Drosophila melanogaster

0 known processes

Pen (Dmel_CG4799)

Pendulin

(Aliases: Dalpha2,Dimp-alpha2,OHO31,oho31,Kpna2,DPend,2.1,alpha2,Kap-alpha2,Dmel\CG4799,Rch1,pen,l(2)k14401,anon-WO0140519.258,imp alpha2,CG4799,Oho31,pen-2,alpha2A-Kap,Kap alpha2,Imp-alpha2,IMPalpha2,importin alpha2/pendulin,oho-31,l(2)144/1,imp-alpha2,bs29g06.y1)

Pen biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
oocyte constructionGO:00073081120.937
oocyte developmentGO:00485991240.814
mrna processingGO:00063971040.773
pole plasm mrna localizationGO:0019094490.736
oocyte axis specificationGO:00073091080.721
mrna metabolic processGO:00160711240.712
anterior posterior pattern specificationGO:00099521360.706
immune responseGO:00069552460.614
cell fate determinationGO:0001709910.537
cell maturationGO:00484691440.514
maternal determination of anterior posterior axis embryoGO:0008358740.503
oocyte anterior posterior axis specificationGO:0007314720.501
muscle structure developmentGO:00610612240.478
blastoderm segmentationGO:00073501590.403
response to abiotic stimulusGO:00096283410.402
Fly
oocyte differentiationGO:00099941450.389
regionalizationGO:00030024160.386
cytoplasmic transport nurse cell to oocyteGO:0007303120.384
immune system processGO:00023763470.375
embryonic pattern specificationGO:00098801740.375
negative regulation of cellular metabolic processGO:00313243820.334
gravitaxisGO:0042332260.331
segmentationGO:00352822070.328
defense responseGO:00069523000.300
negative regulation of translationGO:0017148280.266
mrna catabolic processGO:0006402330.259
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.251
salivary gland morphogenesisGO:00074351450.246
rna splicing via transesterification reactions with bulged adenosine as nucleophileGO:0000377730.243
male gamete generationGO:00482322010.225
embryonic axis specificationGO:00005781070.219
epithelial cell migration open tracheal systemGO:0007427320.217
dendrite developmentGO:00163582040.210
negative regulation of gene expressionGO:00106293870.202
skeletal muscle organ developmentGO:0060538480.200
single organism behaviorGO:00447083910.191
response to gravityGO:0009629260.190
embryonic morphogenesisGO:00485982060.189
taxisGO:00423303040.187
oocyte nucleus localization involved in oocyte dorsal ventral axis specificationGO:0051663120.187
digestive system developmentGO:00551231490.187
developmental maturationGO:00217001720.183
enzyme linked receptor protein signaling pathwayGO:00071671790.180
actin filament based processGO:00300292200.174
response to organic substanceGO:00100332840.173
rna processingGO:00063961470.169
gene silencingGO:00164581380.168
response to other organismGO:00517072930.164
mrna splicing via spliceosomeGO:0000398730.161
spermatogenesisGO:00072832000.154
imaginal disc derived appendage morphogenesisGO:00351143950.152
negative regulation of cellular protein metabolic processGO:0032269850.151
positive regulation of rna metabolic processGO:00512542710.147
anterior posterior axis specification embryoGO:00085951030.134
cell deathGO:00082192790.134
intracellular mrna localization involved in anterior posterior axis specificationGO:0060811530.129
rna splicingGO:0008380830.126
growthGO:00400073590.126
negative regulation of cellular biosynthetic processGO:00313272770.121
nuclear transcribed mrna catabolic processGO:0000956240.114
positive regulation of nitrogen compound metabolic processGO:00511733540.111
positive regulation of mrna metabolic processGO:190331350.111
positive regulation of gene expressionGO:00106282900.109
regulation of defense responseGO:00313471020.108
regulation of multicellular organismal developmentGO:20000264140.108
exocrine system developmentGO:00352721620.105
negative regulation of nitrogen compound metabolic processGO:00511722650.103
tripartite regional subdivisionGO:00073511030.101
regulation of cell differentiationGO:00455953020.099
pole plasm assemblyGO:0007315610.097
oocyte dorsal ventral axis specificationGO:0007310340.097
negative regulation of nervous system developmentGO:0051961920.095
interspecies interaction between organismsGO:0044419160.095
actin polymerization or depolymerizationGO:0008154310.093
cellular response to chemical stimulusGO:00708871990.091
positive regulation of macromolecule metabolic processGO:00106044050.090
regulation of cysteine type endopeptidase activityGO:2000116270.085
rna catabolic processGO:0006401370.084
epithelial cell migrationGO:00106311480.084
defense response to bacteriumGO:00427421780.084
response to bacteriumGO:00096171980.083
cell proliferationGO:00082832990.082
cellular response to organic substanceGO:00713101320.082
negative regulation of macromolecule biosynthetic processGO:00105582700.081
striated muscle cell differentiationGO:0051146900.081
defense response to other organismGO:00985422250.081
asymmetric cell divisionGO:0008356370.079
cellular component assembly involved in morphogenesisGO:00109271510.079
response to external biotic stimulusGO:00432072930.075
positive regulation of nuclear transcribed mrna poly a tail shorteningGO:006021340.075
anterior posterior axis specificationGO:00099481090.074
germarium derived oocyte fate determinationGO:0007294260.072
germ line cyst formationGO:0048134440.071
muscle cell differentiationGO:00426921030.070
somatic muscle developmentGO:0007525660.070
apoptotic processGO:00069151590.065
rna splicing via transesterification reactionsGO:0000375730.065
programmed cell deathGO:00125012570.064
regulation of mrna processingGO:0050684710.062
regulation of apoptotic processGO:00429811300.061
positive regulation of nucleic acid templated transcriptionGO:19035082660.060
lipid storageGO:0019915380.060
kidney epithelium developmentGO:007207330.060
regulation of translationGO:0006417560.057
fusome organizationGO:0045478130.056
regulation of protein metabolic processGO:00512462560.055
imaginal disc derived appendage developmentGO:00487373990.052
deathGO:00162652840.051
cellularizationGO:0007349900.051
positive regulation of nucleobase containing compound metabolic processGO:00459353320.051
oocyte localization involved in germarium derived egg chamber formationGO:0030720120.050
regulation of mrna splicing via spliceosomeGO:0048024640.049
regulation of mrna catabolic processGO:006101350.049
regulation of mrna metabolic processGO:1903311720.048
organic cyclic compound catabolic processGO:19013611680.047
regulation of cellular protein metabolic processGO:00322682430.047
cellular macromolecular complex assemblyGO:00346221530.047
regulation of dendrite developmentGO:0050773370.046
regulation of oocyte developmentGO:0060281270.046
negative regulation of response to stimulusGO:00485852580.044
ovarian fusome organizationGO:0030723110.043
defense response to gram negative bacteriumGO:0050829940.043
protein maturationGO:0051604710.043
gland morphogenesisGO:00226121450.043
appendage developmentGO:00487364010.043
intracellular mrna localization involved in pattern specification processGO:0060810560.043
negative regulation of cell proliferationGO:0008285690.042
morphogenesis of an epitheliumGO:00020092760.042
gland developmentGO:00487321910.042
salivary gland developmentGO:00074311620.042
pole plasm oskar mrna localizationGO:0045451460.040
macromolecular complex assemblyGO:00650032560.039
negative regulation of nucleobase containing compound metabolic processGO:00459342610.038
striated muscle cell developmentGO:0055002500.038
cellular protein complex assemblyGO:0043623710.038
negative regulation of biosynthetic processGO:00098902770.038
regulation of response to stressGO:00801342000.037
establishment or maintenance of microtubule cytoskeleton polarityGO:0030951410.037
negative regulation of protein metabolic processGO:0051248850.036
posttranscriptional regulation of gene expressionGO:00106081450.036
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281250.036
chorion containing eggshell formationGO:00073041050.035
dendrite morphogenesisGO:00488131990.035
multi organism behaviorGO:00517051750.035
regulation of cellular catabolic processGO:00313291570.035
cellular macromolecule localizationGO:00707272200.034
Mouse Worm Fly
regulation of programmed cell deathGO:00430671520.033
regulation of localizationGO:00328792750.033
Fly
heart processGO:0003015370.033
muscle attachmentGO:0016203360.033
protein processingGO:0016485680.033
actin cytoskeleton organizationGO:00300362060.032
cell motilityGO:00488702510.032
positive regulation of cellular biosynthetic processGO:00313283160.032
alternative mrna splicing via spliceosomeGO:0000380600.032
photoreceptor cell axon guidanceGO:0072499230.032
response to ethanolGO:0045471590.032
mrna 3 end processingGO:0031124280.031
larval developmentGO:00021641040.031
negative regulation of nucleic acid templated transcriptionGO:19035072400.031
germarium derived female germ line cyst formationGO:0030727420.031
oocyte microtubule cytoskeleton organizationGO:0016325350.030
heterocycle catabolic processGO:00467001660.030
axis specificationGO:00097981670.030
protein localizationGO:00081042840.030
Mouse Worm Fly
ameboidal type cell migrationGO:00016671510.029
cellular nitrogen compound catabolic processGO:00442701650.029
organic substance catabolic processGO:19015753080.028
axon guidanceGO:00074112330.028
negative regulation of rna biosynthetic processGO:19026792400.028
tissue migrationGO:00901301550.028
regulation of cellular amino acid metabolic processGO:000652100.027
rna 3 end processingGO:0031123450.027
negative regulation of cell cycleGO:00457861160.027
Fly
regulation of alternative mrna splicing via spliceosomeGO:0000381600.026
regulation of actin filament polymerizationGO:0030833250.026
muscle organ developmentGO:00075171270.026
renal system developmentGO:0072001720.026
nuclear transcribed mrna catabolic process deadenylation dependent decayGO:0000288140.026
kidney developmentGO:000182230.026
developmental programmed cell deathGO:00106231380.026
organic substance transportGO:00717022570.026
Mouse Worm Fly
tissue morphogenesisGO:00487292970.025
cellular ketone metabolic processGO:0042180240.025
digestive tract developmentGO:00485651490.025
female germ line stem cell asymmetric divisionGO:0048132140.025
response to endogenous stimulusGO:00097191190.025
positive regulation of response to stimulusGO:00485843230.025
response to biotic stimulusGO:00096072940.025
autophagic cell deathGO:0048102830.025
positive regulation of biosynthetic processGO:00098913160.025
tube morphogenesisGO:00352391910.025
agingGO:00075681430.024
dna biosynthetic processGO:0071897240.024
negative regulation of cell deathGO:0060548810.024
epithelial cell developmentGO:00020642740.024
asymmetric protein localizationGO:0008105330.024
translationGO:0006412690.024
regulation of cell deathGO:00109411730.024
epithelial cell differentiationGO:00308553220.024
negative regulation of synapse assemblyGO:0051964390.024
biological adhesionGO:00226101380.024
regulation of rna splicingGO:0043484690.024
ventral cord developmentGO:0007419160.024
nucleobase containing compound catabolic processGO:00346551650.023
cell adhesionGO:00071551360.023
regulation of catalytic activityGO:00507901850.023
meiotic chromosome condensationGO:001003230.023
female germ line cyst formationGO:0048135420.023
body morphogenesisGO:001017120.023
positive regulation of cell communicationGO:00106472500.022
organ growthGO:0035265560.022
proteolysisGO:00065081920.022
myotube cell developmentGO:001490430.022
positive regulation of apoptotic processGO:0043065470.022
cellular catabolic processGO:00442483720.021
neuron projection guidanceGO:00974852410.021
single organism cell adhesionGO:0098602470.021
epithelial tube morphogenesisGO:0060562880.021
protein complex biogenesisGO:00702712010.021
regulation of proteolysisGO:0030162870.020
regulation of nervous system developmentGO:00519602480.020
histolysisGO:00075591020.020
germarium derived oocyte differentiationGO:0030706290.020
positive regulation of mrna catabolic processGO:006101450.020
actin filament polymerizationGO:0030041270.020
protein complex assemblyGO:00064612000.020
mitotic cell cycle phase transitionGO:00447721380.019
Fly
protein modification by small protein conjugation or removalGO:00706471060.019
cellular response to endogenous stimulusGO:0071495800.019
aromatic compound catabolic processGO:00194391660.019
phosphorylationGO:00163102940.019
axon developmentGO:00615642970.019
regulation of actin polymerization or depolymerizationGO:0008064270.019
regulation of endopeptidase activityGO:0052548360.018
homeostatic processGO:00425921990.018
ribose phosphate metabolic processGO:00196931450.018
multi organism reproductive behaviorGO:00447051210.018
spermatid developmentGO:0007286980.018
microtubule polymerization or depolymerizationGO:0031109390.018
regulation of cell cycleGO:00517262910.018
Fly
protein phosphorylationGO:00064681690.018
ribonucleoprotein complex assemblyGO:0022618230.017
nuclear transcribed mrna poly a tail shorteningGO:0000289120.017
central nervous system developmentGO:00074172010.017
macromolecule catabolic processGO:00090571610.017
regulation of embryonic developmentGO:0045995680.017
tube developmentGO:00352952440.017
intracellular receptor signaling pathwayGO:0030522190.016
dorsal ventral axis specification ovarian follicular epitheliumGO:0008069130.016
salivary gland cell autophagic cell deathGO:0035071830.016
protein polymerizationGO:0051258420.016
regulation of synapse structure and activityGO:00508031280.016
pole plasm rna localizationGO:0007316520.016
karyosome formationGO:0030717220.016
oocyte fate determinationGO:0030716270.016
lipid localizationGO:0010876540.015
activation of cysteine type endopeptidase activity involved in apoptotic processGO:0006919160.015
cellular macromolecule catabolic processGO:00442651360.015
regulation of synapse organizationGO:00508071100.015
cytoplasm organizationGO:0007028640.015
salivary gland histolysisGO:0035070880.015
skeletal muscle fiber developmentGO:004874130.015
positive regulation of defense responseGO:0031349590.015
establishment of protein localizationGO:00451841630.015
Mouse Worm Fly
morphogenesis of a branching structureGO:0001763450.015
camera type eye developmentGO:004301040.015
transcription from rna polymerase ii promoterGO:00063663680.015
maintenance of locationGO:0051235730.015
imaginal disc derived wing morphogenesisGO:00074763370.015
embryo development ending in birth or egg hatchingGO:00097921520.014
Worm
positive regulation of rna biosynthetic processGO:19026802660.014
muscle tissue developmentGO:0060537300.014
regulation of protein polymerizationGO:0032271280.014
nucleobase containing small molecule metabolic processGO:00550861740.014
positive regulation of transcription dna templatedGO:00458932660.014
regulation of catabolic processGO:00098941700.014
response to oxidative stressGO:0006979860.014
positive regulation of peptidase activityGO:0010952290.014
positive regulation of proteolysisGO:0045862520.014
positive regulation of signal transductionGO:00099672230.014
cellular amino acid metabolic processGO:0006520610.013
regulation of immune responseGO:00507761180.013
positive regulation of developmental growthGO:0048639620.013
positive regulation of growthGO:0045927750.013
regulation of hydrolase activityGO:0051336970.013
regulation of meiosisGO:004002030.013
germarium derived egg chamber formationGO:00072931010.013
motor neuron axon guidanceGO:0008045580.013
sensory organ morphogenesisGO:00905962600.013
positive regulation of neuron apoptotic processGO:004352510.013
startle responseGO:0001964160.012
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.012
positive regulation of catabolic processGO:00098961050.012
nephron developmentGO:007200630.012
muscle fiber developmentGO:0048747120.012
negative regulation of cell communicationGO:00106482230.012
tissue deathGO:00162711020.012
negative regulation of growthGO:0045926840.012
positive regulation of immune responseGO:0050778630.012
regulation of anatomical structure morphogenesisGO:00226032420.012
regulation of cell proliferationGO:00421271630.012
regulation of phosphatase activityGO:001092130.012
larval behaviorGO:0030537420.012
regulation of molecular functionGO:00650092170.011
nucleoside phosphate metabolic processGO:00067531620.011
innate immune responseGO:00450871440.011
single organism cellular localizationGO:19025801800.011
Mouse Worm Fly
regulation of cell fate specificationGO:0042659270.011
negative regulation of transcription from rna polymerase ii promoterGO:00001221190.011
regulation of proteolysis involved in cellular protein catabolic processGO:1903050440.011
organelle assemblyGO:00709251980.011
ovarian nurse cell to oocyte transportGO:0007300270.011
peptidyl tyrosine phosphorylationGO:0018108240.011
catabolic processGO:00090564090.011
establishment of oocyte nucleus localization involved in oocyte dorsal ventral axis specificationGO:003072260.011
regulation of peptidase activityGO:0052547390.011
response to hormoneGO:0009725450.011
mitotic nuclear divisionGO:00070672130.011
positive regulation of cell cycle processGO:0090068280.011
negative regulation of programmed cell deathGO:0043069720.011
regulation of cellular component sizeGO:0032535980.011
ribonucleoside triphosphate metabolic processGO:00091991190.011
ribonucleotide catabolic processGO:00092611090.011
specification of symmetryGO:0009799130.010
rna localizationGO:00064031150.010
positive regulation of signalingGO:00230562430.010
chromosome condensationGO:0030261410.010
regulation of phosphorylationGO:00423251470.010
multicellular organismal signalingGO:0035637120.010

Pen disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
musculoskeletal system diseaseDOID:1700.044
disease of anatomical entityDOID:700.044
muscle tissue diseaseDOID:6600.010
muscular diseaseDOID:008000000.010
myopathyDOID:42300.010