IMP: Integrative Multi-species Prediction

Drosophila melanogaster

80 known processes

Eb1 (Dmel_CG3265)

CG3265 gene product from transcript CG3265-RF

(Aliases: anon-EST:Liang-2.33,eb1,l(2)04524,DmEB1,Dm EB1,dEB-1,BcDNA:LD08743,clone 2.52,EB-1,anon-EST:Liang-2.52,BcDNA.LD08743,S(DmcycE[JP])2.5,EB1,clone 2.33,l(2)4524,CG3265,dEb1,dEB1,Dmel\CG3265)

FLYBASE: FBgn0027066
Entrez: 35584
UniProtKB: Q7JZD3
UniProtKB: A1Z6P3
UniProtKB: Q9XZ57

Process Predictions
Disease Predictions

Eb1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
microtubule organizing center organization	GO:0031023	168	0.941
spindle organization	GO:0007051	253	0.908
melanotic encapsulation of foreign target	GO:0035011	30	0.896
establishment or maintenance of cytoskeleton polarity	GO:0030952	44	0.823
secondary metabolic process	GO:0019748	75	0.769
eye morphogenesis	GO:0048592	260	0.745
eye development	GO:0001654	323	0.740
centrosome organization	GO:0051297	163	0.718
mitotic spindle organization	GO:0007052	220	0.630
regulation of microtubule cytoskeleton organization	GO:0070507	41	0.619	Human
centrosome cycle	GO:0007098	137	0.578
pigment metabolic process	GO:0042440	84	0.544
encapsulation of foreign target	GO:0035010	38	0.528
regulation of microtubule based process	GO:0032886	49	0.505	Human
blastoderm segmentation	GO:0007350	159	0.503
protein polymerization	GO:0051258	42	0.493	Human
sensory organ morphogenesis	GO:0090596	260	0.466
regulation of localization	GO:0032879	275	0.451
organic hydroxy compound metabolic process	GO:1901615	83	0.447
cellularization	GO:0007349	90	0.429
organelle localization	GO:0051640	148	0.384
endocytosis	GO:0006897	310	0.382
regulation of cytoskeleton organization	GO:0051493	89	0.371	Human
cell migration	GO:0016477	238	0.369
cellular macromolecular complex assembly	GO:0034622	153	0.368	Human
melanization defense response	GO:0035006	45	0.340
rna localization	GO:0006403	115	0.335
epithelial cell migration	GO:0010631	148	0.328
multicellular organismal aging	GO:0010259	140	0.324
melanin metabolic process	GO:0006582	47	0.321
cellular protein complex assembly	GO:0043623	71	0.318	Human
actin cytoskeleton organization	GO:0030036	206	0.315
microtubule polymerization or depolymerization	GO:0031109	39	0.312	Human
establishment or maintenance of cell polarity	GO:0007163	167	0.299
nuclear division	GO:0000280	332	0.288
regulation of cellular localization	GO:0060341	136	0.288
regulation of cellular component biogenesis	GO:0044087	201	0.277	Human
single organism cellular localization	GO:1902580	180	0.252
sensory perception	GO:0007600	196	0.249
synaptic transmission	GO:0007268	288	0.244
localization of cell	GO:0051674	257	0.241
cortical actin cytoskeleton organization	GO:0030866	24	0.239
spermatid differentiation	GO:0048515	114	0.235
determination of adult lifespan	GO:0008340	137	0.231
compound eye morphogenesis	GO:0001745	249	0.217
cellular macromolecule localization	GO:0070727	220	0.213	Human Mouse
protein complex biogenesis	GO:0070271	201	0.208
positive regulation of cellular component organization	GO:0051130	156	0.206
centrosome duplication	GO:0051298	121	0.204
compound eye development	GO:0048749	307	0.203
protein localization	GO:0008104	284	0.202	Human Mouse
mapk cascade	GO:0000165	107	0.199
regulation of synaptic transmission	GO:0050804	69	0.196
regulation of nervous system development	GO:0051960	248	0.195
protein targeting to nucleus	GO:0044744	51	0.190
actin filament organization	GO:0007015	126	0.186
regulation of intracellular signal transduction	GO:1902531	236	0.184	Fly
embryonic pattern specification	GO:0009880	174	0.181
nucleus localization	GO:0051647	34	0.178
intracellular transport	GO:0046907	228	0.178
phagocytosis	GO:0006909	215	0.175
segmentation	GO:0035282	207	0.171
spindle assembly involved in mitosis	GO:0090307	50	0.165
mitotic spindle elongation	GO:0000022	81	0.162
microtubule polymerization	GO:0046785	15	0.161	Human
regulation of transport	GO:0051049	181	0.157
protein import	GO:0017038	55	0.152
dendrite morphogenesis	GO:0048813	199	0.148
cell motility	GO:0048870	251	0.147
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.141
protein modification process	GO:0036211	438	0.140	Mouse
skeletal muscle organ development	GO:0060538	48	0.137
innate immune response	GO:0045087	144	0.135
eye photoreceptor cell development	GO:0042462	81	0.134
immune effector process	GO:0002252	98	0.131
axon extension involved in axon guidance	GO:0048846	10	0.131
response to light stimulus	GO:0009416	124	0.131
single organism nuclear import	GO:1902593	51	0.129
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.129
pronuclear migration	GO:0035046	4	0.129
microtubule cytoskeleton organization involved in mitosis	GO:1902850	52	0.128
oocyte differentiation	GO:0009994	145	0.126
response to radiation	GO:0009314	155	0.125
embryonic development via the syncytial blastoderm	GO:0001700	148	0.124
small gtpase mediated signal transduction	GO:0007264	88	0.121
establishment of organelle localization	GO:0051656	122	0.119
establishment or maintenance of bipolar cell polarity	GO:0061245	34	0.119
cellular protein localization	GO:0034613	160	0.117	Human Mouse
forebrain development	GO:0030900	2	0.116
vesicle mediated transport	GO:0016192	381	0.116
sister chromatid segregation	GO:0000819	92	0.116
female meiotic division	GO:0007143	70	0.113
neuron projection guidance	GO:0097485	241	0.113
intracellular signal transduction	GO:0035556	300	0.111	Fly
cell cell junction assembly	GO:0007043	38	0.108
immune response regulating signaling pathway	GO:0002764	2	0.108
photoreceptor cell differentiation	GO:0046530	170	0.108
single organism behavior	GO:0044708	391	0.107
immune response	GO:0006955	246	0.107
regulation of intracellular protein transport	GO:0033157	46	0.106
positive regulation of cytoskeleton organization	GO:0051495	21	0.106
response to bacterium	GO:0009617	198	0.105
lateral inhibition	GO:0046331	206	0.105
intracellular mrna localization involved in anterior posterior axis specification	GO:0060811	53	0.104
photoreceptor cell development	GO:0042461	96	0.104
maternal determination of anterior posterior axis embryo	GO:0008358	74	0.103
nucleocytoplasmic transport	GO:0006913	72	0.100
detection of stimulus	GO:0051606	156	0.096
muscle structure development	GO:0061061	224	0.096
actomyosin structure organization	GO:0031032	56	0.090
apoptotic cell clearance	GO:0043277	14	0.088
synapse assembly	GO:0007416	143	0.088
fertilization	GO:0009566	26	0.088
defense response	GO:0006952	300	0.086
locomotory behavior	GO:0007626	176	0.086
neurological system process	GO:0050877	358	0.086
nuclear import	GO:0051170	51	0.085
respiratory system development	GO:0060541	213	0.084
response to abiotic stimulus	GO:0009628	341	0.084
cellular protein complex disassembly	GO:0043624	35	0.081
spindle assembly	GO:0051225	80	0.081
neural precursor cell proliferation	GO:0061351	75	0.080
cortical cytoskeleton organization	GO:0030865	29	0.078
heterocycle catabolic process	GO:0046700	166	0.077
phenol containing compound metabolic process	GO:0018958	57	0.077
open tracheal system development	GO:0007424	204	0.077
pole cell formation	GO:0007279	19	0.077
positive regulation of cell communication	GO:0010647	250	0.076	Fly
actin filament based process	GO:0030029	220	0.076
oocyte anterior posterior axis specification	GO:0007314	72	0.075
regulation of mapk cascade	GO:0043408	92	0.075
positive regulation of nfat protein import into nucleus	GO:0051533	16	0.075
establishment of neuroblast polarity	GO:0045200	2	0.074
positive regulation of phosphorus metabolic process	GO:0010562	139	0.073	Mouse
tissue morphogenesis	GO:0048729	297	0.072
pole cell development	GO:0007277	26	0.071
organelle fission	GO:0048285	340	0.071
head development	GO:0060322	135	0.070
axon development	GO:0061564	297	0.070
muscle cell differentiation	GO:0042692	103	0.069
macromolecular complex disassembly	GO:0032984	37	0.067
salivary gland development	GO:0007431	162	0.067
mitotic nuclear division	GO:0007067	213	0.066
epithelial cell morphogenesis involved in gastrulation	GO:0003381	7	0.065
cellular component disassembly	GO:0022411	46	0.065
regulation of cell morphogenesis	GO:0022604	163	0.064
regulation of protein localization	GO:0032880	76	0.064
transmembrane transport	GO:0055085	139	0.062
macromolecular complex assembly	GO:0065003	256	0.061
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.061
eggshell formation	GO:0030703	105	0.061
eye photoreceptor cell differentiation	GO:0001754	145	0.060
ovarian follicle cell development	GO:0030707	248	0.060
cellular macromolecule catabolic process	GO:0044265	136	0.060
organelle fusion	GO:0048284	46	0.060
negative regulation of signaling	GO:0023057	219	0.059
microtubule based transport	GO:0010970	42	0.058
cell junction organization	GO:0034330	57	0.057
ubiquitin dependent protein catabolic process	GO:0006511	78	0.057
nucleoside triphosphate catabolic process	GO:0009143	108	0.055
response to other organism	GO:0051707	293	0.055
regulation of cellular protein metabolic process	GO:0032268	243	0.054	Mouse
signal transduction by phosphorylation	GO:0023014	107	0.054
positive regulation of apoptotic cell clearance	GO:2000427	2	0.054
single organism intracellular transport	GO:1902582	207	0.053
axonogenesis	GO:0007409	290	0.053
exocrine system development	GO:0035272	162	0.052
developmental growth	GO:0048589	280	0.052
maintenance of cell polarity	GO:0030011	18	0.052
regulation of protein localization to nucleus	GO:1900180	29	0.052
protein localization to organelle	GO:0033365	82	0.051	Human Mouse
microtubule anchoring	GO:0034453	11	0.051
nuclear transport	GO:0051169	72	0.050
phosphorylation	GO:0016310	294	0.050	Mouse
regulation of cell shape	GO:0008360	113	0.050
cytoplasmic transport	GO:0016482	130	0.049
chromosome organization	GO:0051276	360	0.049
organelle assembly	GO:0070925	198	0.049
central nervous system development	GO:0007417	201	0.049
maintenance of protein location	GO:0045185	28	0.049
positive regulation of dendrite morphogenesis	GO:0050775	9	0.048
regulation of anatomical structure morphogenesis	GO:0022603	242	0.048
regulation of protein complex disassembly	GO:0043244	29	0.047
organic substance catabolic process	GO:1901575	308	0.047
vesicle localization	GO:0051648	55	0.046
regulation of protein polymerization	GO:0032271	28	0.046	Human
positive regulation of signal transduction	GO:0009967	223	0.046	Fly
establishment of nucleus localization	GO:0040023	26	0.045
response to biotic stimulus	GO:0009607	294	0.044
protein localization to nucleus	GO:0034504	55	0.044
organic substance transport	GO:0071702	257	0.044
brain development	GO:0007420	120	0.043
response to lipopolysaccharide	GO:0032496	4	0.043
regulation of synapse organization	GO:0050807	110	0.043
detection of external stimulus	GO:0009581	66	0.043
regulation of phosphorus metabolic process	GO:0051174	210	0.043	Mouse
positive regulation of phagocytosis	GO:0050766	3	0.042
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.042
positive regulation of macromolecule metabolic process	GO:0010604	405	0.042	Mouse
immune response activating signal transduction	GO:0002757	2	0.042
protein import into nucleus	GO:0006606	51	0.041
cellular protein catabolic process	GO:0044257	83	0.041
cell cell junction organization	GO:0045216	55	0.041
adult locomotory behavior	GO:0008344	76	0.041
positive regulation of transcription factor import into nucleus	GO:0042993	19	0.041
retina development in camera type eye	GO:0060041	4	0.040
posttranscriptional gene silencing by rna	GO:0035194	45	0.040
regulation of nucleocytoplasmic transport	GO:0046822	35	0.040
establishment of localization in cell	GO:0051649	402	0.040
positive regulation of response to stimulus	GO:0048584	323	0.040	Fly
cellular component assembly involved in morphogenesis	GO:0010927	151	0.040
myosin filament assembly	GO:0031034	5	0.040
positive regulation of lipid biosynthetic process	GO:0046889	3	0.039
negative regulation of cellular component organization	GO:0051129	108	0.039	Human
establishment of protein localization to organelle	GO:0072594	62	0.039
striated muscle myosin thick filament assembly	GO:0071688	3	0.037
protein targeting	GO:0006605	64	0.037
aging	GO:0007568	143	0.037
convergent extension	GO:0060026	2	0.037
glial cell differentiation	GO:0010001	35	0.037
cell proliferation	GO:0008283	299	0.037
establishment or maintenance of neuroblast polarity	GO:0045196	8	0.037
engulfment of apoptotic cell	GO:0043652	6	0.037
nitrogen compound transport	GO:0071705	85	0.036
gland development	GO:0048732	191	0.036
establishment of cell polarity	GO:0030010	40	0.036
organic cyclic compound catabolic process	GO:1901361	168	0.035
microtubule based movement	GO:0007018	51	0.035
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.035
nucleus organization	GO:0006997	45	0.034
positive regulation of cell cycle	GO:0045787	43	0.034	Mouse
embryo development ending in birth or egg hatching	GO:0009792	152	0.034
regulation of centrosome cycle	GO:0046605	7	0.034
positive regulation of phosphate metabolic process	GO:0045937	139	0.034	Mouse
peripheral nervous system development	GO:0007422	52	0.034
morphogenesis of an epithelium	GO:0002009	276	0.034
gland morphogenesis	GO:0022612	145	0.033
pseudocleavage involved in syncytial blastoderm formation	GO:0030589	9	0.033
protein complex assembly	GO:0006461	200	0.033
cellular ketone metabolic process	GO:0042180	24	0.033
camera type eye development	GO:0043010	4	0.033
embryonic morphogenesis	GO:0048598	206	0.032
retina morphogenesis in camera type eye	GO:0060042	2	0.032
positive regulation of intracellular transport	GO:0032388	42	0.032
rhabdomere development	GO:0042052	38	0.032
ras protein signal transduction	GO:0007265	88	0.032
germarium derived oocyte differentiation	GO:0030706	29	0.032
regulation of phosphate metabolic process	GO:0019220	210	0.032	Mouse
meiotic spindle organization	GO:0000212	36	0.031
synaptic growth at neuromuscular junction	GO:0051124	119	0.030
regulation of actin filament length	GO:0030832	27	0.030
tripartite regional subdivision	GO:0007351	103	0.030
dendrite development	GO:0016358	204	0.030
regulation of protein transport	GO:0051223	57	0.030
neuromuscular junction development	GO:0007528	149	0.029
regulation of intracellular transport	GO:0032386	64	0.029
regulation of synapse assembly	GO:0051963	94	0.029
oxoacid metabolic process	GO:0043436	103	0.028
regulation of proteolysis	GO:0030162	87	0.028
neuron maturation	GO:0042551	31	0.028
nucleobase containing compound transport	GO:0015931	56	0.028
positive regulation of nucleocytoplasmic transport	GO:0046824	24	0.028
single organism membrane organization	GO:0044802	93	0.028
gene silencing	GO:0016458	138	0.027
ion transport	GO:0006811	145	0.027
appendage development	GO:0048736	401	0.027
positive regulation of transport	GO:0051050	92	0.027
ribonucleoside monophosphate catabolic process	GO:0009158	39	0.026
regulation of cell cycle phase transition	GO:1901987	130	0.026
telencephalon development	GO:0021537	2	0.026
adult behavior	GO:0030534	137	0.026
regulation of phagocytosis engulfment	GO:0060099	1	0.026
defense response to other organism	GO:0098542	225	0.025
regulation of protein metabolic process	GO:0051246	256	0.025	Mouse
proteasomal protein catabolic process	GO:0010498	59	0.025
establishment of spindle orientation	GO:0051294	18	0.025
meiotic cell cycle process	GO:1903046	132	0.025
positive regulation of catalytic activity	GO:0043085	118	0.025	Mouse
regulation of hemocyte proliferation	GO:0035206	37	0.025
multi organism behavior	GO:0051705	175	0.025
intracellular mrna localization involved in pattern specification process	GO:0060810	56	0.025
axon midline choice point recognition	GO:0016199	26	0.025
negative regulation of phosphatase activity	GO:0010923	3	0.025
oocyte axis specification	GO:0007309	108	0.024
cellular catabolic process	GO:0044248	372	0.024
regulation of synapse structure and activity	GO:0050803	128	0.024
cell junction assembly	GO:0034329	42	0.024
regulation of dendrite morphogenesis	GO:0048814	28	0.023
mitotic sister chromatid segregation	GO:0000070	87	0.023
proteolysis	GO:0006508	192	0.023
olfactory bulb axon guidance	GO:0071678	3	0.023
entry into cell of other organism involved in symbiotic interaction	GO:0051806	3	0.023
purine nucleotide catabolic process	GO:0006195	109	0.023
organonitrogen compound catabolic process	GO:1901565	128	0.023
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.023
single fertilization	GO:0007338	24	0.022
negative regulation of cellular protein metabolic process	GO:0032269	85	0.022
positive regulation of cellular component biogenesis	GO:0044089	80	0.022
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.022
immune system process	GO:0002376	347	0.022
regulation of cytoplasmic transport	GO:1903649	47	0.022
epithelial cell differentiation	GO:0030855	322	0.022
regulation of protein import into nucleus	GO:0042306	28	0.022
nucleobase containing small molecule metabolic process	GO:0055086	174	0.022
regulation of protein phosphatase type 2a activity	GO:0034047	2	0.021
mushroom body development	GO:0016319	70	0.021
regulation of locomotion	GO:0040012	42	0.021
regulation of transcription factor import into nucleus	GO:0042990	22	0.021
regulation of axonogenesis	GO:0050770	32	0.021
steroid catabolic process	GO:0006706	1	0.021
cell projection assembly	GO:0030031	94	0.021
multicellular organismal reproductive behavior	GO:0033057	110	0.021
dna catabolic process	GO:0006308	16	0.021
protein adp ribosylation	GO:0006471	4	0.020
asymmetric neuroblast division	GO:0055059	33	0.020
nuclear migration	GO:0007097	20	0.020
protein catabolic process	GO:0030163	101	0.020
morphogenesis of embryonic epithelium	GO:0016331	94	0.020
anterior posterior axis specification embryo	GO:0008595	103	0.020
appendage morphogenesis	GO:0035107	397	0.020
maintenance of location in cell	GO:0051651	28	0.020
protein transport	GO:0015031	155	0.020
membrane disassembly	GO:0030397	4	0.020
small molecule metabolic process	GO:0044281	305	0.020
positive regulation of phosphorylation	GO:0042327	87	0.019	Mouse
salivary gland morphogenesis	GO:0007435	145	0.019
axon guidance	GO:0007411	233	0.019
positive regulation of immune system process	GO:0002684	68	0.019
maintenance of location	GO:0051235	73	0.019
regulation of molecular function	GO:0065009	217	0.019	Mouse
nucleoside phosphate metabolic process	GO:0006753	162	0.019
cytokinesis	GO:0000910	90	0.019
regulation of cellular amine metabolic process	GO:0033238	3	0.019
carbohydrate derivative metabolic process	GO:1901135	217	0.018
regulation of filopodium assembly	GO:0051489	24	0.018
positive regulation of intracellular signal transduction	GO:1902533	116	0.018	Fly
meiotic nuclear division	GO:0007126	151	0.018
male meiosis cytokinesis	GO:0007112	26	0.018
heparin metabolic process	GO:0030202	4	0.018
compound eye photoreceptor development	GO:0042051	78	0.018
myosin filament organization	GO:0031033	5	0.018
positive regulation of protein import into nucleus	GO:0042307	21	0.018
salivary gland cell autophagic cell death	GO:0035071	83	0.018
purine containing compound catabolic process	GO:0072523	112	0.018
neural retina development	GO:0003407	4	0.018
regulation of multi organism process	GO:0043900	131	0.018
establishment of spindle localization	GO:0051293	22	0.017
gastrulation	GO:0007369	70	0.017
regulation of protein phosphorylation	GO:0001932	64	0.017	Mouse
regulation of metaphase anaphase transition of cell cycle	GO:1902099	26	0.017
learning or memory	GO:0007611	141	0.017
response to external biotic stimulus	GO:0043207	293	0.017
regulation of phosphorylation	GO:0042325	147	0.017	Mouse
positive regulation of protein polymerization	GO:0032273	14	0.017
response to extracellular stimulus	GO:0009991	116	0.017
spermatid nucleus elongation	GO:0007290	4	0.017
positive regulation of nervous system development	GO:0051962	69	0.016
histolysis	GO:0007559	102	0.016
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.016
neuroblast proliferation	GO:0007405	74	0.016
regulation of embryonic cell shape	GO:0016476	30	0.016
phototransduction	GO:0007602	52	0.016
hemocyte migration	GO:0035099	19	0.015
negative regulation of cytoskeleton organization	GO:0051494	30	0.015	Human
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.015
posttranscriptional regulation of gene expression	GO:0010608	145	0.015
regulation of mitosis	GO:0007088	56	0.015
epithelial cell development	GO:0002064	274	0.015
movement in environment of other organism involved in symbiotic interaction	GO:0052192	3	0.015
catabolic process	GO:0009056	409	0.015
regulation of nfat protein import into nucleus	GO:0051532	16	0.015
positive regulation of phagocytosis engulfment	GO:0060100	1	0.015
maintenance of protein location in cell	GO:0032507	26	0.015
g protein coupled receptor signaling pathway	GO:0007186	136	0.014
asymmetric cell division	GO:0008356	37	0.014
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.014
regulation of establishment of protein localization	GO:0070201	61	0.014
phagocytosis engulfment	GO:0006911	11	0.014
positive regulation of proteasomal protein catabolic process	GO:1901800	20	0.014
ribose phosphate metabolic process	GO:0019693	145	0.014
nucleoside catabolic process	GO:0009164	112	0.014
positive regulation of protein localization to nucleus	GO:1900182	21	0.014
epithelial tube morphogenesis	GO:0060562	88	0.014
regulation of cellular ketone metabolic process	GO:0010565	3	0.014
lipid biosynthetic process	GO:0008610	46	0.014
single organism catabolic process	GO:0044712	228	0.014
actin filament based movement	GO:0030048	26	0.014
regulation of ion transmembrane transporter activity	GO:0032412	6	0.014
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	41	0.013
regulation of cell adhesion	GO:0030155	27	0.013
muscle system process	GO:0003012	21	0.013
regulation of cellular protein catabolic process	GO:1903362	44	0.013
positive regulation of establishment of protein localization to plasma membrane	GO:0090004	3	0.013
establishment of protein localization	GO:0045184	163	0.013
atp catabolic process	GO:0006200	38	0.013
regulation of axon regeneration	GO:0048679	4	0.013
myofibril assembly	GO:0030239	36	0.013
regulation of endocytosis	GO:0030100	37	0.013
regulation of cell differentiation	GO:0045595	302	0.013
response to carbon dioxide	GO:0010037	4	0.013
nucleoside phosphate catabolic process	GO:1901292	110	0.013
ovarian follicle cell migration	GO:0007297	121	0.013
centrosome separation	GO:0051299	20	0.013
regulation of striated muscle contraction	GO:0006942	2	0.013
embryonic axis specification	GO:0000578	107	0.012
regulation of cell development	GO:0060284	215	0.012
protein complex disassembly	GO:0043241	36	0.012
salivary gland histolysis	GO:0035070	88	0.012
imaginal disc derived appendage development	GO:0048737	399	0.012
organophosphate catabolic process	GO:0046434	112	0.012
regulation of neuron differentiation	GO:0045664	103	0.012
sensory perception of chemical stimulus	GO:0007606	116	0.012
establishment of monopolar cell polarity	GO:0061162	15	0.012
negative regulation of molecular function	GO:0044092	51	0.012
peripheral nervous system neuron development	GO:0048935	8	0.012
cellular response to carbohydrate stimulus	GO:0071322	4	0.012
organic acid metabolic process	GO:0006082	103	0.012
pole plasm mrna localization	GO:0019094	49	0.012
sensory perception of touch	GO:0050975	11	0.012
glycosyl compound metabolic process	GO:1901657	127	0.012
biological adhesion	GO:0022610	138	0.012
digestive system development	GO:0055123	149	0.012
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	12	0.012
intracellular protein transport	GO:0006886	104	0.012
unidimensional cell growth	GO:0009826	15	0.012
epithelial cell morphogenesis	GO:0003382	25	0.012
neuron remodeling	GO:0016322	29	0.012
regulation of mitotic sister chromatid segregation	GO:0033047	28	0.012
regulation of protein depolymerization	GO:1901879	27	0.012
negative regulation of response to stimulus	GO:0048585	258	0.011
endomembrane system organization	GO:0010256	119	0.011
protein localization to membrane	GO:0072657	19	0.011
morphogenesis of a branching structure	GO:0001763	45	0.011
positive regulation of organelle organization	GO:0010638	65	0.011
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.011
cellular nitrogen compound catabolic process	GO:0044270	165	0.011
regulation of protein export from nucleus	GO:0046825	3	0.011
nfat protein import into nucleus	GO:0051531	16	0.011
compound eye photoreceptor cell differentiation	GO:0001751	140	0.011
regulation of hydrolase activity	GO:0051336	97	0.011
tube development	GO:0035295	244	0.011
germarium derived oocyte fate determination	GO:0007294	26	0.011
intracellular mrna localization	GO:0008298	66	0.011
regulation of mitotic metaphase anaphase transition	GO:0030071	26	0.011
cellular response to molecule of bacterial origin	GO:0071219	3	0.011
positive regulation of endocytosis	GO:0045807	22	0.011
regulation of transmembrane transporter activity	GO:0022898	6	0.011
positive regulation of cell projection organization	GO:0031346	29	0.011
regulation of actin filament based process	GO:0032970	42	0.011
semaphorin plexin signaling pathway	GO:0071526	4	0.011
anterior posterior pattern specification	GO:0009952	136	0.011
regulation of actin filament polymerization	GO:0030833	25	0.011
aromatic compound catabolic process	GO:0019439	166	0.011
positive regulation of mapk cascade	GO:0043410	63	0.011
nucleoside monophosphate catabolic process	GO:0009125	39	0.011
camera type eye morphogenesis	GO:0048593	2	0.010
autophagic cell death	GO:0048102	83	0.010
ribonucleotide catabolic process	GO:0009261	109	0.010
stem cell differentiation	GO:0048863	117	0.010
nonmotile primary cilium assembly	GO:0035058	8	0.010
regulation of phosphatase activity	GO:0010921	3	0.010
pronuclear fusion	GO:0007344	4	0.010
establishment of rna localization	GO:0051236	47	0.010
positive regulation of synaptic growth at neuromuscular junction	GO:0045887	26	0.010
positive regulation of protein transport	GO:0051222	37	0.010
meiotic cell cycle	GO:0051321	171	0.010
positive regulation of protein localization to plasma membrane	GO:1903078	3	0.010

Eb1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
motor neuron disease	DOID:231	0.061
disease of anatomical entity	DOID:7	0.061
amyotrophic lateral sclerosis	DOID:332	0.061
neurodegenerative disease	DOID:1289	0.061
central nervous system disease	DOID:331	0.061
nervous system disease	DOID:863	0.061
disease of metabolism	DOID:0014667	0.013

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