IMP: Integrative Multi-species Prediction

Drosophila melanogaster

112 known processes

grp (Dmel_CG17161)

grapes

(Aliases: Dmel\CG17161,Grp,l(2)k15102,CG17161,CHK1,DmChk1,Chk1,grps,1C,Grp/DChk1,lemp,chk1,dChk1,Pk36A,CHK1/Grapes,grp(chk),Pk?1)

Entrez: 34993
FLYBASE: FBgn0261278
UniProtKB: O61661
UniProtKB: Q59DY7

Process Predictions
Disease Predictions

grp biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
protein modification process	GO:0036211	438	0.410
positive regulation of cellular biosynthetic process	GO:0031328	316	0.410
chromosome organization	GO:0051276	360	0.390
positive regulation of macromolecule metabolic process	GO:0010604	405	0.386
phosphorylation	GO:0016310	294	0.367
transcription from rna polymerase ii promoter	GO:0006366	368	0.363
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.308
regulation of phosphorus metabolic process	GO:0051174	210	0.246
regulation of phosphorylation	GO:0042325	147	0.224
regulation of protein metabolic process	GO:0051246	256	0.218
regulation of intracellular signal transduction	GO:1902531	236	0.210
cellular protein modification process	GO:0006464	438	0.182
dendrite development	GO:0016358	204	0.169
regulation of phosphate metabolic process	GO:0019220	210	0.161
aging	GO:0007568	143	0.158
intracellular signal transduction	GO:0035556	300	0.155
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.154
regulation of multicellular organismal development	GO:2000026	414	0.153
chromatin organization	GO:0006325	207	0.147
negative regulation of cellular metabolic process	GO:0031324	382	0.145
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.144
determination of adult lifespan	GO:0008340	137	0.136
positive regulation of biosynthetic process	GO:0009891	316	0.134
positive regulation of gene expression	GO:0010628	290	0.131
establishment of protein localization	GO:0045184	163	0.122
establishment of localization in cell	GO:0051649	402	0.120
single organism behavior	GO:0044708	391	0.116
regulation of protein localization	GO:0032880	76	0.103
death	GO:0016265	284	0.103
positive regulation of secretion	GO:0051047	22	0.102
histone modification	GO:0016570	106	0.100
negative regulation of response to stimulus	GO:0048585	258	0.098
secretion by cell	GO:0032940	101	0.095
signal transduction by phosphorylation	GO:0023014	107	0.093
regulation of protein transport	GO:0051223	57	0.092
chromatin modification	GO:0016568	147	0.088
organophosphate metabolic process	GO:0019637	195	0.086
nuclear division	GO:0000280	332	0.084
regulation of cell size	GO:0008361	63	0.083
negative regulation of cell communication	GO:0010648	223	0.080
regulation of cell cycle	GO:0051726	291	0.078
regulation of cellular localization	GO:0060341	136	0.077
regulation of immune system process	GO:0002682	176	0.077
locomotory behavior	GO:0007626	176	0.076
response to other organism	GO:0051707	293	0.075
dna metabolic process	GO:0006259	227	0.074
protein dna complex subunit organization	GO:0071824	86	0.073
forebrain development	GO:0030900	2	0.073
regulation of transport	GO:0051049	181	0.073
regulation of neural precursor cell proliferation	GO:2000177	35	0.069
apoptotic process	GO:0006915	159	0.068
protein phosphorylation	GO:0006468	169	0.067
regulation of catalytic activity	GO:0050790	185	0.065
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.063
signal release	GO:0023061	49	0.063
macromolecular complex assembly	GO:0065003	256	0.061
defense response to other organism	GO:0098542	225	0.060
regulation of cell cycle phase transition	GO:1901987	130	0.059
response to endogenous stimulus	GO:0009719	119	0.057
response to external biotic stimulus	GO:0043207	293	0.056
regulation of nervous system development	GO:0051960	248	0.056
gliogenesis	GO:0042063	80	0.056
negative regulation of developmental process	GO:0051093	201	0.055
protein dna complex assembly	GO:0065004	63	0.053
embryonic morphogenesis	GO:0048598	206	0.052
mapk cascade	GO:0000165	107	0.052
cell death	GO:0008219	279	0.051
regulation of cell cycle process	GO:0010564	181	0.051
regulation of mapk cascade	GO:0043408	92	0.051
negative regulation of gene expression	GO:0010629	387	0.050
negative regulation of erk1 and erk2 cascade	GO:0070373	3	0.050
nucleobase containing small molecule metabolic process	GO:0055086	174	0.049
protein localization	GO:0008104	284	0.049
mitotic cell cycle embryonic	GO:0045448	38	0.049
wnt signaling pathway	GO:0016055	98	0.048
regulation of neurogenesis	GO:0050767	158	0.048
cellular macromolecular complex assembly	GO:0034622	153	0.046
defense response	GO:0006952	300	0.046
mitotic nuclear division	GO:0007067	213	0.046
covalent chromatin modification	GO:0016569	106	0.045
response to abiotic stimulus	GO:0009628	341	0.045
negative regulation of phosphorylation	GO:0042326	35	0.044
response to oxygen containing compound	GO:1901700	200	0.043
regulation of protein modification process	GO:0031399	112	0.043
negative regulation of nervous system development	GO:0051961	92	0.043
neural precursor cell proliferation	GO:0061351	75	0.040
regulation of anatomical structure size	GO:0090066	163	0.040
carbohydrate derivative metabolic process	GO:1901135	217	0.040
negative regulation of mitotic cell cycle	GO:0045930	109	0.040
axis specification	GO:0009798	167	0.038
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.038
regulation of cellular protein metabolic process	GO:0032268	243	0.038
ras protein signal transduction	GO:0007265	88	0.037
positive regulation of transport	GO:0051050	92	0.037
negative regulation of apoptotic process	GO:0043066	63	0.037
regulation of localization	GO:0032879	275	0.036
organelle fission	GO:0048285	340	0.036
regulation of protein complex assembly	GO:0043254	42	0.036
innate immune response	GO:0045087	144	0.036
purine containing compound metabolic process	GO:0072521	155	0.035
negative regulation of cell death	GO:0060548	81	0.034
central nervous system development	GO:0007417	201	0.034
negative regulation of neurogenesis	GO:0050768	53	0.033
regulation of dna metabolic process	GO:0051052	34	0.033
cellular macromolecule localization	GO:0070727	220	0.033
positive regulation of phosphate metabolic process	GO:0045937	139	0.033
taxis	GO:0042330	304	0.033
protein transport	GO:0015031	155	0.033
positive regulation of transcription dna templated	GO:0045893	266	0.032
purine nucleotide metabolic process	GO:0006163	146	0.032
positive regulation of rna biosynthetic process	GO:1902680	266	0.032
negative regulation of programmed cell death	GO:0043069	72	0.032
regulation of cell differentiation	GO:0045595	302	0.031
secretion	GO:0046903	109	0.031
regulation of protein kinase activity	GO:0045859	51	0.031
nucleobase containing compound catabolic process	GO:0034655	165	0.031
response to organic substance	GO:0010033	284	0.031
negative regulation of intracellular signal transduction	GO:1902532	57	0.031
negative regulation of rna metabolic process	GO:0051253	251	0.030
positive regulation of rna metabolic process	GO:0051254	271	0.029
regulation of establishment of protein localization	GO:0070201	61	0.029
axon guidance	GO:0007411	233	0.029
nucleoside phosphate metabolic process	GO:0006753	162	0.029
glial cell development	GO:0021782	27	0.029
small gtpase mediated signal transduction	GO:0007264	88	0.029
positive regulation of cellular component organization	GO:0051130	156	0.029
positive regulation of phosphorus metabolic process	GO:0010562	139	0.029
positive regulation of response to stimulus	GO:0048584	323	0.028
purine ribonucleotide metabolic process	GO:0009150	145	0.028
regulation of apoptotic process	GO:0042981	130	0.028
histone deacetylation	GO:0016575	9	0.028
embryo development ending in birth or egg hatching	GO:0009792	152	0.028
nucleoside triphosphate metabolic process	GO:0009141	120	0.027
negative regulation of cell development	GO:0010721	62	0.027
mitotic cell cycle checkpoint	GO:0007093	88	0.027
regulation of cell proliferation	GO:0042127	163	0.027
regulation of cellular component size	GO:0032535	98	0.027
adult locomotory behavior	GO:0008344	76	0.026
response to organonitrogen compound	GO:0010243	75	0.025
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.025
organonitrogen compound metabolic process	GO:1901564	318	0.025
regulation of molecular function	GO:0065009	217	0.024
cellular response to chemical stimulus	GO:0070887	199	0.024
gene silencing	GO:0016458	138	0.024
organonitrogen compound catabolic process	GO:1901565	128	0.024
intracellular protein transport	GO:0006886	104	0.024
regulation of neuron differentiation	GO:0045664	103	0.024
response to bacterium	GO:0009617	198	0.024
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.024
cell cycle comprising mitosis without cytokinesis	GO:0033301	25	0.024
positive regulation of immune system process	GO:0002684	68	0.024
regulation of cell development	GO:0060284	215	0.023
ribonucleoside catabolic process	GO:0042454	112	0.023
multi organism behavior	GO:0051705	175	0.023
melanization defense response	GO:0035006	45	0.023
aromatic compound catabolic process	GO:0019439	166	0.023
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.023
regulation of secretion by cell	GO:1903530	39	0.023
nucleoside monophosphate metabolic process	GO:0009123	52	0.023
programmed cell death	GO:0012501	257	0.023
regulation of transferase activity	GO:0051338	58	0.022
cellular response to external stimulus	GO:0071496	66	0.022
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.022
negative regulation of neural precursor cell proliferation	GO:2000178	27	0.022
ribonucleoside metabolic process	GO:0009119	127	0.022
negative regulation of cell cycle g1 s phase transition	GO:1902807	13	0.022
regulation of ras protein signal transduction	GO:0046578	93	0.022
developmental programmed cell death	GO:0010623	138	0.021
negative regulation of rna biosynthetic process	GO:1902679	240	0.021
negative regulation of phosphorus metabolic process	GO:0010563	45	0.021
regulation of rna splicing	GO:0043484	69	0.021
positive regulation of catabolic process	GO:0009896	105	0.021
regulation of behavior	GO:0050795	75	0.021
eye development	GO:0001654	323	0.021
positive regulation of phosphorylation	GO:0042327	87	0.021
positive regulation of protein modification process	GO:0031401	58	0.021
regulation of kinase activity	GO:0043549	53	0.020
regulation of glial cell differentiation	GO:0045685	1	0.020
regulation of anatomical structure morphogenesis	GO:0022603	242	0.020
regulation of protein phosphorylation	GO:0001932	64	0.020
cellular nitrogen compound catabolic process	GO:0044270	165	0.019
regulation of purine nucleotide metabolic process	GO:1900542	62	0.019
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.019
synaptic growth at neuromuscular junction	GO:0051124	119	0.019
camera type eye development	GO:0043010	4	0.019
mitotic g2 m transition checkpoint	GO:0044818	70	0.019
embryonic development via the syncytial blastoderm	GO:0001700	148	0.019
negative regulation of phosphate metabolic process	GO:0045936	45	0.019
single organism biosynthetic process	GO:0044711	206	0.019
axon development	GO:0061564	297	0.019
protein maturation	GO:0051604	71	0.019
cell adhesion	GO:0007155	136	0.019
heterocycle catabolic process	GO:0046700	166	0.019
protein complex biogenesis	GO:0070271	201	0.018
compound eye morphogenesis	GO:0001745	249	0.018
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.018
immune system process	GO:0002376	347	0.018
defense response to gram positive bacterium	GO:0050830	41	0.018
positive regulation of catalytic activity	GO:0043085	118	0.018
small molecule metabolic process	GO:0044281	305	0.018
nucleoside metabolic process	GO:0009116	127	0.018
chemotaxis	GO:0006935	249	0.018
atp metabolic process	GO:0046034	49	0.018
multicellular organismal aging	GO:0010259	140	0.018
nucleoside triphosphate catabolic process	GO:0009143	108	0.018
positive regulation of melanization defense response	GO:0035008	1	0.018
cellular response to nitrogen compound	GO:1901699	51	0.018
positive regulation of protein metabolic process	GO:0051247	128	0.017
regulation of cell death	GO:0010941	173	0.017
positive regulation of signaling	GO:0023056	243	0.017
mitotic cell cycle phase transition	GO:0044772	138	0.017
cellular response to endogenous stimulus	GO:0071495	80	0.017
rna splicing	GO:0008380	83	0.017
leg disc development	GO:0035218	92	0.017
single organism carbohydrate metabolic process	GO:0044723	72	0.017
tube morphogenesis	GO:0035239	191	0.017
positive regulation of secretion by cell	GO:1903532	20	0.017
negative regulation of cellular protein metabolic process	GO:0032269	85	0.017
anterior posterior pattern specification	GO:0009952	136	0.017
melanin metabolic process	GO:0006582	47	0.016
regulation of mrna processing	GO:0050684	71	0.016
peptide transport	GO:0015833	10	0.016
eye photoreceptor cell differentiation	GO:0001754	145	0.016
negative regulation of signal transduction	GO:0009968	206	0.016
regulation of wnt signaling pathway	GO:0030111	68	0.016
regulation of immune response	GO:0050776	118	0.016
dorsal closure	GO:0007391	79	0.016
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.016
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.016
positive regulation of cell communication	GO:0010647	250	0.016
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.016
tube development	GO:0035295	244	0.016
actin filament bundle assembly	GO:0051017	26	0.015
glycosyl compound metabolic process	GO:1901657	127	0.015
cell cycle checkpoint	GO:0000075	95	0.015
cellular protein complex assembly	GO:0043623	71	0.015
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.015
memory	GO:0007613	94	0.015
positive regulation of molecular function	GO:0044093	136	0.015
melanotic encapsulation of foreign target	GO:0035011	30	0.015
cell growth	GO:0016049	108	0.015
regulation of hormone levels	GO:0010817	40	0.015
dendrite morphogenesis	GO:0048813	199	0.015
embryonic organ development	GO:0048568	50	0.015
cellular response to oxygen containing compound	GO:1901701	79	0.015
axonogenesis	GO:0007409	290	0.015
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.014
oocyte differentiation	GO:0009994	145	0.014
positive regulation of wnt signaling pathway	GO:0030177	25	0.014
maternal determination of anterior posterior axis embryo	GO:0008358	74	0.014
synapse organization	GO:0050808	196	0.014
neuronal action potential	GO:0019228	10	0.014
organic substance transport	GO:0071702	257	0.014
regulation of intracellular protein transport	GO:0033157	46	0.014
stress activated protein kinase signaling cascade	GO:0031098	55	0.014
negative regulation of cellular biosynthetic process	GO:0031327	277	0.014
regulation of peptide secretion	GO:0002791	6	0.014
single organism intracellular transport	GO:1902582	207	0.014
positive regulation of protein transport	GO:0051222	37	0.014
negative regulation of stress activated protein kinase signaling cascade	GO:0070303	20	0.014
regulation of embryonic development	GO:0045995	68	0.014
regulation of cell morphogenesis	GO:0022604	163	0.014
regionalization	GO:0003002	416	0.013
epithelial cell differentiation	GO:0030855	322	0.013
positive regulation of signal transduction	GO:0009967	223	0.013
neuron projection guidance	GO:0097485	241	0.013
defense response to gram negative bacterium	GO:0050829	94	0.013
defense response to bacterium	GO:0042742	178	0.013
protein modification by small protein conjugation or removal	GO:0070647	106	0.013
neuromuscular junction development	GO:0007528	149	0.013
positive regulation of nucleotide catabolic process	GO:0030813	46	0.013
negative regulation of multicellular organismal process	GO:0051241	142	0.013
action potential	GO:0001508	13	0.013
sensory organ morphogenesis	GO:0090596	260	0.013
positive regulation of nucleoside metabolic process	GO:0045979	47	0.013
intracellular mrna localization involved in pattern specification process	GO:0060810	56	0.013
organic cyclic compound catabolic process	GO:1901361	168	0.013
regulation of intracellular transport	GO:0032386	64	0.012
eye photoreceptor cell development	GO:0042462	81	0.012
negative regulation of cell cycle phase transition	GO:1901988	103	0.012
muscle structure development	GO:0061061	224	0.012
regulation of programmed cell death	GO:0043067	152	0.012
negative regulation of biosynthetic process	GO:0009890	277	0.012
amine metabolic process	GO:0009308	12	0.012
rna localization	GO:0006403	115	0.012
negative regulation of mapk cascade	GO:0043409	23	0.012
purine ribonucleoside metabolic process	GO:0046128	127	0.012
regulation of multi organism process	GO:0043900	131	0.012
regulation of mrna metabolic process	GO:1903311	72	0.012
response to biotic stimulus	GO:0009607	294	0.012
response to nutrient levels	GO:0031667	114	0.011
eye morphogenesis	GO:0048592	260	0.011
positive regulation of nucleotide metabolic process	GO:0045981	55	0.011
cellular response to organic substance	GO:0071310	132	0.011
rna processing	GO:0006396	147	0.011
regulation of cellular component biogenesis	GO:0044087	201	0.011
carbohydrate metabolic process	GO:0005975	82	0.011
smoothened signaling pathway	GO:0007224	49	0.011
negative regulation of cell cycle	GO:0045786	116	0.011
positive regulation of hormone secretion	GO:0046887	4	0.011
larval development	GO:0002164	104	0.011
nucleocytoplasmic transport	GO:0006913	72	0.011
spinal cord development	GO:0021510	1	0.011
motor neuron axon guidance	GO:0008045	58	0.011
response to extracellular stimulus	GO:0009991	116	0.011
telencephalon development	GO:0021537	2	0.011
regulation of dendrite morphogenesis	GO:0048814	28	0.011
body morphogenesis	GO:0010171	2	0.010
organic substance catabolic process	GO:1901575	308	0.010
jnk cascade	GO:0007254	50	0.010
spermatogenesis	GO:0007283	200	0.010
muscle organ development	GO:0007517	127	0.010
response to hormone	GO:0009725	45	0.010
positive regulation of developmental process	GO:0051094	143	0.010
developmental growth	GO:0048589	280	0.010
regulation of response to stress	GO:0080134	200	0.010
negative regulation of cellular component organization	GO:0051129	108	0.010
cellular macromolecule catabolic process	GO:0044265	136	0.010

grp disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.026
cancer	DOID:162	0.011
disease of cellular proliferation	DOID:14566	0.011
organ system cancer	DOID:0050686	0.011
disease of metabolism	DOID:0014667	0.010

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