IMP: Integrative Multi-species Prediction

Drosophila melanogaster

42 known processes

Gpo-1 (Dmel_CG8256)

Glycerophosphate oxidase-1

(Aliases: Gpo,GPO,CG18786,Dmel\CG8256,GPO-1,l(2)k05713,alpha-GPO,CG8256,alphaGPO,anon-WO0118547.114)

FLYBASE: FBgn0022160
Entrez: 47611
UniProtKB: Q7K569

Process Predictions
Disease Predictions

Gpo-1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
locomotory behavior	GO:0007626	176	0.469
flight behavior	GO:0007629	26	0.387
mitochondrial transport	GO:0006839	8	0.280
small molecule metabolic process	GO:0044281	305	0.245
adult behavior	GO:0030534	137	0.237
single organism intracellular transport	GO:1902582	207	0.135
vesicle mediated transport	GO:0016192	381	0.122
actin cytoskeleton organization	GO:0030036	206	0.122
protein complex assembly	GO:0006461	200	0.118
protein complex biogenesis	GO:0070271	201	0.115
lipid metabolic process	GO:0006629	121	0.107
response to organophosphorus	GO:0046683	2	0.103
intracellular transport	GO:0046907	228	0.103
endocytosis	GO:0006897	310	0.101
neurological system process	GO:0050877	358	0.099
oxidation reduction process	GO:0055114	123	0.096
organic substance transport	GO:0071702	257	0.093
transmembrane transport	GO:0055085	139	0.091
establishment of localization in cell	GO:0051649	402	0.090
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.089
striated muscle myosin thick filament assembly	GO:0071688	3	0.089
organonitrogen compound metabolic process	GO:1901564	318	0.087
purine nucleotide metabolic process	GO:0006163	146	0.083
cellular component assembly involved in morphogenesis	GO:0010927	151	0.083
nucleobase containing small molecule metabolic process	GO:0055086	174	0.083
organophosphate metabolic process	GO:0019637	195	0.076	Mouse
sarcomere organization	GO:0045214	26	0.075
organic substance catabolic process	GO:1901575	308	0.072
energy derivation by oxidation of organic compounds	GO:0015980	32	0.071
ribose phosphate metabolic process	GO:0019693	145	0.069
positive regulation of catabolic process	GO:0009896	105	0.068
negative regulation of cellular component organization	GO:0051129	108	0.066
skeletal myofibril assembly	GO:0014866	6	0.064
purine ribonucleotide metabolic process	GO:0009150	145	0.064
glycosyl compound metabolic process	GO:1901657	127	0.064
macromolecular complex assembly	GO:0065003	256	0.063
phosphorylation	GO:0016310	294	0.062
myofibril assembly	GO:0030239	36	0.062
nucleoside triphosphate catabolic process	GO:0009143	108	0.060
nucleoside triphosphate metabolic process	GO:0009141	120	0.060
carbohydrate derivative catabolic process	GO:1901136	118	0.058
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.057
purine nucleoside metabolic process	GO:0042278	127	0.057
purine containing compound catabolic process	GO:0072523	112	0.056
regulation of membrane potential	GO:0042391	35	0.055
purine ribonucleoside metabolic process	GO:0046128	127	0.055
actin filament based process	GO:0030029	220	0.055
embryo development ending in birth or egg hatching	GO:0009792	152	0.054
muscle tissue morphogenesis	GO:0060415	2	0.053
ribonucleotide catabolic process	GO:0009261	109	0.053
organic acid metabolic process	GO:0006082	103	0.053
positive regulation of nucleoside metabolic process	GO:0045979	47	0.052
purine containing compound metabolic process	GO:0072521	155	0.051
positive regulation of phosphorus metabolic process	GO:0010562	139	0.050
purine nucleotide catabolic process	GO:0006195	109	0.050
single organism biosynthetic process	GO:0044711	206	0.049	Mouse
nucleotide metabolic process	GO:0009117	161	0.049
adult locomotory behavior	GO:0008344	76	0.048
oxoacid metabolic process	GO:0043436	103	0.048
larval development	GO:0002164	104	0.047
muscle thin filament assembly	GO:0071689	5	0.047
localization of cell	GO:0051674	257	0.046
intracellular signal transduction	GO:0035556	300	0.046
cellular protein complex assembly	GO:0043623	71	0.045
synaptic transmission	GO:0007268	288	0.045
response to purine containing compound	GO:0014074	12	0.044
regulation of localization	GO:0032879	275	0.043
glycosyl compound catabolic process	GO:1901658	112	0.043
regulation of multicellular organismal development	GO:2000026	414	0.043
cellular respiration	GO:0045333	26	0.043
regionalization	GO:0003002	416	0.043
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.043
response to organic cyclic compound	GO:0014070	89	0.042
nucleoside monophosphate catabolic process	GO:0009125	39	0.042
regulation of molecular function	GO:0065009	217	0.042
determination of adult lifespan	GO:0008340	137	0.041
single organism catabolic process	GO:0044712	228	0.041
ribonucleoside metabolic process	GO:0009119	127	0.040
somatic muscle development	GO:0007525	66	0.040
nucleoside metabolic process	GO:0009116	127	0.040
positive regulation of biosynthetic process	GO:0009891	316	0.040
response to wounding	GO:0009611	94	0.039
regulation of neurogenesis	GO:0050767	158	0.038
digestive tract development	GO:0048565	149	0.037
skeletal muscle adaptation	GO:0043501	1	0.037
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.037
purine nucleoside catabolic process	GO:0006152	112	0.037
negative regulation of cellular metabolic process	GO:0031324	382	0.036
actomyosin structure organization	GO:0031032	56	0.036
regulation of cell differentiation	GO:0045595	302	0.036
cellular catabolic process	GO:0044248	372	0.036
striated muscle cell development	GO:0055002	50	0.036
response to abiotic stimulus	GO:0009628	341	0.036
catabolic process	GO:0009056	409	0.036
cellular macromolecular complex assembly	GO:0034622	153	0.035
nucleotide catabolic process	GO:0009166	109	0.034
carboxylic acid metabolic process	GO:0019752	92	0.034
response to lipopolysaccharide	GO:0032496	4	0.034
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.034
response to alcohol	GO:0097305	95	0.034
single organism behavior	GO:0044708	391	0.034
wound healing	GO:0042060	75	0.033
ribonucleoside catabolic process	GO:0042454	112	0.032
nucleoside phosphate metabolic process	GO:0006753	162	0.032
ion transport	GO:0006811	145	0.032
regulation of catalytic activity	GO:0050790	185	0.032
regulation of phosphorus metabolic process	GO:0051174	210	0.032
mitochondrion organization	GO:0007005	65	0.032
nucleoside monophosphate metabolic process	GO:0009123	52	0.031
embryonic morphogenesis	GO:0048598	206	0.030
body morphogenesis	GO:0010171	2	0.030
carbohydrate derivative metabolic process	GO:1901135	217	0.030	Mouse
protein transport	GO:0015031	155	0.029
programmed cell death	GO:0012501	257	0.029
nucleoside catabolic process	GO:0009164	112	0.029
neuron recognition	GO:0008038	101	0.028
kidney development	GO:0001822	3	0.028
purine ribonucleoside catabolic process	GO:0046130	112	0.028
cellular lipid metabolic process	GO:0044255	83	0.027
mitotic cytokinesis	GO:0000281	50	0.027
positive regulation of phosphate metabolic process	GO:0045937	139	0.027
positive regulation of developmental process	GO:0051094	143	0.027
oviposition	GO:0018991	19	0.026
cellular response to organonitrogen compound	GO:0071417	36	0.026
regulation of transport	GO:0051049	181	0.026
nucleobase containing compound catabolic process	GO:0034655	165	0.026
adult somatic muscle development	GO:0007527	14	0.026
cation transport	GO:0006812	110	0.026
negative regulation of cellular biosynthetic process	GO:0031327	277	0.026
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.026
cell death	GO:0008219	279	0.026
electron transport chain	GO:0022900	14	0.025
respiratory electron transport chain	GO:0022904	11	0.025
negative regulation of actin filament depolymerization	GO:0030835	2	0.025
ribonucleotide metabolic process	GO:0009259	145	0.025
phagocytosis	GO:0006909	215	0.025
response to monosaccharide	GO:0034284	4	0.025
aromatic compound catabolic process	GO:0019439	166	0.025
positive regulation of cellular component biogenesis	GO:0044089	80	0.025
microtubule organizing center organization	GO:0031023	168	0.024
glycerolipid metabolic process	GO:0046486	34	0.024
cellular nitrogen compound catabolic process	GO:0044270	165	0.024
regulation of phosphate metabolic process	GO:0019220	210	0.024
regulation of cellular amine metabolic process	GO:0033238	3	0.024
multicellular organismal reproductive behavior	GO:0033057	110	0.024
developmental growth	GO:0048589	280	0.024
growth	GO:0040007	359	0.023	Mouse
wing disc morphogenesis	GO:0007472	344	0.023
regulation of cell death	GO:0010941	173	0.023
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.023
homeostatic process	GO:0042592	199	0.023
l amino acid import	GO:0043092	2	0.023
positive regulation of cellular biosynthetic process	GO:0031328	316	0.023
ovarian follicle cell development	GO:0030707	248	0.023
epithelial cell differentiation	GO:0030855	322	0.022
organic cyclic compound catabolic process	GO:1901361	168	0.022
positive regulation of catalytic activity	GO:0043085	118	0.022
epithelial cell development	GO:0002064	274	0.022
post embryonic appendage morphogenesis	GO:0035120	385	0.022
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.022
response to nitrogen compound	GO:1901698	90	0.022
heterocycle catabolic process	GO:0046700	166	0.021
cell motility	GO:0048870	251	0.021
cardiovascular system development	GO:0072358	82	0.021
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.021
organelle localization	GO:0051640	148	0.021
regulation of catabolic process	GO:0009894	170	0.021
appendage development	GO:0048736	401	0.020
appendage morphogenesis	GO:0035107	397	0.020
muscle cell development	GO:0055001	50	0.020
organelle assembly	GO:0070925	198	0.020
positive regulation of cellular catabolic process	GO:0031331	95	0.019
lipid localization	GO:0010876	54	0.019
alditol phosphate metabolic process	GO:0052646	2	0.019	Mouse
death	GO:0016265	284	0.019
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.019
cell migration	GO:0016477	238	0.019
cellular protein modification process	GO:0006464	438	0.019
response to extracellular stimulus	GO:0009991	116	0.019
ion transmembrane transport	GO:0034220	122	0.019
cytoplasmic transport nurse cell to oocyte	GO:0007303	12	0.018
organophosphate catabolic process	GO:0046434	112	0.018
regulation of protein complex disassembly	GO:0043244	29	0.018
response to oxygen containing compound	GO:1901700	200	0.018
organonitrogen compound catabolic process	GO:1901565	128	0.018
dorsal ventral pattern formation	GO:0009953	133	0.018
regulation of cellular component biogenesis	GO:0044087	201	0.018
establishment of organelle localization	GO:0051656	122	0.017
musculoskeletal movement	GO:0050881	3	0.017
muscle system process	GO:0003012	21	0.017
imaginal disc derived appendage development	GO:0048737	399	0.017
brain development	GO:0007420	120	0.017
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.017
multicellular organismal movement	GO:0050879	3	0.017
generation of precursor metabolites and energy	GO:0006091	42	0.017
telencephalon development	GO:0021537	2	0.017
atp metabolic process	GO:0046034	49	0.017
cellular response to nitrogen compound	GO:1901699	51	0.017
response to hexose	GO:0009746	3	0.017
response to endogenous stimulus	GO:0009719	119	0.016
negative regulation of biosynthetic process	GO:0009890	277	0.016
imaginal disc derived wing morphogenesis	GO:0007476	337	0.016
establishment of nucleus localization	GO:0040023	26	0.016
protein localization	GO:0008104	284	0.016
purine ribonucleoside monophosphate catabolic process	GO:0009169	38	0.016
skeletal muscle myosin thick filament assembly	GO:0030241	3	0.016
cellular response to organic substance	GO:0071310	132	0.016
central nervous system development	GO:0007417	201	0.016
positive regulation of molecular function	GO:0044093	136	0.016
ovarian follicle cell migration	GO:0007297	121	0.016
positive regulation of multicellular organismal process	GO:0051240	143	0.016
ameboidal type cell migration	GO:0001667	151	0.016
innate immune response	GO:0045087	144	0.016
transmission of nerve impulse	GO:0019226	12	0.016
oxidoreduction coenzyme metabolic process	GO:0006733	2	0.016
positive regulation of nucleotide metabolic process	GO:0045981	55	0.015
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.015
acyl coa metabolic process	GO:0006637	3	0.015
cell division	GO:0051301	248	0.015
regulation of cellular localization	GO:0060341	136	0.015
response to organonitrogen compound	GO:0010243	75	0.015
nucleoside phosphate catabolic process	GO:1901292	110	0.015
negative regulation of gene expression	GO:0010629	387	0.015
purine ribonucleotide catabolic process	GO:0009154	109	0.015
tissue morphogenesis	GO:0048729	297	0.015
multi multicellular organism process	GO:0044706	123	0.015
germarium derived egg chamber formation	GO:0007293	101	0.015
response to alkaloid	GO:0043279	26	0.015
columnar cuboidal epithelial cell development	GO:0002066	249	0.015
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.014
regulation of cellular catabolic process	GO:0031329	157	0.014
multi organism reproductive behavior	GO:0044705	121	0.014
secretion by cell	GO:0032940	101	0.014
guanosine containing compound catabolic process	GO:1901069	74	0.014
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.014
regulation of apoptotic process	GO:0042981	130	0.014
immune response	GO:0006955	246	0.014
organelle fission	GO:0048285	340	0.014
regulation of cellular ketone metabolic process	GO:0010565	3	0.014
circulatory system development	GO:0072359	82	0.014
maintenance of location	GO:0051235	73	0.014
response to hypoxia	GO:0001666	53	0.013
sulfur compound metabolic process	GO:0006790	59	0.013
regulation of nucleotide metabolic process	GO:0006140	62	0.013
positive regulation of transport	GO:0051050	92	0.013
embryonic development via the syncytial blastoderm	GO:0001700	148	0.013
cellular carbohydrate catabolic process	GO:0044275	2	0.013
striated muscle contraction	GO:0006941	5	0.013
sex differentiation	GO:0007548	81	0.013
regulation of cellular protein metabolic process	GO:0032268	243	0.013
actin filament based movement	GO:0030048	26	0.013
purine nucleoside biosynthetic process	GO:0042451	3	0.013
defense response	GO:0006952	300	0.013
ras protein signal transduction	GO:0007265	88	0.013
triglyceride metabolic process	GO:0006641	12	0.013
regulation of nucleoside metabolic process	GO:0009118	50	0.013
small gtpase mediated signal transduction	GO:0007264	88	0.013
lipid catabolic process	GO:0016042	21	0.013
positive regulation of gene expression	GO:0010628	290	0.013
multicellular organismal signaling	GO:0035637	12	0.013
cellular homeostasis	GO:0019725	80	0.012
l glutamate import	GO:0051938	1	0.012
cellular response to chemical stimulus	GO:0070887	199	0.012
ovulation	GO:0030728	4	0.012
cognition	GO:0050890	141	0.012
positive regulation of nucleotide catabolic process	GO:0030813	46	0.012
purine nucleoside monophosphate catabolic process	GO:0009128	38	0.012
regulation of developmental growth	GO:0048638	174	0.012
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.012
cytoplasmic transport	GO:0016482	130	0.012
respiratory system development	GO:0060541	213	0.012
regulation of hydrolase activity	GO:0051336	97	0.012
imaginal disc pattern formation	GO:0007447	91	0.012
cytokinesis	GO:0000910	90	0.011
tube morphogenesis	GO:0035239	191	0.011
atp biosynthetic process	GO:0006754	2	0.011
regulation of purine nucleotide metabolic process	GO:1900542	62	0.011
multicellular organismal aging	GO:0010259	140	0.011
salivary gland development	GO:0007431	162	0.011
secretion	GO:0046903	109	0.011
regulation of organelle organization	GO:0033043	196	0.011
response to glucose	GO:0009749	2	0.011
protein modification process	GO:0036211	438	0.011
larval locomotory behavior	GO:0008345	27	0.011
establishment of protein localization	GO:0045184	163	0.011
purine ribonucleoside biosynthetic process	GO:0046129	3	0.011
gland development	GO:0048732	191	0.011
cellular protein localization	GO:0034613	160	0.011
skeletal muscle fiber development	GO:0048741	3	0.011
mitotic nuclear division	GO:0007067	213	0.011
regulation of actin filament depolymerization	GO:0030834	3	0.011
reactive oxygen species metabolic process	GO:0072593	22	0.011
response to hormone	GO:0009725	45	0.011
androgen metabolic process	GO:0008209	1	0.010
regulation of secretion by cell	GO:1903530	39	0.010
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.010
reproductive behavior	GO:0019098	122	0.010
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.010
response to radiation	GO:0009314	155	0.010
nitrogen compound transport	GO:0071705	85	0.010
regulation of protein modification process	GO:0031399	112	0.010
camera type eye development	GO:0043010	4	0.010	Mouse
cellular response to oxygen containing compound	GO:1901701	79	0.010
response to oxygen levels	GO:0070482	59	0.010
regulation of phosphorylation	GO:0042325	147	0.010

Gpo-1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.117
musculoskeletal system disease	DOID:17	0.050
hypophosphatasia	DOID:14213	0.044
nervous system disease	DOID:863	0.029
muscular disease	DOID:0080000	0.025
myopathy	DOID:423	0.025
cardiomyopathy	DOID:0050700	0.025
dilated cardiomyopathy	DOID:12930	0.025
intrinsic cardiomyopathy	DOID:0060036	0.025
muscle tissue disease	DOID:66	0.025
heart disease	DOID:114	0.025
cardiovascular system disease	DOID:1287	0.025
eye disease	DOID:5614	0.018
eye and adnexa disease	DOID:1492	0.018
sensory system disease	DOID:0050155	0.018

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