IMP: Integrative Multi-species Prediction

Drosophila melanogaster

22 known processes

alpha-Est7 (Dmel_CG1112)

alpha-Esterase-7

(Aliases: Dmel\CG1112,EST23,alphaE7,aE7,CG1112,H,Est-23,Ali,DmalphaE7,Est23,alphaest-7,ali,Mce)

Entrez: 40901
FLYBASE: FBgn0015575
UniProtKB: Q9VIB5

Process Predictions
Disease Predictions

alpha-Est7 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
response to mercury ion	GO:0046689	3	0.869
insecticide metabolic process	GO:0017143	2	0.828
organic hydroxy compound metabolic process	GO:1901615	83	0.611	Fly
medium chain fatty acid metabolic process	GO:0051791	1	0.548
small molecule metabolic process	GO:0044281	305	0.505	Fly
secondary metabolite catabolic process	GO:0090487	1	0.453
fat soluble vitamin metabolic process	GO:0006775	1	0.370
single organism behavior	GO:0044708	391	0.368
organonitrogen compound metabolic process	GO:1901564	318	0.346	Fly
regulation of tube size	GO:0035150	46	0.334	Fly
lauric acid metabolic process	GO:0048252	1	0.327
vitamin metabolic process	GO:0006766	2	0.315
single organism biosynthetic process	GO:0044711	206	0.309
epithelial cell development	GO:0002064	274	0.303	Fly
regulation of anatomical structure size	GO:0090066	163	0.303	Fly
polyol biosynthetic process	GO:0046173	3	0.292
border follicle cell migration	GO:0007298	113	0.283	Fly
response to external biotic stimulus	GO:0043207	293	0.258	Fly
vitamin biosynthetic process	GO:0009110	1	0.245
cellular ketone metabolic process	GO:0042180	24	0.235
chemical homeostasis	GO:0048878	92	0.230
sterol metabolic process	GO:0016125	12	0.218
homeostatic process	GO:0042592	199	0.207
columnar cuboidal epithelial cell development	GO:0002066	249	0.204	Fly
response to biotic stimulus	GO:0009607	294	0.190	Fly
alcohol metabolic process	GO:0006066	25	0.187	Fly
alcohol biosynthetic process	GO:0046165	14	0.184
growth	GO:0040007	359	0.179
organic acid metabolic process	GO:0006082	103	0.174
response to organophosphorus	GO:0046683	2	0.174
response to organic substance	GO:0010033	284	0.172
fat soluble vitamin biosynthetic process	GO:0042362	1	0.170
ovarian follicle cell migration	GO:0007297	121	0.169	Fly
epithelium migration	GO:0090132	148	0.169	Fly
response to toxic substance	GO:0009636	22	0.168
organic hydroxy compound biosynthetic process	GO:1901617	21	0.160
steroid catabolic process	GO:0006706	1	0.160
response to glucose	GO:0009749	2	0.159
hormone metabolic process	GO:0042445	33	0.152
acetylcholine metabolic process	GO:0008291	2	0.152	Fly
response to other organism	GO:0051707	293	0.151	Fly
ovarian follicle cell development	GO:0030707	248	0.151	Fly
oxidation reduction process	GO:0055114	123	0.149
cellular catabolic process	GO:0044248	372	0.149	Fly
synaptic transmission	GO:0007268	288	0.144	Fly
oxoacid metabolic process	GO:0043436	103	0.141
axon guidance	GO:0007411	233	0.138	Fly
carboxylic acid metabolic process	GO:0019752	92	0.137
regulation of growth	GO:0040008	233	0.135
aging	GO:0007568	143	0.132
secondary metabolic process	GO:0019748	75	0.132
fatty acid metabolic process	GO:0006631	20	0.127
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.127	Fly
cellular ion homeostasis	GO:0006873	39	0.126
regionalization	GO:0003002	416	0.126	Fly
epithelial cell migration	GO:0010631	148	0.122	Fly
tissue migration	GO:0090130	155	0.119	Fly
epithelial cell differentiation	GO:0030855	322	0.117	Fly
regulation of developmental growth	GO:0048638	174	0.116
cellular hormone metabolic process	GO:0034754	23	0.112
response to insecticide	GO:0017085	14	0.112
hormone biosynthetic process	GO:0042446	20	0.112
ameboidal type cell migration	GO:0001667	151	0.111	Fly
organic substance catabolic process	GO:1901575	308	0.106	Fly
organonitrogen compound catabolic process	GO:1901565	128	0.106	Fly
motor neuron axon guidance	GO:0008045	58	0.106	Fly
response to ddt	GO:0046680	5	0.105
xenobiotic catabolic process	GO:0042178	1	0.104
toxin catabolic process	GO:0009407	1	0.103
insecticide catabolic process	GO:0046701	1	0.100
choline catabolic process	GO:0042426	1	0.100	Fly
defense response to other organism	GO:0098542	225	0.098	Fly
developmental growth	GO:0048589	280	0.098
defense response to gram negative bacterium	GO:0050829	94	0.096
ecdysteroid biosynthetic process	GO:0045456	15	0.089
steroid metabolic process	GO:0008202	20	0.089
response to extracellular stimulus	GO:0009991	116	0.088
single organism catabolic process	GO:0044712	228	0.086	Fly
positive regulation of macromolecule metabolic process	GO:0010604	405	0.085
ethanolamine containing compound metabolic process	GO:0042439	4	0.082	Fly
lipid metabolic process	GO:0006629	121	0.082
sterol biosynthetic process	GO:0016126	9	0.081
monocarboxylic acid metabolic process	GO:0032787	29	0.080
regulation of cellular ketone metabolic process	GO:0010565	3	0.079
response to oxygen containing compound	GO:1901700	200	0.078
sensory perception	GO:0007600	196	0.078
aggressive behavior	GO:0002118	63	0.078
lipid biosynthetic process	GO:0008610	46	0.077
cellular response to chemical stimulus	GO:0070887	199	0.076
choline metabolic process	GO:0019695	1	0.075	Fly
response to light stimulus	GO:0009416	124	0.072	Fly
amine catabolic process	GO:0009310	1	0.072	Fly
ketone biosynthetic process	GO:0042181	16	0.070
ecdysteroid metabolic process	GO:0045455	19	0.068
catabolic process	GO:0009056	409	0.067	Fly
localization of cell	GO:0051674	257	0.066	Fly
response to nutrient levels	GO:0031667	114	0.065
cellular amine metabolic process	GO:0044106	12	0.065	Fly
nucleobase containing small molecule metabolic process	GO:0055086	174	0.065
epidermal cell differentiation	GO:0009913	51	0.063	Fly
cellular homeostasis	GO:0019725	80	0.063
response to oxidative stress	GO:0006979	86	0.062
organelle fission	GO:0048285	340	0.062	Fly
toxin metabolic process	GO:0009404	2	0.061
tube development	GO:0035295	244	0.061
tergite morphogenesis	GO:0007490	1	0.061
chromosome segregation	GO:0007059	157	0.059	Fly
regulation of hormone levels	GO:0010817	40	0.059
response to bacterium	GO:0009617	198	0.059
neurotransmitter catabolic process	GO:0042135	1	0.056	Fly
multi organism behavior	GO:0051705	175	0.056	Fly
response to abiotic stimulus	GO:0009628	341	0.056	Fly
cellular amino acid metabolic process	GO:0006520	61	0.056
ecdysone metabolic process	GO:0008205	11	0.055
small molecule biosynthetic process	GO:0044283	37	0.055
regulation of cellular localization	GO:0060341	136	0.054
organophosphate metabolic process	GO:0019637	195	0.054
neuron projection guidance	GO:0097485	241	0.054	Fly
positive regulation of gene expression	GO:0010628	290	0.054
peptide metabolic process	GO:0006518	80	0.052
anion homeostasis	GO:0055081	3	0.052
positive regulation of multicellular organismal process	GO:0051240	143	0.051
response to nitrogen compound	GO:1901698	90	0.048
amine metabolic process	GO:0009308	12	0.048	Fly
detection of stimulus	GO:0051606	156	0.048
terpenoid metabolic process	GO:0006721	7	0.047
neurological system process	GO:0050877	358	0.047
cellular response to extracellular stimulus	GO:0031668	64	0.047
cellular lipid metabolic process	GO:0044255	83	0.047
neurotransmitter metabolic process	GO:0042133	2	0.047	Fly
cellular nitrogen compound catabolic process	GO:0044270	165	0.047
defense response to bacterium	GO:0042742	178	0.047
cell migration	GO:0016477	238	0.047	Fly
defense response	GO:0006952	300	0.046	Fly
cell death	GO:0008219	279	0.045
nuclear division	GO:0000280	332	0.044	Fly
axonogenesis	GO:0007409	290	0.043	Fly
chemotaxis	GO:0006935	249	0.041	Fly
lipid catabolic process	GO:0016042	21	0.041
female meiosis chromosome segregation	GO:0016321	33	0.041	Fly
meiotic cell cycle	GO:0051321	171	0.040	Fly
response to metal ion	GO:0010038	23	0.040
dorsal closure	GO:0007391	79	0.040
sensory perception of smell	GO:0007608	80	0.039
programmed cell death	GO:0012501	257	0.039
actin cytoskeleton organization	GO:0030036	206	0.039
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.039
response to ethanol	GO:0045471	59	0.039
positive regulation of signaling	GO:0023056	243	0.038
response to monosaccharide	GO:0034284	4	0.038
cellular response to external stimulus	GO:0071496	66	0.038
steroid biosynthetic process	GO:0006694	16	0.037
skin development	GO:0043588	65	0.037	Fly
signal release	GO:0023061	49	0.037
response to fungus	GO:0009620	50	0.036
positive regulation of biosynthetic process	GO:0009891	316	0.036
organic substance transport	GO:0071702	257	0.036
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.036
behavioral response to ethanol	GO:0048149	49	0.036
ion homeostasis	GO:0050801	55	0.036
positive regulation of cell communication	GO:0010647	250	0.035
cellular response to oxidative stress	GO:0034599	28	0.035
acetate ester metabolic process	GO:1900619	2	0.035	Fly
response to temperature stimulus	GO:0009266	106	0.034
negative regulation of cellular metabolic process	GO:0031324	382	0.034
respiratory system development	GO:0060541	213	0.034	Fly
negative regulation of biosynthetic process	GO:0009890	277	0.034
multicellular organismal aging	GO:0010259	140	0.034
epidermis development	GO:0008544	65	0.033	Fly
secretion	GO:0046903	109	0.033
lateral inhibition	GO:0046331	206	0.033
response to endogenous stimulus	GO:0009719	119	0.032
cell motility	GO:0048870	251	0.032	Fly
organic cyclic compound catabolic process	GO:1901361	168	0.032
melanin metabolic process	GO:0006582	47	0.032
pigment metabolic process	GO:0042440	84	0.032
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.031
cellular response to uv	GO:0034644	12	0.031
cell cell junction organization	GO:0045216	55	0.031	Fly
regulation of blood circulation	GO:1903522	21	0.031
cellular amide metabolic process	GO:0043603	80	0.031
post embryonic appendage morphogenesis	GO:0035120	385	0.031	Fly
embryonic development via the syncytial blastoderm	GO:0001700	148	0.031
response to organonitrogen compound	GO:0010243	75	0.030
female meiotic division	GO:0007143	70	0.030	Fly
positive regulation of cellular biosynthetic process	GO:0031328	316	0.030
death	GO:0016265	284	0.030
immune system process	GO:0002376	347	0.029
imaginal disc derived appendage development	GO:0048737	399	0.029	Fly
immune effector process	GO:0002252	98	0.029
purine containing compound metabolic process	GO:0072521	155	0.029
apical junction assembly	GO:0043297	32	0.029	Fly
organonitrogen compound biosynthetic process	GO:1901566	117	0.029
apoptotic process	GO:0006915	159	0.029
immune response	GO:0006955	246	0.028
ecdysone biosynthetic process	GO:0006697	9	0.028
axon development	GO:0061564	297	0.028	Fly
protein complex assembly	GO:0006461	200	0.028
acetylcholine catabolic process	GO:0006581	1	0.028	Fly
chitin based embryonic cuticle biosynthetic process	GO:0008362	16	0.027
detection of chemical stimulus	GO:0009593	93	0.027
camera type eye development	GO:0043010	4	0.027
imaginal disc derived wing morphogenesis	GO:0007476	337	0.027	Fly
regulation of tube architecture open tracheal system	GO:0035152	68	0.027	Fly
cellular response to starvation	GO:0009267	61	0.027
cellular response to heat	GO:0034605	24	0.027
adult behavior	GO:0030534	137	0.026
cuticle development	GO:0042335	86	0.026
cellular chemical homeostasis	GO:0055082	40	0.026
nucleoside phosphate metabolic process	GO:0006753	162	0.026
cell cell junction assembly	GO:0007043	38	0.025	Fly
ras protein signal transduction	GO:0007265	88	0.025
establishment of localization in cell	GO:0051649	402	0.025
spermatogenesis	GO:0007283	200	0.025	Fly
morphogenesis of embryonic epithelium	GO:0016331	94	0.025
morphogenesis of an epithelium	GO:0002009	276	0.025
connective tissue development	GO:0061448	3	0.024
response to alkaloid	GO:0043279	26	0.023
response to hexose	GO:0009746	3	0.023
melanotic encapsulation of foreign target	GO:0035011	30	0.023
wing disc morphogenesis	GO:0007472	344	0.023	Fly
cell junction organization	GO:0034330	57	0.023	Fly
oxidoreduction coenzyme metabolic process	GO:0006733	2	0.023
chaeta development	GO:0022416	97	0.023
central nervous system development	GO:0007417	201	0.022
innate immune response	GO:0045087	144	0.022
digestive system development	GO:0055123	149	0.022
negative regulation of cellular component organization	GO:0051129	108	0.022
negative regulation of cellular biosynthetic process	GO:0031327	277	0.022
cellular biogenic amine catabolic process	GO:0042402	1	0.022	Fly
regulation of transport	GO:0051049	181	0.021
energy derivation by oxidation of organic compounds	GO:0015980	32	0.021
regulation of system process	GO:0044057	36	0.021
cellular protein modification process	GO:0006464	438	0.021
melanization defense response	GO:0035006	45	0.021
circulatory system process	GO:0003013	37	0.021
meiotic cell cycle process	GO:1903046	132	0.021	Fly
open tracheal system development	GO:0007424	204	0.021	Fly
response to caffeine	GO:0031000	12	0.020
wound healing	GO:0042060	75	0.020
energy taxis	GO:0009453	21	0.020	Fly
tissue morphogenesis	GO:0048729	297	0.020
protein modification process	GO:0036211	438	0.020
actin filament based process	GO:0030029	220	0.019
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.019
hair cell differentiation	GO:0035315	47	0.019	Fly
positive regulation of cell migration	GO:0030335	2	0.019
regulation of immune system process	GO:0002682	176	0.019
male gamete generation	GO:0048232	201	0.018	Fly
intracellular signal transduction	GO:0035556	300	0.018
secretion by cell	GO:0032940	101	0.018
appendage morphogenesis	GO:0035107	397	0.018	Fly
carbohydrate derivative metabolic process	GO:1901135	217	0.018
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.018
appendage development	GO:0048736	401	0.018	Fly
mating behavior	GO:0007617	106	0.018	Fly
thermosensory behavior	GO:0040040	19	0.018
organic hydroxy compound catabolic process	GO:1901616	4	0.018	Fly
regulation of neurotransmitter levels	GO:0001505	38	0.017	Fly
regulation of organelle organization	GO:0033043	196	0.017
macromolecular complex assembly	GO:0065003	256	0.017
regulation of secretion by cell	GO:1903530	39	0.017
isoprenoid metabolic process	GO:0006720	8	0.017
blood circulation	GO:0008015	26	0.016
pyridine containing compound metabolic process	GO:0072524	3	0.016
hormone catabolic process	GO:0042447	3	0.016
regulation of apoptotic process	GO:0042981	130	0.016
transcription from rna polymerase ii promoter	GO:0006366	368	0.016
response to purine containing compound	GO:0014074	12	0.016
regulation of localization	GO:0032879	275	0.016
proteolysis	GO:0006508	192	0.016
response to alcohol	GO:0097305	95	0.016
regulation of secretion	GO:0051046	44	0.016
monocarboxylic acid transport	GO:0015718	3	0.015
pyridine nucleotide metabolic process	GO:0019362	2	0.015
response to cadmium ion	GO:0046686	9	0.015
positive regulation of secretion	GO:0051047	22	0.015
salivary gland morphogenesis	GO:0007435	145	0.015
response to radiation	GO:0009314	155	0.015	Fly
digestive tract development	GO:0048565	149	0.015
biological adhesion	GO:0022610	138	0.015	Fly
response to inorganic substance	GO:0010035	44	0.015
circadian behavior	GO:0048512	76	0.015
positive regulation of cellular catabolic process	GO:0031331	95	0.015
purine ribonucleoside metabolic process	GO:0046128	127	0.015
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.015	Fly
chitin based cuticle development	GO:0040003	49	0.015
regulation of cell morphogenesis	GO:0022604	163	0.015
embryonic morphogenesis	GO:0048598	206	0.015
g protein coupled receptor signaling pathway	GO:0007186	136	0.015
positive regulation of cell motility	GO:2000147	3	0.014
dna metabolic process	GO:0006259	227	0.014
multicellular organismal reproductive behavior	GO:0033057	110	0.014	Fly
reproductive behavior	GO:0019098	122	0.014	Fly
nucleobase containing compound catabolic process	GO:0034655	165	0.014
regulation of innate immune response	GO:0045088	71	0.014
positive regulation of response to stimulus	GO:0048584	323	0.014
response to hormone	GO:0009725	45	0.014
phosphorylation	GO:0016310	294	0.014
regulation of cell death	GO:0010941	173	0.014
positive regulation of cell differentiation	GO:0045597	64	0.014
positive regulation of cell death	GO:0010942	69	0.014
phosphatidylinositol mediated signaling	GO:0048015	4	0.013
heterocycle catabolic process	GO:0046700	166	0.013
purine nucleoside metabolic process	GO:0042278	127	0.013
multi multicellular organism process	GO:0044706	123	0.013	Fly
carbohydrate homeostasis	GO:0033500	12	0.013
cellular response to nutrient levels	GO:0031669	62	0.013
cell junction assembly	GO:0034329	42	0.013	Fly
aromatic compound catabolic process	GO:0019439	166	0.013
compound eye morphogenesis	GO:0001745	249	0.013
regulation of cellular component biogenesis	GO:0044087	201	0.013
positive regulation of catabolic process	GO:0009896	105	0.013
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.013
nicotinamide nucleotide metabolic process	GO:0046496	2	0.013
carbohydrate biosynthetic process	GO:0016051	17	0.013
carbohydrate metabolic process	GO:0005975	82	0.012
phototransduction	GO:0007602	52	0.012
response to transition metal nanoparticle	GO:1990267	9	0.012
cellular macromolecule catabolic process	GO:0044265	136	0.012
glycosyl compound metabolic process	GO:1901657	127	0.012
regulation of cell differentiation	GO:0045595	302	0.012
response to organic cyclic compound	GO:0014070	89	0.012
non sensory hair organization	GO:0035316	47	0.012	Fly
regulation of catalytic activity	GO:0050790	185	0.012
heart morphogenesis	GO:0003007	32	0.012	Fly
transmembrane transport	GO:0055085	139	0.012
macromolecule catabolic process	GO:0009057	161	0.012
ribonucleoside metabolic process	GO:0009119	127	0.012
actin filament organization	GO:0007015	126	0.011
cellular response to endogenous stimulus	GO:0071495	80	0.011
neuropeptide signaling pathway	GO:0007218	45	0.011
cellular polysaccharide biosynthetic process	GO:0033692	7	0.011
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.011
positive regulation of transport	GO:0051050	92	0.011
defense response to fungus	GO:0050832	48	0.011
nucleotide metabolic process	GO:0009117	161	0.011
cardiovascular system development	GO:0072358	82	0.011	Fly
hematopoietic progenitor cell differentiation	GO:0002244	1	0.011
retina development in camera type eye	GO:0060041	4	0.011
positive regulation of signal transduction	GO:0009967	223	0.011
cellular modified amino acid metabolic process	GO:0006575	45	0.011
regulation of cellular amino acid metabolic process	GO:0006521	0	0.010
cation homeostasis	GO:0055080	51	0.010
small gtpase mediated signal transduction	GO:0007264	88	0.010
cellular component disassembly	GO:0022411	46	0.010
embryo development ending in birth or egg hatching	GO:0009792	152	0.010
regulation of cellular component size	GO:0032535	98	0.010
regulation of cellular amine metabolic process	GO:0033238	3	0.010
pigment metabolic process involved in pigmentation	GO:0043474	33	0.010
nitrogen compound transport	GO:0071705	85	0.010
peripheral nervous system development	GO:0007422	52	0.010	Fly
multi organism reproductive behavior	GO:0044705	121	0.010	Fly
nucleoside metabolic process	GO:0009116	127	0.010
positive regulation of phosphorus metabolic process	GO:0010562	139	0.010
cellular biogenic amine metabolic process	GO:0006576	9	0.010	Fly

alpha-Est7 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
cardiovascular system disease	DOID:1287	0.408
essential hypertension	DOID:10825	0.408
vascular disease	DOID:178	0.408
hypertension	DOID:10763	0.408
disease of anatomical entity	DOID:7	0.408
artery disease	DOID:0050828	0.408
disease of metabolism	DOID:0014667	0.036
acquired metabolic disease	DOID:0060158	0.018
nervous system disease	DOID:863	0.016
central nervous system disease	DOID:331	0.013
neurodegenerative disease	DOID:1289	0.012
carbohydrate metabolism disease	DOID:0050013	0.011
inherited metabolic disorder	DOID:655	0.011

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