IMP: Integrative Multi-species Prediction

Drosophila melanogaster

0 known processes

Klp31E (Dmel_CG5300)

CG5300 gene product from transcript CG5300-RD

(Aliases: DmCG5300,DmKlp31D,DmKlp31E,Dmel\CG5300,CG5300,KIF21A)

FLYBASE: FBgn0032243
Entrez: 34422
UniProtKB: E1JHE1
UniProtKB: Q9VKW4

Process Predictions
Disease Predictions

Klp31E biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of catabolic process	GO:0009894	170	0.100
organic substance catabolic process	GO:1901575	308	0.092
catabolic process	GO:0009056	409	0.083
regulation of cellular catabolic process	GO:0031329	157	0.079
negative regulation of response to stimulus	GO:0048585	258	0.073
regulation of response to stress	GO:0080134	200	0.069
autophagy	GO:0006914	108	0.068
positive regulation of catabolic process	GO:0009896	105	0.067
cellular response to nutrient levels	GO:0031669	62	0.057
axonogenesis	GO:0007409	290	0.054
protein modification process	GO:0036211	438	0.054
single organism catabolic process	GO:0044712	228	0.052
cellular catabolic process	GO:0044248	372	0.052
cellular protein modification process	GO:0006464	438	0.051
regulation of response to extracellular stimulus	GO:0032104	18	0.047
regionalization	GO:0003002	416	0.046
phagocytosis	GO:0006909	215	0.046
cellular response to chemical stimulus	GO:0070887	199	0.045
organelle localization	GO:0051640	148	0.044
regulation of autophagy	GO:0010506	62	0.041
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.041
sensory organ morphogenesis	GO:0090596	260	0.038
embryonic pattern specification	GO:0009880	174	0.037
regulation of apoptotic process	GO:0042981	130	0.037
nucleobase containing compound catabolic process	GO:0034655	165	0.036
notch signaling pathway	GO:0007219	120	0.036
positive regulation of response to stimulus	GO:0048584	323	0.035
cellular response to starvation	GO:0009267	61	0.035
protein localization	GO:0008104	284	0.035
negative regulation of signaling	GO:0023057	219	0.035
intracellular transport	GO:0046907	228	0.034
regulation of response to external stimulus	GO:0032101	115	0.034
regulation of protein metabolic process	GO:0051246	256	0.034
axon development	GO:0061564	297	0.034
positive regulation of cellular catabolic process	GO:0031331	95	0.034
dendrite development	GO:0016358	204	0.033
regulation of ras protein signal transduction	GO:0046578	93	0.033
eye development	GO:0001654	323	0.033
positive regulation of response to external stimulus	GO:0032103	44	0.033
developmental maturation	GO:0021700	172	0.033
negative regulation of cell communication	GO:0010648	223	0.033
organonitrogen compound metabolic process	GO:1901564	318	0.032
cell division	GO:0051301	248	0.032	Fly
membrane fusion	GO:0061025	42	0.031
vesicle mediated transport	GO:0016192	381	0.031
organic cyclic compound catabolic process	GO:1901361	168	0.030
cell proliferation	GO:0008283	299	0.030
nucleotide catabolic process	GO:0009166	109	0.030
regulation of multicellular organismal development	GO:2000026	414	0.030
telencephalon development	GO:0021537	2	0.030
ion transmembrane transport	GO:0034220	122	0.030
ribonucleoside catabolic process	GO:0042454	112	0.030
purine nucleoside metabolic process	GO:0042278	127	0.030
endocytosis	GO:0006897	310	0.029
single organism membrane organization	GO:0044802	93	0.029
regulation of notch signaling pathway	GO:0008593	100	0.029
negative regulation of signal transduction	GO:0009968	206	0.028
immune system process	GO:0002376	347	0.028
centrosome cycle	GO:0007098	137	0.028
purine containing compound catabolic process	GO:0072523	112	0.028
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.028
establishment or maintenance of cell polarity	GO:0007163	167	0.027
response to starvation	GO:0042594	97	0.027
purine nucleotide metabolic process	GO:0006163	146	0.027
compound eye morphogenesis	GO:0001745	249	0.027
cellularization	GO:0007349	90	0.026
cation transmembrane transport	GO:0098655	88	0.026
programmed cell death	GO:0012501	257	0.026
response to extracellular stimulus	GO:0009991	116	0.026
actin cytoskeleton organization	GO:0030036	206	0.026
nucleoside catabolic process	GO:0009164	112	0.026
response to endogenous stimulus	GO:0009719	119	0.026
gtp metabolic process	GO:0046039	72	0.025
positive regulation of cell communication	GO:0010647	250	0.025
cellular response to extracellular stimulus	GO:0031668	64	0.025
establishment of localization in cell	GO:0051649	402	0.025
heterocycle catabolic process	GO:0046700	166	0.025
negative regulation of notch signaling pathway	GO:0045746	41	0.025
cellular response to external stimulus	GO:0071496	66	0.025
regulation of cell development	GO:0060284	215	0.024
rho protein signal transduction	GO:0007266	14	0.024
purine nucleoside catabolic process	GO:0006152	112	0.024
cellular protein localization	GO:0034613	160	0.024
compound eye development	GO:0048749	307	0.024
cellular nitrogen compound catabolic process	GO:0044270	165	0.024
response to abiotic stimulus	GO:0009628	341	0.024
regulation of cellular localization	GO:0060341	136	0.023
actin filament organization	GO:0007015	126	0.023
organophosphate metabolic process	GO:0019637	195	0.023
regulation of cytoskeleton organization	GO:0051493	89	0.023
spindle organization	GO:0007051	253	0.023	Fly
intracellular protein transport	GO:0006886	104	0.022
wing disc morphogenesis	GO:0007472	344	0.022
cellular lipid metabolic process	GO:0044255	83	0.022
compound eye photoreceptor development	GO:0042051	78	0.022
epithelial cell differentiation	GO:0030855	322	0.022
cellular homeostasis	GO:0019725	80	0.022
segmentation	GO:0035282	207	0.022
purine containing compound metabolic process	GO:0072521	155	0.022
nucleus localization	GO:0051647	34	0.022
carbohydrate derivative catabolic process	GO:1901136	118	0.022
regulation of epithelial cell proliferation	GO:0050678	4	0.022
establishment of protein localization	GO:0045184	163	0.022
cellular protein complex assembly	GO:0043623	71	0.021
positive regulation of developmental process	GO:0051094	143	0.021
protein catabolic process	GO:0030163	101	0.021
macromolecule catabolic process	GO:0009057	161	0.021
cytoplasmic transport	GO:0016482	130	0.021
oxoacid metabolic process	GO:0043436	103	0.021
organelle fusion	GO:0048284	46	0.021
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.021
oocyte differentiation	GO:0009994	145	0.020
cell maturation	GO:0048469	144	0.020
nucleobase containing small molecule metabolic process	GO:0055086	174	0.020
single organism behavior	GO:0044708	391	0.020
developmental growth	GO:0048589	280	0.020
salivary gland morphogenesis	GO:0007435	145	0.020
ribonucleoside metabolic process	GO:0009119	127	0.020
neurological system process	GO:0050877	358	0.020
homeostatic process	GO:0042592	199	0.020
death	GO:0016265	284	0.020
taxis	GO:0042330	304	0.020
positive regulation of cellular biosynthetic process	GO:0031328	316	0.020
regulation of cellular component size	GO:0032535	98	0.020
chromosome segregation	GO:0007059	157	0.020	Fly
positive regulation of molecular function	GO:0044093	136	0.020
regulation of localization	GO:0032879	275	0.020
regulation of organelle organization	GO:0033043	196	0.020	Fly
embryonic development via the syncytial blastoderm	GO:0001700	148	0.020
imaginal disc derived wing morphogenesis	GO:0007476	337	0.020
positive regulation of cell motility	GO:2000147	3	0.019
photoreceptor cell development	GO:0042461	96	0.019
nucleoside phosphate metabolic process	GO:0006753	162	0.019
nucleoside metabolic process	GO:0009116	127	0.019
small molecule metabolic process	GO:0044281	305	0.019
gland morphogenesis	GO:0022612	145	0.019
ribonucleotide catabolic process	GO:0009261	109	0.019
microtubule polymerization or depolymerization	GO:0031109	39	0.019
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.019
cell motility	GO:0048870	251	0.019
eye morphogenesis	GO:0048592	260	0.019
central nervous system development	GO:0007417	201	0.019
cellular macromolecule catabolic process	GO:0044265	136	0.019
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.018
gtp catabolic process	GO:0006184	72	0.018
aromatic compound catabolic process	GO:0019439	166	0.018
positive regulation of ras gtpase activity	GO:0032320	36	0.018
organophosphate catabolic process	GO:0046434	112	0.018
endomembrane system organization	GO:0010256	119	0.018
inorganic ion transmembrane transport	GO:0098660	73	0.018
humoral immune response	GO:0006959	117	0.018
regulation of microtubule based process	GO:0032886	49	0.018
response to oxygen containing compound	GO:1901700	200	0.018
detection of stimulus	GO:0051606	156	0.017
carbohydrate derivative metabolic process	GO:1901135	217	0.017
cell fate determination	GO:0001709	91	0.017
cell death	GO:0008219	279	0.017
positive regulation of immune response	GO:0050778	63	0.017
regulation of microtubule cytoskeleton organization	GO:0070507	41	0.017
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.017
cellular amino acid metabolic process	GO:0006520	61	0.017
maintenance of location	GO:0051235	73	0.017
response to organic substance	GO:0010033	284	0.017
membrane organization	GO:0061024	112	0.017
neuroblast division	GO:0055057	35	0.016
organic acid metabolic process	GO:0006082	103	0.016
mitotic spindle organization	GO:0007052	220	0.016	Fly
cellular macromolecule localization	GO:0070727	220	0.016
positive regulation of macromolecule metabolic process	GO:0010604	405	0.016
nucleoside triphosphate catabolic process	GO:0009143	108	0.016
endosomal transport	GO:0016197	44	0.016
autophagic vacuole fusion	GO:0000046	15	0.016
dna metabolic process	GO:0006259	227	0.016	Fly
cytokinesis	GO:0000910	90	0.016	Fly
actin filament based process	GO:0030029	220	0.016
ras protein signal transduction	GO:0007265	88	0.016
tube morphogenesis	GO:0035239	191	0.016
regulation of cellular amino acid metabolic process	GO:0006521	0	0.016
single fertilization	GO:0007338	24	0.015	Fly
single organism intracellular transport	GO:1902582	207	0.015
histolysis	GO:0007559	102	0.015
regulation of developmental growth	GO:0048638	174	0.015
imaginal disc derived appendage development	GO:0048737	399	0.015
purine nucleotide catabolic process	GO:0006195	109	0.015
regulation of cell death	GO:0010941	173	0.015
axis specification	GO:0009798	167	0.015
purine ribonucleoside metabolic process	GO:0046128	127	0.015
forebrain development	GO:0030900	2	0.015
response to organic cyclic compound	GO:0014070	89	0.015
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.015
ribonucleotide metabolic process	GO:0009259	145	0.015
locomotory behavior	GO:0007626	176	0.015
protein modification by small protein conjugation or removal	GO:0070647	106	0.015
regulation of growth	GO:0040008	233	0.015
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.015
positive regulation of cell migration	GO:0030335	2	0.015
innate immune response	GO:0045087	144	0.015
guanosine containing compound catabolic process	GO:1901069	74	0.015
body morphogenesis	GO:0010171	2	0.015
regulation of cell cycle	GO:0051726	291	0.014	Fly
regulation of programmed cell death	GO:0043067	152	0.014
plasma membrane organization	GO:0007009	26	0.014
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.014
generation of precursor metabolites and energy	GO:0006091	42	0.014
exocrine system development	GO:0035272	162	0.014
carboxylic acid metabolic process	GO:0019752	92	0.014
regulation of rho protein signal transduction	GO:0035023	20	0.014
stem cell proliferation	GO:0072089	88	0.014
regulation of cell cycle phase transition	GO:1901987	130	0.014
adult behavior	GO:0030534	137	0.014
glycosyl compound catabolic process	GO:1901658	112	0.014
camera type eye development	GO:0043010	4	0.014
transmembrane transport	GO:0055085	139	0.014
cation homeostasis	GO:0055080	51	0.014
columnar cuboidal epithelial cell development	GO:0002066	249	0.014
neural precursor cell proliferation	GO:0061351	75	0.014
eye photoreceptor cell differentiation	GO:0001754	145	0.014
developmental programmed cell death	GO:0010623	138	0.014
positive regulation of catalytic activity	GO:0043085	118	0.014
regulation of cellular protein metabolic process	GO:0032268	243	0.014
immune response	GO:0006955	246	0.014
regulation of immune system process	GO:0002682	176	0.014
cellular response to organic substance	GO:0071310	132	0.014
cation transport	GO:0006812	110	0.014
transcription from rna polymerase ii promoter	GO:0006366	368	0.014
intracellular signal transduction	GO:0035556	300	0.014
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.014
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.013
eye photoreceptor cell development	GO:0042462	81	0.013
growth	GO:0040007	359	0.013
blastoderm segmentation	GO:0007350	159	0.013
positive regulation of hydrolase activity	GO:0051345	78	0.013
regulation of ras gtpase activity	GO:0032318	38	0.013
tripartite regional subdivision	GO:0007351	103	0.013
positive regulation of signal transduction	GO:0009967	223	0.013
adult locomotory behavior	GO:0008344	76	0.013
regulation of phosphorus metabolic process	GO:0051174	210	0.013
regulation of catalytic activity	GO:0050790	185	0.013
small gtpase mediated signal transduction	GO:0007264	88	0.013
hindbrain development	GO:0030902	2	0.013
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.013
regulation of purine nucleotide catabolic process	GO:0033121	48	0.013
organonitrogen compound catabolic process	GO:1901565	128	0.013
modification dependent macromolecule catabolic process	GO:0043632	79	0.012
response to radiation	GO:0009314	155	0.012
positive regulation of growth	GO:0045927	75	0.012
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.012
nucleoside triphosphate metabolic process	GO:0009141	120	0.012
appendage development	GO:0048736	401	0.012
positive regulation of signaling	GO:0023056	243	0.012
cellular ion homeostasis	GO:0006873	39	0.012
positive regulation of defense response	GO:0031349	59	0.012
positive regulation of cell death	GO:0010942	69	0.012
molting cycle chitin based cuticle	GO:0007591	56	0.012
negative regulation of erbb signaling pathway	GO:1901185	29	0.012
salivary gland development	GO:0007431	162	0.012
purine ribonucleotide metabolic process	GO:0009150	145	0.012
positive regulation of intracellular signal transduction	GO:1902533	116	0.012
regulation of immune response	GO:0050776	118	0.012
organic hydroxy compound metabolic process	GO:1901615	83	0.012
phosphorylation	GO:0016310	294	0.012
synapse organization	GO:0050808	196	0.012
regulation of behavior	GO:0050795	75	0.012
negative regulation of microtubule polymerization or depolymerization	GO:0031111	21	0.012
regulation of cellular ketone metabolic process	GO:0010565	3	0.012
cellular protein catabolic process	GO:0044257	83	0.012
anterior posterior axis specification	GO:0009948	109	0.012
regulation of anatomical structure size	GO:0090066	163	0.012
negative regulation of cellular metabolic process	GO:0031324	382	0.012
protein modification by small protein conjugation	GO:0032446	79	0.012
regulation of cellular response to stress	GO:0080135	89	0.012
establishment of organelle localization	GO:0051656	122	0.012
retina development in camera type eye	GO:0060041	4	0.012
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.011
protein import	GO:0017038	55	0.011
g protein coupled receptor signaling pathway	GO:0007186	136	0.011
regulation of cellular amine metabolic process	GO:0033238	3	0.011
regulation of nervous system development	GO:0051960	248	0.011
purine ribonucleoside catabolic process	GO:0046130	112	0.011
imaginal disc growth	GO:0007446	37	0.011
molting cycle	GO:0042303	56	0.011
peptide metabolic process	GO:0006518	80	0.011
glycosyl compound metabolic process	GO:1901657	127	0.011
spermatogenesis	GO:0007283	200	0.011
regulation of phosphatidylinositol 3 kinase signaling	GO:0014066	4	0.011
negative regulation of cell death	GO:0060548	81	0.011
circadian behavior	GO:0048512	76	0.011
compound eye photoreceptor cell differentiation	GO:0001751	140	0.011
guanosine containing compound metabolic process	GO:1901068	74	0.011
phenol containing compound metabolic process	GO:0018958	57	0.011
positive regulation of protein metabolic process	GO:0051247	128	0.011
regulation of defense response	GO:0031347	102	0.011
positive regulation of phosphate metabolic process	GO:0045937	139	0.011
negative regulation of rna metabolic process	GO:0051253	251	0.011
positive regulation of immune system process	GO:0002684	68	0.011
nucleoside phosphate catabolic process	GO:1901292	110	0.011
regulation of gtp catabolic process	GO:0033124	44	0.011
protein targeting	GO:0006605	64	0.010
protein phosphorylation	GO:0006468	169	0.010
anterior posterior pattern specification	GO:0009952	136	0.010
ribose phosphate metabolic process	GO:0019693	145	0.010
cellular response to radiation	GO:0071478	52	0.010
oocyte axis specification	GO:0007309	108	0.010
regulation of molecular function	GO:0065009	217	0.010
single organism membrane fusion	GO:0044801	42	0.010
maintenance of protein location in cell	GO:0032507	26	0.010
response to nutrient levels	GO:0031667	114	0.010
organonitrogen compound biosynthetic process	GO:1901566	117	0.010
regulation of protein catabolic process	GO:0042176	55	0.010
macroautophagy	GO:0016236	42	0.010
dephosphorylation	GO:0016311	51	0.010
tissue death	GO:0016271	102	0.010
negative regulation of mitotic cell cycle	GO:0045930	109	0.010
positive regulation of nucleotide catabolic process	GO:0030813	46	0.010
regulation of nucleotide catabolic process	GO:0030811	48	0.010
appendage morphogenesis	GO:0035107	397	0.010
metal ion transport	GO:0030001	74	0.010

Klp31E disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.022
nervous system disease	DOID:863	0.015
disease of cellular proliferation	DOID:14566	0.011
cancer	DOID:162	0.010

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