IMP: Integrative Multi-species Prediction

Drosophila melanogaster

19 known processes

ppk19 (Dmel_CG18287)

pickpocket 19

(Aliases: CG18287,Dmel\CG18287,PPK19)

Entrez: 43489
FLYBASE: FBgn0039679
UniProtKB: Q9VAJ3

Process Predictions
Disease Predictions

ppk19 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
detection of chemical stimulus	GO:0009593	93	0.698
detection of chemical stimulus involved in sensory perception	GO:0050907	75	0.642
detection of disaccharide stimulus	GO:0034288	1	0.504
detection of stimulus involved in sensory perception	GO:0050906	92	0.495	Fly
detection of chemical stimulus involved in sensory perception of taste	GO:0050912	13	0.461
detection of stimulus	GO:0051606	156	0.455	Fly
sensory perception of sweet taste	GO:0050916	14	0.429
detection of hexose stimulus	GO:0009732	1	0.279
sensory perception of chemical stimulus	GO:0007606	116	0.272
detection of chemical stimulus involved in sensory perception of sweet taste	GO:0001582	11	0.239
sensory perception of taste	GO:0050909	25	0.233
response to monosaccharide	GO:0034284	4	0.223
neurological system process	GO:0050877	358	0.222
sensory perception	GO:0007600	196	0.197
sensory perception of salty taste	GO:0050914	3	0.193
detection of glucose	GO:0051594	1	0.175
detection of sucrose stimulus	GO:0009731	1	0.167
single organism behavior	GO:0044708	391	0.143	Fly
detection of carbohydrate stimulus	GO:0009730	1	0.132
response to glucose	GO:0009749	2	0.120
response to hexose	GO:0009746	3	0.103
response to organic substance	GO:0010033	284	0.087	Fly
detection of monosaccharide stimulus	GO:0034287	1	0.070
feeding behavior	GO:0007631	50	0.069
response to oxygen containing compound	GO:1901700	200	0.061	Fly
response to maltose	GO:0034286	1	0.060
salt aversion	GO:0035199	3	0.044
body morphogenesis	GO:0010171	2	0.044
response to trehalose	GO:0010353	3	0.042
courtship behavior	GO:0007619	68	0.040	Fly
cellular catabolic process	GO:0044248	372	0.039
catabolic process	GO:0009056	409	0.039
g protein coupled receptor signaling pathway	GO:0007186	136	0.038
regulation of behavior	GO:0050795	75	0.036	Fly
larval behavior	GO:0030537	42	0.035	Fly
adult behavior	GO:0030534	137	0.033
response to extracellular stimulus	GO:0009991	116	0.032
imaginal disc derived wing morphogenesis	GO:0007476	337	0.032
cellular response to hexose stimulus	GO:0071331	1	0.032
wound healing spreading of epidermal cells	GO:0035313	1	0.031	Rat
regulation of synapse structure and activity	GO:0050803	128	0.031	Fly
cation transmembrane transport	GO:0098655	88	0.031	Human Rat Fly
small molecule metabolic process	GO:0044281	305	0.030
carbohydrate derivative metabolic process	GO:1901135	217	0.030
positive regulation of signal transduction	GO:0009967	223	0.029
organonitrogen compound metabolic process	GO:1901564	318	0.029
nucleobase containing compound catabolic process	GO:0034655	165	0.029
response to nutrient levels	GO:0031667	114	0.029
tissue morphogenesis	GO:0048729	297	0.029	Rat
regulation of multi organism process	GO:0043900	131	0.029
ribonucleoside catabolic process	GO:0042454	112	0.028
response to abiotic stimulus	GO:0009628	341	0.028
multi organism reproductive behavior	GO:0044705	121	0.028	Fly
immune response	GO:0006955	246	0.028
open tracheal system development	GO:0007424	204	0.027	Fly
phototaxis	GO:0042331	21	0.027
nucleoside triphosphate catabolic process	GO:0009143	108	0.027
single organism biosynthetic process	GO:0044711	206	0.026
taxis	GO:0042330	304	0.026
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.026
cyclic nucleotide biosynthetic process	GO:0009190	25	0.025
innate immune response	GO:0045087	144	0.025
appendage development	GO:0048736	401	0.025
kidney development	GO:0001822	3	0.025
chemosensory behavior	GO:0007635	106	0.025
single organism catabolic process	GO:0044712	228	0.025
nucleotide catabolic process	GO:0009166	109	0.025
cellular response to carbohydrate stimulus	GO:0071322	4	0.025
multi organism behavior	GO:0051705	175	0.024	Fly
homeostatic process	GO:0042592	199	0.024	Human
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.024
nucleotide metabolic process	GO:0009117	161	0.024
nucleoside phosphate catabolic process	GO:1901292	110	0.024
heterocycle catabolic process	GO:0046700	166	0.023
purine ribonucleotide metabolic process	GO:0009150	145	0.023
organophosphate metabolic process	GO:0019637	195	0.023
nucleoside phosphate metabolic process	GO:0006753	162	0.023
wing disc morphogenesis	GO:0007472	344	0.023
water homeostasis	GO:0030104	3	0.023	Human
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.023
gtp metabolic process	GO:0046039	72	0.023
purine nucleoside metabolic process	GO:0042278	127	0.022
regulation of cell cycle	GO:0051726	291	0.022
organic cyclic compound catabolic process	GO:1901361	168	0.022
compound eye development	GO:0048749	307	0.022
organonitrogen compound catabolic process	GO:1901565	128	0.022
imaginal disc derived appendage development	GO:0048737	399	0.022
response to biotic stimulus	GO:0009607	294	0.022
positive regulation of signaling	GO:0023056	243	0.022
nucleoside catabolic process	GO:0009164	112	0.022
glycosyl compound catabolic process	GO:1901658	112	0.022
post embryonic appendage morphogenesis	GO:0035120	385	0.022
purine ribonucleotide catabolic process	GO:0009154	109	0.022
purine ribonucleoside catabolic process	GO:0046130	112	0.022
transmembrane transport	GO:0055085	139	0.021	Human Rat Fly
cellular nitrogen compound catabolic process	GO:0044270	165	0.021
ribonucleotide catabolic process	GO:0009261	109	0.021
purine nucleotide metabolic process	GO:0006163	146	0.021
vesicle mediated transport	GO:0016192	381	0.021
organic substance catabolic process	GO:1901575	308	0.021
cellular response to abiotic stimulus	GO:0071214	58	0.021	Fly
morphogenesis of an epithelium	GO:0002009	276	0.021	Rat
cgmp metabolic process	GO:0046068	11	0.021
detection of external stimulus	GO:0009581	66	0.021	Fly
purine ribonucleoside metabolic process	GO:0046128	127	0.021
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.021
ribonucleoside metabolic process	GO:0009119	127	0.021
positive regulation of cell communication	GO:0010647	250	0.021
respiratory system development	GO:0060541	213	0.020	Fly
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.020
phagocytosis	GO:0006909	215	0.020
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.020
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.019
nucleoside triphosphate metabolic process	GO:0009141	120	0.019
cell motility	GO:0048870	251	0.019	Rat
protein complex assembly	GO:0006461	200	0.019
purine nucleotide catabolic process	GO:0006195	109	0.019
neuron recognition	GO:0008038	101	0.019
response to other organism	GO:0051707	293	0.019
epiboly	GO:0090504	2	0.019	Rat
response to oxidative stress	GO:0006979	86	0.019
organonitrogen compound biosynthetic process	GO:1901566	117	0.019
protein localization	GO:0008104	284	0.019
guanosine containing compound metabolic process	GO:1901068	74	0.019
purine containing compound metabolic process	GO:0072521	155	0.019
lateral inhibition	GO:0046331	206	0.018
response to wounding	GO:0009611	94	0.018	Rat
regionalization	GO:0003002	416	0.018
negative regulation of developmental process	GO:0051093	201	0.018
purine nucleoside catabolic process	GO:0006152	112	0.018
cgmp biosynthetic process	GO:0006182	8	0.018
nucleoside metabolic process	GO:0009116	127	0.018
synaptic transmission	GO:0007268	288	0.018	Fly
detection of abiotic stimulus	GO:0009582	66	0.018	Fly
cellular macromolecule localization	GO:0070727	220	0.018
cell division	GO:0051301	248	0.017
male mating behavior	GO:0060179	70	0.017	Fly
defense response to bacterium	GO:0042742	178	0.017
endocytosis	GO:0006897	310	0.017
proteolysis	GO:0006508	192	0.017
inter male aggressive behavior	GO:0002121	60	0.017	Fly
cell proliferation	GO:0008283	299	0.017
protein heterooligomerization	GO:0051291	4	0.017
dendrite development	GO:0016358	204	0.017
energy taxis	GO:0009453	21	0.017
immune system process	GO:0002376	347	0.017
gland morphogenesis	GO:0022612	145	0.017
inorganic cation transmembrane transport	GO:0098662	61	0.016	Human Rat Fly
guanosine containing compound catabolic process	GO:1901069	74	0.016
detection of light stimulus	GO:0009583	58	0.016
camera type eye morphogenesis	GO:0048593	2	0.016
cell death	GO:0008219	279	0.016
establishment of protein localization	GO:0045184	163	0.016
endomembrane system organization	GO:0010256	119	0.016
appendage morphogenesis	GO:0035107	397	0.016
cation transport	GO:0006812	110	0.016	Human Rat Fly
cellular response to chemical stimulus	GO:0070887	199	0.016	Fly
eye morphogenesis	GO:0048592	260	0.016
cellular protein modification process	GO:0006464	438	0.016
carbohydrate derivative catabolic process	GO:1901136	118	0.016
telencephalon development	GO:0021537	2	0.016
nucleobase containing small molecule metabolic process	GO:0055086	174	0.016
ribose phosphate metabolic process	GO:0019693	145	0.016
intracellular signal transduction	GO:0035556	300	0.016
sensory perception of pain	GO:0019233	4	0.015	Fly
drinking behavior	GO:0042756	2	0.015	Fly
regulation of reproductive process	GO:2000241	54	0.015
cellular response to radiation	GO:0071478	52	0.015
gtp catabolic process	GO:0006184	72	0.015
aromatic compound catabolic process	GO:0019439	166	0.015
hindbrain development	GO:0030902	2	0.015
negative regulation of response to stimulus	GO:0048585	258	0.015	Fly
regulation of multicellular organismal development	GO:2000026	414	0.015
ribonucleotide metabolic process	GO:0009259	145	0.015
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.015
developmental maturation	GO:0021700	172	0.015
protein complex biogenesis	GO:0070271	201	0.015
aggressive behavior	GO:0002118	63	0.015	Fly
forebrain development	GO:0030900	2	0.015
glycosyl compound metabolic process	GO:1901657	127	0.015
growth	GO:0040007	359	0.015
positive regulation of response to stimulus	GO:0048584	323	0.015
epithelial cell development	GO:0002064	274	0.015
male courtship behavior tapping to detect pheromone	GO:0016544	1	0.015
sensory organ morphogenesis	GO:0090596	260	0.015
multi multicellular organism process	GO:0044706	123	0.015	Fly
death	GO:0016265	284	0.014
developmental growth	GO:0048589	280	0.014
cyclic nucleotide metabolic process	GO:0009187	28	0.014
carboxylic acid metabolic process	GO:0019752	92	0.014
camera type eye development	GO:0043010	4	0.014
regulation of catalytic activity	GO:0050790	185	0.014
reproductive behavior	GO:0019098	122	0.014	Fly
cellular response to monosaccharide stimulus	GO:0071326	2	0.014
developmental programmed cell death	GO:0010623	138	0.014
rhodopsin mediated signaling pathway	GO:0016056	21	0.014
single organism cellular localization	GO:1902580	180	0.014
response to external biotic stimulus	GO:0043207	293	0.014
response to pain	GO:0048265	3	0.014	Fly
regulation of cell development	GO:0060284	215	0.014
carbohydrate derivative biosynthetic process	GO:1901137	85	0.014
regulation of molecular function	GO:0065009	217	0.014
retina development in camera type eye	GO:0060041	4	0.014
protein modification process	GO:0036211	438	0.014
cellular response to oxygen containing compound	GO:1901701	79	0.014	Fly
behavioral response to pain	GO:0048266	3	0.014	Fly
wound healing	GO:0042060	75	0.014	Rat
regulation of nervous system development	GO:0051960	248	0.014
organophosphate catabolic process	GO:0046434	112	0.013
response to decreased oxygen levels	GO:0036293	58	0.013	Rat
localization of cell	GO:0051674	257	0.013	Rat
organelle assembly	GO:0070925	198	0.013
macromolecular complex assembly	GO:0065003	256	0.013
negative regulation of multicellular organismal process	GO:0051241	142	0.013
cell recognition	GO:0008037	102	0.013
melanization defense response	GO:0035006	45	0.013
regulation of cellular ketone metabolic process	GO:0010565	3	0.013
epithelial cell differentiation	GO:0030855	322	0.013
defense response	GO:0006952	300	0.013
nucleoside phosphate biosynthetic process	GO:1901293	34	0.013
actin filament based process	GO:0030029	220	0.013
regulation of phosphorus metabolic process	GO:0051174	210	0.013
regulation of cell cycle phase transition	GO:1901987	130	0.013
ion transmembrane transport	GO:0034220	122	0.013	Human Rat Fly
cellular protein localization	GO:0034613	160	0.013
sterol homeostasis	GO:0055092	4	0.013
protein phosphorylation	GO:0006468	169	0.013
organic substance transport	GO:0071702	257	0.013
connective tissue development	GO:0061448	3	0.013
regulation of protein metabolic process	GO:0051246	256	0.013
macromolecule catabolic process	GO:0009057	161	0.013
salivary gland cell autophagic cell death	GO:0035071	83	0.013
metal ion transport	GO:0030001	74	0.013	Human Rat Fly
regulation of response to stress	GO:0080134	200	0.013
phosphorylation	GO:0016310	294	0.013
cell maturation	GO:0048469	144	0.012
muscle organ development	GO:0007517	127	0.012
protein transport	GO:0015031	155	0.012
autophagic cell death	GO:0048102	83	0.012
ion transport	GO:0006811	145	0.012	Human Rat Fly
positive regulation of cell migration	GO:0030335	2	0.012
wound healing spreading of cells	GO:0044319	2	0.012	Rat
organic acid metabolic process	GO:0006082	103	0.012
pigment metabolic process	GO:0042440	84	0.012
sensory perception of mechanical stimulus	GO:0050954	72	0.012	Fly
salivary gland histolysis	GO:0035070	88	0.012
embryonic development via the syncytial blastoderm	GO:0001700	148	0.012
compound eye morphogenesis	GO:0001745	249	0.012
small gtpase mediated signal transduction	GO:0007264	88	0.012
response to carbohydrate	GO:0009743	15	0.012
regulation of cellular amine metabolic process	GO:0033238	3	0.012
salivary gland development	GO:0007431	162	0.012
immune response regulating signaling pathway	GO:0002764	2	0.012
male gamete generation	GO:0048232	201	0.012
positive regulation of biosynthetic process	GO:0009891	316	0.012
humoral immune response	GO:0006959	117	0.012
activation of innate immune response	GO:0002218	4	0.012
cellular response to light stimulus	GO:0071482	37	0.012
tissue death	GO:0016271	102	0.012
response to organophosphorus	GO:0046683	2	0.012
eye development	GO:0001654	323	0.012
leg disc morphogenesis	GO:0007478	80	0.012
establishment of localization in cell	GO:0051649	402	0.012
digestive tract development	GO:0048565	149	0.012
steroid catabolic process	GO:0006706	1	0.012
limb development	GO:0060173	1	0.012
embryo development ending in birth or egg hatching	GO:0009792	152	0.012
divalent metal ion transport	GO:0070838	26	0.012
mating behavior	GO:0007617	106	0.012	Fly
cellular ketone metabolic process	GO:0042180	24	0.012
cell cycle phase transition	GO:0044770	140	0.012
cellular component assembly involved in morphogenesis	GO:0010927	151	0.012
programmed cell death	GO:0012501	257	0.012
response to oxygen levels	GO:0070482	59	0.012	Rat
regulation of cell differentiation	GO:0045595	302	0.012
spermatogenesis	GO:0007283	200	0.012
purine ribonucleotide biosynthetic process	GO:0009152	28	0.012
intracellular transport	GO:0046907	228	0.011
dendrite morphogenesis	GO:0048813	199	0.011
histolysis	GO:0007559	102	0.011
cellular response to organic substance	GO:0071310	132	0.011
regulation of intracellular signal transduction	GO:1902531	236	0.011
purine containing compound catabolic process	GO:0072523	112	0.011
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.011
dorsal ventral pattern formation	GO:0009953	133	0.011
oxoacid metabolic process	GO:0043436	103	0.011
nuclear division	GO:0000280	332	0.011
cellular response to dna damage stimulus	GO:0006974	223	0.011
behavioral response to ethanol	GO:0048149	49	0.011
spindle organization	GO:0007051	253	0.011
innate immune response activating signal transduction	GO:0002758	2	0.011
regulation of catabolic process	GO:0009894	170	0.011
phototransduction	GO:0007602	52	0.011
defense response to other organism	GO:0098542	225	0.011
leg disc development	GO:0035218	92	0.011
anion homeostasis	GO:0055081	3	0.011
melanin metabolic process	GO:0006582	47	0.011
organelle fission	GO:0048285	340	0.011
hematopoietic progenitor cell differentiation	GO:0002244	1	0.011
cell migration	GO:0016477	238	0.011	Rat
positive regulation of cell motility	GO:2000147	3	0.011
cellularization	GO:0007349	90	0.011
protein maturation	GO:0051604	71	0.011
regulation of mitotic cell cycle	GO:0007346	190	0.011
exocrine system development	GO:0035272	162	0.011
reflex	GO:0060004	6	0.011
mitotic cell cycle phase transition	GO:0044772	138	0.011
chromosome organization	GO:0051276	360	0.011
regulation of cellular amino acid metabolic process	GO:0006521	0	0.011
hormone catabolic process	GO:0042447	3	0.010
positive regulation of rna biosynthetic process	GO:1902680	266	0.010
dorsal ventral axis specification	GO:0009950	66	0.010
regulation of localization	GO:0032879	275	0.010	Rat
androgen metabolic process	GO:0008209	1	0.010
detection of mechanical stimulus involved in sensory perception of pain	GO:0050966	2	0.010	Fly
negative regulation of gene expression	GO:0010629	387	0.010
response to bacterium	GO:0009617	198	0.010
positive regulation of catalytic activity	GO:0043085	118	0.010
membrane organization	GO:0061024	112	0.010
vitamin biosynthetic process	GO:0009110	1	0.010
sensory perception of touch	GO:0050975	11	0.010	Fly
regulation of notch signaling pathway	GO:0008593	100	0.010
pattern recognition receptor signaling pathway	GO:0002221	2	0.010
stem cell division	GO:0017145	69	0.010
posttranscriptional regulation of gene expression	GO:0010608	145	0.010
protein catabolic process	GO:0030163	101	0.010
spinal cord development	GO:0021510	1	0.010

ppk19 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
respiratory system disease	DOID:1579	0.121	Human
disease of anatomical entity	DOID:7	0.121	Human
bronchiectasis	DOID:9563	0.121	Human
bronchial disease	DOID:1176	0.121	Human
lower respiratory tract disease	DOID:0050161	0.121	Human
renal tubular transport disease	DOID:447	0.056	Human
urinary system disease	DOID:18	0.056	Human
kidney disease	DOID:557	0.056	Human
liddle syndrome	DOID:0050477	0.050	Human
disease of metabolism	DOID:0014667	0.016
nervous system disease	DOID:863	0.016
inherited metabolic disorder	DOID:655	0.014
cardiovascular system disease	DOID:1287	0.012
acquired metabolic disease	DOID:0060158	0.011
central nervous system disease	DOID:331	0.010

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