IMP: Integrative Multi-species Prediction

Drosophila melanogaster

48 known processes

Pgm (Dmel_CG5165)

Phosphogluconate mutase

(Aliases: pgm,PGM,PGM-1,CG5165,Dmel\CG5165)

FLYBASE: FBgn0003076
Entrez: 44010
UniProtKB: Q9VUY9

Process Predictions
Disease Predictions

Pgm biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cellular amino acid metabolic process	GO:0006520	61	0.558
carboxylic acid metabolic process	GO:0019752	92	0.418
carbohydrate biosynthetic process	GO:0016051	17	0.399
organic acid metabolic process	GO:0006082	103	0.382
acetaldehyde metabolic process	GO:0006117	5	0.365
pyruvate metabolic process	GO:0006090	7	0.296
oxoacid metabolic process	GO:0043436	103	0.255
nad metabolic process	GO:0019674	1	0.243
cellular carbohydrate metabolic process	GO:0044262	22	0.238
glutamate metabolic process	GO:0006536	5	0.204
monocarboxylic acid metabolic process	GO:0032787	29	0.173
response to hexose	GO:0009746	3	0.151
catabolic process	GO:0009056	409	0.142
regulation of cellular ketone metabolic process	GO:0010565	3	0.129
response to organic substance	GO:0010033	284	0.123
single organism carbohydrate metabolic process	GO:0044723	72	0.114
negative regulation of biosynthetic process	GO:0009890	277	0.106
organonitrogen compound metabolic process	GO:1901564	318	0.104
carbohydrate metabolic process	GO:0005975	82	0.101
organic substance catabolic process	GO:1901575	308	0.099
response to monosaccharide	GO:0034284	4	0.096
immune system process	GO:0002376	347	0.093
small molecule metabolic process	GO:0044281	305	0.092
single organism catabolic process	GO:0044712	228	0.083
oxidoreduction coenzyme metabolic process	GO:0006733	2	0.080
response to oxygen containing compound	GO:1901700	200	0.077
cellular ketone metabolic process	GO:0042180	24	0.069
carbohydrate catabolic process	GO:0016052	7	0.068
response to glucose	GO:0009749	2	0.068
energy derivation by oxidation of organic compounds	GO:0015980	32	0.067
thiosulfate transport	GO:0015709	2	0.064
secretion by cell	GO:0032940	101	0.064
cellular catabolic process	GO:0044248	372	0.063
regulation of glucan biosynthetic process	GO:0010962	1	0.059
aging	GO:0007568	143	0.058
response to organophosphorus	GO:0046683	2	0.057
determination of adult lifespan	GO:0008340	137	0.056
multicellular organismal aging	GO:0010259	140	0.052
pyridine containing compound metabolic process	GO:0072524	3	0.052
lateral inhibition	GO:0046331	206	0.052
response to biotic stimulus	GO:0009607	294	0.051
multi multicellular organism process	GO:0044706	123	0.051
reproductive behavior	GO:0019098	122	0.050
monosaccharide metabolic process	GO:0005996	9	0.048	Mouse
pyridine nucleotide metabolic process	GO:0019362	2	0.046
imaginal disc derived appendage development	GO:0048737	399	0.046
cellular carbohydrate biosynthetic process	GO:0034637	7	0.045
homeostatic process	GO:0042592	199	0.044
alpha amino acid metabolic process	GO:1901605	20	0.044
hexose metabolic process	GO:0019318	8	0.043	Mouse
epithelial cell differentiation	GO:0030855	322	0.042
negative regulation of cellular biosynthetic process	GO:0031327	277	0.040
glucose metabolic process	GO:0006006	5	0.040	Mouse
posttranscriptional regulation of gene expression	GO:0010608	145	0.039
positive regulation of macromolecule metabolic process	GO:0010604	405	0.037
single organism biosynthetic process	GO:0044711	206	0.037
spermatogenesis	GO:0007283	200	0.037
single organism carbohydrate catabolic process	GO:0044724	7	0.037
defense response	GO:0006952	300	0.036
sterol metabolic process	GO:0016125	12	0.036
cellular amine metabolic process	GO:0044106	12	0.036
death	GO:0016265	284	0.034
post embryonic appendage morphogenesis	GO:0035120	385	0.031
response to other organism	GO:0051707	293	0.031
appendage morphogenesis	GO:0035107	397	0.030
oxidation reduction process	GO:0055114	123	0.030
cell maturation	GO:0048469	144	0.030
camera type eye development	GO:0043010	4	0.030
peptide metabolic process	GO:0006518	80	0.029
cellular biogenic amine catabolic process	GO:0042402	1	0.029
positive regulation of cell communication	GO:0010647	250	0.028
positive regulation of secretion	GO:0051047	22	0.027
epidermis development	GO:0008544	65	0.026
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.026
response to ethanol	GO:0045471	59	0.025
appendage development	GO:0048736	401	0.025
heart morphogenesis	GO:0003007	32	0.025
positive regulation of signaling	GO:0023056	243	0.025
cellular component assembly involved in morphogenesis	GO:0010927	151	0.025
cellular carbohydrate catabolic process	GO:0044275	2	0.024
wing disc morphogenesis	GO:0007472	344	0.024
cellular macromolecular complex assembly	GO:0034622	153	0.024
innate immune response	GO:0045087	144	0.024
glutamine family amino acid metabolic process	GO:0009064	12	0.023
synaptic transmission	GO:0007268	288	0.023
open tracheal system development	GO:0007424	204	0.021
positive regulation of biosynthetic process	GO:0009891	316	0.021
glycolytic process	GO:0006096	6	0.021
response to external biotic stimulus	GO:0043207	293	0.021
macromolecule catabolic process	GO:0009057	161	0.020
detection of hexose stimulus	GO:0009732	1	0.020
nadh metabolic process	GO:0006734	1	0.020
lipid localization	GO:0010876	54	0.020
protein complex assembly	GO:0006461	200	0.020
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.020
retina development in camera type eye	GO:0060041	4	0.020
organonitrogen compound biosynthetic process	GO:1901566	117	0.019
response to endogenous stimulus	GO:0009719	119	0.019
cellular modified amino acid metabolic process	GO:0006575	45	0.019
chemical homeostasis	GO:0048878	92	0.019
regulation of developmental growth	GO:0048638	174	0.019
male gamete generation	GO:0048232	201	0.019
larval development	GO:0002164	104	0.019
somatic muscle development	GO:0007525	66	0.019
regionalization	GO:0003002	416	0.018
nicotinamide nucleotide metabolic process	GO:0046496	2	0.018
cell type specific apoptotic process	GO:0097285	38	0.018
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.018
imaginal disc derived wing morphogenesis	GO:0007476	337	0.017
amine catabolic process	GO:0009310	1	0.017
organic hydroxy compound catabolic process	GO:1901616	4	0.017
neuron projection guidance	GO:0097485	241	0.016
amine metabolic process	GO:0009308	12	0.016
programmed cell death	GO:0012501	257	0.016
response to heat	GO:0009408	63	0.016
organonitrogen compound catabolic process	GO:1901565	128	0.016
epithelial tube morphogenesis	GO:0060562	88	0.016
negative regulation of developmental process	GO:0051093	201	0.016
carbohydrate derivative metabolic process	GO:1901135	217	0.016
transcription from rna polymerase ii promoter	GO:0006366	368	0.016
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.016
cellular response to chemical stimulus	GO:0070887	199	0.015
cell migration	GO:0016477	238	0.015
secretion	GO:0046903	109	0.015
detection of glucose	GO:0051594	1	0.015
positive regulation of cell death	GO:0010942	69	0.015
cellular protein complex assembly	GO:0043623	71	0.015
regulation of localization	GO:0032879	275	0.014
positive regulation of cellular biosynthetic process	GO:0031328	316	0.014
cellular protein modification process	GO:0006464	438	0.014
negative regulation of cell differentiation	GO:0045596	143	0.014
cell death	GO:0008219	279	0.014
reproductive structure development	GO:0048608	74	0.014
neurotransmitter catabolic process	GO:0042135	1	0.014
small molecule catabolic process	GO:0044282	21	0.014
cell aging	GO:0007569	2	0.014
negative regulation of cellular metabolic process	GO:0031324	382	0.014
response to abiotic stimulus	GO:0009628	341	0.014
macromolecular complex assembly	GO:0065003	256	0.014
multi organism behavior	GO:0051705	175	0.013
negative regulation of cell cycle	GO:0045786	116	0.013
protein modification process	GO:0036211	438	0.013
nuclear division	GO:0000280	332	0.013
regulation of multicellular organismal development	GO:2000026	414	0.012
positive regulation of secretion by cell	GO:1903532	20	0.012
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.012
regulation of anatomical structure size	GO:0090066	163	0.012
protein complex biogenesis	GO:0070271	201	0.012
regulation of notch signaling pathway	GO:0008593	100	0.012
positive regulation of glycogen biosynthetic process	GO:0045725	1	0.012
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.011
negative regulation of neuroblast proliferation	GO:0007406	27	0.011
chromosome segregation	GO:0007059	157	0.011
organelle assembly	GO:0070925	198	0.011
sensory organ morphogenesis	GO:0090596	260	0.011
lipid metabolic process	GO:0006629	121	0.011
negative regulation of rna biosynthetic process	GO:1902679	240	0.011
adult locomotory behavior	GO:0008344	76	0.011
glutathione metabolic process	GO:0006749	37	0.011
cellular homeostasis	GO:0019725	80	0.011
tricarboxylic acid metabolic process	GO:0072350	1	0.011
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.011
water homeostasis	GO:0030104	3	0.011
regulation of cell cycle	GO:0051726	291	0.010
transition metal ion homeostasis	GO:0055076	17	0.010
cellular amino acid biosynthetic process	GO:0008652	9	0.010
gland development	GO:0048732	191	0.010
acyl coa biosynthetic process	GO:0071616	2	0.010
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.010
axon guidance	GO:0007411	233	0.010
age dependent general metabolic decline	GO:0007571	3	0.010
ion transport	GO:0006811	145	0.010
positive regulation of response to stimulus	GO:0048584	323	0.010
telencephalon development	GO:0021537	2	0.010

Pgm disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.063
acquired metabolic disease	DOID:0060158	0.063
disease of anatomical entity	DOID:7	0.053
hematopoietic system disease	DOID:74	0.048
immune system disease	DOID:2914	0.048
anemia	DOID:2355	0.048
glucose metabolism disease	DOID:4194	0.032
carbohydrate metabolism disease	DOID:0050013	0.032
inherited metabolic disorder	DOID:655	0.011

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