Drosophila melanogaster

44 known processes

Top3alpha (Dmel_CG10123)

Topoisomerase 3alpha

(Aliases: DmTop3alpha,Topo IIIalpha,Dmel\CG10123,CG10123,Top3a,top3alpha,dTopoIIIa)

Top3alpha biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
catabolic processGO:00090564090.382
organonitrogen compound metabolic processGO:19015643180.337
amine metabolic processGO:0009308120.307
gland developmentGO:00487321910.248
nucleobase containing compound catabolic processGO:00346551650.240
meiotic cell cycle processGO:19030461320.234
purine nucleoside metabolic processGO:00422781270.220
regulation of cellular component biogenesisGO:00440872010.214
axon developmentGO:00615642970.210
protein complex assemblyGO:00064612000.190
organic acid metabolic processGO:00060821030.189
negative regulation of cellular metabolic processGO:00313243820.182
cellular nitrogen compound catabolic processGO:00442701650.175
enzyme linked receptor protein signaling pathwayGO:00071671790.171
regulation of anatomical structure sizeGO:00900661630.169
heterocycle catabolic processGO:00467001660.167
positive regulation of hydrolase activityGO:0051345780.165
single organism catabolic processGO:00447122280.158
regulation of cellular amino acid metabolic processGO:000652100.157
nucleotide catabolic processGO:00091661090.144
response to abiotic stimulusGO:00096283410.140
cellular amine metabolic processGO:0044106120.139
actin filament based processGO:00300292200.136
positive regulation of cellular catabolic processGO:0031331950.132
cellular catabolic processGO:00442483720.130
cellular amino acid metabolic processGO:0006520610.126
carbohydrate derivative metabolic processGO:19011352170.125
positive regulation of molecular functionGO:00440931360.124
central nervous system developmentGO:00074172010.120
purine nucleoside catabolic processGO:00061521120.117
ribonucleoside catabolic processGO:00424541120.111
negative regulation of biosynthetic processGO:00098902770.109
morphogenesis of embryonic epitheliumGO:0016331940.087
small molecule metabolic processGO:00442813050.085
organic cyclic compound catabolic processGO:19013611680.085
aromatic compound catabolic processGO:00194391660.085
protein complex biogenesisGO:00702712010.084
growthGO:00400073590.083
dna metabolic processGO:00062592270.081
organonitrogen compound catabolic processGO:19015651280.080
organic substance catabolic processGO:19015753080.080
dna replicationGO:0006260480.079
axonogenesisGO:00074092900.078
protein phosphorylationGO:00064681690.075
nucleobase containing small molecule metabolic processGO:00550861740.074
regulation of hydrolase activityGO:0051336970.074
regulation of cellular response to stressGO:0080135890.070
nucleotide metabolic processGO:00091171610.070
regulation of cellular ketone metabolic processGO:001056530.069
regulation of cell cycleGO:00517262910.066
negative regulation of phosphorus metabolic processGO:0010563450.065
purine ribonucleoside metabolic processGO:00461281270.064
neurological system processGO:00508773580.062
nucleoside metabolic processGO:00091161270.061
brain developmentGO:00074201200.060
negative regulation of cell communicationGO:00106482230.060
multicellular organism growthGO:0035264460.058
negative regulation of response to stimulusGO:00485852580.058
ribonucleotide metabolic processGO:00092591450.055
negative regulation of cell cycle processGO:00109481090.053
regulation of cellular protein metabolic processGO:00322682430.053
positive regulation of macromolecule metabolic processGO:00106044050.053
oxoacid metabolic processGO:00434361030.052
response to light stimulusGO:00094161240.052
cellular response to dna damage stimulusGO:00069742230.052
positive regulation of nucleobase containing compound metabolic processGO:00459353320.051
macromolecular complex assemblyGO:00650032560.049
regulation of protein metabolic processGO:00512462560.048
ribonucleotide catabolic processGO:00092611090.048
ribose phosphate metabolic processGO:00196931450.048
spermatogenesisGO:00072832000.048
negative regulation of phosphorylationGO:0042326350.047
positive regulation of catalytic activityGO:00430851180.046
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092380.045
transmembrane transportGO:00550851390.045
negative regulation of erbb signaling pathwayGO:1901185290.045
regulation of molecular functionGO:00650092170.044
male gamete generationGO:00482322010.044
response to radiationGO:00093141550.044
macromolecule catabolic processGO:00090571610.043
regulation of cell deathGO:00109411730.042
positive regulation of peptidase activityGO:0010952290.042
carbohydrate derivative catabolic processGO:19011361180.042
negative regulation of macromolecule biosynthetic processGO:00105582700.042
regulation of cell cycle phase transitionGO:19019871300.042
establishment or maintenance of cell polarityGO:00071631670.041
positive regulation of catabolic processGO:00098961050.041
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280230.041
organelle assemblyGO:00709251980.040
purine nucleotide catabolic processGO:00061951090.039
head developmentGO:00603221350.038
glycosyl compound catabolic processGO:19016581120.038
embryonic morphogenesisGO:00485982060.037
regulation of catalytic activityGO:00507901850.037
signal transduction in response to dna damageGO:004277030.037
regulation of cellular catabolic processGO:00313291570.036
multicellular organismal agingGO:00102591400.036
negative regulation of signal transductionGO:00099682060.035
positive regulation of protein metabolic processGO:00512471280.034
regulation of response to stressGO:00801342000.034
actin cytoskeleton organizationGO:00300362060.034
ribonucleoside metabolic processGO:00091191270.034
ribonucleoside triphosphate catabolic processGO:00092031080.033
negative regulation of cellular biosynthetic processGO:00313272770.033
ribonucleoside monophosphate catabolic processGO:0009158390.033
organophosphate metabolic processGO:00196371950.032
peptidyl tyrosine phosphorylationGO:0018108240.031
forebrain developmentGO:003090020.031
programmed cell deathGO:00125012570.031
cellular macromolecular complex assemblyGO:00346221530.030
regulation of organelle organizationGO:00330431960.030
single organism intracellular transportGO:19025822070.029
apoptotic processGO:00069151590.029
regulation of gene expression epigeneticGO:00400291280.029
intracellular signal transductionGO:00355563000.029
negative regulation of signalingGO:00230572190.029
positive regulation of nitrogen compound metabolic processGO:00511733540.029
purine nucleotide metabolic processGO:00061631460.029
positive regulation of cellular biosynthetic processGO:00313283160.028
regulation of catabolic processGO:00098941700.028
positive regulation of proteolysisGO:0045862520.028
nucleoside catabolic processGO:00091641120.028
embryo development ending in birth or egg hatchingGO:00097921520.027
carboxylic acid metabolic processGO:0019752920.027
gland morphogenesisGO:00226121450.027
response to organic substanceGO:00100332840.027
nucleoside phosphate catabolic processGO:19012921100.027
nucleoside phosphate metabolic processGO:00067531620.026
negative regulation of phosphate metabolic processGO:0045936450.026
negative regulation of catalytic activityGO:0043086420.026
purine ribonucleoside catabolic processGO:00461301120.026
heart processGO:0003015370.025
positive regulation of phosphorus metabolic processGO:00105621390.025
kidney developmentGO:000182230.025
response to endogenous stimulusGO:00097191190.025
nucleoside triphosphate catabolic processGO:00091431080.025
cellular response to organic substanceGO:00713101320.024
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.024
regulation of blood circulationGO:1903522210.024
regulation of purine nucleotide metabolic processGO:1900542620.023
deathGO:00162652840.022
positive regulation of purine nucleotide metabolic processGO:1900544550.022
regulation of system processGO:0044057360.022
regulation of mitotic cell cycleGO:00073461900.022
glycosyl compound metabolic processGO:19016571270.022
regulation of nucleotide metabolic processGO:0006140620.022
cellular macromolecule catabolic processGO:00442651360.021
regulation of cellular component sizeGO:0032535980.021
larval developmentGO:00021641040.021
imaginal disc derived appendage developmentGO:00487373990.021
purine ribonucleoside triphosphate catabolic processGO:00092071080.021
nucleoside triphosphate metabolic processGO:00091411200.021
regulation of protein modification processGO:00313991120.021
developmental growthGO:00485892800.020
heart contractionGO:0060047260.020
compound eye retinal cell programmed cell deathGO:0046667230.020
regulation of apoptotic processGO:00429811300.020
cell growthGO:00160491080.020
ras protein signal transductionGO:0007265880.020
positive regulation of cellular component biogenesisGO:0044089800.020
blood circulationGO:0008015260.020
regulation of anatomical structure morphogenesisGO:00226032420.019
proteolysisGO:00065081920.019
negative regulation of cell cycle phase transitionGO:19019881030.019
negative regulation of cellular protein metabolic processGO:0032269850.019
single organism biosynthetic processGO:00447112060.019
regulation of programmed cell deathGO:00430671520.019
intracellular transportGO:00469072280.019
agingGO:00075681430.019
purine ribonucleoside triphosphate metabolic processGO:00092051190.018
oocyte constructionGO:00073081120.018
non recombinational repairGO:000072670.018
posttranscriptional regulation of gene expressionGO:00106081450.018
positive regulation of cellular protein metabolic processGO:00322701180.018
regulation of proteolysisGO:0030162870.018
purine ribonucleotide metabolic processGO:00091501450.018
rhythmic processGO:00485111060.017
histolysisGO:00075591020.017
mitotic g2 m transition checkpointGO:0044818700.017
pole plasm protein localizationGO:0007318100.017
epidermal growth factor receptor signaling pathwayGO:0007173580.017
purine ribonucleotide catabolic processGO:00091541090.017
organophosphate catabolic processGO:00464341120.017
regulation of nucleoside metabolic processGO:0009118500.017
purine nucleoside triphosphate catabolic processGO:00091461080.016
positive regulation of cellular amino acid metabolic processGO:004576400.016
purine containing compound metabolic processGO:00725211550.016
cuticle developmentGO:0042335860.016
regionalizationGO:00030024160.016
spermatid differentiationGO:00485151140.016
actin filament organizationGO:00070151260.016
negative regulation of peptidyl tyrosine phosphorylationGO:005073260.016
dendrite developmentGO:00163582040.016
vitelline membrane formationGO:0030704110.015
single organism cellular localizationGO:19025801800.015
regulation of cellular amine metabolic processGO:003323830.015
cell deathGO:00082192790.015
anterior posterior axis specificationGO:00099481090.015
response to alkaloidGO:0043279260.015
tissue morphogenesisGO:00487292970.015
cellular response to organic cyclic compoundGO:0071407320.015
cell maturationGO:00484691440.015
negative regulation of protein phosphorylationGO:0001933170.015
negative regulation of nitrogen compound metabolic processGO:00511722650.014
activation of cysteine type endopeptidase activityGO:0097202170.014
regulation of transferase activityGO:0051338580.014
homeostatic processGO:00425921990.014
purine nucleoside triphosphate metabolic processGO:00091441190.014
body morphogenesisGO:001017120.014
regulation of multicellular organismal developmentGO:20000264140.014
positive regulation of rna biosynthetic processGO:19026802660.013
columnar cuboidal epithelial cell developmentGO:00020662490.013
carbohydrate metabolic processGO:0005975820.013
positive regulation of signalingGO:00230562430.013
ribonucleoside triphosphate metabolic processGO:00091991190.013
regulation of erbb signaling pathwayGO:1901184420.013
antimicrobial humoral responseGO:0019730990.013
regulation of response to dna damage stimulusGO:2001020230.013
regulation of actin polymerization or depolymerizationGO:0008064270.013
regulation of organ morphogenesisGO:2000027780.012
regulation of phosphorylationGO:00423251470.012
sex determinationGO:0007530180.012
connective tissue developmentGO:006144830.012
response to organic cyclic compoundGO:0014070890.012
positive regulation of protein complex assemblyGO:0031334220.012
locomotory behaviorGO:00076261760.012
purine nucleoside monophosphate catabolic processGO:0009128380.012
positive regulation of cellular amine metabolic processGO:003324000.012
regulation of peptidyl tyrosine phosphorylationGO:0050730100.012
cellular response to oxygen containing compoundGO:1901701790.012
negative regulation of gene expressionGO:00106293870.012
response to oxygen containing compoundGO:19017002000.012
regulation of localizationGO:00328792750.012
negative regulation of intracellular signal transductionGO:1902532570.012
positive regulation of purine nucleotide catabolic processGO:0033123460.012
lipid metabolic processGO:00066291210.011
regulation of nucleotide catabolic processGO:0030811480.011
cellular response to external stimulusGO:0071496660.011
response to nitrogen compoundGO:1901698900.011
digestive system developmentGO:00551231490.011
embryonic development via the syncytial blastodermGO:00017001480.011
endocytosisGO:00068973100.011
negative regulation of nucleobase containing compound metabolic processGO:00459342610.011
gtp catabolic processGO:0006184720.011
taxisGO:00423303040.011
negative regulation of erk1 and erk2 cascadeGO:007037330.011
action potentialGO:0001508130.011
cell proliferationGO:00082832990.011
telencephalon developmentGO:002153720.011
response to organophosphorusGO:004668320.010
sensory perceptionGO:00076001960.010
compound eye photoreceptor cell differentiationGO:00017511400.010
regulation of nervous system developmentGO:00519602480.010
reciprocal meiotic recombinationGO:0007131190.010
cellular response to nitrogen compoundGO:1901699510.010
compound eye developmentGO:00487493070.010
peptidyl tyrosine modificationGO:0018212240.010
pole cell developmentGO:0007277260.010
cell fate specificationGO:0001708710.010

Top3alpha disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
cardiovascular system diseaseDOID:128700.052
disease of anatomical entityDOID:700.052
disease of cellular proliferationDOID:1456600.029
cancerDOID:16200.029
organ system cancerDOID:005068600.021
musculoskeletal system cancerDOID:006010000.021
nervous system diseaseDOID:86300.011
sensory system diseaseDOID:005015500.011