IMP: Integrative Multi-species Prediction

Drosophila melanogaster

91 known processes

MRP (Dmel_CG6214)

Multidrug-Resistance like Protein 1

(Aliases: Dmel\CG6214,dMRP/CG6214,CG6214,dMRP)

FLYBASE: FBgn0032456
Entrez: 34686
UniProtKB: Q7KTD0
UniProtKB: Q7KTC6
UniProtKB: Q7KTC3
UniProtKB: Q7KTC8
UniProtKB: Q7KTC9
UniProtKB: Q7KTC5
UniProtKB: Q7KTC2
UniProtKB: Q7KTB9
UniProtKB: Q9I7N0
UniProtKB: Q7KTC4
UniProtKB: Q7KTC7
UniProtKB: Q7KTC0
UniProtKB: Q7KTC1
UniProtKB: Q9VK56
UniProtKB: Q7KTB7
UniProtKB: Q7KTB8

Process Predictions
Disease Predictions

MRP biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
ion transmembrane transport	GO:0034220	122	0.351	Yeast Rat
transmembrane transport	GO:0055085	139	0.203
cation transmembrane transport	GO:0098655	88	0.172	Yeast
inorganic cation transmembrane transport	GO:0098662	61	0.164	Yeast
metal ion transport	GO:0030001	74	0.153	Yeast
inorganic ion transmembrane transport	GO:0098660	73	0.150	Yeast
anion transmembrane transport	GO:0098656	26	0.110	Rat
cellular response to dna damage stimulus	GO:0006974	223	0.090
protein complex assembly	GO:0006461	200	0.089
homeostatic process	GO:0042592	199	0.089	Yeast
regulation of transport	GO:0051049	181	0.080
mrna metabolic process	GO:0016071	124	0.074
organelle fission	GO:0048285	340	0.071
nuclear division	GO:0000280	332	0.070
vesicle mediated transport	GO:0016192	381	0.066
cation transport	GO:0006812	110	0.065	Yeast Rat
central nervous system development	GO:0007417	201	0.062
negative regulation of developmental process	GO:0051093	201	0.057
negative regulation of gene expression	GO:0010629	387	0.057
macromolecular complex assembly	GO:0065003	256	0.057
dna damage checkpoint	GO:0000077	78	0.056
dorsal ventral pattern formation	GO:0009953	133	0.054
ion transport	GO:0006811	145	0.054	Yeast Rat
aging	GO:0007568	143	0.053
response to abiotic stimulus	GO:0009628	341	0.051
response to lipopolysaccharide	GO:0032496	4	0.047	Rat
regulation of translation	GO:0006417	56	0.047
single organism intracellular transport	GO:1902582	207	0.047
protein complex biogenesis	GO:0070271	201	0.046
regulation of cellular protein metabolic process	GO:0032268	243	0.044
intracellular transport	GO:0046907	228	0.040
cell cycle checkpoint	GO:0000075	95	0.040
negative regulation of cell communication	GO:0010648	223	0.037
cellular protein complex assembly	GO:0043623	71	0.035
imaginal disc pattern formation	GO:0007447	91	0.035
multicellular organismal aging	GO:0010259	140	0.034
inorganic anion transmembrane transport	GO:0098661	14	0.033
regionalization	GO:0003002	416	0.032
negative regulation of multicellular organismal process	GO:0051241	142	0.030
monovalent inorganic cation transport	GO:0015672	40	0.029
endocytosis	GO:0006897	310	0.029
muscle system process	GO:0003012	21	0.027
protein transport	GO:0015031	155	0.027
regulation of localization	GO:0032879	275	0.027	Rat
posttranscriptional regulation of gene expression	GO:0010608	145	0.025
regulation of cellular localization	GO:0060341	136	0.025
centrosome cycle	GO:0007098	137	0.025
organelle localization	GO:0051640	148	0.024
g2 dna damage checkpoint	GO:0031572	69	0.023
body morphogenesis	GO:0010171	2	0.023
determination of adult lifespan	GO:0008340	137	0.023
forebrain development	GO:0030900	2	0.023
regulation of neurogenesis	GO:0050767	158	0.022
maintenance of location	GO:0051235	73	0.022
translation	GO:0006412	69	0.022
establishment of localization in cell	GO:0051649	402	0.022
response to copper ion	GO:0046688	4	0.022
regulation of cell proliferation	GO:0042127	163	0.022
establishment of protein localization	GO:0045184	163	0.022
metal ion homeostasis	GO:0055065	44	0.021
cell proliferation	GO:0008283	299	0.021
cytoplasmic transport	GO:0016482	130	0.021
dna integrity checkpoint	GO:0031570	81	0.020
developmental growth	GO:0048589	280	0.020
positive regulation of signal transduction	GO:0009967	223	0.020
cell division	GO:0051301	248	0.019
regulation of neuron differentiation	GO:0045664	103	0.019
mrna catabolic process	GO:0006402	33	0.019
regulation of cellular ketone metabolic process	GO:0010565	3	0.019
positive regulation of gliogenesis	GO:0014015	5	0.018
response to metal ion	GO:0010038	23	0.018	Yeast
organic substance transport	GO:0071702	257	0.018	Yeast Rat
negative regulation of signaling	GO:0023057	219	0.018
regulation of cell cycle	GO:0051726	291	0.018
dorsal ventral pattern formation imaginal disc	GO:0007450	51	0.018
immune response activating signal transduction	GO:0002757	2	0.018
spindle organization	GO:0007051	253	0.018
gland development	GO:0048732	191	0.018
cellular homeostasis	GO:0019725	80	0.018	Yeast
regulation of cell development	GO:0060284	215	0.018
protein import	GO:0017038	55	0.017
regulation of cell cycle process	GO:0010564	181	0.017
eye development	GO:0001654	323	0.017
protein targeting to nucleus	GO:0044744	51	0.017
mitotic spindle organization	GO:0007052	220	0.017
regulation of synapse structure and activity	GO:0050803	128	0.017
regulation of cell differentiation	GO:0045595	302	0.017
neurological system process	GO:0050877	358	0.016
mitotic g2 m transition checkpoint	GO:0044818	70	0.015
membrane organization	GO:0061024	112	0.015	Yeast
single organism biosynthetic process	GO:0044711	206	0.015
single organism behavior	GO:0044708	391	0.015
regulation of anatomical structure morphogenesis	GO:0022603	242	0.015
protein localization to nucleus	GO:0034504	55	0.014
intracellular protein transport	GO:0006886	104	0.014
muscle structure development	GO:0061061	224	0.014
telencephalon development	GO:0021537	2	0.014
negative regulation of nervous system development	GO:0051961	92	0.014
organ growth	GO:0035265	56	0.014
protein targeting	GO:0006605	64	0.014
chaperone mediated protein folding	GO:0061077	2	0.014
response to other organism	GO:0051707	293	0.013	Rat
wing disc pattern formation	GO:0035222	66	0.013
negative regulation of signal transduction	GO:0009968	206	0.013
regulation of protein metabolic process	GO:0051246	256	0.013
adult behavior	GO:0030534	137	0.013
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.013
stem cell differentiation	GO:0048863	117	0.013
immune response regulating signaling pathway	GO:0002764	2	0.013
regulation of intracellular transport	GO:0032386	64	0.013
wing disc morphogenesis	GO:0007472	344	0.013
cellular response to molecule of bacterial origin	GO:0071219	3	0.013
biological adhesion	GO:0022610	138	0.013
cellular ketone metabolic process	GO:0042180	24	0.013
growth	GO:0040007	359	0.013
larval development	GO:0002164	104	0.013
eye morphogenesis	GO:0048592	260	0.013
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.013
imaginal disc growth	GO:0007446	37	0.013
proteolysis	GO:0006508	192	0.013
carboxylic acid metabolic process	GO:0019752	92	0.013	Yeast
positive regulation of multi organism process	GO:0043902	40	0.012
compound eye development	GO:0048749	307	0.012
regulation of microtubule cytoskeleton organization	GO:0070507	41	0.012
cellular macromolecular complex assembly	GO:0034622	153	0.012
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.012
regulation of mrna metabolic process	GO:1903311	72	0.012
regulation of ion transport	GO:0043269	39	0.012
extracellular structure organization	GO:0043062	46	0.012
anterior posterior axis specification	GO:0009948	109	0.012
appendage morphogenesis	GO:0035107	397	0.012
regulation of proteolysis	GO:0030162	87	0.012
positive regulation of response to stimulus	GO:0048584	323	0.011
amine metabolic process	GO:0009308	12	0.011
negative regulation of cellular metabolic process	GO:0031324	382	0.011
regulation of steroid metabolic process	GO:0019218	2	0.011
centrosome duplication	GO:0051298	121	0.011
single organism nuclear import	GO:1902593	51	0.011
response to oxygen levels	GO:0070482	59	0.011
notch signaling pathway	GO:0007219	120	0.011
post embryonic appendage morphogenesis	GO:0035120	385	0.011
negative regulation of smoothened signaling pathway	GO:0045879	16	0.011
cellular response to biotic stimulus	GO:0071216	4	0.011
lateral inhibition	GO:0046331	206	0.011
synaptic vesicle localization	GO:0097479	53	0.010
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.010
establishment of protein localization to organelle	GO:0072594	62	0.010
mrna processing	GO:0006397	104	0.010
negative regulation of response to stimulus	GO:0048585	258	0.010
regulation of mitosis	GO:0007088	56	0.010

MRP disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of anatomical entity	DOID:7	0.016	Human
nervous system disease	DOID:863	0.015
central nervous system disease	DOID:331	0.012

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network