IMP: Integrative Multi-species Prediction

Drosophila melanogaster

270 known processes

Tsc1 (Dmel_CG6147)

CG6147 gene product from transcript CG6147-RA

(Aliases: CG6147,dTsc1,dTSC1,rocky,TSC,dTSC,Dmel\CG6147,tsc1,TSC1)

Entrez: 42862
FLYBASE: FBgn0026317
UniProtKB: Q9VCC9

Process Predictions
Disease Predictions

Tsc1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
open tracheal system development	GO:0007424	204	0.985
respiratory system development	GO:0060541	213	0.936
eye morphogenesis	GO:0048592	260	0.923
sensory organ morphogenesis	GO:0090596	260	0.916
membrane organization	GO:0061024	112	0.909
compound eye photoreceptor development	GO:0042051	78	0.908
trachea morphogenesis	GO:0060439	22	0.853
compound eye morphogenesis	GO:0001745	249	0.844
small molecule metabolic process	GO:0044281	305	0.844
response to extracellular stimulus	GO:0009991	116	0.836
compound eye photoreceptor cell differentiation	GO:0001751	140	0.793
regulation of anatomical structure morphogenesis	GO:0022603	242	0.769
autophagic vacuole fusion	GO:0000046	15	0.758
organic substance transport	GO:0071702	257	0.756	Human Mouse
appendage development	GO:0048736	401	0.752
regulation of phosphorylation	GO:0042325	147	0.750
negative regulation of developmental process	GO:0051093	201	0.732
eye photoreceptor cell differentiation	GO:0001754	145	0.727
nucleotide metabolic process	GO:0009117	161	0.727
cellular protein modification process	GO:0006464	438	0.707	Mouse
muscle structure development	GO:0061061	224	0.681	Mouse
tube development	GO:0035295	244	0.670	Mouse
striated muscle cell differentiation	GO:0051146	90	0.668	Mouse
protein transport	GO:0015031	155	0.666
regulation of cellular catabolic process	GO:0031329	157	0.666
protein localization	GO:0008104	284	0.664
regulation of localization	GO:0032879	275	0.655
negative regulation of response to stimulus	GO:0048585	258	0.654
protein modification process	GO:0036211	438	0.649	Mouse
appendage morphogenesis	GO:0035107	397	0.643
negative regulation of signal transduction	GO:0009968	206	0.641
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.639
regulation of anatomical structure size	GO:0090066	163	0.638
trachea development	GO:0060438	29	0.630
negative regulation of cellular metabolic process	GO:0031324	382	0.607	Human
immune response	GO:0006955	246	0.601
tube morphogenesis	GO:0035239	191	0.598	Mouse
regulation of nervous system development	GO:0051960	248	0.597
negative regulation of cell communication	GO:0010648	223	0.596
response to external biotic stimulus	GO:0043207	293	0.590
positive regulation of wnt signaling pathway	GO:0030177	25	0.583
negative regulation of multicellular organismal process	GO:0051241	142	0.574
immune system process	GO:0002376	347	0.566
circulatory system development	GO:0072359	82	0.558	Mouse
single organism cellular localization	GO:1902580	180	0.556
endomembrane system organization	GO:0010256	119	0.537
nucleoside phosphate metabolic process	GO:0006753	162	0.532
determination of adult lifespan	GO:0008340	137	0.527
chemotaxis	GO:0006935	249	0.525
positive regulation of phosphorus metabolic process	GO:0010562	139	0.522
purine containing compound metabolic process	GO:0072521	155	0.519
epithelial cell differentiation	GO:0030855	322	0.518
regulation of transport	GO:0051049	181	0.516
eye development	GO:0001654	323	0.513
regulation of programmed cell death	GO:0043067	152	0.512
post embryonic appendage morphogenesis	GO:0035120	385	0.500
photoreceptor cell differentiation	GO:0046530	170	0.491
growth	GO:0040007	359	0.489
regulation of multicellular organismal development	GO:2000026	414	0.489
single organism membrane organization	GO:0044802	93	0.487
secretion	GO:0046903	109	0.482
programmed cell death	GO:0012501	257	0.466
negative regulation of cell death	GO:0060548	81	0.465
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.465
regulation of protein modification process	GO:0031399	112	0.450	Mouse
tissue morphogenesis	GO:0048729	297	0.449	Mouse
digestive tract development	GO:0048565	149	0.448
compound eye development	GO:0048749	307	0.448
response to organic substance	GO:0010033	284	0.446
organophosphate metabolic process	GO:0019637	195	0.445
muscle organ development	GO:0007517	127	0.441
regulation of phosphorus metabolic process	GO:0051174	210	0.429
establishment of localization in cell	GO:0051649	402	0.424	Human
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.417
death	GO:0016265	284	0.417
wing disc morphogenesis	GO:0007472	344	0.414
cellular catabolic process	GO:0044248	372	0.414
regulation of wnt signaling pathway	GO:0030111	68	0.414
catabolic process	GO:0009056	409	0.410
cellular amino acid metabolic process	GO:0006520	61	0.405
carbohydrate derivative metabolic process	GO:1901135	217	0.397
stem cell maintenance	GO:0019827	67	0.392
muscle cell differentiation	GO:0042692	103	0.385	Mouse
response to nutrient levels	GO:0031667	114	0.382
negative regulation of signaling	GO:0023057	219	0.378
negative regulation of growth	GO:0045926	84	0.375
cellular protein localization	GO:0034613	160	0.374
chromosome organization	GO:0051276	360	0.372
glycosyl compound catabolic process	GO:1901658	112	0.371
larval development	GO:0002164	104	0.370
regulation of catabolic process	GO:0009894	170	0.369
imaginal disc derived appendage development	GO:0048737	399	0.369
regulation of cell differentiation	GO:0045595	302	0.368
regulation of cell proliferation	GO:0042127	163	0.367
ribonucleoside catabolic process	GO:0042454	112	0.367
ribonucleotide catabolic process	GO:0009261	109	0.359
organonitrogen compound metabolic process	GO:1901564	318	0.359
nucleoside phosphate catabolic process	GO:1901292	110	0.358
negative regulation of organ growth	GO:0046621	15	0.357
secretion by cell	GO:0032940	101	0.350
nucleoside metabolic process	GO:0009116	127	0.347
wnt signaling pathway	GO:0016055	98	0.334
regulation of cellular component size	GO:0032535	98	0.332
purine ribonucleoside metabolic process	GO:0046128	127	0.318
vesicle mediated transport	GO:0016192	381	0.318
reproductive behavior	GO:0019098	122	0.317
intracellular transport	GO:0046907	228	0.316	Human
cellular response to extracellular stimulus	GO:0031668	64	0.313
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.302
intracellular signal transduction	GO:0035556	300	0.297
lipid localization	GO:0010876	54	0.294
positive regulation of macromolecule metabolic process	GO:0010604	405	0.294
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.291
ribose phosphate metabolic process	GO:0019693	145	0.289
regulation of cell development	GO:0060284	215	0.284
eye photoreceptor cell development	GO:0042462	81	0.284
regulation of cell morphogenesis	GO:0022604	163	0.272
regulation of cell cycle	GO:0051726	291	0.265
response to other organism	GO:0051707	293	0.264
cell proliferation	GO:0008283	299	0.264
cell death	GO:0008219	279	0.261
regulation of phosphate metabolic process	GO:0019220	210	0.260
embryo development ending in birth or egg hatching	GO:0009792	152	0.259	Mouse
gtp catabolic process	GO:0006184	72	0.259
negative regulation of intracellular signal transduction	GO:1902532	57	0.254
stem cell differentiation	GO:0048863	117	0.252
positive regulation of cellular protein metabolic process	GO:0032270	118	0.251
oxoacid metabolic process	GO:0043436	103	0.248
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.244
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.243
regulation of cell death	GO:0010941	173	0.241
regulation of protein transport	GO:0051223	57	0.237
negative regulation of cell differentiation	GO:0045596	143	0.232
morphogenesis of an epithelium	GO:0002009	276	0.229	Mouse
regulation of cellular localization	GO:0060341	136	0.223
golgi to plasma membrane protein transport	GO:0043001	8	0.221
epithelial cell development	GO:0002064	274	0.216
purine containing compound catabolic process	GO:0072523	112	0.216
stem cell development	GO:0048864	79	0.212
positive regulation of cellular biosynthetic process	GO:0031328	316	0.211
negative regulation of developmental growth	GO:0048640	64	0.210
vesicle organization	GO:0016050	44	0.208
aging	GO:0007568	143	0.204
purine ribonucleotide catabolic process	GO:0009154	109	0.202
regulation of growth	GO:0040008	233	0.201
localization of cell	GO:0051674	257	0.198
regulation of organ growth	GO:0046620	42	0.197
multi multicellular organism process	GO:0044706	123	0.196
muscle tissue development	GO:0060537	30	0.192	Mouse
positive regulation of cell differentiation	GO:0045597	64	0.190
cell growth	GO:0016049	108	0.189
maintenance of location	GO:0051235	73	0.187
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.186
phagocytosis	GO:0006909	215	0.181
regulation of cellular protein metabolic process	GO:0032268	243	0.180	Human Mouse
defense response to other organism	GO:0098542	225	0.180
positive regulation of response to stimulus	GO:0048584	323	0.178
positive regulation of signal transduction	GO:0009967	223	0.176
negative regulation of programmed cell death	GO:0043069	72	0.176
positive regulation of signaling	GO:0023056	243	0.176
organonitrogen compound catabolic process	GO:1901565	128	0.174
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.174
multicellular organismal aging	GO:0010259	140	0.173
membrane fusion	GO:0061025	42	0.169
cell cycle phase transition	GO:0044770	140	0.169
negative regulation of mitotic cell cycle	GO:0045930	109	0.168
homeostatic process	GO:0042592	199	0.168
response to organic cyclic compound	GO:0014070	89	0.168
carboxylic acid metabolic process	GO:0019752	92	0.168
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.166
carbohydrate derivative catabolic process	GO:1901136	118	0.163
organic acid metabolic process	GO:0006082	103	0.162
locomotory behavior	GO:0007626	176	0.162
nucleobase containing small molecule metabolic process	GO:0055086	174	0.161
regulation of apoptotic process	GO:0042981	130	0.160
ribonucleotide metabolic process	GO:0009259	145	0.160
cytoplasmic transport	GO:0016482	130	0.158	Human
somatic stem cell maintenance	GO:0035019	14	0.156
heart development	GO:0007507	82	0.154	Mouse
response to biotic stimulus	GO:0009607	294	0.153
regulation of intracellular signal transduction	GO:1902531	236	0.152
lysosomal transport	GO:0007041	13	0.151
regulation of neurogenesis	GO:0050767	158	0.149
phosphorylation	GO:0016310	294	0.147
cellular response to chemical stimulus	GO:0070887	199	0.146
guanosine containing compound metabolic process	GO:1901068	74	0.146
organelle membrane fusion	GO:0090174	16	0.146
cellular amine metabolic process	GO:0044106	12	0.144
response to wounding	GO:0009611	94	0.144
striated muscle tissue development	GO:0014706	27	0.144	Mouse
positive regulation of protein modification process	GO:0031401	58	0.143
photoreceptor cell development	GO:0042461	96	0.143
organic substance catabolic process	GO:1901575	308	0.142
establishment of protein localization	GO:0045184	163	0.141
digestive tract morphogenesis	GO:0048546	127	0.139
regulation of cellular amine metabolic process	GO:0033238	3	0.139
positive regulation of phosphorylation	GO:0042327	87	0.139
regulation of protein localization	GO:0032880	76	0.138
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.136
response to nitrogen compound	GO:1901698	90	0.136
positive regulation of developmental process	GO:0051094	143	0.135
nucleoside triphosphate catabolic process	GO:0009143	108	0.134
purine ribonucleoside catabolic process	GO:0046130	112	0.133
regulation of protein metabolic process	GO:0051246	256	0.132	Human Mouse
cell division	GO:0051301	248	0.128
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.128	Human
adherens junction organization	GO:0034332	27	0.126	Human
regulation of cell cycle process	GO:0010564	181	0.125
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.125
cell migration	GO:0016477	238	0.124
response to starvation	GO:0042594	97	0.124
negative regulation of cell cycle g1 s phase transition	GO:1902807	13	0.123
positive regulation of protein phosphorylation	GO:0001934	34	0.123
branching morphogenesis of an epithelial tube	GO:0048754	45	0.122
regulation of protein kinase activity	GO:0045859	51	0.121	Mouse
hindbrain development	GO:0030902	2	0.121
negative regulation of cell cycle	GO:0045786	116	0.120
regulation of cytoplasmic transport	GO:1903649	47	0.119
skin development	GO:0043588	65	0.119
regulation of secretion	GO:0051046	44	0.118
negative regulation of biosynthetic process	GO:0009890	277	0.118	Human
mitotic cell cycle phase transition	GO:0044772	138	0.118
protein phosphorylation	GO:0006468	169	0.116	Mouse
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.112
rhabdomere development	GO:0042052	38	0.110
anatomical structure homeostasis	GO:0060249	97	0.110
positive regulation of phosphate metabolic process	GO:0045937	139	0.110
brain development	GO:0007420	120	0.109	Mouse
regulation of intracellular protein transport	GO:0033157	46	0.108
ovarian follicle cell development	GO:0030707	248	0.107
defense response to virus	GO:0051607	23	0.106
production of small rna involved in gene silencing by rna	GO:0070918	15	0.106
negative regulation of rna metabolic process	GO:0051253	251	0.106
purine nucleoside metabolic process	GO:0042278	127	0.105
branching involved in open tracheal system development	GO:0060446	45	0.105
endocytosis	GO:0006897	310	0.104
lipid metabolic process	GO:0006629	121	0.103
positive regulation of cellular amine metabolic process	GO:0033240	0	0.103
membrane biogenesis	GO:0044091	8	0.101
lipid storage	GO:0019915	38	0.101
axon guidance	GO:0007411	233	0.100
columnar cuboidal epithelial cell development	GO:0002066	249	0.100
positive regulation of nucleotide metabolic process	GO:0045981	55	0.099
regulation of mapk cascade	GO:0043408	92	0.099
negative regulation of apoptotic process	GO:0043066	63	0.098
transcription from rna polymerase ii promoter	GO:0006366	368	0.098
intracellular protein transport	GO:0006886	104	0.098
cell motility	GO:0048870	251	0.097
canonical wnt signaling pathway	GO:0060070	21	0.097
apoptotic process	GO:0006915	159	0.097
morphogenesis of a branching epithelium	GO:0061138	45	0.096
response to abiotic stimulus	GO:0009628	341	0.096
signal transduction by phosphorylation	GO:0023014	107	0.095
axonogenesis	GO:0007409	290	0.094
regulation of transferase activity	GO:0051338	58	0.094	Mouse
organ growth	GO:0035265	56	0.094
developmental programmed cell death	GO:0010623	138	0.093
cellular macromolecule localization	GO:0070727	220	0.093
establishment of protein localization to membrane	GO:0090150	11	0.092
response to endogenous stimulus	GO:0009719	119	0.092
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.092
macromolecular complex assembly	GO:0065003	256	0.089
striated muscle cell development	GO:0055002	50	0.089
cholesterol homeostasis	GO:0042632	3	0.089
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.089
oxidation reduction process	GO:0055114	123	0.088
regulation of cell division	GO:0051302	72	0.088
positive regulation of neurogenesis	GO:0050769	41	0.088
embryonic morphogenesis	GO:0048598	206	0.087	Mouse
single organism catabolic process	GO:0044712	228	0.085
regulation of organ morphogenesis	GO:2000027	78	0.084
germarium derived female germ line cyst formation	GO:0030727	42	0.083
mitotic nuclear division	GO:0007067	213	0.082
establishment of protein localization to plasma membrane	GO:0090002	9	0.081
positive regulation of transcription dna templated	GO:0045893	266	0.081
regulation of intracellular transport	GO:0032386	64	0.080
cardiocyte differentiation	GO:0035051	29	0.080	Mouse
peptidyl lysine modification	GO:0018205	57	0.080
regulation of protein phosphorylation	GO:0001932	64	0.079	Mouse
nucleoside triphosphate metabolic process	GO:0009141	120	0.079
regulation of epithelial cell differentiation	GO:0030856	4	0.078
negative regulation of glial cell proliferation	GO:0060253	6	0.078
regulation of cellular amino acid metabolic process	GO:0006521	0	0.078
negative regulation of epithelial cell proliferation	GO:0050680	4	0.078
regulation of neuron differentiation	GO:0045664	103	0.077
nucleobase containing compound catabolic process	GO:0034655	165	0.077
cellular response to oxygen containing compound	GO:1901701	79	0.077
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.076
regulation of gtp catabolic process	GO:0033124	44	0.076
ribonucleoside metabolic process	GO:0009119	127	0.074
regulation of developmental growth	GO:0048638	174	0.074
mapk cascade	GO:0000165	107	0.073
multicellular organismal reproductive behavior	GO:0033057	110	0.072
regulation of epithelial cell proliferation	GO:0050678	4	0.072
regulation of canonical wnt signaling pathway	GO:0060828	15	0.072
positive regulation of nucleotide catabolic process	GO:0030813	46	0.071
organophosphate catabolic process	GO:0046434	112	0.071
guanosine containing compound catabolic process	GO:1901069	74	0.070
negative regulation of cell cycle phase transition	GO:1901988	103	0.069
positive regulation of protein metabolic process	GO:0051247	128	0.068
amine metabolic process	GO:0009308	12	0.068
body morphogenesis	GO:0010171	2	0.068
regulation of cell migration	GO:0030334	22	0.067
aromatic compound catabolic process	GO:0019439	166	0.067
single organism membrane fusion	GO:0044801	42	0.067
purine ribonucleotide metabolic process	GO:0009150	145	0.067
male mating behavior	GO:0060179	70	0.066
positive regulation of ras gtpase activity	GO:0032320	36	0.066
chemical homeostasis	GO:0048878	92	0.065
cell cell junction organization	GO:0045216	55	0.065	Human
purine nucleoside catabolic process	GO:0006152	112	0.064
nuclear body organization	GO:0030575	6	0.064
imaginal disc derived wing morphogenesis	GO:0007476	337	0.063
positive regulation of canonical wnt signaling pathway	GO:0090263	7	0.063
positive regulation of catalytic activity	GO:0043085	118	0.063
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.063
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.063
development of primary sexual characteristics	GO:0045137	50	0.062
negative regulation of transcription dna templated	GO:0045892	237	0.062
regulation of immune response	GO:0050776	118	0.062
regulation of molecular function	GO:0065009	217	0.061
cellular lipid metabolic process	GO:0044255	83	0.061
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.060
protein localization to organelle	GO:0033365	82	0.060
positive regulation of proteasomal protein catabolic process	GO:1901800	20	0.060
positive regulation of cell communication	GO:0010647	250	0.060
epidermal cell differentiation	GO:0009913	51	0.059
cell substrate adhesion	GO:0031589	10	0.059	Human
purine nucleotide metabolic process	GO:0006163	146	0.059
sex differentiation	GO:0007548	81	0.059
defense response to gram negative bacterium	GO:0050829	94	0.059
telencephalon development	GO:0021537	2	0.058	Mouse
regulation of cellular ketone metabolic process	GO:0010565	3	0.058
regulation of establishment of protein localization	GO:0070201	61	0.057
cellular response to organonitrogen compound	GO:0071417	36	0.057
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.057
regulation of innate immune response	GO:0045088	71	0.057
mesenchymal cell differentiation	GO:0048762	1	0.056
muscle cell development	GO:0055001	50	0.055
negative regulation of g1 s transition of mitotic cell cycle	GO:2000134	13	0.054
golgi to plasma membrane transport	GO:0006893	8	0.054
autophagy	GO:0006914	108	0.053
cellular nitrogen compound catabolic process	GO:0044270	165	0.053
morphogenesis of a branching structure	GO:0001763	45	0.053
digestive system development	GO:0055123	149	0.052
regulation of cell size	GO:0008361	63	0.052
g1 s transition of mitotic cell cycle	GO:0000082	31	0.052
regulation of gtpase activity	GO:0043087	44	0.052
eye antennal disc development	GO:0035214	60	0.052
reproductive system development	GO:0061458	74	0.051
protein localization to nucleus	GO:0034504	55	0.050
positive regulation of multicellular organismal process	GO:0051240	143	0.050
nucleoside catabolic process	GO:0009164	112	0.050
neuron projection guidance	GO:0097485	241	0.050
regulation of purine nucleotide metabolic process	GO:1900542	62	0.049
response to organonitrogen compound	GO:0010243	75	0.049
epithelial tube morphogenesis	GO:0060562	88	0.049	Mouse
cardioblast differentiation	GO:0010002	20	0.049
larval midgut histolysis	GO:0035069	22	0.049
cell cycle g1 s phase transition	GO:0044843	31	0.048
rhythmic behavior	GO:0007622	76	0.048
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.048	Human
mesenchymal cell development	GO:0014031	1	0.048
regulation of glial cell proliferation	GO:0060251	11	0.047
dormancy process	GO:0022611	2	0.047
myotube differentiation	GO:0014902	46	0.047
positive regulation of nervous system development	GO:0051962	69	0.047
epithelial cell proliferation	GO:0050673	15	0.047
gtp metabolic process	GO:0046039	72	0.047
determination of bilateral symmetry	GO:0009855	13	0.047	Zebrafish
specification of symmetry	GO:0009799	13	0.047	Zebrafish
negative regulation of phosphorus metabolic process	GO:0010563	45	0.047
covalent chromatin modification	GO:0016569	106	0.046
purine nucleotide catabolic process	GO:0006195	109	0.046
endosome to lysosome transport	GO:0008333	7	0.046
cellular response to nitrogen compound	GO:1901699	51	0.046
cardiovascular system development	GO:0072358	82	0.045	Mouse
negative regulation of phosphate metabolic process	GO:0045936	45	0.045
positive regulation of gtpase activity	GO:0043547	43	0.044
single organism behavior	GO:0044708	391	0.044
instar larval development	GO:0002168	55	0.044
positive regulation of transport	GO:0051050	92	0.044
protein catabolic process	GO:0030163	101	0.044
negative regulation of rna biosynthetic process	GO:1902679	240	0.044
organic hydroxy compound metabolic process	GO:1901615	83	0.043
ras protein signal transduction	GO:0007265	88	0.043
gliogenesis	GO:0042063	80	0.043
head development	GO:0060322	135	0.043	Mouse
negative regulation of cellular protein metabolic process	GO:0032269	85	0.043	Human
gland development	GO:0048732	191	0.042
regulation of immune system process	GO:0002682	176	0.042
negative regulation of gene expression	GO:0010629	387	0.042	Human
positive regulation of gtp catabolic process	GO:0033126	43	0.042
muscle organ morphogenesis	GO:0048644	7	0.041
regulation of nucleocytoplasmic transport	GO:0046822	35	0.041
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.041
posttranscriptional regulation of gene expression	GO:0010608	145	0.041	Human
negative regulation of phosphorylation	GO:0042326	35	0.041
positive regulation of programmed cell death	GO:0043068	62	0.041
single organism biosynthetic process	GO:0044711	206	0.040
nuclear import	GO:0051170	51	0.040
rhythmic process	GO:0048511	106	0.040
regulation of tor signaling	GO:0032006	21	0.040
epithelial cell migration	GO:0010631	148	0.040
protein acylation	GO:0043543	42	0.040
regulation of nucleotide catabolic process	GO:0030811	48	0.039
regulation of developmental pigmentation	GO:0048070	24	0.039
apoptotic signaling pathway	GO:0097190	27	0.039
forebrain development	GO:0030900	2	0.039	Mouse
multi organism reproductive behavior	GO:0044705	121	0.039
positive regulation of cell development	GO:0010720	61	0.038
border follicle cell migration	GO:0007298	113	0.038
cellular response to organic substance	GO:0071310	132	0.038
protein complex biogenesis	GO:0070271	201	0.037
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.037
tissue migration	GO:0090130	155	0.037
molting cycle	GO:0042303	56	0.037
organelle fission	GO:0048285	340	0.036
regulation of phosphatase activity	GO:0010921	3	0.036	Human
cellular response to nutrient levels	GO:0031669	62	0.036
positive regulation of catabolic process	GO:0009896	105	0.036
glycosyl compound metabolic process	GO:1901657	127	0.036
negative regulation of kinase activity	GO:0033673	16	0.035
taxis	GO:0042330	304	0.035
organonitrogen compound biosynthetic process	GO:1901566	117	0.035
positive regulation of cellular component organization	GO:0051130	156	0.035	Human
chromatin organization	GO:0006325	207	0.035
negative regulation of nervous system development	GO:0051961	92	0.035
cation transport	GO:0006812	110	0.034	Mouse
positive regulation of cell growth	GO:0030307	19	0.034
r8 cell fate specification	GO:0045464	5	0.034
positive regulation of immune system process	GO:0002684	68	0.033
regulation of secretion by cell	GO:1903530	39	0.033
macromolecule catabolic process	GO:0009057	161	0.032
camera type eye morphogenesis	GO:0048593	2	0.032
protein modification by small protein conjugation or removal	GO:0070647	106	0.032
cellular response to hormone stimulus	GO:0032870	44	0.032
regulation of behavior	GO:0050795	75	0.032
multi organism behavior	GO:0051705	175	0.032
embryonic digestive tract morphogenesis	GO:0048557	4	0.032
imaginal disc growth	GO:0007446	37	0.032
protein import into nucleus	GO:0006606	51	0.031
positive regulation of cellular catabolic process	GO:0031331	95	0.031
protein targeting to nucleus	GO:0044744	51	0.031
autophagic vacuole assembly	GO:0000045	2	0.031
central nervous system development	GO:0007417	201	0.031	Mouse
regulation of cell cycle phase transition	GO:1901987	130	0.030
regulation of protein modification by small protein conjugation or removal	GO:1903320	25	0.030
actin cytoskeleton organization	GO:0030036	206	0.030	Human
positive regulation of biosynthetic process	GO:0009891	316	0.030
tor signaling	GO:0031929	32	0.030
regulation of gliogenesis	GO:0014013	11	0.030
negative regulation of notch signaling pathway	GO:0045746	41	0.030
negative regulation of cellular biosynthetic process	GO:0031327	277	0.029	Human
response to sterol	GO:0036314	34	0.029
defense response to bacterium	GO:0042742	178	0.029
response to bacterium	GO:0009617	198	0.029
positive regulation of molecular function	GO:0044093	136	0.029
convergent extension involved in gastrulation	GO:0060027	2	0.028
regulation of imaginal disc growth	GO:0045570	26	0.028
peptidyl amino acid modification	GO:0018193	105	0.028
myoblast migration	GO:0051451	2	0.028
regulation of nuclear division	GO:0051783	58	0.028
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.028
regulation of stem cell proliferation	GO:0072091	40	0.027
internal peptidyl lysine acetylation	GO:0018393	38	0.027
protein localization to plasma membrane	GO:0072659	13	0.027
regulation of notch signaling pathway	GO:0008593	100	0.027
positive regulation of kinase activity	GO:0033674	25	0.027
compound eye pigmentation	GO:0048072	17	0.027
regulation of mitosis	GO:0007088	56	0.027
regulation of defense response	GO:0031347	102	0.027
positive regulation of immune response	GO:0050778	63	0.026
carbohydrate metabolic process	GO:0005975	82	0.026
rhabdomere membrane biogenesis	GO:0045313	6	0.026
actin filament organization	GO:0007015	126	0.026	Human
ameboidal type cell migration	GO:0001667	151	0.026
histone modification	GO:0016570	106	0.026
negative regulation of cyclin dependent protein serine threonine kinase activity	GO:0045736	1	0.026
convergent extension	GO:0060026	2	0.025
cuticle development	GO:0042335	86	0.025
regulation of cell motility	GO:2000145	23	0.025
negative regulation of insulin receptor signaling pathway	GO:0046627	11	0.025
negative regulation of tor signaling	GO:0032007	5	0.025
regulation of multicellular organism growth	GO:0040014	40	0.025
positive regulation of rna metabolic process	GO:0051254	271	0.025
r8 cell fate commitment	GO:0007460	6	0.025
salivary gland development	GO:0007431	162	0.025
negative regulation of cell cycle process	GO:0010948	109	0.024
regulation of cell cycle g1 s phase transition	GO:1902806	23	0.024
developmental maturation	GO:0021700	172	0.024
embryonic organ development	GO:0048568	50	0.024
compound eye photoreceptor fate commitment	GO:0001752	36	0.024

Tsc1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.137
cancer	DOID:162	0.107
organ system cancer	DOID:0050686	0.107
disease of anatomical entity	DOID:7	0.087

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