Drosophila melanogaster

176 known processes

Mhc (Dmel_CG17927)

Myosin heavy chain

(Aliases: Dmel\CG17927,mMHC,CG17927,l(2)36Ae,Bsh,Mrp,DmMHC,Sht,l(2)k10423,MRP,Dm II,MHC,Ifm(2)2,DroMII,Stp,Nup,FBgn0002741,sMHC,DROMHC,l(2)M66,mhc,ifm(2)2,Mhc36B,Myo)

Mhc biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
sarcomere organizationGO:0045214261.000
muscle structure developmentGO:00610612241.000
striated muscle tissue developmentGO:0014706270.993
Zebrafish Mouse
muscle organ developmentGO:00075171270.991
somatic muscle developmentGO:0007525660.987
muscle cell differentiationGO:00426921030.987
striated muscle cell differentiationGO:0051146900.977
myofibril assemblyGO:0030239360.976
striated muscle cell developmentGO:0055002500.975
cell motilityGO:00488702510.968
localization of cellGO:00516742570.957
actomyosin structure organizationGO:0031032560.952
actin filament based processGO:00300292200.948
cell migrationGO:00164772380.933
muscle tissue developmentGO:0060537300.933
Zebrafish Mouse
muscle cell developmentGO:0055001500.933
heart developmentGO:0007507820.933
Mouse
response to abiotic stimulusGO:00096283410.911
Rat
circulatory system developmentGO:0072359820.856
Mouse
muscle system processGO:0003012210.855
vesicle mediated transportGO:00161923810.830
Worm
regulation of cell differentiationGO:00455953020.799
Mouse
regulation of organelle organizationGO:00330431960.739
Mouse
regulation of programmed cell deathGO:00430671520.733
cardiovascular system developmentGO:0072358820.732
Mouse
cellular component assembly involved in morphogenesisGO:00109271510.719
skeletal muscle organ developmentGO:0060538480.718
Zebrafish Mouse
imaginal disc derived appendage morphogenesisGO:00351143950.692
ameboidal type cell migrationGO:00016671510.691
actin cytoskeleton organizationGO:00300362060.674
dendrite developmentGO:00163582040.665
epithelium migrationGO:00901321480.658
heart processGO:0003015370.637
Mouse
transmembrane transportGO:00550851390.608
muscle tissue morphogenesisGO:006041520.573
ion transportGO:00068111450.560
circulatory system processGO:0003013370.548
Mouse
regionalizationGO:00030024160.547
Zebrafish
regulation of cell proliferationGO:00421271630.546
skin developmentGO:0043588650.545
heart morphogenesisGO:0003007320.541
growthGO:00400073590.532
Mouse
actin filament organizationGO:00070151260.527
epithelial cell developmentGO:00020642740.512
muscle contractionGO:0006936130.506
cell proliferationGO:00082832990.494
regulation of localizationGO:00328792750.476
negative regulation of cellular metabolic processGO:00313243820.471
regulation of apoptotic processGO:00429811300.450
locomotory behaviorGO:00076261760.448
Worm
muscle thin filament assemblyGO:007168950.408
regulation of cell adhesionGO:0030155270.402
response to oxygen levelsGO:0070482590.392
positive regulation of macromolecule biosynthetic processGO:00105572830.384
cellular response to chemical stimulusGO:00708871990.358
divalent inorganic cation homeostasisGO:0072507290.353
apoptotic processGO:00069151590.349
striated muscle contractionGO:000694150.346
Zebrafish Mouse
protein modification processGO:00362114380.346
regulation of cell deathGO:00109411730.337
cardiac muscle tissue developmentGO:004873890.337
Mouse
endocytosisGO:00068973100.336
Worm
connective tissue developmentGO:006144830.331
regulation of cellular component movementGO:0051270420.330
response to endogenous stimulusGO:00097191190.329
regulation of cell developmentGO:00602842150.328
Mouse
cellular protein modification processGO:00064644380.323
head developmentGO:00603221350.318
regulation of blood circulationGO:1903522210.310
Mouse
positive regulation of nucleic acid templated transcriptionGO:19035082660.299
columnar cuboidal epithelial cell differentiationGO:00020652560.297
camera type eye developmentGO:004301040.276
synaptic transmissionGO:00072682880.271
homeostatic processGO:00425921990.268
positive regulation of cellular component organizationGO:00511301560.267
regulation of phosphorus metabolic processGO:00511742100.262
Mouse
cell deathGO:00082192790.261
regulation of system processGO:0044057360.259
Mouse
embryo development ending in birth or egg hatchingGO:00097921520.259
Zebrafish Mouse Worm
regulation of anatomical structure morphogenesisGO:00226032420.254
Mouse
hematopoietic or lymphoid organ developmentGO:0048534570.254
regulation of cellular component biogenesisGO:00440872010.246
Mouse
central nervous system developmentGO:00074172010.235
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.234
organelle assemblyGO:00709251980.233
single organism intracellular transportGO:19025822070.229
positive regulation of macromolecule metabolic processGO:00106044050.226
male mating behaviorGO:0060179700.224
muscle fiber developmentGO:0048747120.222
Zebrafish Mouse
positive regulation of gene expressionGO:00106282900.215
negative regulation of signal transductionGO:00099682060.213
regulation of locomotionGO:0040012420.204
anatomical structure homeostasisGO:0060249970.202
establishment of localization in cellGO:00516494020.185
positive regulation of transcription dna templatedGO:00458932660.182
cellular response to oxygen containing compoundGO:1901701790.182
negative regulation of response to stimulusGO:00485852580.180
ion transmembrane transportGO:00342201220.176
immune system processGO:00023763470.175
columnar cuboidal epithelial cell developmentGO:00020662490.174
skeletal muscle adaptationGO:004350110.172
Mouse
epithelial cell differentiationGO:00308553220.164
adult behaviorGO:00305341370.164
regulation of cell motilityGO:2000145230.164
matingGO:00076181200.161
chromosome organizationGO:00512763600.159
skeletal myofibril assemblyGO:001486660.159
protein complex assemblyGO:00064612000.158
positive regulation of cellular biosynthetic processGO:00313283160.156
negative regulation of nitrogen compound metabolic processGO:00511722650.156
positive regulation of cellular component biogenesisGO:0044089800.155
regulation of epithelial cell proliferationGO:005067840.155
single organism behaviorGO:00447083910.154
muscle organ morphogenesisGO:004864470.154
larval somatic muscle developmentGO:0007526190.152
tissue migrationGO:00901301550.149
stem cell differentiationGO:00488631170.149
wing disc morphogenesisGO:00074723440.141
ovarian follicle cell migrationGO:00072971210.139
cellular protein complex assemblyGO:0043623710.138
cardiocyte differentiationGO:0035051290.136
Mouse
imaginal disc derived appendage developmentGO:00487373990.136
heart contractionGO:0060047260.135
Mouse
positive regulation of cell proliferationGO:0008284470.133
response to organic substanceGO:00100332840.133
regulation of cell migrationGO:0030334220.133
negative regulation of nucleobase containing compound metabolic processGO:00459342610.132
epithelial cell migrationGO:00106311480.131
eye developmentGO:00016543230.129
positive regulation of nucleobase containing compound metabolic processGO:00459353320.129
regulation of phosphate metabolic processGO:00192202100.128
Mouse
cellular response to organic substanceGO:00713101320.128
blood circulationGO:0008015260.126
Mouse
positive regulation of transportGO:0051050920.124
regulation of cellular localizationGO:00603411360.122
positive regulation of developmental processGO:00510941430.120
chemical homeostasisGO:0048878920.118
negative regulation of biosynthetic processGO:00098902770.115
positive regulation of cell differentiationGO:0045597640.112
negative regulation of gene expressionGO:00106293870.109
small molecule metabolic processGO:00442813050.108
regulation of cellular amino acid metabolic processGO:000652100.106
cation homeostasisGO:0055080510.106
reproductive behaviorGO:00190981220.105
Worm
brain developmentGO:00074201200.105
response to nitrogen compoundGO:1901698900.104
cation transmembrane transportGO:0098655880.103
response to hypoxiaGO:0001666530.103
organelle localizationGO:00516401480.102
tissue morphogenesisGO:00487292970.100
organic substance catabolic processGO:19015753080.099
digestive tract morphogenesisGO:00485461270.098
striated muscle adaptationGO:001488810.096
Mouse
phagocytosisGO:00069092150.096
cytoplasmic transportGO:00164821300.096
chromatin organizationGO:00063252070.095
post embryonic appendage morphogenesisGO:00351203850.095
skeletal muscle fiber developmentGO:004874130.092
Zebrafish Mouse
cellular protein localizationGO:00346131600.092
muscle attachmentGO:0016203360.091
cellular macromolecule localizationGO:00707272200.091
epidermis developmentGO:0008544650.090
cell type specific apoptotic processGO:0097285380.087
immune system developmentGO:0002520570.083
multi organism behaviorGO:00517051750.083
Worm
response to woundingGO:0009611940.081
oocyte differentiationGO:00099941450.081
myotube cell developmentGO:001490430.081
Zebrafish Mouse
protein phosphorylationGO:00064681690.081
multi multicellular organism processGO:00447061230.079
Worm
regulation of cellular ketone metabolic processGO:001056530.078
appendage morphogenesisGO:00351073970.078
negative regulation of cellular biosynthetic processGO:00313272770.076
negative regulation of macromolecule biosynthetic processGO:00105582700.075
positive regulation of catalytic activityGO:00430851180.075
embryonic morphogenesisGO:00485982060.075
metal ion homeostasisGO:0055065440.074
regulation of cellular protein metabolic processGO:00322682430.074
positive regulation of rna metabolic processGO:00512542710.074
negative regulation of programmed cell deathGO:0043069720.074
protein localizationGO:00081042840.072
reactive oxygen species metabolic processGO:0072593220.072
multi organism reproductive behaviorGO:00447051210.072
Worm
deathGO:00162652840.072
regulation of catalytic activityGO:00507901850.071
Mouse
regulation of catabolic processGO:00098941700.071
Mouse
digestive tract developmentGO:00485651490.071
myotube differentiationGO:0014902460.070
Zebrafish Mouse
nucleoside triphosphate catabolic processGO:00091431080.069
kidney developmentGO:000182230.069
response to decreased oxygen levelsGO:0036293580.068
appendage developmentGO:00487364010.068
regulation of actin filament lengthGO:0030832270.067
dendrite morphogenesisGO:00488131990.066
regulation of protein modification processGO:00313991120.065
photoreceptor cell differentiationGO:00465301700.065
positive regulation of phosphate metabolic processGO:00459371390.064
peptidyl amino acid modificationGO:00181931050.064
catabolic processGO:00090564090.064
nephron developmentGO:007200630.063
regulation of multicellular organismal developmentGO:20000264140.063
Mouse
germarium derived egg chamber formationGO:00072931010.063
positive regulation of cell adhesionGO:0045785100.062
tube developmentGO:00352952440.062
cellular amine metabolic processGO:0044106120.061
positive regulation of biosynthetic processGO:00098913160.061
regulation of protein metabolic processGO:00512462560.061
positive regulation of molecular functionGO:00440931360.060
negative regulation of cell cycleGO:00457861160.059
organic substance transportGO:00717022570.057
positive regulation of phosphorus metabolic processGO:00105621390.057
regulation of intracellular signal transductionGO:19025312360.057
regulation of dna templated transcription elongationGO:0032784170.056
regulation of protein phosphorylationGO:0001932640.056
neurological system processGO:00508773580.056
regulation of protein localizationGO:0032880760.055
regulation of cellular amine metabolic processGO:003323830.055
multicellular organismal reproductive behaviorGO:00330571100.054
Worm
cell cell junction organizationGO:0045216550.052
regulation of phosphatase activityGO:001092130.052
regulation of protein complex assemblyGO:0043254420.052
response to oxygen containing compoundGO:19017002000.051
Rat
regulation of immune system processGO:00026821760.051
actin filament based movementGO:0030048260.050
Mouse
cytokinesisGO:0000910900.050
cell recognitionGO:00080371020.049
Worm
calcium ion homeostasisGO:0055074230.049
body morphogenesisGO:001017120.047
Worm
negative regulation of cell deathGO:0060548810.046
ovulationGO:003072840.046
organophosphate metabolic processGO:00196371950.046
positive regulation of nitrogen compound metabolic processGO:00511733540.045
negative regulation of nucleic acid templated transcriptionGO:19035072400.044
skeletal muscle tissue developmentGO:0007519130.044
Zebrafish Mouse
positive regulation of multicellular organismal processGO:00512401430.044
mitochondrion organizationGO:0007005650.043
regulation of cellular catabolic processGO:00313291570.043
Mouse
flight behaviorGO:0007629260.043
regulation of transcription from rna polymerase ii promoterGO:00063573780.042
Mouse
imaginal disc derived wing morphogenesisGO:00074763370.041
regulation of actin filament based processGO:0032970420.041
Mouse
cognitionGO:00508901410.041
regulation of intracellular transportGO:0032386640.040
extracellular structure organizationGO:0043062460.040
amine metabolic processGO:0009308120.039
cellular cation homeostasisGO:0030003380.039
purine ribonucleoside triphosphate metabolic processGO:00092051190.038
cellular catabolic processGO:00442483720.038
regulation of heart contractionGO:0008016210.038
Mouse
regulation of muscle contractionGO:000693750.037
chemotaxisGO:00069352490.037
neuromuscular synaptic transmissionGO:0007274670.037
transcription from rna polymerase ii promoterGO:00063663680.037
Mouse
organic acid metabolic processGO:00060821030.036
regulation of membrane potentialGO:0042391350.036
actin mediated cell contractionGO:0070252210.035
negative regulation of cell communicationGO:00106482230.035
morphogenesis of a branching structureGO:0001763450.034
macromolecular complex assemblyGO:00650032560.034
regulation of anatomical structure sizeGO:00900661630.033
mating behaviorGO:00076171060.033
circadian rhythmGO:00076231050.033
adult locomotory behaviorGO:0008344760.033
axonal fasciculationGO:0007413120.032
Worm
cellular amino acid metabolic processGO:0006520610.032
purine containing compound catabolic processGO:00725231120.032
response to organonitrogen compoundGO:0010243750.032
positive regulation of cell developmentGO:0010720610.031
negative regulation of molecular functionGO:0044092510.031
regulation of molecular functionGO:00650092170.031
Mouse
protein complex biogenesisGO:00702712010.030
response to organic cyclic compoundGO:0014070890.030
reproductive system developmentGO:0061458740.028
cation transportGO:00068121100.028
regulation of response to stressGO:00801342000.028
programmed cell deathGO:00125012570.028
positive regulation of rna biosynthetic processGO:19026802660.027
regulation of protein transportGO:0051223570.027
renal system developmentGO:0072001720.026
urogenital system developmentGO:0001655720.026
negative regulation of apoptotic processGO:0043066630.025
positive regulation of cell motilityGO:200014730.025
mitotic cytokinesisGO:0000281500.025
mapk cascadeGO:00001651070.025
cellular chemical homeostasisGO:0055082400.025
sensory perception of mechanical stimulusGO:0050954720.024
anterior posterior pattern specificationGO:00099521360.024
Zebrafish
organonitrogen compound metabolic processGO:19015643180.024
heterocycle catabolic processGO:00467001660.024
cell divisionGO:00513012480.024
oocyte developmentGO:00485991240.024
cuticle developmentGO:0042335860.024
hemopoiesisGO:0030097460.024
carboxylic acid metabolic processGO:0019752920.024
cellular macromolecular complex assemblyGO:00346221530.024
ion homeostasisGO:0050801550.024
cellular ion homeostasisGO:0006873390.024
glycosyl compound metabolic processGO:19016571270.023
hematopoietic progenitor cell differentiationGO:000224410.023
feeding behaviorGO:0007631500.023
Worm
eye antennal disc morphogenesisGO:0007455340.023
wound healingGO:0042060750.022
negative regulation of transcription dna templatedGO:00458922370.022
compound eye developmentGO:00487493070.022
negative regulation of developmental processGO:00510932010.022
regulation of nucleotide metabolic processGO:0006140620.022
Mouse
response to oxidative stressGO:0006979860.021
Rat
actin filament bundle organizationGO:0061572280.021
reproductive structure developmentGO:0048608740.021
renal tubule developmentGO:0061326640.021
cellular response to endogenous stimulusGO:0071495800.021
organic cyclic compound catabolic processGO:19013611680.021
embryonic pattern specificationGO:00098801740.020
Zebrafish
oxoacid metabolic processGO:00434361030.020
embryonic organ developmentGO:0048568500.020
negative regulation of rna biosynthetic processGO:19026792400.020
regulation of ion transportGO:0043269390.020
negative regulation of phosphorus metabolic processGO:0010563450.020
regulation of cell cycle processGO:00105641810.020
positive regulation of cellular protein metabolic processGO:00322701180.020
regulation of establishment of protein localizationGO:0070201610.020
multicellular organism growthGO:0035264460.020
blastoderm segmentationGO:00073501590.019
sensory perception of soundGO:0007605560.019
regulation of phosphorylationGO:00423251470.019
developmental maturationGO:00217001720.019
mesoderm developmentGO:0007498780.019
nucleoside catabolic processGO:00091641120.019
organonitrogen compound catabolic processGO:19015651280.018
covalent chromatin modificationGO:00165691060.018
striated muscle myosin thick filament assemblyGO:007168830.018
regulation of protein polymerizationGO:0032271280.018
chromatin modificationGO:00165681470.018
negative regulation of actin filament depolymerizationGO:003083520.018
negative regulation of cell migrationGO:003033650.018
eye morphogenesisGO:00485922600.018
imaginal disc derived wing hair organizationGO:0035317450.018
cell projection assemblyGO:0030031940.018
morphogenesis of an epitheliumGO:00020092760.017
segmentationGO:00352822070.017
Zebrafish
positive regulation of actin filament polymerizationGO:0030838110.017
sex differentiationGO:0007548810.017
negative regulation of rna metabolic processGO:00512532510.017
regulation of cell substrate adhesionGO:001081020.017
regulation of cell cycleGO:00517262910.017
signal transduction by phosphorylationGO:00230141070.017
glycosyl compound catabolic processGO:19016581120.017
negative regulation of cell differentiationGO:00455961430.017
nucleotide metabolic processGO:00091171610.017
positive regulation of protein complex assemblyGO:0031334220.017
cellular homeostasisGO:0019725800.016
regulation of tube sizeGO:0035150460.016
negative regulation of signalingGO:00230572190.016
actin filament bundle assemblyGO:0051017260.016
purine nucleoside metabolic processGO:00422781270.016
regulation of protein complex disassemblyGO:0043244290.016
regulation of cytoskeleton organizationGO:0051493890.016
Mouse
compound eye morphogenesisGO:00017452490.016
organophosphate catabolic processGO:00464341120.016
phosphorylationGO:00163102940.016
carbohydrate derivative catabolic processGO:19011361180.016
purine nucleoside triphosphate catabolic processGO:00091461080.016
histone modificationGO:00165701060.015
cellular response to hormone stimulusGO:0032870440.015
cellular lipid metabolic processGO:0044255830.015
response to hormoneGO:0009725450.015
developmental growthGO:00485892800.015
Mouse
regulation of actin filament depolymerizationGO:003083430.015
nucleotide catabolic processGO:00091661090.015
purine ribonucleotide metabolic processGO:00091501450.015
response to radiationGO:00093141550.015
cardiac muscle cell differentiationGO:005500740.014
Mouse
negative regulation of intracellular signal transductionGO:1902532570.014
negative regulation of phosphatase activityGO:001092330.014
positive regulation of catabolic processGO:00098961050.014
intracellular signal transductionGO:00355563000.014
Worm
establishment of organelle localizationGO:00516561220.014
rho protein signal transductionGO:0007266140.014
epithelial cell migration open tracheal systemGO:0007427320.014
regulation of apoptotic signaling pathwayGO:2001233100.014
positive regulation of organelle organizationGO:0010638650.014
regulation of synapse assemblyGO:0051963940.014
nuclear transportGO:0051169720.014
multicellular organismal signalingGO:0035637120.014
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.014
cellular metal ion homeostasisGO:0006875310.014
negative regulation of mapk cascadeGO:0043409230.014
regulation of actin polymerization or depolymerizationGO:0008064270.013
lipid storageGO:0019915380.013
muscle adaptationGO:004350010.013
Mouse
renal tubule morphogenesisGO:0061333440.013
larval developmentGO:00021641040.013
Worm
substrate dependent cell migrationGO:000692930.013
cellular response to decreased oxygen levelsGO:0036294300.013
intracellular transportGO:00469072280.013
cellular response to abiotic stimulusGO:0071214580.013
single organism catabolic processGO:00447122280.013
gonad developmentGO:0008406500.013
cellular response to nitrogen compoundGO:1901699510.013
regulation of ion transmembrane transportGO:0034765270.013
positive regulation of hydrolase activityGO:0051345780.013
cytoplasmic transport nurse cell to oocyteGO:0007303120.013
cellular response to oxygen levelsGO:0071453300.013
biological adhesionGO:00226101380.012
negative regulation of epithelial cell proliferationGO:005068040.012
cellular response to growth factor stimulusGO:0071363300.012
cytoskeleton dependent cytokinesisGO:0061640810.012
eye photoreceptor cell differentiationGO:00017541450.012
cell adhesionGO:00071551360.012
negative regulation of cytoskeleton organizationGO:0051494300.012
neuron projection guidanceGO:00974852410.012
cell cycle phase transitionGO:00447701400.012
courtship behaviorGO:0007619680.012
single organism biosynthetic processGO:00447112060.012
positive regulation of programmed cell deathGO:0043068620.012
macromolecule catabolic processGO:00090571610.012
positive regulation of protein modification processGO:0031401580.012
regulation of actin cytoskeleton organizationGO:0032956420.012
Mouse
actin filament polymerizationGO:0030041270.012
purine ribonucleoside metabolic processGO:00461281270.011
agingGO:00075681430.011
rhythmic processGO:00485111060.011
negative regulation of catalytic activityGO:0043086420.011
nuclear importGO:0051170510.011
response to growth factorGO:0070848310.011
extrinsic apoptotic signaling pathwayGO:009719110.011
cell junction organizationGO:0034330570.011
male courtship behavior veined wing extensionGO:0048065220.011
cellular divalent inorganic cation homeostasisGO:0072503230.011
regulation of transcription elongation from rna polymerase ii promoterGO:0034243150.011
cell junction assemblyGO:0034329420.011
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediatorGO:190225410.011
cellular response to organonitrogen compoundGO:0071417360.011
response to purine containing compoundGO:0014074120.010
cell substrate adhesionGO:0031589100.010
response to temperature stimulusGO:00092661060.010
Rat
cardiac muscle cell developmentGO:005501330.010
Mouse
regulation of spindle checkpointGO:009023120.010
cell fate specificationGO:0001708710.010
response to hexoseGO:000974630.010
regulation of dna templated transcription in response to stressGO:004362040.010
protein transportGO:00150311550.010

Mhc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
myopathyDOID:42300.690
heart diseaseDOID:11400.690
cardiomyopathyDOID:005070000.690
cardiovascular system diseaseDOID:128700.690
disease of anatomical entityDOID:700.690
musculoskeletal system diseaseDOID:1700.690
muscle tissue diseaseDOID:6600.690
muscular diseaseDOID:008000000.690
intrinsic cardiomyopathyDOID:006003600.643
dilated cardiomyopathyDOID:1293000.643
nervous system diseaseDOID:86300.023