IMP: Integrative Multi-species Prediction

Drosophila melanogaster

82 known processes

Pat1 (Dmel_CG10695)

Protein interacting with APP tail-1

(Aliases: CG10695,Dmel\CG10695,PAT1)

Entrez: 31593
FLYBASE: FBgn0029878
UniProtKB: M9PGT5
UniProtKB: Q9W3Y7

Process Predictions
Disease Predictions

Pat1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
establishment of localization in cell	GO:0051649	402	0.234
epithelial cell development	GO:0002064	274	0.174
synapse organization	GO:0050808	196	0.133
cellularization	GO:0007349	90	0.126
imaginal disc derived appendage development	GO:0048737	399	0.125
catabolic process	GO:0009056	409	0.114
positive regulation of biosynthetic process	GO:0009891	316	0.095
epithelial cell differentiation	GO:0030855	322	0.093
columnar cuboidal epithelial cell development	GO:0002066	249	0.090
cellular protein modification process	GO:0006464	438	0.087
vesicle mediated transport	GO:0016192	381	0.084
ovarian follicle cell development	GO:0030707	248	0.080
organonitrogen compound metabolic process	GO:1901564	318	0.079
macromolecule catabolic process	GO:0009057	161	0.071
cellular macromolecule catabolic process	GO:0044265	136	0.066
regulation of multicellular organismal development	GO:2000026	414	0.064
wing disc morphogenesis	GO:0007472	344	0.063
organic substance transport	GO:0071702	257	0.063
negative regulation of cell communication	GO:0010648	223	0.062
cellular component assembly involved in morphogenesis	GO:0010927	151	0.061
post embryonic appendage morphogenesis	GO:0035120	385	0.059
intracellular transport	GO:0046907	228	0.058
imaginal disc derived wing morphogenesis	GO:0007476	337	0.057
regulation of response to stress	GO:0080134	200	0.056
regulation of synapse structure and activity	GO:0050803	128	0.055
epithelium migration	GO:0090132	148	0.054
cellular catabolic process	GO:0044248	372	0.053
cellular lipid metabolic process	GO:0044255	83	0.052
regulation of catalytic activity	GO:0050790	185	0.051
compound eye development	GO:0048749	307	0.051
muscle cell differentiation	GO:0042692	103	0.051
cell motility	GO:0048870	251	0.051
organic substance catabolic process	GO:1901575	308	0.050
protein modification process	GO:0036211	438	0.049
organophosphate metabolic process	GO:0019637	195	0.049
immune response	GO:0006955	246	0.049
negative regulation of signal transduction	GO:0009968	206	0.048
humoral immune response	GO:0006959	117	0.048
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.047
localization of cell	GO:0051674	257	0.045
appendage development	GO:0048736	401	0.045
regulation of cellular component biogenesis	GO:0044087	201	0.043
regulation of synapse organization	GO:0050807	110	0.041
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.040
tissue death	GO:0016271	102	0.040
endocytosis	GO:0006897	310	0.039
regulation of localization	GO:0032879	275	0.039
kidney epithelium development	GO:0072073	3	0.039
regulation of cellular response to stress	GO:0080135	89	0.039
developmental programmed cell death	GO:0010623	138	0.038
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.038
organic cyclic compound catabolic process	GO:1901361	168	0.035
protein localization	GO:0008104	284	0.035
compound eye morphogenesis	GO:0001745	249	0.034
lipid metabolic process	GO:0006629	121	0.033
nucleobase containing small molecule metabolic process	GO:0055086	174	0.033
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.032
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.032
cell migration	GO:0016477	238	0.032
nucleobase containing compound catabolic process	GO:0034655	165	0.032
small molecule metabolic process	GO:0044281	305	0.032
protein modification by small protein conjugation	GO:0032446	79	0.031
translation	GO:0006412	69	0.031
response to external biotic stimulus	GO:0043207	293	0.030
single organism intracellular transport	GO:1902582	207	0.030
carbohydrate derivative catabolic process	GO:1901136	118	0.029
nucleoside catabolic process	GO:0009164	112	0.029
dendrite development	GO:0016358	204	0.029
sodium dependent phosphate transport	GO:0044341	2	0.029
heterocycle catabolic process	GO:0046700	166	0.029
notch signaling pathway	GO:0007219	120	0.028
immune response activating signal transduction	GO:0002757	2	0.028
stress activated mapk cascade	GO:0051403	52	0.028
programmed cell death	GO:0012501	257	0.028
negative regulation of cellular protein metabolic process	GO:0032269	85	0.027
aromatic compound catabolic process	GO:0019439	166	0.027
dorsal ventral pattern formation	GO:0009953	133	0.027
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.027
carboxylic acid transport	GO:0046942	18	0.027
response to bacterium	GO:0009617	198	0.026
embryonic development via the syncytial blastoderm	GO:0001700	148	0.026
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.026
nephron development	GO:0072006	3	0.025
immune response regulating signaling pathway	GO:0002764	2	0.025
appendage morphogenesis	GO:0035107	397	0.025
regulation of phosphorus metabolic process	GO:0051174	210	0.025
regulation of alternative mrna splicing via spliceosome	GO:0000381	60	0.025
single organism membrane organization	GO:0044802	93	0.025
membrane organization	GO:0061024	112	0.024
positive regulation of immune response	GO:0050778	63	0.024
negative regulation of gene expression	GO:0010629	387	0.024
regulation of stress activated mapk cascade	GO:0032872	41	0.023
regulation of response to dna damage stimulus	GO:2001020	23	0.023
anterior posterior axis specification embryo	GO:0008595	103	0.023
negative regulation of intracellular signal transduction	GO:1902532	57	0.023
actin filament based process	GO:0030029	220	0.023
stress activated protein kinase signaling cascade	GO:0031098	55	0.023
exocrine system development	GO:0035272	162	0.023
mapk cascade	GO:0000165	107	0.023
single organism biosynthetic process	GO:0044711	206	0.022
defense response	GO:0006952	300	0.022
glycosyl compound metabolic process	GO:1901657	127	0.022
dorsal ventral pattern formation imaginal disc	GO:0007450	51	0.022
protein ubiquitination	GO:0016567	70	0.022
anterior posterior pattern specification	GO:0009952	136	0.022
cellular amino acid metabolic process	GO:0006520	61	0.022
tripartite regional subdivision	GO:0007351	103	0.022
positive regulation of protein metabolic process	GO:0051247	128	0.021
negative regulation of signaling	GO:0023057	219	0.021
anterior posterior axis specification	GO:0009948	109	0.021
stem cell differentiation	GO:0048863	117	0.021
developmental growth	GO:0048589	280	0.021
developmental maturation	GO:0021700	172	0.021
eye development	GO:0001654	323	0.020
multi organism behavior	GO:0051705	175	0.020
salivary gland morphogenesis	GO:0007435	145	0.020
positive regulation of multicellular organismal process	GO:0051240	143	0.020
salivary gland development	GO:0007431	162	0.020
striated muscle cell development	GO:0055002	50	0.020
negative regulation of molecular function	GO:0044092	51	0.020
regulation of cell cycle	GO:0051726	291	0.020
regulation of kinase activity	GO:0043549	53	0.020
neurological system process	GO:0050877	358	0.019
sensory organ morphogenesis	GO:0090596	260	0.019
autophagy	GO:0006914	108	0.019
regulation of molecular function	GO:0065009	217	0.019
spermatogenesis	GO:0007283	200	0.019
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.019
regulation of growth	GO:0040008	233	0.019
locomotory behavior	GO:0007626	176	0.019	Fly
purine nucleotide metabolic process	GO:0006163	146	0.019
eye morphogenesis	GO:0048592	260	0.018
response to endogenous stimulus	GO:0009719	119	0.018
muscle structure development	GO:0061061	224	0.018
phagocytosis	GO:0006909	215	0.018
pigmentation	GO:0043473	75	0.018
regulation of cellular ketone metabolic process	GO:0010565	3	0.018
regulation of nervous system development	GO:0051960	248	0.018
regulation of catabolic process	GO:0009894	170	0.018
immune system process	GO:0002376	347	0.018
regulation of intracellular signal transduction	GO:1902531	236	0.018
mrna metabolic process	GO:0016071	124	0.018
gland morphogenesis	GO:0022612	145	0.017
ribonucleotide catabolic process	GO:0009261	109	0.017
single organism behavior	GO:0044708	391	0.017	Fly
regulation of jnk cascade	GO:0046328	40	0.017
regulation of hydrolase activity	GO:0051336	97	0.017
negative regulation of phosphate metabolic process	GO:0045936	45	0.017
nucleoside triphosphate metabolic process	GO:0009141	120	0.017
purine ribonucleotide metabolic process	GO:0009150	145	0.017
growth	GO:0040007	359	0.017
negative regulation of response to stimulus	GO:0048585	258	0.017
lipid modification	GO:0030258	24	0.017
purine nucleotide catabolic process	GO:0006195	109	0.017
amine metabolic process	GO:0009308	12	0.017
defense response to other organism	GO:0098542	225	0.016
sperm individualization	GO:0007291	48	0.016
mrna catabolic process	GO:0006402	33	0.016
cognition	GO:0050890	141	0.016
regulation of protein metabolic process	GO:0051246	256	0.016
nitrogen compound transport	GO:0071705	85	0.016
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.016
purine containing compound metabolic process	GO:0072521	155	0.016
regulation of cellular protein metabolic process	GO:0032268	243	0.016
regulation of mrna splicing via spliceosome	GO:0048024	64	0.016
endomembrane system organization	GO:0010256	119	0.015
actin cytoskeleton organization	GO:0030036	206	0.015
glycerolipid metabolic process	GO:0046486	34	0.015
nuclear transcribed mrna catabolic process	GO:0000956	24	0.015
gtp catabolic process	GO:0006184	72	0.015
organelle assembly	GO:0070925	198	0.015
body morphogenesis	GO:0010171	2	0.015
regulation of cellular amino acid metabolic process	GO:0006521	0	0.015
positive regulation of signaling	GO:0023056	243	0.015
axonogenesis	GO:0007409	290	0.015
rna localization	GO:0006403	115	0.015
negative regulation of cellular metabolic process	GO:0031324	382	0.015
rna catabolic process	GO:0006401	37	0.015
cellular macromolecule localization	GO:0070727	220	0.015
histolysis	GO:0007559	102	0.014
gtp metabolic process	GO:0046039	72	0.014
secondary metabolic process	GO:0019748	75	0.014
gland development	GO:0048732	191	0.014
nucleoside phosphate metabolic process	GO:0006753	162	0.014
regulation of phosphate metabolic process	GO:0019220	210	0.014
positive regulation of catabolic process	GO:0009896	105	0.014
inter male aggressive behavior	GO:0002121	60	0.014
germ cell migration	GO:0008354	43	0.014
regulation of organelle organization	GO:0033043	196	0.014
regulation of cellular localization	GO:0060341	136	0.014
regulation of intracellular transport	GO:0032386	64	0.014
kidney development	GO:0001822	3	0.014
regulation of autophagy	GO:0010506	62	0.014
response to other organism	GO:0051707	293	0.014
cellular ketone metabolic process	GO:0042180	24	0.014
purine ribonucleotide catabolic process	GO:0009154	109	0.014
regulation of cell cycle process	GO:0010564	181	0.014
cell death	GO:0008219	279	0.014
cellular amine metabolic process	GO:0044106	12	0.013
wound healing	GO:0042060	75	0.013
organic acid metabolic process	GO:0006082	103	0.013
guanosine containing compound catabolic process	GO:1901069	74	0.013
regulation of anatomical structure size	GO:0090066	163	0.013
intracellular signal transduction	GO:0035556	300	0.013
oxoacid metabolic process	GO:0043436	103	0.013
ribonucleotide metabolic process	GO:0009259	145	0.013
signal transduction by phosphorylation	GO:0023014	107	0.013
positive regulation of cellular component organization	GO:0051130	156	0.013
organonitrogen compound catabolic process	GO:1901565	128	0.013
defense response to bacterium	GO:0042742	178	0.013
regulation of cellular catabolic process	GO:0031329	157	0.013
protein phosphorylation	GO:0006468	169	0.013
carboxylic acid metabolic process	GO:0019752	92	0.013
wing disc pattern formation	GO:0035222	66	0.013
reproductive structure development	GO:0048608	74	0.013
regulation of phosphorylation	GO:0042325	147	0.013
regulation of cell differentiation	GO:0045595	302	0.013
larval behavior	GO:0030537	42	0.013
regulation of actin filament based process	GO:0032970	42	0.012
nucleoside metabolic process	GO:0009116	127	0.012
transcription from rna polymerase ii promoter	GO:0006366	368	0.012
alternative mrna splicing via spliceosome	GO:0000380	60	0.012
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.012
purine ribonucleoside metabolic process	GO:0046128	127	0.012
response to oxygen containing compound	GO:1901700	200	0.012
regulation of cholesterol transport	GO:0032374	1	0.012
salivary gland histolysis	GO:0035070	88	0.012
jnk cascade	GO:0007254	50	0.012
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.012
positive regulation of hydrolase activity	GO:0051345	78	0.012
nephron epithelium development	GO:0072009	3	0.012
response to organic substance	GO:0010033	284	0.012
eggshell chorion assembly	GO:0007306	66	0.012
regulation of erbb signaling pathway	GO:1901184	42	0.011
regulation of imaginal disc derived wing size	GO:0044719	20	0.011
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.011
proteolysis	GO:0006508	192	0.011
cholesterol transport	GO:0030301	2	0.011
actomyosin structure organization	GO:0031032	56	0.011
organelle fission	GO:0048285	340	0.011
positive regulation of phosphorus metabolic process	GO:0010562	139	0.011
negative regulation of developmental process	GO:0051093	201	0.011
cellular response to dna damage stimulus	GO:0006974	223	0.011
response to abiotic stimulus	GO:0009628	341	0.011	Fly
regulation of immune system process	GO:0002682	176	0.011
purine nucleoside catabolic process	GO:0006152	112	0.011
negative regulation of peptidyl tyrosine phosphorylation	GO:0050732	6	0.011
regulation of lipid transport	GO:0032368	3	0.010
response to lipopolysaccharide	GO:0032496	4	0.010
negative regulation of protein metabolic process	GO:0051248	85	0.010
glycosyl compound catabolic process	GO:1901658	112	0.010
negative regulation of multicellular organismal process	GO:0051241	142	0.010
cellular response to organic substance	GO:0071310	132	0.010
nucleoside triphosphate catabolic process	GO:0009143	108	0.010
positive regulation of cellular biosynthetic process	GO:0031328	316	0.010
positive regulation of gene expression	GO:0010628	290	0.010
tissue migration	GO:0090130	155	0.010
purine ribonucleoside catabolic process	GO:0046130	112	0.010
purine containing compound catabolic process	GO:0072523	112	0.010
l amino acid import	GO:0043092	2	0.010

Pat1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.083
nervous system disease	DOID:863	0.022
disease of metabolism	DOID:0014667	0.021
central nervous system disease	DOID:331	0.015
neurodegenerative disease	DOID:1289	0.014
motor neuron disease	DOID:231	0.014
disease of cellular proliferation	DOID:14566	0.012

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