IMP: Integrative Multi-species Prediction

Drosophila melanogaster

12 known processes

Irk3 (Dmel_CG10369)

Inwardly rectifying potassium channel 3

(Aliases: Dmel\CG10369,CG10369,dKirIII,irk3)

FLYBASE: FBgn0032706
Entrez: 35131
UniProtKB: B7YZX2
UniProtKB: X2JAW9
UniProtKB: Q9VJ56

Process Predictions
Disease Predictions

Irk3 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
response to mechanical stimulus	GO:0009612	28	0.704	Rat
single organism behavior	GO:0044708	391	0.608	Fly
l amino acid import	GO:0043092	2	0.420	Rat
feeding behavior	GO:0007631	50	0.368
male mating behavior	GO:0060179	70	0.366
sensory perception of salty taste	GO:0050914	3	0.344
mating	GO:0007618	120	0.342
salt aversion	GO:0035199	3	0.334
homeostatic process	GO:0042592	199	0.324	Rat
synaptic transmission	GO:0007268	288	0.320
inter male aggressive behavior	GO:0002121	60	0.300
cellular response to abiotic stimulus	GO:0071214	58	0.287	Rat
response to abiotic stimulus	GO:0009628	341	0.268	Rat
sensory perception	GO:0007600	196	0.244	Rat
locomotory behavior	GO:0007626	176	0.240	Fly
negative regulation of biosynthetic process	GO:0009890	277	0.238
multi multicellular organism process	GO:0044706	123	0.237
response to pain	GO:0048265	3	0.232
detection of mechanical stimulus involved in sensory perception of pain	GO:0050966	2	0.226
cellular response to water stimulus	GO:0071462	2	0.225
aggressive behavior	GO:0002118	63	0.220
negative regulation of cellular biosynthetic process	GO:0031327	277	0.210
cation homeostasis	GO:0055080	51	0.207
ion transmembrane transport	GO:0034220	122	0.199	Human Mouse Rat Fly
mating behavior	GO:0007617	106	0.193
male courtship behavior	GO:0008049	63	0.184
sensory perception of mechanical stimulus	GO:0050954	72	0.179
negative regulation of gene expression	GO:0010629	387	0.170
regulation of synaptic transmission	GO:0050804	69	0.169
multicellular organismal reproductive behavior	GO:0033057	110	0.167
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.164
cation transmembrane transport	GO:0098655	88	0.162	Human Mouse Rat Fly
detection of stimulus involved in sensory perception	GO:0050906	92	0.154
sensory perception of pain	GO:0019233	4	0.153	Rat
regulation of behavior	GO:0050795	75	0.152
chemical homeostasis	GO:0048878	92	0.152	Rat
response to oxygen containing compound	GO:1901700	200	0.151	Human Rat
behavioral response to pain	GO:0048266	3	0.150
cell migration	GO:0016477	238	0.142
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.138
response to pheromone	GO:0019236	19	0.137
negative regulation of insulin secretion	GO:0046676	1	0.134	Human
metal ion homeostasis	GO:0055065	44	0.132
response to organic substance	GO:0010033	284	0.131	Human Rat
regulation of transport	GO:0051049	181	0.131	Human Rat Fly
cellular response to acid chemical	GO:0071229	8	0.126
response to glucose	GO:0009749	2	0.121	Rat
sensory perception of touch	GO:0050975	11	0.120
sensory perception of chemical stimulus	GO:0007606	116	0.119
negative regulation of response to stimulus	GO:0048585	258	0.118	Fly
negative regulation of signaling	GO:0023057	219	0.114	Human Fly
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.114
morphogenesis of an epithelium	GO:0002009	276	0.112
tissue morphogenesis	GO:0048729	297	0.110
negative regulation of cell communication	GO:0010648	223	0.106	Human Fly
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.105
regulation of synapse structure and activity	GO:0050803	128	0.105
monovalent inorganic cation transport	GO:0015672	40	0.104	Human Mouse Rat Fly
negative regulation of cellular metabolic process	GO:0031324	382	0.104
regulation of ion transport	GO:0043269	39	0.103	Human Rat Fly
neurological system process	GO:0050877	358	0.101	Human Rat
inorganic cation transmembrane transport	GO:0098662	61	0.100	Human Mouse Rat Fly
multi organism behavior	GO:0051705	175	0.100
wound healing spreading of epidermal cells	GO:0035313	1	0.098
response to osmotic stress	GO:0006970	14	0.097
water homeostasis	GO:0030104	3	0.097
establishment of localization in cell	GO:0051649	402	0.095	Human
negative regulation of rna biosynthetic process	GO:1902679	240	0.095
larval behavior	GO:0030537	42	0.091
localization of cell	GO:0051674	257	0.089
response to hexose	GO:0009746	3	0.089	Rat
appendage morphogenesis	GO:0035107	397	0.088
inorganic ion transmembrane transport	GO:0098660	73	0.087	Human Mouse Rat Fly
secretion by cell	GO:0032940	101	0.087	Human
courtship behavior	GO:0007619	68	0.086
cellular response to oxygen containing compound	GO:1901701	79	0.085	Rat
response to monosaccharide	GO:0034284	4	0.083	Rat
locomotor rhythm	GO:0045475	56	0.083	Fly
response to organonitrogen compound	GO:0010243	75	0.080	Human Rat
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.080
negative regulation of peptide secretion	GO:0002792	1	0.078	Human
multi organism reproductive behavior	GO:0044705	121	0.077
epiboly	GO:0090504	2	0.077
negative regulation of transcription dna templated	GO:0045892	237	0.076
epithelial cell development	GO:0002064	274	0.076
detection of stimulus	GO:0051606	156	0.074
transmembrane transport	GO:0055085	139	0.074	Human Mouse Rat Fly
vesicle mediated transport	GO:0016192	381	0.073
central nervous system development	GO:0007417	201	0.072
cell motility	GO:0048870	251	0.069
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.069	Fly
negative regulation of peptide hormone secretion	GO:0090278	1	0.069	Human
kidney development	GO:0001822	3	0.065	Rat
regulation of localization	GO:0032879	275	0.065	Human Rat Fly
reproductive behavior	GO:0019098	122	0.065
positive regulation of gene expression	GO:0010628	290	0.065
rhythmic process	GO:0048511	106	0.065	Fly
drinking behavior	GO:0042756	2	0.065
negative regulation of camp metabolic process	GO:0030815	3	0.064
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.064
cellular response to chemical stimulus	GO:0070887	199	0.064	Rat
rhythmic behavior	GO:0007622	76	0.063	Fly
l glutamate import	GO:0051938	1	0.061	Rat
cation transport	GO:0006812	110	0.061	Human Mouse Rat Fly
negative regulation of rna metabolic process	GO:0051253	251	0.060
regionalization	GO:0003002	416	0.059
cellular response to endogenous stimulus	GO:0071495	80	0.058	Rat
regulation of secretion by cell	GO:1903530	39	0.058	Human
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.057
regulation of synaptic activity	GO:0060025	9	0.057
organic substance transport	GO:0071702	257	0.056	Human Rat
positive regulation of macromolecule metabolic process	GO:0010604	405	0.056
cellular response to mechanical stimulus	GO:0071260	2	0.056	Rat
response to acid chemical	GO:0001101	25	0.054
response to wounding	GO:0009611	94	0.052
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.052
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.051
cellular response to external stimulus	GO:0071496	66	0.050	Rat
response to organophosphorus	GO:0046683	2	0.049	Human
secretion	GO:0046903	109	0.049	Human
musculoskeletal movement	GO:0050881	3	0.049	Human
regulation of secretion	GO:0051046	44	0.049	Human
dendrite development	GO:0016358	204	0.048
wound healing	GO:0042060	75	0.047
ion homeostasis	GO:0050801	55	0.046
eye development	GO:0001654	323	0.046
transcription from rna polymerase ii promoter	GO:0006366	368	0.046
positive regulation of transcription dna templated	GO:0045893	266	0.046
wound healing spreading of cells	GO:0044319	2	0.045
multicellular organismal response to stress	GO:0033555	5	0.045
regulation of cellular localization	GO:0060341	136	0.045	Human
cellular response to organic substance	GO:0071310	132	0.044	Rat
positive regulation of biosynthetic process	GO:0009891	316	0.042
compound eye development	GO:0048749	307	0.042
negative regulation of nucleotide biosynthetic process	GO:0030809	3	0.042
immune response regulating signaling pathway	GO:0002764	2	0.042
columnar cuboidal epithelial cell development	GO:0002066	249	0.042
organelle fusion	GO:0048284	46	0.042
cell proliferation	GO:0008283	299	0.041
positive regulation of rna metabolic process	GO:0051254	271	0.041
circadian rhythm	GO:0007623	105	0.041	Fly
positive regulation of cellular biosynthetic process	GO:0031328	316	0.041
heart process	GO:0003015	37	0.041	Human Rat
fluid transport	GO:0042044	19	0.041
sodium ion transport	GO:0006814	22	0.040
appendage development	GO:0048736	401	0.040
circadian behavior	GO:0048512	76	0.040	Fly
response to lipopolysaccharide	GO:0032496	4	0.040
g protein coupled receptor signaling pathway	GO:0007186	136	0.039
adult behavior	GO:0030534	137	0.039
larval locomotory behavior	GO:0008345	27	0.039
intracellular signal transduction	GO:0035556	300	0.038
imaginal disc derived appendage development	GO:0048737	399	0.038
potassium ion transport	GO:0006813	20	0.037	Human Mouse Rat Fly
cellular response to monosaccharide stimulus	GO:0071326	2	0.036	Rat
response to salt stress	GO:0009651	11	0.036
cellular response to organonitrogen compound	GO:0071417	36	0.036	Rat
eye morphogenesis	GO:0048592	260	0.036
regulation of cellular protein metabolic process	GO:0032268	243	0.035
protein phosphorylation	GO:0006468	169	0.035
regulation of peptide secretion	GO:0002791	6	0.035	Human
respiratory system development	GO:0060541	213	0.035
actin filament based movement	GO:0030048	26	0.035	Rat
regulation of protein metabolic process	GO:0051246	256	0.035
positive regulation of ion transmembrane transporter activity	GO:0032414	4	0.034	Rat
regulation of epithelial cell proliferation	GO:0050678	4	0.034
cranial nerve development	GO:0021545	1	0.033	Rat
regulation of metal ion transport	GO:0010959	15	0.033	Rat
regulation of feeding behavior	GO:0060259	16	0.033
taxis	GO:0042330	304	0.033
ion transport	GO:0006811	145	0.033	Human Mouse Rat Fly
positive regulation of response to stimulus	GO:0048584	323	0.033
immune response activating signal transduction	GO:0002757	2	0.033
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.032
mechanosensory behavior	GO:0007638	12	0.032
sensory organ morphogenesis	GO:0090596	260	0.032
response to nitrogen compound	GO:1901698	90	0.032	Human Rat
ovarian follicle cell development	GO:0030707	248	0.032
nitrogen compound transport	GO:0071705	85	0.032	Human Rat
chemosensory behavior	GO:0007635	106	0.032
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.032
amino acid transport	GO:0006865	12	0.031	Rat
embryonic morphogenesis	GO:0048598	206	0.031
positive regulation of rna biosynthetic process	GO:1902680	266	0.031
regulation of multicellular organismal development	GO:2000026	414	0.031
anatomical structure homeostasis	GO:0060249	97	0.031
metal ion transport	GO:0030001	74	0.031	Human Mouse Rat Fly
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.030	Fly
camera type eye morphogenesis	GO:0048593	2	0.030
regulation of phosphate metabolic process	GO:0019220	210	0.030
positive regulation of signal transduction	GO:0009967	223	0.030
actin mediated cell contraction	GO:0070252	21	0.029	Rat
activation of innate immune response	GO:0002218	4	0.029
photoreceptor cell differentiation	GO:0046530	170	0.029
macromolecular complex assembly	GO:0065003	256	0.029	Human Rat
connective tissue development	GO:0061448	3	0.029
response to decreased oxygen levels	GO:0036293	58	0.029
posttranscriptional regulation of gene expression	GO:0010608	145	0.029
camera type eye development	GO:0043010	4	0.029
eye photoreceptor cell differentiation	GO:0001754	145	0.029
negative regulation of signal transduction	GO:0009968	206	0.028	Fly
response to inorganic substance	GO:0010035	44	0.028
regulation of catalytic activity	GO:0050790	185	0.028
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.028
wing disc morphogenesis	GO:0007472	344	0.028
response to endogenous stimulus	GO:0009719	119	0.028	Human Rat
compound eye morphogenesis	GO:0001745	249	0.028
aging	GO:0007568	143	0.028
single organism carbohydrate metabolic process	GO:0044723	72	0.028	Human
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.028
epithelium migration	GO:0090132	148	0.028
response to hypoxia	GO:0001666	53	0.028
gene silencing	GO:0016458	138	0.028
regulation of mitotic cell cycle	GO:0007346	190	0.027
regulation of cell proliferation	GO:0042127	163	0.027
epithelial cell differentiation	GO:0030855	322	0.027
digestive tract development	GO:0048565	149	0.027
death	GO:0016265	284	0.027
cellular response to nitrogen compound	GO:1901699	51	0.026	Rat
endocytosis	GO:0006897	310	0.026
carbohydrate homeostasis	GO:0033500	12	0.026	Rat
negative regulation of purine nucleotide biosynthetic process	GO:1900372	3	0.026
protein complex biogenesis	GO:0070271	201	0.026	Human Rat
protein modification process	GO:0036211	438	0.026
organic substance catabolic process	GO:1901575	308	0.026
cell growth	GO:0016049	108	0.026
membrane organization	GO:0061024	112	0.026
cell death	GO:0008219	279	0.025
regulation of molecular function	GO:0065009	217	0.025	Rat
body morphogenesis	GO:0010171	2	0.025
monovalent inorganic cation homeostasis	GO:0055067	7	0.025
regulation of organ morphogenesis	GO:2000027	78	0.025
small molecule metabolic process	GO:0044281	305	0.025
biological adhesion	GO:0022610	138	0.025
regulation of anatomical structure morphogenesis	GO:0022603	242	0.025
response to radiation	GO:0009314	155	0.025	Rat
regulation of sodium ion transport	GO:0002028	5	0.025
negative regulation of cell differentiation	GO:0045596	143	0.025
stress activated mapk cascade	GO:0051403	52	0.025
regulation of response to stress	GO:0080134	200	0.025
muscle contraction	GO:0006936	13	0.024	Human Rat
forebrain development	GO:0030900	2	0.024
retina development in camera type eye	GO:0060041	4	0.024
chemotaxis	GO:0006935	249	0.024
mitotic nuclear division	GO:0007067	213	0.023
cellular response to hexose stimulus	GO:0071331	1	0.023	Rat
urogenital system development	GO:0001655	72	0.023	Rat
post embryonic appendage morphogenesis	GO:0035120	385	0.023
innate immune response activating signal transduction	GO:0002758	2	0.023
endodermal cell fate commitment	GO:0001711	3	0.023
positive regulation of cell communication	GO:0010647	250	0.023
cell maturation	GO:0048469	144	0.023
developmental pigmentation	GO:0048066	68	0.023
phosphorylation	GO:0016310	294	0.023
chromosome organization	GO:0051276	360	0.022
pattern recognition receptor signaling pathway	GO:0002221	2	0.022
olfactory behavior	GO:0042048	97	0.022
regulation of immune system process	GO:0002682	176	0.022
positive regulation of intracellular signal transduction	GO:1902533	116	0.022
protein localization	GO:0008104	284	0.022
response to ethanol	GO:0045471	59	0.022
regulation of growth	GO:0040008	233	0.022
dendrite morphogenesis	GO:0048813	199	0.022
peptide metabolic process	GO:0006518	80	0.022
imaginal disc derived wing morphogenesis	GO:0007476	337	0.022
cellular protein modification process	GO:0006464	438	0.022
regulation of gene expression epigenetic	GO:0040029	128	0.022
axis specification	GO:0009798	167	0.022
regulation of intracellular signal transduction	GO:1902531	236	0.022
catabolic process	GO:0009056	409	0.022
positive regulation of cell motility	GO:2000147	3	0.022
determination of adult lifespan	GO:0008340	137	0.022
hippo signaling	GO:0035329	20	0.022
cellular amine metabolic process	GO:0044106	12	0.021
regulation of stress activated mapk cascade	GO:0032872	41	0.021
gland development	GO:0048732	191	0.021
positive regulation of signaling	GO:0023056	243	0.021
positive regulation of multicellular organismal process	GO:0051240	143	0.021
cognition	GO:0050890	141	0.021
digestive system development	GO:0055123	149	0.021
jnk cascade	GO:0007254	50	0.021
multicellular organismal movement	GO:0050879	3	0.021	Human
developmental growth	GO:0048589	280	0.021
embryonic axis specification	GO:0000578	107	0.021
cellular amino acid metabolic process	GO:0006520	61	0.021
negative regulation of cyclic nucleotide biosynthetic process	GO:0030803	3	0.021
response to organic cyclic compound	GO:0014070	89	0.021	Human Rat
regulation of cellular ketone metabolic process	GO:0010565	3	0.021
epiboly involved in wound healing	GO:0090505	2	0.021
response to hormone	GO:0009725	45	0.021	Rat
regulation of decapentaplegic signaling pathway	GO:0090097	8	0.021	Fly
segmentation	GO:0035282	207	0.021
organelle localization	GO:0051640	148	0.021
negative regulation of cell cycle	GO:0045786	116	0.020
response to biotic stimulus	GO:0009607	294	0.020
kidney morphogenesis	GO:0060993	3	0.020
establishment of organelle localization	GO:0051656	122	0.020
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.020
cellular ketone metabolic process	GO:0042180	24	0.020
male courtship behavior veined wing generated song production	GO:0045433	20	0.020
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.020
response to ketone	GO:1901654	34	0.020	Rat
organic acid metabolic process	GO:0006082	103	0.020
nucleoside phosphate metabolic process	GO:0006753	162	0.020
brain development	GO:0007420	120	0.020
response to external biotic stimulus	GO:0043207	293	0.020
negative regulation of organelle organization	GO:0010639	56	0.020
positive regulation of cellular catabolic process	GO:0031331	95	0.020
tube development	GO:0035295	244	0.020
cellular response to dna damage stimulus	GO:0006974	223	0.020
protein complex assembly	GO:0006461	200	0.020	Human Rat
mitotic spindle organization	GO:0007052	220	0.019
photoreceptor cell fate commitment	GO:0046552	41	0.019
response to light stimulus	GO:0009416	124	0.019	Rat
cellular response to lipopolysaccharide	GO:0071222	3	0.019
cellular macromolecule localization	GO:0070727	220	0.019
positive regulation of cell migration	GO:0030335	2	0.019
single organism intracellular transport	GO:1902582	207	0.019
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.019
extrinsic apoptotic signaling pathway	GO:0097191	1	0.019
monocarboxylic acid transport	GO:0015718	3	0.019
amine metabolic process	GO:0009308	12	0.019
response to alkaloid	GO:0043279	26	0.019	Rat
negative regulation of cell cycle phase transition	GO:1901988	103	0.019
nuclear division	GO:0000280	332	0.019
regulation of neurogenesis	GO:0050767	158	0.019
regulation of transmembrane transport	GO:0034762	27	0.019	Human Rat Fly
phagocytosis	GO:0006909	215	0.019
outflow tract morphogenesis	GO:0003151	4	0.019
single organism membrane organization	GO:0044802	93	0.019
regulation of cellular amine metabolic process	GO:0033238	3	0.019
response to extracellular stimulus	GO:0009991	116	0.019
nephron tubule development	GO:0072080	3	0.019
response to alcohol	GO:0097305	95	0.018	Rat
defense response	GO:0006952	300	0.018	Rat
regulation of cell cycle phase transition	GO:1901987	130	0.018
gland morphogenesis	GO:0022612	145	0.018
cellular response to molecule of bacterial origin	GO:0071219	3	0.018
ameboidal type cell migration	GO:0001667	151	0.018
epithelial cell migration	GO:0010631	148	0.018
purine nucleotide metabolic process	GO:0006163	146	0.018
retina morphogenesis in camera type eye	GO:0060042	2	0.018
regulation of developmental growth	GO:0048638	174	0.018
regulation of insulin secretion	GO:0050796	5	0.018	Human
mitotic g2 m transition checkpoint	GO:0044818	70	0.018
insulin receptor signaling pathway	GO:0008286	25	0.018
mitotic g2 dna damage checkpoint	GO:0007095	69	0.018
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.018
neuroblast development	GO:0014019	13	0.018
single organism membrane fusion	GO:0044801	42	0.018
mitotic cell cycle phase transition	GO:0044772	138	0.018
mapk cascade	GO:0000165	107	0.018
kidney epithelium development	GO:0072073	3	0.018
eggshell formation	GO:0030703	105	0.018
cellular potassium ion transport	GO:0071804	18	0.018	Human Mouse Rat Fly
regulation of programmed cell death	GO:0043067	152	0.018
limb morphogenesis	GO:0035108	1	0.017
cellular chemical homeostasis	GO:0055082	40	0.017	Rat
cell cycle phase transition	GO:0044770	140	0.017
compound eye photoreceptor cell differentiation	GO:0001751	140	0.017
regulation of phosphorylation	GO:0042325	147	0.017
spermatogenesis	GO:0007283	200	0.017
immune system process	GO:0002376	347	0.017
positive regulation of jun kinase activity	GO:0043507	4	0.017
stress activated protein kinase signaling cascade	GO:0031098	55	0.017
neuroblast differentiation	GO:0014016	29	0.017
muscle system process	GO:0003012	21	0.017	Human Rat
neuron projection guidance	GO:0097485	241	0.017
chaeta development	GO:0022416	97	0.017
regulation of membrane potential	GO:0042391	35	0.017	Human Rat Fly
positive regulation of phosphorylation	GO:0042327	87	0.017
regulation of nervous system development	GO:0051960	248	0.017
embryonic pattern specification	GO:0009880	174	0.017
digestive tract morphogenesis	GO:0048546	127	0.017
regulation of cell death	GO:0010941	173	0.017
regulation of cellular response to stress	GO:0080135	89	0.017
positive regulation of response to external stimulus	GO:0032103	44	0.017
regulation of cell cycle process	GO:0010564	181	0.017
detection of abiotic stimulus	GO:0009582	66	0.017
limb development	GO:0060173	1	0.017
negative regulation of hormone secretion	GO:0046888	1	0.017	Human
intracellular mrna localization involved in pattern specification process	GO:0060810	56	0.017
proteolysis	GO:0006508	192	0.017
regulation of multi organism process	GO:0043900	131	0.017
negative regulation of developmental process	GO:0051093	201	0.017
multicellular organismal aging	GO:0010259	140	0.017
endodermal cell differentiation	GO:0035987	3	0.017
mesenchymal cell differentiation	GO:0048762	1	0.017
dorsal ventral pattern formation	GO:0009953	133	0.017
imaginal disc derived wing vein specification	GO:0007474	48	0.017
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.017
dorsal ventral axis specification	GO:0009950	66	0.016
regulation of hormone levels	GO:0010817	40	0.016	Human
regulation of cellular amino acid metabolic process	GO:0006521	0	0.016
carbohydrate derivative metabolic process	GO:1901135	217	0.016
behavioral response to ethanol	GO:0048149	49	0.016
somatic muscle development	GO:0007525	66	0.016
salivary gland morphogenesis	GO:0007435	145	0.016
blood circulation	GO:0008015	26	0.016	Human Rat
cellular component assembly involved in morphogenesis	GO:0010927	151	0.016
positive regulation of developmental process	GO:0051094	143	0.016
larval development	GO:0002164	104	0.016
cellular homeostasis	GO:0019725	80	0.016	Rat
membrane fusion	GO:0061025	42	0.016
skeletal muscle fiber development	GO:0048741	3	0.016
sensory perception of taste	GO:0050909	25	0.016
regulation of response to external stimulus	GO:0032101	115	0.016
negative regulation of phosphate metabolic process	GO:0045936	45	0.016
nucleobase containing small molecule metabolic process	GO:0055086	174	0.016
regulation of cell differentiation	GO:0045595	302	0.016
organonitrogen compound catabolic process	GO:1901565	128	0.016
erbb signaling pathway	GO:0038127	58	0.016
positive regulation of epithelial cell differentiation	GO:0030858	1	0.016
regulation of lyase activity	GO:0051339	14	0.016
spindle organization	GO:0007051	253	0.016
response to oxygen levels	GO:0070482	59	0.016
developmental programmed cell death	GO:0010623	138	0.016
peptide hormone secretion	GO:0030072	5	0.016	Human
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.016	Fly
programmed cell death	GO:0012501	257	0.016
synaptic vesicle localization	GO:0097479	53	0.016
response to lipid	GO:0033993	38	0.016	Rat
regulation of cell fate commitment	GO:0010453	29	0.015
negative regulation of mitotic cell cycle	GO:0045930	109	0.015
nephron epithelium development	GO:0072009	3	0.015
regulation of epithelial cell differentiation	GO:0030856	4	0.015
regulation of organelle organization	GO:0033043	196	0.015
response to ionizing radiation	GO:0010212	32	0.015
signal transduction by phosphorylation	GO:0023014	107	0.015
positive regulation of transport	GO:0051050	92	0.015	Rat
gene silencing by mirna	GO:0035195	22	0.015
positive regulation of cell death	GO:0010942	69	0.015
hormone catabolic process	GO:0042447	3	0.015
cellular catabolic process	GO:0044248	372	0.015
response to other organism	GO:0051707	293	0.015
smoothened signaling pathway	GO:0007224	49	0.015
detection of mechanical stimulus	GO:0050982	6	0.015
response to insulin	GO:0032868	29	0.015
positive regulation of cellular amine metabolic process	GO:0033240	0	0.015
cell surface receptor signaling pathway involved in heart development	GO:0061311	3	0.015
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.015
regulation of insulin receptor signaling pathway	GO:0046626	17	0.015
cellular response to biotic stimulus	GO:0071216	4	0.015
chromatin modification	GO:0016568	147	0.015
hindbrain development	GO:0030902	2	0.015
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.015
regulation of embryonic development	GO:0045995	68	0.015
chromatin silencing	GO:0006342	76	0.015
developmental maturation	GO:0021700	172	0.015
mitochondrion organization	GO:0007005	65	0.015
nephron development	GO:0072006	3	0.015
myotube cell development	GO:0014904	3	0.015
response to water	GO:0009415	8	0.015
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.015
developmental induction	GO:0031128	3	0.015
nucleoside phosphate catabolic process	GO:1901292	110	0.015
eye photoreceptor cell development	GO:0042462	81	0.015
cellular response to carbohydrate stimulus	GO:0071322	4	0.015	Rat
anterior posterior axis specification embryo	GO:0008595	103	0.015
positive regulation of immune response	GO:0050778	63	0.015
single organism biosynthetic process	GO:0044711	206	0.015
organelle fission	GO:0048285	340	0.014
cellular response to peptide	GO:1901653	28	0.014
spinal cord development	GO:0021510	1	0.014
regulation of cellular component movement	GO:0051270	42	0.014	Human Rat
negative regulation of cell cycle process	GO:0010948	109	0.014
negative regulation of epithelial cell proliferation	GO:0050680	4	0.014
nephron epithelium morphogenesis	GO:0072088	3	0.014
peptide secretion	GO:0002790	7	0.014	Human

Irk3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
kidney disease	DOID:557	0.936	Human
urinary system disease	DOID:18	0.936	Human
disease of anatomical entity	DOID:7	0.936	Human
renal tubular transport disease	DOID:447	0.936	Human
bronchial disease	DOID:1176	0.670
lower respiratory tract disease	DOID:0050161	0.670
respiratory system disease	DOID:1579	0.670
liddle syndrome	DOID:0050477	0.395
glucose metabolism disease	DOID:4194	0.268	Human
carbohydrate metabolism disease	DOID:0050013	0.268	Human
disease of metabolism	DOID:0014667	0.268	Human
acquired metabolic disease	DOID:0060158	0.268	Human
heart conduction disease	DOID:10273	0.264	Human
cardiovascular system disease	DOID:1287	0.264	Human
bronchiectasis	DOID:9563	0.239
diabetes mellitus	DOID:9351	0.111	Human
eye and adnexa disease	DOID:1492	0.064	Human
eye disease	DOID:5614	0.064	Human
sensory system disease	DOID:0050155	0.064	Human
nervous system disease	DOID:863	0.064	Human
type 2 diabetes mellitus	DOID:9352	0.057	Human
bartter disease	DOID:445	0.043	Human
inherited metabolic disorder	DOID:655	0.033	Human
disease of cellular proliferation	DOID:14566	0.027
cancer	DOID:162	0.027
organ system cancer	DOID:0050686	0.016

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