	0.015
locomotory behavior	GO:0007626	176	0.015
positive regulation of phosphorylation	GO:0042327	87	0.015
negative regulation of rna metabolic process	GO:0051253	251	0.015
positive regulation of jun kinase activity	GO:0043507	4	0.015
mesenchyme development	GO:0060485	9	0.015
regulation of cellular catabolic process	GO:0031329	157	0.015
response to nutrient levels	GO:0031667	114	0.015
cellular response to abiotic stimulus	GO:0071214	58	0.015
axis elongation	GO:0003401	3	0.015
cellular response to nitrogen compound	GO:1901699	51	0.015
negative regulation of response to external stimulus	GO:0032102	22	0.015
intracellular protein transport	GO:0006886	104	0.015
segmentation	GO:0035282	207	0.015
macromolecular complex disassembly	GO:0032984	37	0.014
regulation of cell motility	GO:2000145	23	0.014
regulation of hemocyte proliferation	GO:0035206	37	0.014
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.014
tube formation	GO:0035148	21	0.014
development of primary sexual characteristics	GO:0045137	50	0.014
cellular amine metabolic process	GO:0044106	12	0.014
stem cell differentiation	GO:0048863	117	0.014
sex differentiation	GO:0007548	81	0.014
positive regulation of phosphorus metabolic process	GO:0010562	139	0.014
regulation of multicellular organism growth	GO:0040014	40	0.014
chitin based cuticle development	GO:0040003	49	0.014
actin mediated cell contraction	GO:0070252	21	0.014
imaginal disc growth	GO:0007446	37	0.014
cellular response to lipid	GO:0071396	20	0.014
positive regulation of cellular component biogenesis	GO:0044089	80	0.014
regulation of cellular component size	GO:0032535	98	0.014
nuclear division	GO:0000280	332	0.013
multicellular organism growth	GO:0035264	46	0.013
cardiovascular system development	GO:0072358	82	0.013
multicellular organismal signaling	GO:0035637	12	0.013
negative regulation of phosphate metabolic process	GO:0045936	45	0.013	Mouse
positive regulation of macromolecule metabolic process	GO:0010604	405	0.013
developmental cell growth	GO:0048588	52	0.013
regulation of cell substrate adhesion	GO:0010810	2	0.013
regulation of protein targeting	GO:1903533	29	0.013
organelle localization	GO:0051640	148	0.013
response to axon injury	GO:0048678	12	0.012
mitochondrial membrane organization	GO:0007006	3	0.012
male genitalia development	GO:0030539	19	0.012
single organism intracellular transport	GO:1902582	207	0.012
ras protein signal transduction	GO:0007265	88	0.012
salivary gland development	GO:0007431	162	0.012
cellular response to organic cyclic compound	GO:0071407	32	0.012
formation of primary germ layer	GO:0001704	24	0.012
negative regulation of cellular protein metabolic process	GO:0032269	85	0.012	Mouse
establishment or maintenance of cell polarity	GO:0007163	167	0.012
regulation of developmental growth	GO:0048638	174	0.012
synapse assembly	GO:0007416	143	0.012
asymmetric protein localization involved in cell fate determination	GO:0045167	9	0.012
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	1	0.012
blastoderm segmentation	GO:0007350	159	0.012
negative regulation of signaling	GO:0023057	219	0.012
sarcomere organization	GO:0045214	26	0.012
epithelial cell migration open tracheal system	GO:0007427	32	0.012
social behavior	GO:0035176	4	0.012
response to lipid	GO:0033993	38	0.011
nephron development	GO:0072006	3	0.011
regulation of embryonic cell shape	GO:0016476	30	0.011
regulation of protein localization	GO:0032880	76	0.011
microtubule based movement	GO:0007018	51	0.011
regulation of cytoplasmic transport	GO:1903649	47	0.011
activation of innate immune response	GO:0002218	4	0.011
positive regulation of growth	GO:0045927	75	0.011
mesenchymal cell differentiation	GO:0048762	1	0.011
cytoplasmic transport	GO:0016482	130	0.011
regulation of purine nucleotide metabolic process	GO:1900542	62	0.011
regulation of protein complex assembly	GO:0043254	42	0.011
chemosensory behavior	GO:0007635	106	0.011
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.011
response to extracellular stimulus	GO:0009991	116	0.011
tissue homeostasis	GO:0001894	36	0.011
negative regulation of cell communication	GO:0010648	223	0.011
nucleocytoplasmic transport	GO:0006913	72	0.011
basement membrane organization	GO:0071711	10	0.011
regulation of actin polymerization or depolymerization	GO:0008064	27	0.010
regulation of protein import into nucleus	GO:0042306	28	0.010
positive regulation of intracellular protein transport	GO:0090316	30	0.010
antimicrobial humoral response	GO:0019730	99	0.010	Fly
positive regulation of intracellular signal transduction	GO:1902533	116	0.010
response to alcohol	GO:0097305	95	0.010
regulation of neuron differentiation	GO:0045664	103	0.010
vesicle mediated transport	GO:0016192	381	0.010	Fly
cellular protein complex assembly	GO:0043623	71	0.010
positive regulation of protein modification process	GO:0031401	58	0.010
oocyte construction	GO:0007308	112	0.010
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	12	0.010
regulation of protein phosphorylation	GO:0001932	64	0.010	Mouse

Mcr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.086
disease of cellular proliferation	DOID:14566	0.014
benign neoplasm	DOID:0060072	0.014

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