IMP: Integrative Multi-species Prediction

Drosophila melanogaster

49 known processes

mri (Dmel_CG1216)

mrityu

(Aliases: CG1216,Dmel\CG1216)

Entrez: 38028
FLYBASE: FBgn0035107
UniProtKB: X2J8G3
UniProtKB: Q0E8K5

Process Predictions
Disease Predictions

mri biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
negative regulation of cell communication	GO:0010648	223	0.409
negative regulation of response to stimulus	GO:0048585	258	0.324
negative regulation of signal transduction	GO:0009968	206	0.251
small gtpase mediated signal transduction	GO:0007264	88	0.240
meiotic cell cycle process	GO:1903046	132	0.181
death	GO:0016265	284	0.164
cell motility	GO:0048870	251	0.151
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.126
meiotic cell cycle	GO:0051321	171	0.115
homeostatic process	GO:0042592	199	0.115
negative regulation of signaling	GO:0023057	219	0.111
embryo development ending in birth or egg hatching	GO:0009792	152	0.108	Worm
protein dna complex subunit organization	GO:0071824	86	0.102
regulation of ras protein signal transduction	GO:0046578	93	0.100
intracellular signal transduction	GO:0035556	300	0.093
protein modification process	GO:0036211	438	0.083
body morphogenesis	GO:0010171	2	0.081
chromosome segregation	GO:0007059	157	0.070
post embryonic appendage morphogenesis	GO:0035120	385	0.068
protein catabolic process	GO:0030163	101	0.065
cell migration	GO:0016477	238	0.063
macromolecular complex assembly	GO:0065003	256	0.062
positive regulation of cellular component biogenesis	GO:0044089	80	0.061
regulation of cell morphogenesis	GO:0022604	163	0.060
organelle fission	GO:0048285	340	0.059
signal transduction by phosphorylation	GO:0023014	107	0.057
cellular response to abiotic stimulus	GO:0071214	58	0.057
protein complex biogenesis	GO:0070271	201	0.056
cellular response to dna damage stimulus	GO:0006974	223	0.056
ras protein signal transduction	GO:0007265	88	0.055
synaptic transmission	GO:0007268	288	0.053
detection of stimulus	GO:0051606	156	0.050
response to radiation	GO:0009314	155	0.047
negative regulation of small gtpase mediated signal transduction	GO:0051058	13	0.047
imaginal disc derived wing morphogenesis	GO:0007476	337	0.045
response to abiotic stimulus	GO:0009628	341	0.044
regulation of cell cycle	GO:0051726	291	0.044
modification dependent protein catabolic process	GO:0019941	78	0.044
response to oxygen containing compound	GO:1901700	200	0.044
cellular protein catabolic process	GO:0044257	83	0.043
regulation of intracellular signal transduction	GO:1902531	236	0.042
columnar cuboidal epithelial cell development	GO:0002066	249	0.041
response to organic substance	GO:0010033	284	0.040
regulation of anatomical structure morphogenesis	GO:0022603	242	0.039
localization of cell	GO:0051674	257	0.038
cellular macromolecular complex assembly	GO:0034622	153	0.038
regulation of cellular protein metabolic process	GO:0032268	243	0.036
multi organism reproductive behavior	GO:0044705	121	0.035
dendrite development	GO:0016358	204	0.033
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.033
nuclear division	GO:0000280	332	0.032
spermatid differentiation	GO:0048515	114	0.032
reproductive behavior	GO:0019098	122	0.031
epithelial cell development	GO:0002064	274	0.031
proteolysis	GO:0006508	192	0.030
phosphorylation	GO:0016310	294	0.030
eye development	GO:0001654	323	0.030
positive regulation of signaling	GO:0023056	243	0.029
regulation of localization	GO:0032879	275	0.029
single organism behavior	GO:0044708	391	0.029
tissue morphogenesis	GO:0048729	297	0.029
protein complex assembly	GO:0006461	200	0.028
dendrite morphogenesis	GO:0048813	199	0.028
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.027
regulation of transport	GO:0051049	181	0.026
regulation of synapse structure and activity	GO:0050803	128	0.026
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.026
response to temperature stimulus	GO:0009266	106	0.026
regulation of mitotic cell cycle	GO:0007346	190	0.025
positive regulation of response to stimulus	GO:0048584	323	0.025
protein localization	GO:0008104	284	0.025
protein modification by small protein conjugation or removal	GO:0070647	106	0.025
cellular catabolic process	GO:0044248	372	0.025
macromolecule catabolic process	GO:0009057	161	0.024
cellular protein modification process	GO:0006464	438	0.024
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.024
negative regulation of intracellular signal transduction	GO:1902532	57	0.024
phagocytosis	GO:0006909	215	0.023
mitotic dna integrity checkpoint	GO:0044774	75	0.023
regulation of phosphorylation	GO:0042325	147	0.022
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.022
cell division	GO:0051301	248	0.021
endocytosis	GO:0006897	310	0.021
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.021
catabolic process	GO:0009056	409	0.021
vesicle mediated transport	GO:0016192	381	0.021
negative regulation of ras protein signal transduction	GO:0046580	13	0.021
organic substance catabolic process	GO:1901575	308	0.021
negative regulation of cellular metabolic process	GO:0031324	382	0.020
mechanosensory behavior	GO:0007638	12	0.020
peptidyl lysine modification	GO:0018205	57	0.020
cellular response to organic substance	GO:0071310	132	0.020
cell death	GO:0008219	279	0.019
regulation of catalytic activity	GO:0050790	185	0.019
cell cycle checkpoint	GO:0000075	95	0.019
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.019
programmed cell death	GO:0012501	257	0.019
proteasome assembly	GO:0043248	2	0.019
cellular response to chemical stimulus	GO:0070887	199	0.019
regulation of proteolysis	GO:0030162	87	0.019
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.019
open tracheal system development	GO:0007424	204	0.018
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.018
epithelial cell differentiation	GO:0030855	322	0.018
mitotic nuclear division	GO:0007067	213	0.017
larval development	GO:0002164	104	0.017
transcription from rna polymerase ii promoter	GO:0006366	368	0.017
wing disc morphogenesis	GO:0007472	344	0.017
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.017
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	18	0.017
epiboly	GO:0090504	2	0.017
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.017
regulation of meiosis	GO:0040020	3	0.017
positive regulation of phosphorus metabolic process	GO:0010562	139	0.017
morphogenesis of an epithelium	GO:0002009	276	0.017
establishment of localization in cell	GO:0051649	402	0.016
regulation of synapse assembly	GO:0051963	94	0.016
posttranscriptional gene silencing by rna	GO:0035194	45	0.016
actin cytoskeleton organization	GO:0030036	206	0.016
positive regulation of cell communication	GO:0010647	250	0.016
regulation of protein metabolic process	GO:0051246	256	0.016
meiotic nuclear division	GO:0007126	151	0.016
wnt signaling pathway	GO:0016055	98	0.016
ovarian follicle cell development	GO:0030707	248	0.016
metal ion transport	GO:0030001	74	0.016
camera type eye development	GO:0043010	4	0.016
protein secretion	GO:0009306	45	0.016
negative regulation of phosphorus metabolic process	GO:0010563	45	0.016
cation homeostasis	GO:0055080	51	0.015
cell cycle comprising mitosis without cytokinesis	GO:0033301	25	0.015
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.015
regulation of behavior	GO:0050795	75	0.015
negative regulation of protein metabolic process	GO:0051248	85	0.015
appendage morphogenesis	GO:0035107	397	0.015
positive regulation of intracellular signal transduction	GO:1902533	116	0.015
mitotic cell cycle phase transition	GO:0044772	138	0.014
sensory organ morphogenesis	GO:0090596	260	0.014
sensory perception of mechanical stimulus	GO:0050954	72	0.014
rna polymerase ii transcriptional preinitiation complex assembly	GO:0051123	20	0.014
spermatogenesis	GO:0007283	200	0.014
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.014
regulation of phosphorus metabolic process	GO:0051174	210	0.014
regulation of mapk cascade	GO:0043408	92	0.014
multi organism behavior	GO:0051705	175	0.014
proteasomal protein catabolic process	GO:0010498	59	0.014
respiratory system development	GO:0060541	213	0.013
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.013
protein modification by small protein conjugation	GO:0032446	79	0.013
regulation of cellular localization	GO:0060341	136	0.013
mitotic dna damage checkpoint	GO:0044773	74	0.013
male meiosis	GO:0007140	52	0.013
neurological system process	GO:0050877	358	0.013
compound eye photoreceptor cell differentiation	GO:0001751	140	0.013
taxis	GO:0042330	304	0.013
sensory perception of pain	GO:0019233	4	0.013
regulation of phosphate metabolic process	GO:0019220	210	0.013
monovalent inorganic cation homeostasis	GO:0055067	7	0.012
cell cycle phase transition	GO:0044770	140	0.012
regulation of programmed cell death	GO:0043067	152	0.012
regulation of wnt signaling pathway	GO:0030111	68	0.012
positive regulation of transcription dna templated	GO:0045893	266	0.012
negative regulation of gene expression	GO:0010629	387	0.012
g2 dna damage checkpoint	GO:0031572	69	0.012
regulation of cell differentiation	GO:0045595	302	0.012
negative regulation of cell cycle phase transition	GO:1901988	103	0.011
regulation of response to stress	GO:0080134	200	0.011
protein maturation	GO:0051604	71	0.011
photoreceptor cell development	GO:0042461	96	0.011
regulation of molecular function	GO:0065009	217	0.011
cellular macromolecule catabolic process	GO:0044265	136	0.011
regulation of erbb signaling pathway	GO:1901184	42	0.011
detection of mechanical stimulus involved in sensory perception of pain	GO:0050966	2	0.011
ubiquitin dependent protein catabolic process	GO:0006511	78	0.011
negative regulation of rna biosynthetic process	GO:1902679	240	0.011
protein transport	GO:0015031	155	0.011
mesenchymal cell development	GO:0014031	1	0.011
apoptotic process	GO:0006915	159	0.011
mesenchymal cell differentiation	GO:0048762	1	0.011
mitotic g2 m transition checkpoint	GO:0044818	70	0.011
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.011
cognition	GO:0050890	141	0.011
internal protein amino acid acetylation	GO:0006475	38	0.010
internal peptidyl lysine acetylation	GO:0018393	38	0.010
chromosome organization	GO:0051276	360	0.010
negative regulation of mitotic cell cycle	GO:0045930	109	0.010
ameboidal type cell migration	GO:0001667	151	0.010
regulation of cell cycle phase transition	GO:1901987	130	0.010
membrane organization	GO:0061024	112	0.010
protein ubiquitination	GO:0016567	70	0.010

mri disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.145
kidney disease	DOID:557	0.056
urinary system disease	DOID:18	0.056
nervous system disease	DOID:863	0.030
lower respiratory tract disease	DOID:0050161	0.025
respiratory system disease	DOID:1579	0.025

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