IMP: Integrative Multi-species Prediction

Drosophila melanogaster

88 known processes

wds (Dmel_CG17437)

will die slowly

(Aliases: zw8,l(1)zw8,l(1)16-94,Dmel\CG17437,CG17437,zw-8,l(1)G0251,WDS,EG:BACR25B3.7,l(1)3Ad,Wds)

FLYBASE: FBgn0040066
Entrez: 53428
UniProtKB: Q9V3J8
UniProtKB: M9NDM4

Process Predictions
Disease Predictions

wds biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
histone modification	GO:0016570	106	0.919
protein acetylation	GO:0006473	39	0.914
covalent chromatin modification	GO:0016569	106	0.912
peptidyl lysine modification	GO:0018205	57	0.841
chromatin organization	GO:0006325	207	0.825
histone h4 acetylation	GO:0043967	13	0.779	Human
positive regulation of rna metabolic process	GO:0051254	271	0.759	Mouse
histone acetylation	GO:0016573	38	0.685
protein modification process	GO:0036211	438	0.658
positive regulation of gene expression	GO:0010628	290	0.608	Mouse
internal peptidyl lysine acetylation	GO:0018393	38	0.588
protein acylation	GO:0043543	42	0.559
positive regulation of transcription dna templated	GO:0045893	266	0.538	Mouse
chromatin remodeling	GO:0006338	72	0.475
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.444
imaginal disc derived appendage development	GO:0048737	399	0.443
chromatin modification	GO:0016568	147	0.437
negative regulation of cellular metabolic process	GO:0031324	382	0.407
wing disc morphogenesis	GO:0007472	344	0.357
positive regulation of rna biosynthetic process	GO:1902680	266	0.347	Mouse
positive regulation of macromolecule metabolic process	GO:0010604	405	0.338	Mouse
regionalization	GO:0003002	416	0.329
positive regulation of biosynthetic process	GO:0009891	316	0.320	Mouse
peptidyl amino acid modification	GO:0018193	105	0.304
chromosome organization	GO:0051276	360	0.304
cellular protein modification process	GO:0006464	438	0.293
cellular component assembly involved in morphogenesis	GO:0010927	151	0.288
peptidyl lysine acetylation	GO:0018394	39	0.275
appendage morphogenesis	GO:0035107	397	0.206
alternative mrna splicing via spliceosome	GO:0000380	60	0.190
negative regulation of rna metabolic process	GO:0051253	251	0.187
internal protein amino acid acetylation	GO:0006475	38	0.183
negative regulation of cell cycle process	GO:0010948	109	0.183
compound eye photoreceptor cell differentiation	GO:0001751	140	0.181
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.180	Mouse
negative regulation of gene expression	GO:0010629	387	0.166
vesicle mediated transport	GO:0016192	381	0.166
cellular amino acid metabolic process	GO:0006520	61	0.154
positive regulation of cellular biosynthetic process	GO:0031328	316	0.150	Mouse
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.150
cellular response to dna damage stimulus	GO:0006974	223	0.150
intracellular signal transduction	GO:0035556	300	0.149
imaginal disc derived wing morphogenesis	GO:0007476	337	0.148
transcription from rna polymerase ii promoter	GO:0006366	368	0.147	Mouse
establishment of localization in cell	GO:0051649	402	0.145
dendrite morphogenesis	GO:0048813	199	0.142
negative regulation of cellular biosynthetic process	GO:0031327	277	0.141
muscle cell development	GO:0055001	50	0.139
open tracheal system development	GO:0007424	204	0.139
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.137
regulation of protein modification process	GO:0031399	112	0.135
stem cell differentiation	GO:0048863	117	0.134
organelle assembly	GO:0070925	198	0.133
post embryonic appendage morphogenesis	GO:0035120	385	0.131
muscle cell differentiation	GO:0042692	103	0.128
methylation	GO:0032259	47	0.127
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.122
stem cell maintenance	GO:0019827	67	0.118
dendrite development	GO:0016358	204	0.117
response to abiotic stimulus	GO:0009628	341	0.115
molting cycle	GO:0042303	56	0.115
axon development	GO:0061564	297	0.114
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.111	Mouse
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.111	Mouse
rna splicing	GO:0008380	83	0.109
regulation of multicellular organismal development	GO:2000026	414	0.102	Worm
regulation of cellular amine metabolic process	GO:0033238	3	0.101
appendage development	GO:0048736	401	0.101
cell motility	GO:0048870	251	0.094	Worm
actin cytoskeleton organization	GO:0030036	206	0.092
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.086	Mouse
regulation of nervous system development	GO:0051960	248	0.086
regulation of cellular protein metabolic process	GO:0032268	243	0.085
proteolysis	GO:0006508	192	0.084
eye photoreceptor cell differentiation	GO:0001754	145	0.080
cytoplasmic transport	GO:0016482	130	0.079
regulation of cellular ketone metabolic process	GO:0010565	3	0.079	Mouse
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.078
body morphogenesis	GO:0010171	2	0.076
immune response	GO:0006955	246	0.074
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.074	Mouse
spermatogenesis	GO:0007283	200	0.071
axonogenesis	GO:0007409	290	0.070
dna biosynthetic process	GO:0071897	24	0.069
imaginal disc derived wing vein specification	GO:0007474	48	0.069
response to radiation	GO:0009314	155	0.068
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.068
striated muscle cell development	GO:0055002	50	0.067
neuronal stem cell maintenance	GO:0097150	4	0.066
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.064
positive regulation of signaling	GO:0023056	243	0.063
central nervous system development	GO:0007417	201	0.061
regulation of cellular amino acid metabolic process	GO:0006521	0	0.060
photoreceptor cell differentiation	GO:0046530	170	0.058
regulation of rna splicing	GO:0043484	69	0.056
intracellular transport	GO:0046907	228	0.055
histone h3 acetylation	GO:0043966	11	0.051	Human
establishment of protein localization	GO:0045184	163	0.050
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.050
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	73	0.048
phosphorylation	GO:0016310	294	0.047
negative regulation of developmental process	GO:0051093	201	0.047	Worm
cellular response to chemical stimulus	GO:0070887	199	0.047
amine metabolic process	GO:0009308	12	0.046
regulation of cell differentiation	GO:0045595	302	0.046
regulation of erbb signaling pathway	GO:1901184	42	0.046
nucleosome organization	GO:0034728	59	0.044
mrna splicing via spliceosome	GO:0000398	73	0.043
muscle structure development	GO:0061061	224	0.041
dna damage checkpoint	GO:0000077	78	0.040
negative regulation of cell cycle	GO:0045786	116	0.040
rna processing	GO:0006396	147	0.040
actomyosin structure organization	GO:0031032	56	0.039
regulation of protein metabolic process	GO:0051246	256	0.039
transmembrane transport	GO:0055085	139	0.039
cellular amine metabolic process	GO:0044106	12	0.038
immune system process	GO:0002376	347	0.037
phagocytosis	GO:0006909	215	0.037
myofibril assembly	GO:0030239	36	0.037
modification dependent macromolecule catabolic process	GO:0043632	79	0.036
single organism intracellular transport	GO:1902582	207	0.036
postreplication repair	GO:0006301	2	0.036
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.035	Mouse
response to endogenous stimulus	GO:0009719	119	0.035
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.034
positive regulation of signal transduction	GO:0009967	223	0.034
dorsal ventral pattern formation	GO:0009953	133	0.033
organic acid metabolic process	GO:0006082	103	0.033
anterior posterior axis specification	GO:0009948	109	0.032
regulation of bmp signaling pathway	GO:0030510	23	0.032
regulation of immune response	GO:0050776	118	0.032
cellular protein localization	GO:0034613	160	0.032
respiratory system development	GO:0060541	213	0.031
neuron fate commitment	GO:0048663	50	0.030
nucleocytoplasmic transport	GO:0006913	72	0.029
axon guidance	GO:0007411	233	0.028
protein catabolic process	GO:0030163	101	0.028
defense response	GO:0006952	300	0.028
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.028
spindle organization	GO:0007051	253	0.028
inter male aggressive behavior	GO:0002121	60	0.028
proteasomal protein catabolic process	GO:0010498	59	0.028
mrna metabolic process	GO:0016071	124	0.028
regulation of immune system process	GO:0002682	176	0.027
positive regulation of cell communication	GO:0010647	250	0.027
tube morphogenesis	GO:0035239	191	0.026
regulation of gene expression epigenetic	GO:0040029	128	0.026
male gamete generation	GO:0048232	201	0.026
regulation of mrna splicing via spliceosome	GO:0048024	64	0.025
carboxylic acid metabolic process	GO:0019752	92	0.025
erbb signaling pathway	GO:0038127	58	0.025
forebrain development	GO:0030900	2	0.025
regulation of phosphorylation	GO:0042325	147	0.025
regulation of phosphorus metabolic process	GO:0051174	210	0.024
embryo development ending in birth or egg hatching	GO:0009792	152	0.024
macromolecule methylation	GO:0043414	45	0.024
regulation of intracellular signal transduction	GO:1902531	236	0.022
neurological system process	GO:0050877	358	0.021
negative regulation of cell differentiation	GO:0045596	143	0.021
axis specification	GO:0009798	167	0.021
stem cell development	GO:0048864	79	0.021
cell fate specification	GO:0001708	71	0.021
organonitrogen compound metabolic process	GO:1901564	318	0.021
cellular macromolecule catabolic process	GO:0044265	136	0.021
head development	GO:0060322	135	0.020
germ line stem cell maintenance	GO:0030718	50	0.020
positive regulation of immune response	GO:0050778	63	0.020
actin filament based process	GO:0030029	220	0.020
nuclear export	GO:0051168	24	0.020
response to alcohol	GO:0097305	95	0.020
translesion synthesis	GO:0019985	2	0.020
positive regulation of response to stimulus	GO:0048584	323	0.019
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.019
regulation of notch signaling pathway	GO:0008593	100	0.019
negative regulation of signal transduction	GO:0009968	206	0.019
protein alkylation	GO:0008213	43	0.019
spindle assembly involved in mitosis	GO:0090307	50	0.019
regulation of transport	GO:0051049	181	0.019
striated muscle cell differentiation	GO:0051146	90	0.019
response to organic substance	GO:0010033	284	0.019
olfactory behavior	GO:0042048	97	0.019
nuclear transport	GO:0051169	72	0.018
positive regulation of immune system process	GO:0002684	68	0.018
protein transport	GO:0015031	155	0.018
negative regulation of protein modification process	GO:0031400	29	0.018
protein localization to organelle	GO:0033365	82	0.018
organic substance transport	GO:0071702	257	0.018
embryonic pattern specification	GO:0009880	174	0.018
negative regulation of protein metabolic process	GO:0051248	85	0.018
regulation of alternative mrna splicing via spliceosome	GO:0000381	60	0.018
protein complex assembly	GO:0006461	200	0.018
positive regulation of histone deacetylation	GO:0031065	2	0.018
regulation of response to stress	GO:0080134	200	0.018
cell death	GO:0008219	279	0.017	Worm
protein targeting to nucleus	GO:0044744	51	0.017
endocytosis	GO:0006897	310	0.017
defense response to other organism	GO:0098542	225	0.017
apoptotic process	GO:0006915	159	0.017	Worm
regulation of phosphatase activity	GO:0010921	3	0.016
negative regulation of rna biosynthetic process	GO:1902679	240	0.016
gtp metabolic process	GO:0046039	72	0.016
oxoacid metabolic process	GO:0043436	103	0.016
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.016
developmental maturation	GO:0021700	172	0.016
hematopoietic progenitor cell differentiation	GO:0002244	1	0.016
macromolecule catabolic process	GO:0009057	161	0.016
protein maturation	GO:0051604	71	0.015
ubiquitin dependent protein catabolic process	GO:0006511	78	0.015
regulation of nucleocytoplasmic transport	GO:0046822	35	0.015
rna splicing via transesterification reactions	GO:0000375	73	0.015
nucleobase containing compound transport	GO:0015931	56	0.015
organelle localization	GO:0051640	148	0.015
aging	GO:0007568	143	0.015	Worm
regulation of mrna metabolic process	GO:1903311	72	0.014
negative regulation of cellular protein metabolic process	GO:0032269	85	0.014
single organism cellular localization	GO:1902580	180	0.014
mitotic cytokinesis	GO:0000281	50	0.014
larval development	GO:0002164	104	0.014	Worm
establishment or maintenance of cell polarity	GO:0007163	167	0.014
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	18	0.014
regulation of cell cycle phase transition	GO:1901987	130	0.014
negative regulation of response to stimulus	GO:0048585	258	0.014
negative regulation of transcription dna templated	GO:0045892	237	0.014
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.014
mrna processing	GO:0006397	104	0.013
small molecule metabolic process	GO:0044281	305	0.013	Mouse
positive regulation of protein deacetylation	GO:0090312	2	0.013
regulation of molecular function	GO:0065009	217	0.013
histone deubiquitination	GO:0016578	8	0.013
neuron recognition	GO:0008038	101	0.013
negative regulation of biosynthetic process	GO:0009890	277	0.013
positive regulation of cellular component organization	GO:0051130	156	0.013
cell cycle checkpoint	GO:0000075	95	0.013
compound eye development	GO:0048749	307	0.013
regulation of neuron differentiation	GO:0045664	103	0.013
protein processing	GO:0016485	68	0.013
intracellular protein transport	GO:0006886	104	0.013
mitochondrion organization	GO:0007005	65	0.013
cellular macromolecule localization	GO:0070727	220	0.012
neuron projection guidance	GO:0097485	241	0.012
regulation of hemocyte proliferation	GO:0035206	37	0.012
nucleobase containing compound catabolic process	GO:0034655	165	0.012
bmp signaling pathway	GO:0030509	27	0.012
protein phosphorylation	GO:0006468	169	0.012
cell migration	GO:0016477	238	0.012	Worm
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.011
oocyte development	GO:0048599	124	0.011
exocrine system development	GO:0035272	162	0.011
response to biotic stimulus	GO:0009607	294	0.011
regulation of meiosis	GO:0040020	3	0.011
eye photoreceptor cell fate commitment	GO:0042706	37	0.011
salivary gland development	GO:0007431	162	0.011
regulation of cytoplasmic transport	GO:1903649	47	0.011
positive regulation of notch signaling pathway	GO:0045747	34	0.011
segmentation	GO:0035282	207	0.011
dna metabolic process	GO:0006259	227	0.011
ras protein signal transduction	GO:0007265	88	0.011
hindbrain development	GO:0030902	2	0.011
anatomical structure homeostasis	GO:0060249	97	0.011
protein targeting	GO:0006605	64	0.010
notch signaling pathway	GO:0007219	120	0.010
cell maturation	GO:0048469	144	0.010
striated muscle myosin thick filament assembly	GO:0071688	3	0.010
regulation of phosphate metabolic process	GO:0019220	210	0.010
chemosensory behavior	GO:0007635	106	0.010
cellular protein catabolic process	GO:0044257	83	0.010

wds disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	nervous system disease	DOID:863	0	0.013
	disease of anatomical entity	DOID:7	0	0.013

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