IMP: Integrative Multi-species Prediction

Drosophila melanogaster

34 known processes

Unc-89 (Dmel_CG33519)

CG33519 gene product from transcript CG33519-RC

(Aliases: Dmel\CG33519,CT40322,CG3901,CG33519,unc-89,CG18020,CG18021,UNC-89,CG30171,CG18019,CG30175,CT12925,BEST:HL01080,CT40326)

Entrez: 3346201
FLYBASE: FBgn0053519
UniProtKB: Q59E65
UniProtKB: A8DYP0

Process Predictions
Disease Predictions

Unc-89 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
macromolecular complex assembly	GO:0065003	256	0.172	Worm
actomyosin structure organization	GO:0031032	56	0.153
cellular component assembly involved in morphogenesis	GO:0010927	151	0.146
striated muscle cell differentiation	GO:0051146	90	0.123
actin filament based process	GO:0030029	220	0.117
muscle cell development	GO:0055001	50	0.114
organelle assembly	GO:0070925	198	0.103
protein complex assembly	GO:0006461	200	0.101	Worm
actin cytoskeleton organization	GO:0030036	206	0.085
catabolic process	GO:0009056	409	0.079	Worm
striated muscle cell development	GO:0055002	50	0.068
actin filament organization	GO:0007015	126	0.055
muscle structure development	GO:0061061	224	0.045
imaginal disc derived appendage development	GO:0048737	399	0.044
organic substance catabolic process	GO:1901575	308	0.042	Worm
vesicle mediated transport	GO:0016192	381	0.038
protein complex biogenesis	GO:0070271	201	0.038	Worm
sarcomere organization	GO:0045214	26	0.037
regulation of organelle organization	GO:0033043	196	0.036
endocytosis	GO:0006897	310	0.033
cellular protein complex assembly	GO:0043623	71	0.032	Worm
small molecule metabolic process	GO:0044281	305	0.031	Worm
muscle cell differentiation	GO:0042692	103	0.030
single organism behavior	GO:0044708	391	0.030
chemical homeostasis	GO:0048878	92	0.030
regulation of cell cycle	GO:0051726	291	0.028
regulation of cell differentiation	GO:0045595	302	0.027
cholesterol homeostasis	GO:0042632	3	0.027
cellular macromolecular complex assembly	GO:0034622	153	0.026	Worm
tissue morphogenesis	GO:0048729	297	0.025
carbohydrate derivative metabolic process	GO:1901135	217	0.024	Worm
organic substance transport	GO:0071702	257	0.024
cell adhesion	GO:0007155	136	0.024
muscle organ development	GO:0007517	127	0.022
appendage development	GO:0048736	401	0.022
regulation of phosphate metabolic process	GO:0019220	210	0.022	Worm
positive regulation of transport	GO:0051050	92	0.022
regulation of cellular component biogenesis	GO:0044087	201	0.021
alditol phosphate metabolic process	GO:0052646	2	0.021
regulation of anatomical structure size	GO:0090066	163	0.021
organophosphate metabolic process	GO:0019637	195	0.020	Worm
regulation of cytoskeleton organization	GO:0051493	89	0.020
organonitrogen compound metabolic process	GO:1901564	318	0.020	Worm
single organism cellular localization	GO:1902580	180	0.019
regulation of catabolic process	GO:0009894	170	0.019	Worm
myofibril assembly	GO:0030239	36	0.019
cellular catabolic process	GO:0044248	372	0.019	Worm
biological adhesion	GO:0022610	138	0.019
mesoderm development	GO:0007498	78	0.018
regulation of molecular function	GO:0065009	217	0.018	Worm
regulation of localization	GO:0032879	275	0.018
sterol homeostasis	GO:0055092	4	0.018
phagocytosis	GO:0006909	215	0.018
single organism biosynthetic process	GO:0044711	206	0.018
post embryonic appendage morphogenesis	GO:0035120	385	0.018
imaginal disc derived wing morphogenesis	GO:0007476	337	0.017
protein modification process	GO:0036211	438	0.017
regulation of transport	GO:0051049	181	0.017
organelle fission	GO:0048285	340	0.017
carbohydrate derivative catabolic process	GO:1901136	118	0.017	Worm
single organism intracellular transport	GO:1902582	207	0.017
organophosphate catabolic process	GO:0046434	112	0.017	Worm
lipid homeostasis	GO:0055088	33	0.016
negative regulation of gene expression	GO:0010629	387	0.016
adult behavior	GO:0030534	137	0.016
response to extracellular stimulus	GO:0009991	116	0.016
wound healing	GO:0042060	75	0.016
body morphogenesis	GO:0010171	2	0.016	Worm
positive regulation of cellular catabolic process	GO:0031331	95	0.016	Worm
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.015
negative regulation of organelle organization	GO:0010639	56	0.015
intracellular transport	GO:0046907	228	0.015
camera type eye development	GO:0043010	4	0.015
cellular amino acid metabolic process	GO:0006520	61	0.015
anion homeostasis	GO:0055081	3	0.015
regulation of cellular component size	GO:0032535	98	0.015
ion homeostasis	GO:0050801	55	0.015
regulation of sterol transport	GO:0032371	1	0.015
maintenance of location	GO:0051235	73	0.014
neurological system process	GO:0050877	358	0.014
triglyceride biosynthetic process	GO:0019432	2	0.014
appendage morphogenesis	GO:0035107	397	0.014
homeostatic process	GO:0042592	199	0.014
establishment of localization in cell	GO:0051649	402	0.014
striated muscle myosin thick filament assembly	GO:0071688	3	0.013	Worm
cellular protein modification process	GO:0006464	438	0.013
negative regulation of cellular component organization	GO:0051129	108	0.013
nuclear division	GO:0000280	332	0.013
transmembrane transport	GO:0055085	139	0.013
locomotory behavior	GO:0007626	176	0.013
ion transport	GO:0006811	145	0.013
carboxylic acid metabolic process	GO:0019752	92	0.013
epithelial cell differentiation	GO:0030855	322	0.013
single organism catabolic process	GO:0044712	228	0.012	Worm
open tracheal system development	GO:0007424	204	0.012
cellular response to chemical stimulus	GO:0070887	199	0.012
cellular macromolecule localization	GO:0070727	220	0.012
regulation of cell development	GO:0060284	215	0.012
positive regulation of response to stimulus	GO:0048584	323	0.012
regulation of cell death	GO:0010941	173	0.012
positive regulation of catabolic process	GO:0009896	105	0.012	Worm
somatic muscle development	GO:0007525	66	0.012
embryo development ending in birth or egg hatching	GO:0009792	152	0.012	Mouse
regulation of cell morphogenesis	GO:0022604	163	0.012
regulation of protein complex assembly	GO:0043254	42	0.011
digestive system development	GO:0055123	149	0.011
tube development	GO:0035295	244	0.011
positive regulation of multicellular organismal process	GO:0051240	143	0.011
heterocycle catabolic process	GO:0046700	166	0.011	Worm
regulation of actin filament length	GO:0030832	27	0.011
regulation of growth	GO:0040008	233	0.011
mitotic nuclear division	GO:0007067	213	0.011
response to lipopolysaccharide	GO:0032496	4	0.011
oocyte axis specification	GO:0007309	108	0.011
regulation of multicellular organismal development	GO:2000026	414	0.011
acylglycerol biosynthetic process	GO:0046463	2	0.011
adult locomotory behavior	GO:0008344	76	0.011
compound eye morphogenesis	GO:0001745	249	0.011
establishment of protein localization	GO:0045184	163	0.011
regulation of cholesterol transport	GO:0032374	1	0.011
acylglycerol catabolic process	GO:0046464	3	0.011
wing disc morphogenesis	GO:0007472	344	0.011
embryonic development via the syncytial blastoderm	GO:0001700	148	0.010
cellular protein localization	GO:0034613	160	0.010
cellular protein complex disassembly	GO:0043624	35	0.010
regulation of cellular localization	GO:0060341	136	0.010
membrane organization	GO:0061024	112	0.010
oocyte construction	GO:0007308	112	0.010
ribonucleoside metabolic process	GO:0009119	127	0.010	Worm

Unc-89 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.082
musculoskeletal system disease	DOID:17	0.015
nervous system disease	DOID:863	0.013
lipid metabolism disorder	DOID:3146	0.011
familial lipoprotein lipase deficiency	DOID:14118	0.011
disease of metabolism	DOID:0014667	0.011
inherited metabolic disorder	DOID:655	0.011
familial hyperlipidemia	DOID:1168	0.011
neurodegenerative disease	DOID:1289	0.010
central nervous system disease	DOID:331	0.010

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