IMP: Integrative Multi-species Prediction

Drosophila melanogaster

47 known processes

CG7033 (Dmel_CG7033)

CG7033 gene product from transcript CG7033-RC

(Aliases: CCT2,Dmel\CG7033,TCP-1beta,SD02216p)

Entrez: 31838
FLYBASE: FBgn0030086
UniProtKB: Q9W392

Process Predictions
Disease Predictions

CG7033 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
mitotic spindle organization	GO:0007052	220	0.898
cytoplasmic microtubule organization	GO:0031122	22	0.836
protein complex biogenesis	GO:0070271	201	0.736
spindle organization	GO:0007051	253	0.628
spindle assembly involved in mitosis	GO:0090307	50	0.625
organic substance transport	GO:0071702	257	0.587
vesicle mediated transport	GO:0016192	381	0.505	Worm
death	GO:0016265	284	0.446	Worm
protein complex assembly	GO:0006461	200	0.402
activation of cysteine type endopeptidase activity	GO:0097202	17	0.391
programmed cell death	GO:0012501	257	0.343	Worm
single fertilization	GO:0007338	24	0.343	Mouse
regulation of cell death	GO:0010941	173	0.331
protein transport	GO:0015031	155	0.320
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.293
muscle structure development	GO:0061061	224	0.286
organelle fission	GO:0048285	340	0.279
positive regulation of developmental process	GO:0051094	143	0.276	Worm
establishment of protein localization	GO:0045184	163	0.265
macromolecular complex assembly	GO:0065003	256	0.256
microtubule cytoskeleton organization involved in mitosis	GO:1902850	52	0.253
negative regulation of gene expression	GO:0010629	387	0.223
spindle assembly	GO:0051225	80	0.217
negative regulation of cellular biosynthetic process	GO:0031327	277	0.216
regulation of apoptotic process	GO:0042981	130	0.213
activation of cysteine type endopeptidase activity involved in apoptotic process	GO:0006919	16	0.206
apoptotic process	GO:0006915	159	0.196	Worm
organelle assembly	GO:0070925	198	0.195
cellular macromolecule localization	GO:0070727	220	0.192
cell recognition	GO:0008037	102	0.191	Mouse
cell death	GO:0008219	279	0.183	Worm
cytoplasmic transport	GO:0016482	130	0.177
endocytosis	GO:0006897	310	0.164	Worm
negative regulation of biosynthetic process	GO:0009890	277	0.160
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.150
intracellular transport	GO:0046907	228	0.149
mitotic nuclear division	GO:0007067	213	0.149
cellular protein complex assembly	GO:0043623	71	0.143	Human
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	23	0.130
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.117
regulation of cell differentiation	GO:0045595	302	0.107
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.102
regulation of programmed cell death	GO:0043067	152	0.101
establishment of localization in cell	GO:0051649	402	0.101
regulation of cell development	GO:0060284	215	0.100
small molecule metabolic process	GO:0044281	305	0.092
response to peptide	GO:1901652	29	0.088
positive regulation of protein metabolic process	GO:0051247	128	0.087
response to virus	GO:0009615	28	0.084
intracellular protein transport	GO:0006886	104	0.079
cell motility	GO:0048870	251	0.079
protein localization	GO:0008104	284	0.077
fertilization	GO:0009566	26	0.076	Mouse
positive regulation of cellular protein metabolic process	GO:0032270	118	0.076
regulation of proteolysis	GO:0030162	87	0.076
regulation of peptidase activity	GO:0052547	39	0.074
protein modification process	GO:0036211	438	0.072
purine containing compound metabolic process	GO:0072521	155	0.072
cellular macromolecular complex assembly	GO:0034622	153	0.068	Human
regulation of protein metabolic process	GO:0051246	256	0.068
mitotic spindle elongation	GO:0000022	81	0.067
positive regulation of endopeptidase activity	GO:0010950	26	0.066
intracellular signal transduction	GO:0035556	300	0.066
positive regulation of catalytic activity	GO:0043085	118	0.064
larval development	GO:0002164	104	0.063	Worm
positive regulation of peptidase activity	GO:0010952	29	0.063
multicellular organism growth	GO:0035264	46	0.061	Worm
immune system process	GO:0002376	347	0.060
response to abiotic stimulus	GO:0009628	341	0.058
determination of adult lifespan	GO:0008340	137	0.056	Worm
stem cell differentiation	GO:0048863	117	0.055
establishment of protein localization to organelle	GO:0072594	62	0.054
cellular amino acid metabolic process	GO:0006520	61	0.054
positive regulation of cell death	GO:0010942	69	0.054
response to biotic stimulus	GO:0009607	294	0.053
negative regulation of rna metabolic process	GO:0051253	251	0.052
nuclear division	GO:0000280	332	0.051
positive regulation of proteolysis	GO:0045862	52	0.049
organic substance catabolic process	GO:1901575	308	0.049
regulation of anatomical structure morphogenesis	GO:0022603	242	0.048
negative regulation of cellular metabolic process	GO:0031324	382	0.047
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.047
proteolysis	GO:0006508	192	0.046
response to peptide hormone	GO:0043434	29	0.045
cellular protein localization	GO:0034613	160	0.045
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.044
negative regulation of programmed cell death	GO:0043069	72	0.044
chromatin remodeling	GO:0006338	72	0.044
positive regulation of cysteine type endopeptidase activity	GO:2001056	24	0.043
organic acid metabolic process	GO:0006082	103	0.043
single organism cellular localization	GO:1902580	180	0.043
response to organic substance	GO:0010033	284	0.042
phosphorylation	GO:0016310	294	0.042
single organism intracellular transport	GO:1902582	207	0.042
cellular protein modification process	GO:0006464	438	0.041
actin cytoskeleton organization	GO:0030036	206	0.041
response to decreased oxygen levels	GO:0036293	58	0.039
carboxylic acid metabolic process	GO:0019752	92	0.039
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.038
regulation of multicellular organism growth	GO:0040014	40	0.038	Worm
chromosome organization	GO:0051276	360	0.038
regulation of multi organism process	GO:0043900	131	0.037
positive regulation of programmed cell death	GO:0043068	62	0.037
protein localization to organelle	GO:0033365	82	0.037
multicellular organismal aging	GO:0010259	140	0.037	Worm
response to oxygen containing compound	GO:1901700	200	0.036
response to external biotic stimulus	GO:0043207	293	0.036
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.035
negative regulation of apoptotic process	GO:0043066	63	0.035
protein localization to nucleus	GO:0034504	55	0.035
camera type eye development	GO:0043010	4	0.034
ribonucleoprotein complex biogenesis	GO:0022613	31	0.034
regulation of cellular protein metabolic process	GO:0032268	243	0.034
striated muscle cell differentiation	GO:0051146	90	0.033
protein import	GO:0017038	55	0.033
positive regulation of apoptotic process	GO:0043065	47	0.033
eye development	GO:0001654	323	0.032
negative regulation of cell differentiation	GO:0045596	143	0.032
positive regulation of molecular function	GO:0044093	136	0.031
negative regulation of cell death	GO:0060548	81	0.031
oxoacid metabolic process	GO:0043436	103	0.031
nucleoside phosphate metabolic process	GO:0006753	162	0.030
gene silencing	GO:0016458	138	0.029
sensory organ morphogenesis	GO:0090596	260	0.028
developmental growth	GO:0048589	280	0.028	Worm
response to hypoxia	GO:0001666	53	0.028
body morphogenesis	GO:0010171	2	0.028
nucleoside monophosphate metabolic process	GO:0009123	52	0.027
cell division	GO:0051301	248	0.027
nuclear transport	GO:0051169	72	0.027
organonitrogen compound metabolic process	GO:1901564	318	0.027
establishment or maintenance of cell polarity	GO:0007163	167	0.027
centrosome duplication	GO:0051298	121	0.027
regulation of retinal cell programmed cell death	GO:0046668	18	0.027
positive regulation of macromolecule metabolic process	GO:0010604	405	0.027
regulation of protein transport	GO:0051223	57	0.026
glycosyl compound catabolic process	GO:1901658	112	0.026
aromatic compound catabolic process	GO:0019439	166	0.026
axonogenesis	GO:0007409	290	0.026
negative regulation of protein metabolic process	GO:0051248	85	0.026
cardiovascular system development	GO:0072358	82	0.025
response to oxygen levels	GO:0070482	59	0.025
purine ribonucleoside metabolic process	GO:0046128	127	0.025
regulation of cell cycle process	GO:0010564	181	0.025
regulation of intracellular signal transduction	GO:1902531	236	0.024
negative regulation of cell cycle process	GO:0010948	109	0.024
response to endogenous stimulus	GO:0009719	119	0.024
gland morphogenesis	GO:0022612	145	0.024
protein maturation	GO:0051604	71	0.024
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.023
negative regulation of response to stimulus	GO:0048585	258	0.023
cell proliferation	GO:0008283	299	0.023
developmental programmed cell death	GO:0010623	138	0.023
cellular response to chemical stimulus	GO:0070887	199	0.023
positive regulation of signal transduction	GO:0009967	223	0.023
macromolecule catabolic process	GO:0009057	161	0.023
positive regulation of cell migration	GO:0030335	2	0.023
cellular catabolic process	GO:0044248	372	0.022
response to bacterium	GO:0009617	198	0.022
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.022
response to other organism	GO:0051707	293	0.022
eye morphogenesis	GO:0048592	260	0.022
actin filament based process	GO:0030029	220	0.021
chromatin modification	GO:0016568	147	0.021
sex differentiation	GO:0007548	81	0.021	Worm
gland development	GO:0048732	191	0.021
response to organonitrogen compound	GO:0010243	75	0.021
regulation of molecular function	GO:0065009	217	0.021
negative regulation of transcription dna templated	GO:0045892	237	0.021
localization of cell	GO:0051674	257	0.021
regulation of cellular ketone metabolic process	GO:0010565	3	0.021
rna splicing via transesterification reactions	GO:0000375	73	0.021
forebrain development	GO:0030900	2	0.021
organic cyclic compound catabolic process	GO:1901361	168	0.021
single organism catabolic process	GO:0044712	228	0.021
receptor mediated endocytosis	GO:0006898	21	0.020	Worm
protein phosphorylation	GO:0006468	169	0.020
response to nitrogen compound	GO:1901698	90	0.020
positive regulation of cellular biosynthetic process	GO:0031328	316	0.020
regulation of cell morphogenesis	GO:0022604	163	0.020
negative regulation of developmental process	GO:0051093	201	0.020
positive regulation of growth	GO:0045927	75	0.019	Worm
axon development	GO:0061564	297	0.019
anatomical structure homeostasis	GO:0060249	97	0.019
head development	GO:0060322	135	0.019
nucleocytoplasmic transport	GO:0006913	72	0.019
positive regulation of response to stimulus	GO:0048584	323	0.019
positive regulation of cell communication	GO:0010647	250	0.019
catabolic process	GO:0009056	409	0.018
regulation of defense response	GO:0031347	102	0.018
regulation of organ morphogenesis	GO:2000027	78	0.018
muscle cell differentiation	GO:0042692	103	0.018
regulation of transport	GO:0051049	181	0.018
transcription from rna polymerase ii promoter	GO:0006366	368	0.018
regulation of cellular amine metabolic process	GO:0033238	3	0.018
positive regulation of hydrolase activity	GO:0051345	78	0.018
organophosphate catabolic process	GO:0046434	112	0.018
growth	GO:0040007	359	0.018	Worm
g1 s transition of mitotic cell cycle	GO:0000082	31	0.018
positive regulation of signaling	GO:0023056	243	0.018
organonitrogen compound catabolic process	GO:1901565	128	0.018
cell cycle g1 s phase transition	GO:0044843	31	0.018
protein targeting to nucleus	GO:0044744	51	0.018
nuclear import	GO:0051170	51	0.017
protein import into nucleus	GO:0006606	51	0.017
dna replication	GO:0006260	48	0.017
positive regulation of rna biosynthetic process	GO:1902680	266	0.017
microtubule polymerization or depolymerization	GO:0031109	39	0.017
negative regulation of signal transduction	GO:0009968	206	0.017
reactive oxygen species metabolic process	GO:0072593	22	0.017
positive regulation of multicellular organismal process	GO:0051240	143	0.017	Worm
urogenital system development	GO:0001655	72	0.017
negative regulation of multicellular organismal process	GO:0051241	142	0.016
protein destabilization	GO:0031648	2	0.016
negative regulation of signaling	GO:0023057	219	0.016
embryonic morphogenesis	GO:0048598	206	0.016
zymogen activation	GO:0031638	20	0.016
ribonucleoside metabolic process	GO:0009119	127	0.016
negative regulation of cell development	GO:0010721	62	0.016
regulation of phosphate metabolic process	GO:0019220	210	0.016
regulation of phosphorus metabolic process	GO:0051174	210	0.016
regulation of hydrolase activity	GO:0051336	97	0.016
retinal cell programmed cell death	GO:0046666	25	0.016
cellular response to dna damage stimulus	GO:0006974	223	0.015
regulation of protein localization	GO:0032880	76	0.015
positive regulation of cellular component organization	GO:0051130	156	0.015
taxis	GO:0042330	304	0.015
regulation of catalytic activity	GO:0050790	185	0.015
regulation of cellular protein catabolic process	GO:1903362	44	0.015
response to lipopolysaccharide	GO:0032496	4	0.015
epithelial cell differentiation	GO:0030855	322	0.015
protein processing	GO:0016485	68	0.015
actin filament organization	GO:0007015	126	0.015
purine ribonucleotide catabolic process	GO:0009154	109	0.015
developmental pigmentation	GO:0048066	68	0.014
cell type specific apoptotic process	GO:0097285	38	0.014
protein catabolic process	GO:0030163	101	0.014
phagocytosis	GO:0006909	215	0.014
regulation of meiosis	GO:0040020	3	0.014
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.014
muscle organ development	GO:0007517	127	0.014
embryo development ending in birth or egg hatching	GO:0009792	152	0.014	Worm
positive regulation of gene expression	GO:0010628	290	0.014
cellular response to extracellular stimulus	GO:0031668	64	0.014
negative regulation of rna biosynthetic process	GO:1902679	240	0.014
purine nucleotide catabolic process	GO:0006195	109	0.014
cell cycle phase transition	GO:0044770	140	0.014
connective tissue development	GO:0061448	3	0.014
microtubule organizing center organization	GO:0031023	168	0.013
stem cell development	GO:0048864	79	0.013
protein targeting	GO:0006605	64	0.013
immune effector process	GO:0002252	98	0.013
response to alcohol	GO:0097305	95	0.013
heterocycle catabolic process	GO:0046700	166	0.013
negative regulation of cell cycle	GO:0045786	116	0.013
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	25	0.013
cellular response to organic substance	GO:0071310	132	0.012
dna metabolic process	GO:0006259	227	0.012
reproductive structure development	GO:0048608	74	0.012	Worm
defense response	GO:0006952	300	0.012
regulation of cellular component biogenesis	GO:0044087	201	0.012
regulation of multicellular organismal development	GO:2000026	414	0.012
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.012
regulation of cellular localization	GO:0060341	136	0.012
purine nucleoside metabolic process	GO:0042278	127	0.012
cell projection assembly	GO:0030031	94	0.012
chromatin organization	GO:0006325	207	0.012
dendrite morphogenesis	GO:0048813	199	0.012
kidney development	GO:0001822	3	0.011
nucleoside catabolic process	GO:0009164	112	0.011
positive regulation of organelle organization	GO:0010638	65	0.011
purine ribonucleotide metabolic process	GO:0009150	145	0.011
cellular response to hormone stimulus	GO:0032870	44	0.011
regulation of catabolic process	GO:0009894	170	0.011
negative regulation of protein processing	GO:0010955	31	0.011
purine nucleotide metabolic process	GO:0006163	146	0.011
cell migration	GO:0016477	238	0.011
single organism behavior	GO:0044708	391	0.011
negative regulation of cell communication	GO:0010648	223	0.011
genitalia development	GO:0048806	26	0.011	Worm
embryonic organ development	GO:0048568	50	0.011
developmental maturation	GO:0021700	172	0.011
cellular ketone metabolic process	GO:0042180	24	0.011
regulation of cellular amino acid metabolic process	GO:0006521	0	0.011
mitotic cell cycle phase transition	GO:0044772	138	0.011
regulation of endopeptidase activity	GO:0052548	36	0.010
positive regulation of transcription dna templated	GO:0045893	266	0.010
amine metabolic process	GO:0009308	12	0.010
regulation of cell shape	GO:0008360	113	0.010
purine ribonucleoside catabolic process	GO:0046130	112	0.010
positive regulation of multicellular organism growth	GO:0040018	21	0.010	Worm
hematopoietic or lymphoid organ development	GO:0048534	57	0.010
cellular response to oxygen containing compound	GO:1901701	79	0.010
response to hormone	GO:0009725	45	0.010
cellular nitrogen compound catabolic process	GO:0044270	165	0.010
regulation of localization	GO:0032879	275	0.010
positive regulation of cell differentiation	GO:0045597	64	0.010

CG7033 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.016
cancer	DOID:162	0.013
disease of cellular proliferation	DOID:14566	0.013
organ system cancer	DOID:0050686	0.013
musculoskeletal system disease	DOID:17	0.010
connective tissue disease	DOID:65	0.010

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