IMP: Integrative Multi-species Prediction

Drosophila melanogaster

15 known processes

Pde9 (Dmel_CG42276)

Phosphodiesterase 9

(Aliases: Dmel_CG32648,Dmel\CG42276,CG1627,Dmel_CG3754,CG3761,CG42276,PDE9,CG3754,CG3765,CG32648)

Entrez: 32233
FLYBASE: FBgn0259171
UniProtKB: Q9VYJ0
UniProtKB: Q9I7S6

Process Predictions
Disease Predictions

Pde9 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
vesicle mediated transport	GO:0016192	381	0.078
response to external biotic stimulus	GO:0043207	293	0.076
organic acid metabolic process	GO:0006082	103	0.069
neurological system process	GO:0050877	358	0.067
establishment of localization in cell	GO:0051649	402	0.064
regulation of localization	GO:0032879	275	0.056
single organism behavior	GO:0044708	391	0.052
imaginal disc derived appendage development	GO:0048737	399	0.050
positive regulation of signal transduction	GO:0009967	223	0.048
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.047
positive regulation of response to stimulus	GO:0048584	323	0.046
appendage morphogenesis	GO:0035107	397	0.045
protein modification process	GO:0036211	438	0.044
endocytosis	GO:0006897	310	0.042
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.041
neuron recognition	GO:0008038	101	0.041
regulation of neurogenesis	GO:0050767	158	0.040
regulation of transport	GO:0051049	181	0.039
phagocytosis	GO:0006909	215	0.039
axon development	GO:0061564	297	0.038
innate immune response	GO:0045087	144	0.037
death	GO:0016265	284	0.037
adult behavior	GO:0030534	137	0.036
oxoacid metabolic process	GO:0043436	103	0.036
carboxylic acid metabolic process	GO:0019752	92	0.036
axis specification	GO:0009798	167	0.035
imaginal disc derived wing morphogenesis	GO:0007476	337	0.035
small gtpase mediated signal transduction	GO:0007264	88	0.035
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.035
intracellular signal transduction	GO:0035556	300	0.035
cellular protein modification process	GO:0006464	438	0.034
regulation of intracellular signal transduction	GO:1902531	236	0.034
wing disc morphogenesis	GO:0007472	344	0.034
response to biotic stimulus	GO:0009607	294	0.034
mating	GO:0007618	120	0.034
positive regulation of rna biosynthetic process	GO:1902680	266	0.034
organonitrogen compound metabolic process	GO:1901564	318	0.033
positive regulation of cell communication	GO:0010647	250	0.033
positive regulation of intracellular signal transduction	GO:1902533	116	0.032
regulation of molecular function	GO:0065009	217	0.032
appendage development	GO:0048736	401	0.032
transmembrane transport	GO:0055085	139	0.031
regulation of neuron differentiation	GO:0045664	103	0.031
positive regulation of biosynthetic process	GO:0009891	316	0.031
small molecule metabolic process	GO:0044281	305	0.031
cell death	GO:0008219	279	0.030
centrosome cycle	GO:0007098	137	0.030
positive regulation of macromolecule metabolic process	GO:0010604	405	0.030
cellular amino acid metabolic process	GO:0006520	61	0.029
defense response	GO:0006952	300	0.029
cellular amine metabolic process	GO:0044106	12	0.029
benzene containing compound metabolic process	GO:0042537	3	0.028
response to bacterium	GO:0009617	198	0.028
response to organic substance	GO:0010033	284	0.028
single organism cellular localization	GO:1902580	180	0.028
positive regulation of signaling	GO:0023056	243	0.028
single organism intracellular transport	GO:1902582	207	0.027
transcription from rna polymerase ii promoter	GO:0006366	368	0.027
gland development	GO:0048732	191	0.027
dendrite development	GO:0016358	204	0.027
synaptic transmission	GO:0007268	288	0.026
ion transport	GO:0006811	145	0.026
g protein coupled receptor signaling pathway	GO:0007186	136	0.026
cation transport	GO:0006812	110	0.026
salivary gland morphogenesis	GO:0007435	145	0.026
immune system process	GO:0002376	347	0.025
microtubule organizing center organization	GO:0031023	168	0.025
regulation of catalytic activity	GO:0050790	185	0.025
cellular ketone metabolic process	GO:0042180	24	0.025
positive regulation of phosphate metabolic process	GO:0045937	139	0.025
reproductive behavior	GO:0019098	122	0.025
regionalization	GO:0003002	416	0.024
positive regulation of rna metabolic process	GO:0051254	271	0.024
negative regulation of response to stimulus	GO:0048585	258	0.024
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.024
post embryonic appendage morphogenesis	GO:0035120	385	0.024
intracellular transport	GO:0046907	228	0.023
regulation of protein metabolic process	GO:0051246	256	0.023
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.023
regulation of phosphate metabolic process	GO:0019220	210	0.023
amine metabolic process	GO:0009308	12	0.023
gene silencing	GO:0016458	138	0.023
organic substance transport	GO:0071702	257	0.023
eye development	GO:0001654	323	0.023
nuclear division	GO:0000280	332	0.022
negative regulation of signaling	GO:0023057	219	0.022
positive regulation of cellular biosynthetic process	GO:0031328	316	0.022
proteolysis	GO:0006508	192	0.022
epithelial cell differentiation	GO:0030855	322	0.022
centrosome organization	GO:0051297	163	0.022
regulation of catabolic process	GO:0009894	170	0.022
embryonic development via the syncytial blastoderm	GO:0001700	148	0.022
response to abiotic stimulus	GO:0009628	341	0.022
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.022
regulation of cellular amine metabolic process	GO:0033238	3	0.021
defense response to bacterium	GO:0042742	178	0.021
regulation of cellular amino acid metabolic process	GO:0006521	0	0.021
immune response	GO:0006955	246	0.021
positive regulation of transport	GO:0051050	92	0.021
regulation of cellular protein metabolic process	GO:0032268	243	0.021
catabolic process	GO:0009056	409	0.021
regulation of cellular ketone metabolic process	GO:0010565	3	0.021
forebrain development	GO:0030900	2	0.021
defense response to other organism	GO:0098542	225	0.020
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.020
positive regulation of phosphorus metabolic process	GO:0010562	139	0.020
response to other organism	GO:0051707	293	0.020
establishment of protein localization	GO:0045184	163	0.020
cellular macromolecule localization	GO:0070727	220	0.020
programmed cell death	GO:0012501	257	0.020
regulation of gene expression epigenetic	GO:0040029	128	0.020
phosphorylation	GO:0016310	294	0.019
regulation of phosphorus metabolic process	GO:0051174	210	0.019
synapse assembly	GO:0007416	143	0.019
l amino acid import	GO:0043092	2	0.019
camera type eye development	GO:0043010	4	0.019
developmental maturation	GO:0021700	172	0.019
negative regulation of gene expression	GO:0010629	387	0.019
positive regulation of transcription dna templated	GO:0045893	266	0.019
chromosome organization	GO:0051276	360	0.019
tissue death	GO:0016271	102	0.019
protein localization	GO:0008104	284	0.019
chemosensory behavior	GO:0007635	106	0.019
regulation of ion transport	GO:0043269	39	0.019
histolysis	GO:0007559	102	0.019
response to oxygen containing compound	GO:1901700	200	0.019
negative regulation of cellular metabolic process	GO:0031324	382	0.019
sensory perception of pain	GO:0019233	4	0.019
positive regulation of catalytic activity	GO:0043085	118	0.018
positive regulation of phosphorylation	GO:0042327	87	0.018
organelle fission	GO:0048285	340	0.018
centrosome duplication	GO:0051298	121	0.018
organic substance catabolic process	GO:1901575	308	0.018
olfactory behavior	GO:0042048	97	0.018
regulation of cell death	GO:0010941	173	0.018
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.018
positive regulation of cellular amine metabolic process	GO:0033240	0	0.018
axonogenesis	GO:0007409	290	0.018
negative regulation of cell communication	GO:0010648	223	0.017
compound eye development	GO:0048749	307	0.017
lateral inhibition	GO:0046331	206	0.017
regulation of phosphorylation	GO:0042325	147	0.017
epithelial cell development	GO:0002064	274	0.017
locomotory behavior	GO:0007626	176	0.017
organophosphate metabolic process	GO:0019637	195	0.017
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.017
synapse organization	GO:0050808	196	0.017
salivary gland cell autophagic cell death	GO:0035071	83	0.017
ras protein signal transduction	GO:0007265	88	0.017
regulation of organelle organization	GO:0033043	196	0.017
male gamete generation	GO:0048232	201	0.017
endomembrane system organization	GO:0010256	119	0.017
regulation of response to stress	GO:0080134	200	0.017
regulation of vesicle mediated transport	GO:0060627	59	0.017
synaptic target recognition	GO:0008039	45	0.017
dorsal ventral pattern formation	GO:0009953	133	0.017
multi organism behavior	GO:0051705	175	0.017
body morphogenesis	GO:0010171	2	0.016
chromatin organization	GO:0006325	207	0.016
tube development	GO:0035295	244	0.016
positive regulation of gene expression	GO:0010628	290	0.016
carbohydrate derivative metabolic process	GO:1901135	217	0.016
regulation of neuron projection development	GO:0010975	69	0.016
sterol homeostasis	GO:0055092	4	0.016
regulation of multicellular organismal development	GO:2000026	414	0.016
posttranscriptional regulation of gene expression	GO:0010608	145	0.016
single organism catabolic process	GO:0044712	228	0.016
photoreceptor cell differentiation	GO:0046530	170	0.016
developmental pigmentation	GO:0048066	68	0.016
salivary gland development	GO:0007431	162	0.015
positive regulation of protein metabolic process	GO:0051247	128	0.015
kidney development	GO:0001822	3	0.015
ion transmembrane transport	GO:0034220	122	0.015
carbohydrate metabolic process	GO:0005975	82	0.015
regulation of dendrite development	GO:0050773	37	0.015
inter male aggressive behavior	GO:0002121	60	0.015
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.015
regulation of cell development	GO:0060284	215	0.015
positive regulation of neurogenesis	GO:0050769	41	0.015
central nervous system development	GO:0007417	201	0.015
cholesterol homeostasis	GO:0042632	3	0.015
purine nucleotide metabolic process	GO:0006163	146	0.015
sensory perception	GO:0007600	196	0.015
single organism biosynthetic process	GO:0044711	206	0.015
salivary gland histolysis	GO:0035070	88	0.015
dendrite morphogenesis	GO:0048813	199	0.015
regulation of cell differentiation	GO:0045595	302	0.015
autophagic cell death	GO:0048102	83	0.015
exocrine system development	GO:0035272	162	0.015
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.015
single organism carbohydrate metabolic process	GO:0044723	72	0.015
columnar cuboidal epithelial cell development	GO:0002066	249	0.015
positive regulation of developmental process	GO:0051094	143	0.015
cellular response to ethanol	GO:0071361	4	0.014
spermatogenesis	GO:0007283	200	0.014
neuropeptide signaling pathway	GO:0007218	45	0.014
positive regulation of mapk cascade	GO:0043410	63	0.014
meiotic cell cycle	GO:0051321	171	0.014
regulation of ras protein signal transduction	GO:0046578	93	0.014
organelle localization	GO:0051640	148	0.014
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.014
regulation of gene silencing	GO:0060968	63	0.014
cellular catabolic process	GO:0044248	372	0.014
regulation of apoptotic process	GO:0042981	130	0.013
negative regulation of cellular component organization	GO:0051129	108	0.013
ribonucleotide metabolic process	GO:0009259	145	0.013
single organism membrane organization	GO:0044802	93	0.013
regulation of synaptic transmission	GO:0050804	69	0.013
cellular response to chemical stimulus	GO:0070887	199	0.013
membrane organization	GO:0061024	112	0.013
inorganic ion transmembrane transport	GO:0098660	73	0.013
regulation of synapse structure and activity	GO:0050803	128	0.013
response to lipopolysaccharide	GO:0032496	4	0.013
regulation of immune system process	GO:0002682	176	0.013
negative regulation of biosynthetic process	GO:0009890	277	0.013
eggshell formation	GO:0030703	105	0.013
positive regulation of exocytosis	GO:0045921	4	0.013
cellularization	GO:0007349	90	0.013
regulation of membrane potential	GO:0042391	35	0.013
protein modification by small protein conjugation or removal	GO:0070647	106	0.013
response to copper ion	GO:0046688	4	0.013
response to wounding	GO:0009611	94	0.013
detection of light stimulus	GO:0009583	58	0.013
positive regulation of calcium ion transport	GO:0051928	4	0.013
negative regulation of rna metabolic process	GO:0051253	251	0.013
pigment metabolic process	GO:0042440	84	0.013
regulation of cellular catabolic process	GO:0031329	157	0.013
regulation of transferase activity	GO:0051338	58	0.013
heterocycle catabolic process	GO:0046700	166	0.013
synaptic vesicle transport	GO:0048489	50	0.013
dorsal ventral axis specification	GO:0009950	66	0.013
signal transduction by phosphorylation	GO:0023014	107	0.013
compound eye photoreceptor cell differentiation	GO:0001751	140	0.013
protein phosphorylation	GO:0006468	169	0.013
adult locomotory behavior	GO:0008344	76	0.012
dna metabolic process	GO:0006259	227	0.012
response to endogenous stimulus	GO:0009719	119	0.012
eye photoreceptor cell development	GO:0042462	81	0.012
positive regulation of cell death	GO:0010942	69	0.012
cell maturation	GO:0048469	144	0.012
regulation of protein modification process	GO:0031399	112	0.012
negative regulation of signal transduction	GO:0009968	206	0.012
cellular macromolecule catabolic process	GO:0044265	136	0.012
protein processing	GO:0016485	68	0.012
positive regulation of erk1 and erk2 cascade	GO:0070374	36	0.012
detection of stimulus	GO:0051606	156	0.012
positive regulation of molecular function	GO:0044093	136	0.012
lipid metabolic process	GO:0006629	121	0.012
tissue morphogenesis	GO:0048729	297	0.012
positive regulation of catabolic process	GO:0009896	105	0.012
regulation of cell cycle phase transition	GO:1901987	130	0.012
developmental programmed cell death	GO:0010623	138	0.012
tube morphogenesis	GO:0035239	191	0.012
cellular modified amino acid metabolic process	GO:0006575	45	0.012
ovarian follicle cell development	GO:0030707	248	0.012
intracellular protein transport	GO:0006886	104	0.012
mapk cascade	GO:0000165	107	0.012
cellular protein localization	GO:0034613	160	0.012
mitotic spindle organization	GO:0007052	220	0.012
regulation of programmed cell death	GO:0043067	152	0.011
chemical homeostasis	GO:0048878	92	0.011
telencephalon development	GO:0021537	2	0.011
secretion by cell	GO:0032940	101	0.011
regulation of nervous system development	GO:0051960	248	0.011
establishment of organelle localization	GO:0051656	122	0.011
negative regulation of cell differentiation	GO:0045596	143	0.011
regulation of sterol transport	GO:0032371	1	0.011
positive regulation of cellular protein metabolic process	GO:0032270	118	0.011
androgen metabolic process	GO:0008209	1	0.011
gtp catabolic process	GO:0006184	72	0.011
positive regulation of hydrolase activity	GO:0051345	78	0.011
compound eye morphogenesis	GO:0001745	249	0.011
purine ribonucleotide metabolic process	GO:0009150	145	0.011
cellular response to organic substance	GO:0071310	132	0.011
rna localization	GO:0006403	115	0.011
secondary metabolic process	GO:0019748	75	0.011
phosphatidylethanolamine metabolic process	GO:0046337	1	0.011
cholesterol transport	GO:0030301	2	0.011
organophosphate catabolic process	GO:0046434	112	0.011
homeostatic process	GO:0042592	199	0.011
regulation of gtpase activity	GO:0043087	44	0.011
apoptotic process	GO:0006915	159	0.011
xenobiotic catabolic process	GO:0042178	1	0.011
digestive system development	GO:0055123	149	0.011
ribosomal large subunit biogenesis	GO:0042273	1	0.011
protein ubiquitination	GO:0016567	70	0.011
digestive tract development	GO:0048565	149	0.011
nucleobase containing small molecule metabolic process	GO:0055086	174	0.011
synaptic vesicle localization	GO:0097479	53	0.011
response to nitrogen compound	GO:1901698	90	0.011
response to radiation	GO:0009314	155	0.011
phototransduction	GO:0007602	52	0.011
secretion	GO:0046903	109	0.011
regulation of mapk cascade	GO:0043408	92	0.011
cell proliferation	GO:0008283	299	0.011
kidney epithelium development	GO:0072073	3	0.011
taxis	GO:0042330	304	0.011
protein transport	GO:0015031	155	0.011
regulation of synapse organization	GO:0050807	110	0.011
protein modification by small protein conjugation	GO:0032446	79	0.011
anatomical structure homeostasis	GO:0060249	97	0.010
spermatid differentiation	GO:0048515	114	0.010
modification dependent protein catabolic process	GO:0019941	78	0.010
respiratory system development	GO:0060541	213	0.010
dna conformation change	GO:0071103	105	0.010
sulfur compound metabolic process	GO:0006790	59	0.010
anterior posterior pattern specification	GO:0009952	136	0.010
negative regulation of protein metabolic process	GO:0051248	85	0.010
oocyte construction	GO:0007308	112	0.010
regulation of erk1 and erk2 cascade	GO:0070372	39	0.010
negative regulation of transcription dna templated	GO:0045892	237	0.010
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.010
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.010
regulation of lipid transport	GO:0032368	3	0.010
response to glucose	GO:0009749	2	0.010
nucleotide metabolic process	GO:0009117	161	0.010
regulation of mitotic cell cycle	GO:0007346	190	0.010

Pde9 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.047
nervous system disease	DOID:863	0.023
inherited metabolic disorder	DOID:655	0.019
familial hyperlipidemia	DOID:1168	0.019
lipid metabolism disorder	DOID:3146	0.019
disease of metabolism	DOID:0014667	0.019
sensory system disease	DOID:0050155	0.014
eye disease	DOID:5614	0.013
eye and adnexa disease	DOID:1492	0.013

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