IMP: Integrative Multi-species Prediction

Drosophila melanogaster

41 known processes

Zasp52 (Dmel_CG30084)

Z band alternatively spliced PDZ-motif protein 52

(Aliases: CG30084,CG12969,CG12968,Zasp,zasp,tungus,tun,CG8242,Dmel\CG30084)

Entrez: 36740
FLYBASE: FBgn0083919
UniProtKB: G3JX33
UniProtKB: G3JX32
UniProtKB: G3JX31
UniProtKB: G3JX30
UniProtKB: G3JX29
UniProtKB: G3JX25
UniProtKB: G3JX27
UniProtKB: G3JX28
UniProtKB: A1ZA47
UniProtKB: C1C3E7

Process Predictions
Disease Predictions

Zasp52 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
striated muscle cell differentiation	GO:0051146	90	0.998
muscle structure development	GO:0061061	224	0.998
sarcomere organization	GO:0045214	26	0.997	Mouse
actomyosin structure organization	GO:0031032	56	0.996
myofibril assembly	GO:0030239	36	0.994
muscle cell differentiation	GO:0042692	103	0.991
muscle cell development	GO:0055001	50	0.935
striated muscle cell development	GO:0055002	50	0.933
somatic muscle development	GO:0007525	66	0.797
actin filament based process	GO:0030029	220	0.659
striated muscle myosin thick filament assembly	GO:0071688	3	0.633
cellular component assembly involved in morphogenesis	GO:0010927	151	0.628
muscle attachment	GO:0016203	36	0.559
adult behavior	GO:0030534	137	0.528
organelle assembly	GO:0070925	198	0.503
regulation of cytoskeleton organization	GO:0051493	89	0.498
protein complex assembly	GO:0006461	200	0.484
striated muscle tissue development	GO:0014706	27	0.402
muscle organ development	GO:0007517	127	0.390
circulatory system development	GO:0072359	82	0.384	Zebrafish Mouse
body morphogenesis	GO:0010171	2	0.379
skeletal muscle organ development	GO:0060538	48	0.379
skeletal muscle adaptation	GO:0043501	1	0.340
protein complex biogenesis	GO:0070271	201	0.279
muscle thin filament assembly	GO:0071689	5	0.272
macromolecular complex assembly	GO:0065003	256	0.253
cellular macromolecular complex assembly	GO:0034622	153	0.228
cation transmembrane transport	GO:0098655	88	0.193
organonitrogen compound metabolic process	GO:1901564	318	0.182
locomotory behavior	GO:0007626	176	0.160
ion transmembrane transport	GO:0034220	122	0.153
flight behavior	GO:0007629	26	0.149
transmembrane transport	GO:0055085	139	0.145
inorganic ion transmembrane transport	GO:0098660	73	0.141
organelle fission	GO:0048285	340	0.133
aromatic compound catabolic process	GO:0019439	166	0.130
growth	GO:0040007	359	0.125
organic substance catabolic process	GO:1901575	308	0.120
catabolic process	GO:0009056	409	0.117
striated muscle contraction	GO:0006941	5	0.117
skeletal myofibril assembly	GO:0014866	6	0.111
nucleobase containing compound catabolic process	GO:0034655	165	0.108
regulation of actin cytoskeleton organization	GO:0032956	42	0.108
small molecule metabolic process	GO:0044281	305	0.107
heterocycle catabolic process	GO:0046700	166	0.106
muscle tissue development	GO:0060537	30	0.103
homeostatic process	GO:0042592	199	0.103
actin filament organization	GO:0007015	126	0.103	Mouse
cellular protein complex assembly	GO:0043623	71	0.102
regulation of protein complex disassembly	GO:0043244	29	0.101
regulation of actin filament based process	GO:0032970	42	0.099
regulation of organelle organization	GO:0033043	196	0.097
organic cyclic compound catabolic process	GO:1901361	168	0.096
cuticle development	GO:0042335	86	0.092
heart development	GO:0007507	82	0.091	Zebrafish Mouse
regulation of cellular component size	GO:0032535	98	0.090
ribonucleoside monophosphate catabolic process	GO:0009158	39	0.086
mesoderm development	GO:0007498	78	0.086
actin cytoskeleton organization	GO:0030036	206	0.085
cardiac muscle tissue development	GO:0048738	9	0.081
regulation of cellular component biogenesis	GO:0044087	201	0.081	Rat
regulation of actin filament length	GO:0030832	27	0.078
purine ribonucleotide catabolic process	GO:0009154	109	0.077
cellular response to heat	GO:0034605	24	0.077
skeletal muscle fiber development	GO:0048741	3	0.075
myosin filament assembly	GO:0031034	5	0.074
organic acid metabolic process	GO:0006082	103	0.069
purine ribonucleotide metabolic process	GO:0009150	145	0.066
purine containing compound catabolic process	GO:0072523	112	0.066
regulation of cell death	GO:0010941	173	0.066
muscle tissue morphogenesis	GO:0060415	2	0.065
muscle system process	GO:0003012	21	0.062
cellular catabolic process	GO:0044248	372	0.060
inorganic cation transmembrane transport	GO:0098662	61	0.059
skeletal muscle myosin thick filament assembly	GO:0030241	3	0.057
larval somatic muscle development	GO:0007526	19	0.056
vesicle mediated transport	GO:0016192	381	0.055
negative regulation of cellular metabolic process	GO:0031324	382	0.053
appendage morphogenesis	GO:0035107	397	0.053
regulation of actin filament polymerization	GO:0030833	25	0.053
ameboidal type cell migration	GO:0001667	151	0.052
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.052
cardiovascular system development	GO:0072358	82	0.052	Zebrafish Mouse
regulation of rna splicing	GO:0043484	69	0.052
macromolecule catabolic process	GO:0009057	161	0.051
nucleotide metabolic process	GO:0009117	161	0.051
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.050
cell proliferation	GO:0008283	299	0.050
myotube cell development	GO:0014904	3	0.049
mating behavior	GO:0007617	106	0.048
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.048
cellular nitrogen compound catabolic process	GO:0044270	165	0.048
purine ribonucleoside catabolic process	GO:0046130	112	0.047
positive regulation of cell death	GO:0010942	69	0.047
response to mechanical stimulus	GO:0009612	28	0.046
regulation of protein complex assembly	GO:0043254	42	0.046
negative regulation of protein complex disassembly	GO:0043242	23	0.046
positive regulation of lipid catabolic process	GO:0050996	1	0.045
negative regulation of cytoskeleton organization	GO:0051494	30	0.044
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.043
regulation of catalytic activity	GO:0050790	185	0.043
positive regulation of actin filament polymerization	GO:0030838	11	0.042
tube development	GO:0035295	244	0.042
cellular response to reactive oxygen species	GO:0034614	14	0.042
adult somatic muscle development	GO:0007527	14	0.041
multicellular organismal aging	GO:0010259	140	0.040
nucleoside triphosphate catabolic process	GO:0009143	108	0.040
positive regulation of catabolic process	GO:0009896	105	0.040
positive regulation of molecular function	GO:0044093	136	0.039
purine nucleoside metabolic process	GO:0042278	127	0.039
oxoacid metabolic process	GO:0043436	103	0.038
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.038
myosin filament organization	GO:0031033	5	0.038
purine nucleoside monophosphate catabolic process	GO:0009128	38	0.038
regulation of cell proliferation	GO:0042127	163	0.037
purine nucleotide catabolic process	GO:0006195	109	0.036
programmed cell death	GO:0012501	257	0.036
purine ribonucleoside metabolic process	GO:0046128	127	0.036
nucleoside phosphate catabolic process	GO:1901292	110	0.035
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.035
negative regulation of cellular component organization	GO:0051129	108	0.035
nucleoside phosphate metabolic process	GO:0006753	162	0.034
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.034
regulation of actin filament depolymerization	GO:0030834	3	0.033
protein catabolic process	GO:0030163	101	0.033
negative regulation of response to stimulus	GO:0048585	258	0.033
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.033
mrna metabolic process	GO:0016071	124	0.033
positive regulation of phosphate metabolic process	GO:0045937	139	0.033
response to abiotic stimulus	GO:0009628	341	0.032	Rat
muscle fiber development	GO:0048747	12	0.031
apoptotic process	GO:0006915	159	0.031
cell death	GO:0008219	279	0.031
cellular amino acid metabolic process	GO:0006520	61	0.031
carbohydrate derivative metabolic process	GO:1901135	217	0.031
glycosyl compound metabolic process	GO:1901657	127	0.031
regulation of programmed cell death	GO:0043067	152	0.030
organelle localization	GO:0051640	148	0.030
regulation of immune system process	GO:0002682	176	0.030
regulation of apoptotic process	GO:0042981	130	0.030
atp catabolic process	GO:0006200	38	0.029
maintenance of location	GO:0051235	73	0.028
catechol containing compound biosynthetic process	GO:0009713	3	0.028
actin polymerization or depolymerization	GO:0008154	31	0.028
ribonucleotide catabolic process	GO:0009261	109	0.028
response to oxygen containing compound	GO:1901700	200	0.027
cell junction assembly	GO:0034329	42	0.027
ribonucleoside catabolic process	GO:0042454	112	0.027
nucleobase containing small molecule metabolic process	GO:0055086	174	0.027
axon development	GO:0061564	297	0.027
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.027
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.027
visceral muscle development	GO:0007522	14	0.027
cellular protein complex disassembly	GO:0043624	35	0.026
death	GO:0016265	284	0.026
lipid storage	GO:0019915	38	0.026
regulation of phosphatase activity	GO:0010921	3	0.026
purine nucleotide metabolic process	GO:0006163	146	0.026
cognition	GO:0050890	141	0.026
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.026
organophosphate catabolic process	GO:0046434	112	0.026
ribonucleoside metabolic process	GO:0009119	127	0.025
positive regulation of gene expression	GO:0010628	290	0.025
lipid metabolic process	GO:0006629	121	0.025
response to oxidative stress	GO:0006979	86	0.024
nuclear division	GO:0000280	332	0.024
ribose phosphate metabolic process	GO:0019693	145	0.024
mating	GO:0007618	120	0.024
response to organic cyclic compound	GO:0014070	89	0.024
regulation of actin polymerization or depolymerization	GO:0008064	27	0.024
organophosphate metabolic process	GO:0019637	195	0.023
notch signaling pathway	GO:0007219	120	0.023
muscle organ morphogenesis	GO:0048644	7	0.023
response to nutrient levels	GO:0031667	114	0.023
response to heat	GO:0009408	63	0.022
purine nucleoside biosynthetic process	GO:0042451	3	0.022
regulation of endocytosis	GO:0030100	37	0.022
response to lipid	GO:0033993	38	0.022
response to alkaloid	GO:0043279	26	0.022
digestive tract development	GO:0048565	149	0.022
actin filament bundle assembly	GO:0051017	26	0.022
regulation of sarcomere organization	GO:0060297	2	0.021
actin filament bundle organization	GO:0061572	28	0.021
mitotic nuclear division	GO:0007067	213	0.021
larval development	GO:0002164	104	0.020
macromolecular complex disassembly	GO:0032984	37	0.020
response to other organism	GO:0051707	293	0.020
purine nucleoside catabolic process	GO:0006152	112	0.020
regulation of purine nucleotide metabolic process	GO:1900542	62	0.020
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.020
mitochondrion organization	GO:0007005	65	0.020
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.020
purine ribonucleoside monophosphate catabolic process	GO:0009169	38	0.020
multi organism behavior	GO:0051705	175	0.020
negative regulation of protein depolymerization	GO:1901880	23	0.020
chemotaxis	GO:0006935	249	0.019
positive regulation of phosphorus metabolic process	GO:0010562	139	0.019
regulation of anatomical structure size	GO:0090066	163	0.019
cell type specific apoptotic process	GO:0097285	38	0.019
actin filament polymerization	GO:0030041	27	0.019
molting cycle	GO:0042303	56	0.019
regulation of nucleoside metabolic process	GO:0009118	50	0.019
negative regulation of multicellular organismal process	GO:0051241	142	0.019
heart morphogenesis	GO:0003007	32	0.019
purine containing compound metabolic process	GO:0072521	155	0.019
glycosyl compound catabolic process	GO:1901658	112	0.019
cell motility	GO:0048870	251	0.018
glycoprotein biosynthetic process	GO:0009101	41	0.018
phagocytosis	GO:0006909	215	0.018
carboxylic acid metabolic process	GO:0019752	92	0.018
negative regulation of gene expression	GO:0010629	387	0.018
regulation of nucleotide metabolic process	GO:0006140	62	0.018
carbohydrate metabolic process	GO:0005975	82	0.018
response to extracellular stimulus	GO:0009991	116	0.017
regulation of vesicle mediated transport	GO:0060627	59	0.017
response to wounding	GO:0009611	94	0.017
regulation of microtubule polymerization or depolymerization	GO:0031110	27	0.017
alternative mrna splicing via spliceosome	GO:0000380	60	0.017
axon guidance	GO:0007411	233	0.017
negative regulation of actin filament depolymerization	GO:0030835	2	0.017
protein complex disassembly	GO:0043241	36	0.017
organonitrogen compound catabolic process	GO:1901565	128	0.017
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.017
regulation of purine nucleotide catabolic process	GO:0033121	48	0.016
cellular macromolecule localization	GO:0070727	220	0.016
nucleoside catabolic process	GO:0009164	112	0.016
developmental cell growth	GO:0048588	52	0.016
positive regulation of organelle organization	GO:0010638	65	0.016
regulation of protein polymerization	GO:0032271	28	0.016
cell cycle arrest	GO:0007050	4	0.016
action potential	GO:0001508	13	0.016
camera type eye development	GO:0043010	4	0.016
negative regulation of organelle organization	GO:0010639	56	0.016
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.015
nucleoside monophosphate metabolic process	GO:0009123	52	0.015
nucleoside triphosphate metabolic process	GO:0009141	120	0.015
cell migration	GO:0016477	238	0.015
nucleotide catabolic process	GO:0009166	109	0.015
single organism catabolic process	GO:0044712	228	0.015
muscle contraction	GO:0006936	13	0.015
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.015
regulation of membrane potential	GO:0042391	35	0.015
outflow tract morphogenesis	GO:0003151	4	0.014
neuron projection guidance	GO:0097485	241	0.014
cellular potassium ion transport	GO:0071804	18	0.014
synaptic transmission	GO:0007268	288	0.014	Rat
negative regulation of cell death	GO:0060548	81	0.014
striated muscle adaptation	GO:0014888	1	0.014
connective tissue development	GO:0061448	3	0.014
regulation of alternative mrna splicing via spliceosome	GO:0000381	60	0.014
response to peptide hormone	GO:0043434	29	0.014
cardiac muscle cell differentiation	GO:0055007	4	0.014
musculoskeletal movement	GO:0050881	3	0.014
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.014
cellular macromolecule catabolic process	GO:0044265	136	0.014
negative regulation of gene expression epigenetic	GO:0045814	77	0.014
cellular response to oxygen containing compound	GO:1901701	79	0.013
protein polymerization	GO:0051258	42	0.013
skeletal muscle tissue development	GO:0007519	13	0.013
appendage development	GO:0048736	401	0.013
negative regulation of protein metabolic process	GO:0051248	85	0.013
lateral inhibition	GO:0046331	206	0.013
synapse assembly	GO:0007416	143	0.013	Rat
cellular response to oxygen levels	GO:0071453	30	0.013
immune system process	GO:0002376	347	0.012
heart contraction	GO:0060047	26	0.012
catecholamine biosynthetic process	GO:0042423	3	0.012
carbohydrate derivative catabolic process	GO:1901136	118	0.012
response to reactive oxygen species	GO:0000302	24	0.012
regulation of mrna processing	GO:0050684	71	0.012
regulation of dna templated transcription elongation	GO:0032784	17	0.012
cellular amine metabolic process	GO:0044106	12	0.012
open tracheal system development	GO:0007424	204	0.012
actin cytoskeleton reorganization	GO:0031532	22	0.012
cellular response to nitrogen compound	GO:1901699	51	0.012
regulation of phosphorus metabolic process	GO:0051174	210	0.012
single organism carbohydrate metabolic process	GO:0044723	72	0.012
rna splicing via transesterification reactions	GO:0000375	73	0.012
regulation of sequestering of calcium ion	GO:0051282	3	0.012
cell division	GO:0051301	248	0.012
nicotinamide nucleotide metabolic process	GO:0046496	2	0.012
post embryonic appendage morphogenesis	GO:0035120	385	0.012
inositol lipid mediated signaling	GO:0048017	4	0.012
regulation of phosphate metabolic process	GO:0019220	210	0.012
single organism behavior	GO:0044708	391	0.012
nucleoside metabolic process	GO:0009116	127	0.012
cell projection assembly	GO:0030031	94	0.012
regulation of cellular catabolic process	GO:0031329	157	0.012
protein depolymerization	GO:0051261	31	0.012
neuronal action potential	GO:0019228	10	0.011
regulation of catabolic process	GO:0009894	170	0.011
regulation of molecular function	GO:0065009	217	0.011
multicellular organismal movement	GO:0050879	3	0.011
organelle fusion	GO:0048284	46	0.011
rhythmic process	GO:0048511	106	0.011
cellular response to peptide	GO:1901653	28	0.011
ribonucleotide metabolic process	GO:0009259	145	0.011
regulation of growth	GO:0040008	233	0.011
single organism cellular localization	GO:1902580	180	0.011
cellular response to chemical stimulus	GO:0070887	199	0.011
branching involved in open tracheal system development	GO:0060446	45	0.011
purine nucleotide biosynthetic process	GO:0006164	29	0.011
axonogenesis	GO:0007409	290	0.011
cellular protein modification process	GO:0006464	438	0.011
epithelial cell migration open tracheal system	GO:0007427	32	0.011
positive regulation of programmed cell death	GO:0043068	62	0.011
immune system development	GO:0002520	57	0.011
response to glucose	GO:0009749	2	0.010
response to decreased oxygen levels	GO:0036293	58	0.010	Rat
ovarian follicle cell migration	GO:0007297	121	0.010
response to temperature stimulus	GO:0009266	106	0.010
monovalent inorganic cation transport	GO:0015672	40	0.010
regulation of cellular component movement	GO:0051270	42	0.010
endocytosis	GO:0006897	310	0.010
response to calcium ion	GO:0051592	1	0.010
establishment of organelle localization	GO:0051656	122	0.010
regulation of locomotion	GO:0040012	42	0.010
response to alcohol	GO:0097305	95	0.010
cell cell adhesion mediated by integrin	GO:0033631	1	0.010
response to nitrogen compound	GO:1901698	90	0.010

Zasp52 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of anatomical entity	DOID:7	0.105	Human
muscular disease	DOID:0080000	0.070	Human
musculoskeletal system disease	DOID:17	0.070	Human
muscle tissue disease	DOID:66	0.070	Human
myopathy	DOID:423	0.044	Human
cardiovascular system disease	DOID:1287	0.044	Human
heart disease	DOID:114	0.044	Human
cardiomyopathy	DOID:0050700	0.044	Human
intrinsic cardiomyopathy	DOID:0060036	0.044	Human
urinary system disease	DOID:18	0.024
dilated cardiomyopathy	DOID:12930	0.022	Human
kidney disease	DOID:557	0.014
nervous system disease	DOID:863	0.011

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