IMP: Integrative Multi-species Prediction

Drosophila melanogaster

52 known processes

tra2 (Dmel_CG10128)

transformer 2

(Aliases: Tra2,Tra-2,tra-2,TRA-2,TRA 2,TRA2,CG10128,Dmel\CG10128)

Entrez: 36619
FLYBASE: FBgn0003742
UniProtKB: P19018

Process Predictions
Disease Predictions

tra2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
positive regulation of macromolecule metabolic process	GO:0010604	405	0.763	Human
positive regulation of gene expression	GO:0010628	290	0.688	Human
multi multicellular organism process	GO:0044706	123	0.629
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.548	Human
positive regulation of biosynthetic process	GO:0009891	316	0.445
positive regulation of rna metabolic process	GO:0051254	271	0.422	Human
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.401
negative regulation of rna metabolic process	GO:0051253	251	0.359
negative regulation of cellular biosynthetic process	GO:0031327	277	0.357
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.318
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.307
gene silencing	GO:0016458	138	0.300
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.279
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.275
locomotory behavior	GO:0007626	176	0.252
sex determination	GO:0007530	18	0.243
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.235
intracellular signal transduction	GO:0035556	300	0.224
negative regulation of biosynthetic process	GO:0009890	277	0.221
negative regulation of cellular metabolic process	GO:0031324	382	0.214
positive regulation of rna biosynthetic process	GO:1902680	266	0.214
negative regulation of cell cycle	GO:0045786	116	0.201
mrna processing	GO:0006397	104	0.176
chromatin modification	GO:0016568	147	0.167
transcription initiation from rna polymerase ii promoter	GO:0006367	25	0.167
oocyte differentiation	GO:0009994	145	0.164
response to abiotic stimulus	GO:0009628	341	0.148
response to oxygen containing compound	GO:1901700	200	0.143	Rat
regulation of phosphorus metabolic process	GO:0051174	210	0.141
negative regulation of rna biosynthetic process	GO:1902679	240	0.139
negative regulation of mitotic cell cycle	GO:0045930	109	0.136
positive regulation of cellular biosynthetic process	GO:0031328	316	0.129
mitotic cell cycle phase transition	GO:0044772	138	0.127
single organism behavior	GO:0044708	391	0.127
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.124
positive regulation of phosphate metabolic process	GO:0045937	139	0.123
spindle organization	GO:0007051	253	0.118
transcription from rna polymerase ii promoter	GO:0006366	368	0.115
regulation of cell cycle phase transition	GO:1901987	130	0.115
regulation of cell cycle	GO:0051726	291	0.113
mitotic nuclear division	GO:0007067	213	0.111
axonogenesis	GO:0007409	290	0.111
regulation of localization	GO:0032879	275	0.107
regulation of phosphate metabolic process	GO:0019220	210	0.106
posttranscriptional gene silencing by rna	GO:0035194	45	0.104
phosphorylation	GO:0016310	294	0.103
segmentation	GO:0035282	207	0.100
cytoskeleton dependent cytokinesis	GO:0061640	81	0.097
eye photoreceptor cell development	GO:0042462	81	0.093
negative regulation of organelle organization	GO:0010639	56	0.093
negative regulation of gene expression	GO:0010629	387	0.090
imaginal disc growth	GO:0007446	37	0.089
taxis	GO:0042330	304	0.087
regulation of transport	GO:0051049	181	0.087
sister chromatid segregation	GO:0000819	92	0.087
regulation of multicellular organismal development	GO:2000026	414	0.087
regulation of meiosis	GO:0040020	3	0.086
mitotic cytokinesis	GO:0000281	50	0.085
carbohydrate derivative metabolic process	GO:1901135	217	0.085
dna damage checkpoint	GO:0000077	78	0.083
reproductive system development	GO:0061458	74	0.082
developmental programmed cell death	GO:0010623	138	0.081
cognition	GO:0050890	141	0.078
regulation of gene expression epigenetic	GO:0040029	128	0.074
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.073	Human
multi organism behavior	GO:0051705	175	0.068
establishment of localization in cell	GO:0051649	402	0.066
nuclear division	GO:0000280	332	0.066
positive regulation of transcription dna templated	GO:0045893	266	0.064
regulation of ras protein signal transduction	GO:0046578	93	0.061
single organism intracellular transport	GO:1902582	207	0.061
cellular response to dna damage stimulus	GO:0006974	223	0.061
chemotaxis	GO:0006935	249	0.061
organophosphate metabolic process	GO:0019637	195	0.060
posttranscriptional regulation of gene expression	GO:0010608	145	0.059
neuron projection guidance	GO:0097485	241	0.058
development of primary sexual characteristics	GO:0045137	50	0.057
appendage morphogenesis	GO:0035107	397	0.055
positive regulation of signaling	GO:0023056	243	0.052
dna templated transcription initiation	GO:0006352	25	0.052
regulation of mrna metabolic process	GO:1903311	72	0.050
regulation of gene silencing	GO:0060968	63	0.049
female sex differentiation	GO:0046660	20	0.048
sensory organ morphogenesis	GO:0090596	260	0.048
male gamete generation	GO:0048232	201	0.048
cell death	GO:0008219	279	0.047
regulation of cell cycle process	GO:0010564	181	0.046
rna processing	GO:0006396	147	0.046
mitotic sister chromatid segregation	GO:0000070	87	0.045
chromatin organization	GO:0006325	207	0.045
mitotic spindle organization	GO:0007052	220	0.045
cell cycle phase transition	GO:0044770	140	0.045
rna splicing	GO:0008380	83	0.043
negative regulation of cell cycle process	GO:0010948	109	0.043
regulation of mitotic metaphase anaphase transition	GO:0030071	26	0.043
sex differentiation	GO:0007548	81	0.042
microtubule cytoskeleton organization involved in mitosis	GO:1902850	52	0.042
negative regulation of gene expression epigenetic	GO:0045814	77	0.042
dna conformation change	GO:0071103	105	0.042
negative regulation of meiotic cell cycle	GO:0051447	2	0.042
mitotic g2 m transition checkpoint	GO:0044818	70	0.042
regulation of intracellular signal transduction	GO:1902531	236	0.041
cytoplasmic transport	GO:0016482	130	0.041
chromatin remodeling	GO:0006338	72	0.039
myofibril assembly	GO:0030239	36	0.039
gonad development	GO:0008406	50	0.039
oocyte development	GO:0048599	124	0.038
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.038
negative regulation of cellular component organization	GO:0051129	108	0.037
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.037
organelle fission	GO:0048285	340	0.037
developmental maturation	GO:0021700	172	0.036
regulation of mitotic cell cycle	GO:0007346	190	0.036
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.035
regulation of meiotic cell cycle	GO:0051445	9	0.035
developmental growth	GO:0048589	280	0.035
multi organism reproductive behavior	GO:0044705	121	0.034
imaginal disc derived appendage development	GO:0048737	399	0.033
positive regulation of phosphorylation	GO:0042327	87	0.032
axon guidance	GO:0007411	233	0.032
chromatin mediated maintenance of transcription	GO:0048096	7	0.032
organelle assembly	GO:0070925	198	0.032
negative regulation of cellular catabolic process	GO:0031330	34	0.031
response to external biotic stimulus	GO:0043207	293	0.031
response to radiation	GO:0009314	155	0.030
regulation of chromatin silencing	GO:0031935	36	0.030
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.030
mrna splice site selection	GO:0006376	1	0.030
regulation of protein modification process	GO:0031399	112	0.030
nucleoside phosphate metabolic process	GO:0006753	162	0.029
cellular component disassembly	GO:0022411	46	0.029
ncrna metabolic process	GO:0034660	43	0.029
germ cell migration	GO:0008354	43	0.028
protein complex assembly	GO:0006461	200	0.028
regulation of intracellular transport	GO:0032386	64	0.028
spermatid development	GO:0007286	98	0.028
mitotic dna integrity checkpoint	GO:0044774	75	0.027
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.027
protein modification process	GO:0036211	438	0.027
negative regulation of cell cycle phase transition	GO:1901988	103	0.027
chromatin silencing	GO:0006342	76	0.027
response to organic substance	GO:0010033	284	0.027
negative regulation of transcription dna templated	GO:0045892	237	0.027
regulation of rna splicing	GO:0043484	69	0.026
mrna metabolic process	GO:0016071	124	0.026
tissue morphogenesis	GO:0048729	297	0.026
response to other organism	GO:0051707	293	0.025
gene silencing by rna	GO:0031047	57	0.025
g2 dna damage checkpoint	GO:0031572	69	0.025
oocyte construction	GO:0007308	112	0.024
regulation of molecular function	GO:0065009	217	0.024
signal transduction by phosphorylation	GO:0023014	107	0.024
positive regulation of cell communication	GO:0010647	250	0.023
regulation of phosphorylation	GO:0042325	147	0.023
single organism membrane organization	GO:0044802	93	0.023
peptidyl amino acid modification	GO:0018193	105	0.022
regulation of dna recombination	GO:0000018	4	0.022
regulation of mapk cascade	GO:0043408	92	0.022
regulation of erk1 and erk2 cascade	GO:0070372	39	0.022
positive regulation of transcription factor import into nucleus	GO:0042993	19	0.022
synapse organization	GO:0050808	196	0.022
central nervous system development	GO:0007417	201	0.021
regulation of cellular localization	GO:0060341	136	0.021
multicellular organismal reproductive behavior	GO:0033057	110	0.020
chromosome separation	GO:0051304	42	0.020
cell maturation	GO:0048469	144	0.020
axon development	GO:0061564	297	0.020
protein localization	GO:0008104	284	0.019
small molecule metabolic process	GO:0044281	305	0.019
regulation of developmental growth	GO:0048638	174	0.019
regionalization	GO:0003002	416	0.019
meiotic cell cycle	GO:0051321	171	0.019
regulation of cell division	GO:0051302	72	0.019
response to bacterium	GO:0009617	198	0.019
organic substance transport	GO:0071702	257	0.018
endocytosis	GO:0006897	310	0.018
positive regulation of molecular function	GO:0044093	136	0.018
cellular protein complex disassembly	GO:0043624	35	0.018
reproductive structure development	GO:0048608	74	0.018
skin development	GO:0043588	65	0.018
chromosome segregation	GO:0007059	157	0.018
negative regulation of cell communication	GO:0010648	223	0.018
positive regulation of developmental process	GO:0051094	143	0.018
positive regulation of phosphorus metabolic process	GO:0010562	139	0.018
camera type eye development	GO:0043010	4	0.017
protein complex disassembly	GO:0043241	36	0.017
poly a mrna export from nucleus	GO:0016973	5	0.017
positive regulation of transport	GO:0051050	92	0.017
embryo development ending in birth or egg hatching	GO:0009792	152	0.016
mapk cascade	GO:0000165	107	0.016
response to alcohol	GO:0097305	95	0.016
defense response to other organism	GO:0098542	225	0.016
germ line stem cell maintenance	GO:0030718	50	0.016
negative regulation of cellular protein metabolic process	GO:0032269	85	0.016
nucleoside metabolic process	GO:0009116	127	0.016
positive regulation of signal transduction	GO:0009967	223	0.016
positive regulation of intracellular transport	GO:0032388	42	0.016
protein complex biogenesis	GO:0070271	201	0.015
ubiquitin dependent protein catabolic process	GO:0006511	78	0.015
purine ribonucleoside metabolic process	GO:0046128	127	0.015
regulation of wnt signaling pathway	GO:0030111	68	0.015
spindle stabilization	GO:0043146	14	0.014
embryonic development via the syncytial blastoderm	GO:0001700	148	0.014
nucleobase containing small molecule metabolic process	GO:0055086	174	0.014
ion transport	GO:0006811	145	0.014
spindle assembly involved in mitosis	GO:0090307	50	0.014
membrane organization	GO:0061024	112	0.014
anterior posterior pattern specification	GO:0009952	136	0.013
posttranscriptional gene silencing	GO:0016441	46	0.013
respiratory system development	GO:0060541	213	0.013
negative regulation of mitotic sister chromatid separation	GO:2000816	13	0.013
synaptic growth at neuromuscular junction	GO:0051124	119	0.013
proteasomal protein catabolic process	GO:0010498	59	0.013
positive regulation of atp catabolic process	GO:1903291	3	0.013
negative regulation of cell differentiation	GO:0045596	143	0.013
maternal determination of anterior posterior axis embryo	GO:0008358	74	0.013
extrinsic apoptotic signaling pathway	GO:0097191	1	0.013
positive regulation of erk1 and erk2 cascade	GO:0070374	36	0.013
camera type eye morphogenesis	GO:0048593	2	0.013
regulation of organelle organization	GO:0033043	196	0.013
dna integrity checkpoint	GO:0031570	81	0.012
heterocycle catabolic process	GO:0046700	166	0.012
regulation of cell differentiation	GO:0045595	302	0.012
ribose phosphate metabolic process	GO:0019693	145	0.012
chromosome organization	GO:0051276	360	0.012
negative regulation of cardioblast differentiation	GO:0051892	7	0.012
carbohydrate derivative biosynthetic process	GO:1901137	85	0.012
genitalia development	GO:0048806	26	0.011
regulation of cell development	GO:0060284	215	0.011
cellular protein modification process	GO:0006464	438	0.011
negative regulation of signaling	GO:0023057	219	0.011
positive regulation of mapk cascade	GO:0043410	63	0.011
regulation of epidermal cell differentiation	GO:0045604	3	0.011
regulation of multi organism process	GO:0043900	131	0.011
cellular response to nutrient	GO:0031670	1	0.011
regulation of sister chromatid segregation	GO:0033045	28	0.011
histone h3 k4 methylation	GO:0051568	16	0.011
positive regulation of mitotic cell cycle	GO:0045931	34	0.011
cell division	GO:0051301	248	0.011
positive regulation of multi organism process	GO:0043902	40	0.010
positive regulation of cell cycle process	GO:0090068	28	0.010
regulation of protein localization	GO:0032880	76	0.010
regulation of cellular component movement	GO:0051270	42	0.010
regulation of nuclear division	GO:0051783	58	0.010
reproductive behavior	GO:0019098	122	0.010
female gonad development	GO:0008585	12	0.010
regulation of nervous system development	GO:0051960	248	0.010
salivary gland histolysis	GO:0035070	88	0.010
nucleotide catabolic process	GO:0009166	109	0.010

tra2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.058
	nervous system disease	DOID:863	0	0.058

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