IMP: Integrative Multi-species Prediction

Drosophila melanogaster

209 known processes

Cbl (Dmel_CG7037)

CG7037 gene product from transcript CG7037-RB

(Aliases: CG7037,DCbl,cbl,anon-WO0118547.68,D-cblS,F165,CBL,D-cbl,D-Cbl L,D-cblL,Dv-cbl,CG7043,dCbl,d-cbl,D-Cbl,Dmel\CG7037,Dv-Cbl,Dcbl)

Entrez: 38961
FLYBASE: FBgn0020224
UniProtKB: O46034
UniProtKB: Q9VSK2

Process Predictions
Disease Predictions

Cbl biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
epithelial cell migration	GO:0010631	148	0.997
ovarian follicle cell development	GO:0030707	248	0.983
chorion containing eggshell formation	GO:0007304	105	0.979
columnar cuboidal epithelial cell development	GO:0002066	249	0.894
tissue migration	GO:0090130	155	0.890
border follicle cell migration	GO:0007298	113	0.869
eye photoreceptor cell differentiation	GO:0001754	145	0.860
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.778
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.764
eggshell chorion assembly	GO:0007306	66	0.759
immune response	GO:0006955	246	0.712	Mouse
programmed cell death	GO:0012501	257	0.708	Human
epithelial cell development	GO:0002064	274	0.686
eye development	GO:0001654	323	0.667
cellular ketone metabolic process	GO:0042180	24	0.665
respiratory system development	GO:0060541	213	0.649
cellular component assembly involved in morphogenesis	GO:0010927	151	0.642
eggshell formation	GO:0030703	105	0.638
epithelial cell differentiation	GO:0030855	322	0.574
erbb signaling pathway	GO:0038127	58	0.539
regionalization	GO:0003002	416	0.529
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.516
positive regulation of signaling	GO:0023056	243	0.501	Human
carboxylic acid metabolic process	GO:0019752	92	0.414
myotube cell development	GO:0014904	3	0.414
sensory organ morphogenesis	GO:0090596	260	0.411
axonogenesis	GO:0007409	290	0.408
regulation of protein metabolic process	GO:0051246	256	0.403
body morphogenesis	GO:0010171	2	0.392
r7 cell differentiation	GO:0045466	43	0.385
ameboidal type cell migration	GO:0001667	151	0.381
positive regulation of gene expression	GO:0010628	290	0.366
regulation of cellular ketone metabolic process	GO:0010565	3	0.359
compound eye morphogenesis	GO:0001745	249	0.357
death	GO:0016265	284	0.353
regulation of intracellular signal transduction	GO:1902531	236	0.346	Human
chromosome organization	GO:0051276	360	0.345
ovarian follicle cell migration	GO:0007297	121	0.338
negative regulation of cellular metabolic process	GO:0031324	382	0.331
positive regulation of rna biosynthetic process	GO:1902680	266	0.325
regulation of cellular amino acid metabolic process	GO:0006521	0	0.299
dorsal appendage formation	GO:0046843	47	0.298
protein modification process	GO:0036211	438	0.298
regulation of protein tyrosine kinase activity	GO:0061097	9	0.297
photoreceptor cell differentiation	GO:0046530	170	0.297
central nervous system development	GO:0007417	201	0.290
compound eye photoreceptor fate commitment	GO:0001752	36	0.290
localization of cell	GO:0051674	257	0.282
regulation of programmed cell death	GO:0043067	152	0.278	Human
carbohydrate derivative metabolic process	GO:1901135	217	0.268
establishment of localization in cell	GO:0051649	402	0.266
cell motility	GO:0048870	251	0.263
epithelium migration	GO:0090132	148	0.261
immune system process	GO:0002376	347	0.260	Mouse
reproductive structure development	GO:0048608	74	0.250
cell migration	GO:0016477	238	0.250
regulation of cellular catabolic process	GO:0031329	157	0.248
positive regulation of cell communication	GO:0010647	250	0.247	Human
positive regulation of rna metabolic process	GO:0051254	271	0.236
tissue morphogenesis	GO:0048729	297	0.230
regulation of mitotic cell cycle	GO:0007346	190	0.228
homeostatic process	GO:0042592	199	0.225
regulation of cellular protein metabolic process	GO:0032268	243	0.222
regulation of apoptotic process	GO:0042981	130	0.221	Human
embryonic digestive tract development	GO:0048566	5	0.219
dorsal ventral axis specification	GO:0009950	66	0.218
imaginal disc derived wing morphogenesis	GO:0007476	337	0.215
regulation of catalytic activity	GO:0050790	185	0.214
compound eye photoreceptor cell differentiation	GO:0001751	140	0.209
compound eye development	GO:0048749	307	0.205
r7 cell fate commitment	GO:0007465	12	0.196
biological adhesion	GO:0022610	138	0.191
imaginal disc derived appendage development	GO:0048737	399	0.191
macromolecule catabolic process	GO:0009057	161	0.186	Human Mouse
dorsal ventral pattern formation	GO:0009953	133	0.185
positive regulation of signal transduction	GO:0009967	223	0.179	Human
protein ubiquitination	GO:0016567	70	0.179	Human
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.178
positive regulation of macromolecule metabolic process	GO:0010604	405	0.175	Mouse
mitotic cell cycle phase transition	GO:0044772	138	0.172
cell death	GO:0008219	279	0.170
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.168
catabolic process	GO:0009056	409	0.168	Human Mouse
oocyte dorsal ventral axis specification	GO:0007310	34	0.168
positive regulation of cellular protein metabolic process	GO:0032270	118	0.157
camera type eye development	GO:0043010	4	0.153
axon development	GO:0061564	297	0.153
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.151
apoptotic process	GO:0006915	159	0.149	Human
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.148
positive regulation of biosynthetic process	GO:0009891	316	0.147
positive regulation of phosphate metabolic process	GO:0045937	139	0.147
imaginal disc derived wing vein specification	GO:0007474	48	0.146
regulation of epidermal growth factor receptor signaling pathway	GO:0042058	42	0.146
cellular protein modification process	GO:0006464	438	0.144
negative regulation of biosynthetic process	GO:0009890	277	0.143
regulation of cell death	GO:0010941	173	0.143
wing disc morphogenesis	GO:0007472	344	0.141
regulation of peptidyl tyrosine phosphorylation	GO:0050730	10	0.140
nuclear import	GO:0051170	51	0.135
establishment or maintenance of cell polarity	GO:0007163	167	0.134
anterior posterior pattern specification	GO:0009952	136	0.134
cellular catabolic process	GO:0044248	372	0.133	Human
posttranscriptional gene silencing	GO:0016441	46	0.133
nucleocytoplasmic transport	GO:0006913	72	0.133
regulation of molecular function	GO:0065009	217	0.130
positive regulation of intracellular signal transduction	GO:1902533	116	0.130	Human
peptidyl amino acid modification	GO:0018193	105	0.130
regulation of cell cycle	GO:0051726	291	0.128
regulation of catabolic process	GO:0009894	170	0.127	Mouse
negative regulation of gene expression	GO:0010629	387	0.127
transcription from rna polymerase ii promoter	GO:0006366	368	0.123
protein modification by small protein conjugation or removal	GO:0070647	106	0.122	Human
cellular macromolecular complex assembly	GO:0034622	153	0.120
appendage morphogenesis	GO:0035107	397	0.120
regulation of cellular localization	GO:0060341	136	0.119
regulation of epidermal growth factor activated receptor activity	GO:0007176	4	0.119
negative regulation of autophagy	GO:0010507	16	0.119
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.118
positive regulation of proteolysis	GO:0045862	52	0.117
negative regulation of response to stimulus	GO:0048585	258	0.117
cellular response to chemical stimulus	GO:0070887	199	0.117
positive regulation of hydrolase activity	GO:0051345	78	0.115
regulation of cell cycle phase transition	GO:1901987	130	0.114
nucleotide metabolic process	GO:0009117	161	0.113
tube morphogenesis	GO:0035239	191	0.112
developmental maturation	GO:0021700	172	0.111
response to organic substance	GO:0010033	284	0.111	Rat
head development	GO:0060322	135	0.110
positive regulation of transcription dna templated	GO:0045893	266	0.110
protein complex assembly	GO:0006461	200	0.110
negative regulation of signal transduction	GO:0009968	206	0.107
compound eye photoreceptor development	GO:0042051	78	0.105
positive regulation of protein metabolic process	GO:0051247	128	0.103	Mouse
positive regulation of cellular amine metabolic process	GO:0033240	0	0.101
single organismal cell cell adhesion	GO:0016337	45	0.100
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.100
protein maturation	GO:0051604	71	0.099
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.099
phosphorylation	GO:0016310	294	0.096
positive regulation of phosphorus metabolic process	GO:0010562	139	0.096
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.096
mapk cascade	GO:0000165	107	0.096	Human
growth	GO:0040007	359	0.095
cellular protein catabolic process	GO:0044257	83	0.094	Human
regulation of ras protein signal transduction	GO:0046578	93	0.093
aging	GO:0007568	143	0.093
cell maturation	GO:0048469	144	0.090
male gamete generation	GO:0048232	201	0.090
cellular response to organic substance	GO:0071310	132	0.088
eye morphogenesis	GO:0048592	260	0.088
blastoderm segmentation	GO:0007350	159	0.087
nucleoside triphosphate metabolic process	GO:0009141	120	0.086
organic acid metabolic process	GO:0006082	103	0.086
modification dependent macromolecule catabolic process	GO:0043632	79	0.086	Human
regulation of cellular response to stress	GO:0080135	89	0.085
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.085
protein catabolic process	GO:0030163	101	0.085	Human Mouse
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.084
positive regulation of reactive oxygen species metabolic process	GO:2000379	0	0.083
oxoacid metabolic process	GO:0043436	103	0.083
negative regulation of transcription dna templated	GO:0045892	237	0.083
spermatogenesis	GO:0007283	200	0.081
posttranscriptional regulation of gene expression	GO:0010608	145	0.080
negative regulation of signaling	GO:0023057	219	0.080
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.080
positive regulation of multicellular organismal process	GO:0051240	143	0.080	Mouse
regulation of cell cycle g1 s phase transition	GO:1902806	23	0.079
purine nucleotide metabolic process	GO:0006163	146	0.077
striated muscle cell differentiation	GO:0051146	90	0.076
spindle organization	GO:0007051	253	0.076
tube development	GO:0035295	244	0.076
embryonic development via the syncytial blastoderm	GO:0001700	148	0.076
organelle fission	GO:0048285	340	0.075
positive regulation of r7 cell differentiation	GO:0045678	7	0.074
actin filament based process	GO:0030029	220	0.074
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.073
dna metabolic process	GO:0006259	227	0.072
single organism cell adhesion	GO:0098602	47	0.072
response to oxygen radical	GO:0000305	3	0.072
positive regulation of nucleocytoplasmic transport	GO:0046824	24	0.070
phosphatidylinositol mediated signaling	GO:0048015	4	0.069	Human
cell cycle phase transition	GO:0044770	140	0.068
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.068
secretion	GO:0046903	109	0.065
positive regulation of cellular biosynthetic process	GO:0031328	316	0.065
regulation of nucleocytoplasmic transport	GO:0046822	35	0.065
positive regulation of cellular catabolic process	GO:0031331	95	0.065
organophosphate metabolic process	GO:0019637	195	0.064
positive regulation of mapk cascade	GO:0043410	63	0.064
axis specification	GO:0009798	167	0.063
negative regulation of cell cycle g1 s phase transition	GO:1902807	13	0.062
regulation of r7 cell differentiation	GO:0045676	15	0.062
organic cyclic compound catabolic process	GO:1901361	168	0.062
positive regulation of catabolic process	GO:0009896	105	0.061	Mouse
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.061
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.060
stress activated protein kinase signaling cascade	GO:0031098	55	0.060
chemotaxis	GO:0006935	249	0.059
intracellular transport	GO:0046907	228	0.059
negative regulation of g1 s transition of mitotic cell cycle	GO:2000134	13	0.058
autophagy	GO:0006914	108	0.057
positive regulation of cell adhesion	GO:0045785	10	0.057
muscle structure development	GO:0061061	224	0.057
regulation of cellular amine metabolic process	GO:0033238	3	0.057
small gtpase mediated signal transduction	GO:0007264	88	0.057
photoreceptor cell development	GO:0042461	96	0.057
organonitrogen compound metabolic process	GO:1901564	318	0.056
regulation of cell cycle process	GO:0010564	181	0.056
positive regulation of nucleoside metabolic process	GO:0045979	47	0.055
stress activated mapk cascade	GO:0051403	52	0.055
negative regulation of cell cycle process	GO:0010948	109	0.055
organic substance catabolic process	GO:1901575	308	0.054	Human Mouse
inositol lipid mediated signaling	GO:0048017	4	0.054	Human
small molecule metabolic process	GO:0044281	305	0.054
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.054
protein modification by small protein conjugation	GO:0032446	79	0.053	Human
protein complex biogenesis	GO:0070271	201	0.053
neuron projection guidance	GO:0097485	241	0.052
regulation of protein kinase activity	GO:0045859	51	0.052
proteolysis	GO:0006508	192	0.052	Human
cell cycle g1 s phase transition	GO:0044843	31	0.052
negative regulation of protein tyrosine kinase activity	GO:0061099	5	0.051
single organism cellular localization	GO:1902580	180	0.050
anterior posterior axis specification embryo	GO:0008595	103	0.050
photoreceptor cell fate commitment	GO:0046552	41	0.049
cell fate determination	GO:0001709	91	0.049
response to external biotic stimulus	GO:0043207	293	0.049
regulation of organ morphogenesis	GO:2000027	78	0.048
regulation of hydrolase activity	GO:0051336	97	0.048
response to fungus	GO:0009620	50	0.048
rna processing	GO:0006396	147	0.048
carbohydrate derivative biosynthetic process	GO:1901137	85	0.047
muscle cell differentiation	GO:0042692	103	0.047
meiotic cell cycle	GO:0051321	171	0.047
negative regulation of cell cycle	GO:0045786	116	0.046
oocyte development	GO:0048599	124	0.046
cell adhesion	GO:0007155	136	0.045
regulation of cell morphogenesis	GO:0022604	163	0.045
regulation of embryonic development	GO:0045995	68	0.045
negative regulation of cell death	GO:0060548	81	0.045	Human
regulation of growth	GO:0040008	233	0.045
positive regulation of nucleotide metabolic process	GO:0045981	55	0.045
torc1 signaling	GO:0038202	12	0.045
positive regulation of protein catabolic process	GO:0045732	34	0.044	Mouse
eye photoreceptor cell development	GO:0042462	81	0.044
regulation of vesicle mediated transport	GO:0060627	59	0.044
skeletal muscle fiber development	GO:0048741	3	0.043
peptidyl threonine phosphorylation	GO:0018107	2	0.043
multicellular organism growth	GO:0035264	46	0.043
appendage development	GO:0048736	401	0.042
imaginal disc derived wing margin morphogenesis	GO:0008587	41	0.042
intrinsic apoptotic signaling pathway	GO:0097193	16	0.042
nuclear transport	GO:0051169	72	0.042
ribonucleotide biosynthetic process	GO:0009260	28	0.042
nucleoside phosphate catabolic process	GO:1901292	110	0.041
response to organic cyclic compound	GO:0014070	89	0.041
regulation of cell development	GO:0060284	215	0.040
segmentation	GO:0035282	207	0.039
negative regulation of cell communication	GO:0010648	223	0.039
ras protein signal transduction	GO:0007265	88	0.039
response to other organism	GO:0051707	293	0.039
regulation of protein phosphorylation	GO:0001932	64	0.039
adherens junction organization	GO:0034332	27	0.038
regulation of neurogenesis	GO:0050767	158	0.038
regulation of hormone levels	GO:0010817	40	0.038
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.038
actin cytoskeleton organization	GO:0030036	206	0.038
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.038
synaptic vesicle transport	GO:0048489	50	0.038
negative regulation of cell cycle phase transition	GO:1901988	103	0.038
regulation of purine nucleotide metabolic process	GO:1900542	62	0.038
cell cycle checkpoint	GO:0000075	95	0.037
regulation of autophagy	GO:0010506	62	0.037
peptidyl tyrosine modification	GO:0018212	24	0.037
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	12	0.037
single organism biosynthetic process	GO:0044711	206	0.037
embryonic pattern specification	GO:0009880	174	0.037
striated muscle cell development	GO:0055002	50	0.037
regulation of mapk cascade	GO:0043408	92	0.036	Human
negative regulation of cell proliferation	GO:0008285	69	0.036	Mouse
activation of protein kinase activity	GO:0032147	12	0.036
positive regulation of catalytic activity	GO:0043085	118	0.035
oocyte differentiation	GO:0009994	145	0.035
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.035
regulation of apoptotic signaling pathway	GO:2001233	10	0.035
negative regulation of apoptotic process	GO:0043066	63	0.035	Human
forebrain development	GO:0030900	2	0.035
dorsal ventral axis specification ovarian follicular epithelium	GO:0008069	13	0.035
oocyte axis specification	GO:0007309	108	0.035
embryonic digestive tract morphogenesis	GO:0048557	4	0.034
single organism intracellular transport	GO:1902582	207	0.034
g1 s transition of mitotic cell cycle	GO:0000082	31	0.034
establishment of organelle localization	GO:0051656	122	0.034
secretion by cell	GO:0032940	101	0.034
brain development	GO:0007420	120	0.034
positive regulation of protein modification process	GO:0031401	58	0.034
regulation of transport	GO:0051049	181	0.034
negative regulation of cell adhesion	GO:0007162	9	0.034
oocyte construction	GO:0007308	112	0.033
response to biotic stimulus	GO:0009607	294	0.033
cytoplasmic transport	GO:0016482	130	0.033
protein phosphorylation	GO:0006468	169	0.033
salivary gland cell autophagic cell death	GO:0035071	83	0.033
neuron fate commitment	GO:0048663	50	0.033
regulation of response to external stimulus	GO:0032101	115	0.032
histolysis	GO:0007559	102	0.032
mitotic spindle organization	GO:0007052	220	0.032
regulation of cell division	GO:0051302	72	0.032
regulation of cytoplasmic transport	GO:1903649	47	0.032
positive regulation of response to stimulus	GO:0048584	323	0.032	Human Mouse
regulation of protein modification process	GO:0031399	112	0.031
regulation of g1 s transition of mitotic cell cycle	GO:2000045	23	0.031
oocyte nucleus localization involved in oocyte dorsal ventral axis specification	GO:0051663	12	0.031
positive regulation of mitotic cell cycle	GO:0045931	34	0.031
defense response to fungus	GO:0050832	48	0.030
dendrite morphogenesis	GO:0048813	199	0.030
reproductive system development	GO:0061458	74	0.030
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.029
positive regulation of phosphorylation	GO:0042327	87	0.029
germarium derived oocyte fate determination	GO:0007294	26	0.029
meiosis i	GO:0007127	59	0.029
macromolecular complex assembly	GO:0065003	256	0.029
head involution	GO:0008258	35	0.029
positive regulation of cell cycle process	GO:0090068	28	0.029
defense response to gram negative bacterium	GO:0050829	94	0.028
cellular amine metabolic process	GO:0044106	12	0.028
regulation of translation	GO:0006417	56	0.028
lipid metabolic process	GO:0006629	121	0.028
response to alcohol	GO:0097305	95	0.028
negative regulation of catalytic activity	GO:0043086	42	0.027
regulation of nuclear division	GO:0051783	58	0.027
hematopoietic or lymphoid organ development	GO:0048534	57	0.027
cell fate specification	GO:0001708	71	0.027
determination of adult lifespan	GO:0008340	137	0.027
positive regulation of photoreceptor cell differentiation	GO:0046534	12	0.027
nuclear division	GO:0000280	332	0.027
response to ecdysone	GO:0035075	34	0.027
regulation of proteolysis	GO:0030162	87	0.027
regulation of ras gtpase activity	GO:0032318	38	0.027
dendrite development	GO:0016358	204	0.027
ribonucleoside catabolic process	GO:0042454	112	0.026
positive regulation of apoptotic process	GO:0043065	47	0.026
erk1 and erk2 cascade	GO:0070371	39	0.026
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.026
modification dependent protein catabolic process	GO:0019941	78	0.026	Human
axon guidance	GO:0007411	233	0.026
response to sterol	GO:0036314	34	0.026
cellular response to oxygen containing compound	GO:1901701	79	0.026
negative regulation of epidermal growth factor receptor signaling pathway	GO:0042059	29	0.026
regulation of anatomical structure morphogenesis	GO:0022603	242	0.026
chromatin modification	GO:0016568	147	0.026
developmental growth	GO:0048589	280	0.026
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.026
chromatin organization	GO:0006325	207	0.026
histoblast morphogenesis	GO:0007488	9	0.026
cell aging	GO:0007569	2	0.025
regulation of protein catabolic process	GO:0042176	55	0.025	Mouse
regulation of phosphorus metabolic process	GO:0051174	210	0.025
mrna metabolic process	GO:0016071	124	0.025
morphogenesis of a branching structure	GO:0001763	45	0.025
protein import	GO:0017038	55	0.025
skeletal muscle organ development	GO:0060538	48	0.025
phosphatidylinositol 3 kinase signaling	GO:0014065	4	0.025	Human
regulation of protein import into nucleus	GO:0042306	28	0.025
regulation of nucleoside metabolic process	GO:0009118	50	0.025
protein processing	GO:0016485	68	0.025
negative regulation of cellular protein metabolic process	GO:0032269	85	0.025
mitotic nuclear division	GO:0007067	213	0.025
stem cell maintenance	GO:0019827	67	0.025
positive regulation of protein transport	GO:0051222	37	0.025
heart development	GO:0007507	82	0.024
negative regulation of protein metabolic process	GO:0051248	85	0.024
response to nitrogen compound	GO:1901698	90	0.024
regulation of gtpase activity	GO:0043087	44	0.024
negative regulation of programmed cell death	GO:0043069	72	0.024	Human
developmental programmed cell death	GO:0010623	138	0.024
reactive oxygen species metabolic process	GO:0072593	22	0.023
regulation of cellular protein catabolic process	GO:1903362	44	0.023
intracellular signal transduction	GO:0035556	300	0.023	Human Mouse
response to superoxide	GO:0000303	3	0.023
regulation of anatomical structure size	GO:0090066	163	0.023
rho protein signal transduction	GO:0007266	14	0.023
embryonic morphogenesis	GO:0048598	206	0.023
response to oxygen containing compound	GO:1901700	200	0.023
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.023	Human
response to ketone	GO:1901654	34	0.023
ribonucleotide metabolic process	GO:0009259	145	0.023
regulation of kinase activity	GO:0043549	53	0.023
regulation of cardioblast differentiation	GO:0051890	9	0.022
gtp catabolic process	GO:0006184	72	0.022
leg disc development	GO:0035218	92	0.022
sex differentiation	GO:0007548	81	0.022
negative regulation of rna metabolic process	GO:0051253	251	0.022
proteasomal protein catabolic process	GO:0010498	59	0.022
negative regulation of catabolic process	GO:0009895	36	0.022
hematopoietic progenitor cell differentiation	GO:0002244	1	0.022
nucleoside phosphate metabolic process	GO:0006753	162	0.022
exocrine system development	GO:0035272	162	0.022
purine containing compound metabolic process	GO:0072521	155	0.022
ribonucleotide catabolic process	GO:0009261	109	0.021
cellular macromolecule catabolic process	GO:0044265	136	0.021	Human
defense response to other organism	GO:0098542	225	0.021
regulation of secretion by cell	GO:1903530	39	0.021
autophagic cell death	GO:0048102	83	0.021
response to endogenous stimulus	GO:0009719	119	0.021	Rat
positive regulation of gtp catabolic process	GO:0033126	43	0.021
cellular amino acid metabolic process	GO:0006520	61	0.021
regulation of mitosis	GO:0007088	56	0.021
cell cell junction organization	GO:0045216	55	0.021
regulation of cell growth	GO:0001558	43	0.021
divalent metal ion transport	GO:0070838	26	0.020
regulation of organelle organization	GO:0033043	196	0.020
apoptotic signaling pathway	GO:0097190	27	0.020
peptidyl tyrosine phosphorylation	GO:0018108	24	0.020
regulation of stress activated mapk cascade	GO:0032872	41	0.020
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.020
negative regulation of mitotic cell cycle	GO:0045930	109	0.020
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.020
purine ribonucleotide metabolic process	GO:0009150	145	0.020
ribonucleoside metabolic process	GO:0009119	127	0.020
cell division	GO:0051301	248	0.019
embryonic axis specification	GO:0000578	107	0.019
innate immune response	GO:0045087	144	0.019
specification of organ identity	GO:0010092	3	0.019
single organism catabolic process	GO:0044712	228	0.019
eye photoreceptor cell fate commitment	GO:0042706	37	0.019
mitotic sister chromatid segregation	GO:0000070	87	0.019
ribose phosphate biosynthetic process	GO:0046390	28	0.019
regulation of developmental growth	GO:0048638	174	0.019
gland development	GO:0048732	191	0.019
regulation of gtp catabolic process	GO:0033124	44	0.018
single organism carbohydrate metabolic process	GO:0044723	72	0.018
cellular macromolecule localization	GO:0070727	220	0.018
regulation of rna splicing	GO:0043484	69	0.018
determination of left right symmetry	GO:0007368	9	0.018
positive regulation of lipid metabolic process	GO:0045834	4	0.018
response to bacterium	GO:0009617	198	0.018
regulation of erk1 and erk2 cascade	GO:0070372	39	0.018
salivary gland development	GO:0007431	162	0.018
rna splicing	GO:0008380	83	0.018
organ growth	GO:0035265	56	0.018
regulation of cell adhesion	GO:0030155	27	0.018
amine metabolic process	GO:0009308	12	0.018
regulation of cellular response to oxidative stress	GO:1900407	4	0.018
carbohydrate metabolic process	GO:0005975	82	0.018
positive regulation of transport	GO:0051050	92	0.018
muscle cell development	GO:0055001	50	0.018
terminal region determination	GO:0007362	25	0.018
regulation of response to stress	GO:0080134	200	0.017
cellular response to dna damage stimulus	GO:0006974	223	0.017
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.017
regulation of nucleotide metabolic process	GO:0006140	62	0.017
regulation of secretion	GO:0051046	44	0.017
positive regulation of protein phosphorylation	GO:0001934	34	0.017
positive regulation of organelle organization	GO:0010638	65	0.017
positive regulation of molecular function	GO:0044093	136	0.017
regulation of intracellular transport	GO:0032386	64	0.017
response to abiotic stimulus	GO:0009628	341	0.017	Rat
response to oxidative stress	GO:0006979	86	0.017
regulation of immune response	GO:0050776	118	0.017	Mouse
regulation of establishment of protein localization	GO:0070201	61	0.017
protein localization	GO:0008104	284	0.017
open tracheal system development	GO:0007424	204	0.017
synaptic vesicle localization	GO:0097479	53	0.017
protein transport	GO:0015031	155	0.017
immune effector process	GO:0002252	98	0.017
regulation of multicellular organismal development	GO:2000026	414	0.017	Mouse Worm
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.017
retina development in camera type eye	GO:0060041	4	0.016
positive regulation of cell development	GO:0010720	61	0.016
rna splicing via transesterification reactions	GO:0000375	73	0.016
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.016
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.016
defense response to bacterium	GO:0042742	178	0.016
purine nucleoside metabolic process	GO:0042278	127	0.016
regulation of map kinase activity	GO:0043405	17	0.016	Human
wound healing	GO:0042060	75	0.016
protein targeting to nucleus	GO:0044744	51	0.016
single organism nuclear import	GO:1902593	51	0.016
connective tissue development	GO:0061448	3	0.016
negative regulation of phosphorus metabolic process	GO:0010563	45	0.016
membrane organization	GO:0061024	112	0.016
cellular nitrogen compound catabolic process	GO:0044270	165	0.015
anterior posterior axis specification	GO:0009948	109	0.015
positive regulation of kinase activity	GO:0033674	25	0.015
glycosyl compound metabolic process	GO:1901657	127	0.015
regulation of protein localization	GO:0032880	76	0.015
regulation of behavior	GO:0050795	75	0.015
stem cell development	GO:0048864	79	0.015
intracellular protein transport	GO:0006886	104	0.015
cellular homeostasis	GO:0019725	80	0.015
regulation of mrna metabolic process	GO:1903311	72	0.015
embryo development ending in birth or egg hatching	GO:0009792	152	0.015

Cbl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
organ system cancer	DOID:0050686	0.030
disease of cellular proliferation	DOID:14566	0.030
cancer	DOID:162	0.030
thoracic cancer	DOID:5093	0.015
breast cancer	DOID:1612	0.015

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