IMP: Integrative Multi-species Prediction

Drosophila melanogaster

175 known processes

tws (Dmel_CG6235)

twins

(Aliases: DPR55,B/PR55,l(3)S049902,l(3)S024838,l(3)S101413b,tw,l(3)S029110,l(3)S023938,l(3)S088513,l(3)S032303,l(3)S061915,l(3)j11C8,l(3)S042630,l(3)S132907,l(3)S023206,2414,l(3)S046918,l(3)S075902b,l(3)S066017,l(3)S060203,v158,l(3)S029701a,Dmel\CG6235,l(3)S066813,l(3)S110815,l(3)S042629,CG6235,l(3)S075110,l(3)S022440,l(3)S063110,l(3)S141309,l(3)S022361,l(3)S027313,l(3)S029403,l(3)s1801,l(3)S043008b,l(3)S023141a,l(3)S048013,l(3)S024834a,l(3)S024455,l(3)S045519,Tws,l(3)S061805,l(3)S076415,l(3)01436,dPR55,l(3)S025913,l(3)S032708c,l(3)S052810,l(3)S119908,l(3)02414,l(3)S048006,l(3)S111515,l(3)S105605,l(3)S053011,l(3)S023013,tws/aar,l(3)S035505b,1466/06,l(3)S080409,l(3)S031006,l(3)S026326,l(3)S067915,l(3)S075515b,aar,PR55,Pp2A-85F,PP2a,l(3)S069206a,l(3)S048507,l(3)S067109b,l(3)S060804,l(3)S027127,l(3)S146606,l(3)S025832,PP2A,l(3)S033903,l(3)S134601a,l(3)S043029,l(3)S028707,dPP2A,l(3)S023309,l(3)S026226,l(3)S110008a,l(3)S025806,l(3)S022205b,l(3)S091905)

Entrez: 47877
FLYBASE: FBgn0004889
UniProtKB: P36872
UniProtKB: C8VV30

Process Predictions
Disease Predictions

tws biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
positive regulation of macromolecule metabolic process	GO:0010604	405	0.989	Yeast
post embryonic appendage morphogenesis	GO:0035120	385	0.981
appendage development	GO:0048736	401	0.976
asymmetric neuroblast division	GO:0055059	33	0.969
transcription from rna polymerase ii promoter	GO:0006366	368	0.965
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.963
imaginal disc derived wing morphogenesis	GO:0007476	337	0.961
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.945
ion transport	GO:0006811	145	0.925
meiotic cell cycle process	GO:1903046	132	0.924
spermatogenesis	GO:0007283	200	0.915	Rat
wing disc morphogenesis	GO:0007472	344	0.908
regulation of phosphate metabolic process	GO:0019220	210	0.901	Rat
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.898
positive regulation of protein metabolic process	GO:0051247	128	0.888
growth	GO:0040007	359	0.887
organelle fission	GO:0048285	340	0.880
cell proliferation	GO:0008283	299	0.874
mitochondrion organization	GO:0007005	65	0.856	Rat
regulation of transport	GO:0051049	181	0.853
meiotic cell cycle	GO:0051321	171	0.849
single organism behavior	GO:0044708	391	0.840
generation of precursor metabolites and energy	GO:0006091	42	0.827
regulation of growth	GO:0040008	233	0.816
organic substance transport	GO:0071702	257	0.808	Rat
spermatid differentiation	GO:0048515	114	0.770	Rat
regulation of catalytic activity	GO:0050790	185	0.763
regulation of protein modification process	GO:0031399	112	0.760
negative regulation of rna biosynthetic process	GO:1902679	240	0.751
eye development	GO:0001654	323	0.748
positive regulation of cellular protein metabolic process	GO:0032270	118	0.746
morphogenesis of an epithelium	GO:0002009	276	0.739	Zebrafish
regulation of molecular function	GO:0065009	217	0.730
imaginal disc derived appendage development	GO:0048737	399	0.715
positive regulation of mitotic cell cycle phase transition	GO:1901992	20	0.699	Yeast
epithelial cell differentiation	GO:0030855	322	0.694
histone modification	GO:0016570	106	0.686
chromatin modification	GO:0016568	147	0.685
intracellular signal transduction	GO:0035556	300	0.684
regulation of cell death	GO:0010941	173	0.684	Rat
programmed cell death	GO:0012501	257	0.682	Rat
protein complex assembly	GO:0006461	200	0.671
negative regulation of developmental process	GO:0051093	201	0.668
regulation of protein metabolic process	GO:0051246	256	0.667
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.664	Yeast
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.663
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.659
neuroblast division	GO:0055057	35	0.653
establishment of localization in cell	GO:0051649	402	0.650	Rat
gliogenesis	GO:0042063	80	0.641
axon guidance	GO:0007411	233	0.629
regulation of cellular protein metabolic process	GO:0032268	243	0.625
neuronal stem cell division	GO:0036445	35	0.619
negative regulation of transcription dna templated	GO:0045892	237	0.618
protein phosphorylation	GO:0006468	169	0.590
intracellular protein transport	GO:0006886	104	0.585	Rat
regulation of cell cycle	GO:0051726	291	0.584
regulation of anatomical structure size	GO:0090066	163	0.577
spermatid development	GO:0007286	98	0.568	Rat
multi organism behavior	GO:0051705	175	0.555	Worm
negative regulation of cell differentiation	GO:0045596	143	0.551
positive regulation of cellular biosynthetic process	GO:0031328	316	0.542	Yeast
protein modification process	GO:0036211	438	0.537	Yeast
stem cell division	GO:0017145	69	0.535
tissue morphogenesis	GO:0048729	297	0.531	Zebrafish
cell cycle phase transition	GO:0044770	140	0.524
oxidation reduction process	GO:0055114	123	0.522
regulation of cell differentiation	GO:0045595	302	0.491
regulation of cell cycle phase transition	GO:1901987	130	0.491
regulation of catabolic process	GO:0009894	170	0.472
cell fate determination	GO:0001709	91	0.467
protein catabolic process	GO:0030163	101	0.463
positive regulation of catabolic process	GO:0009896	105	0.459
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.458
cellular protein modification process	GO:0006464	438	0.458	Yeast
protein transport	GO:0015031	155	0.445	Rat
multicellular organismal aging	GO:0010259	140	0.443
phosphorylation	GO:0016310	294	0.439
developmental growth	GO:0048589	280	0.436
cellular protein localization	GO:0034613	160	0.427	Yeast Rat
actin cytoskeleton organization	GO:0030036	206	0.423
regulation of organelle organization	GO:0033043	196	0.417
cell division	GO:0051301	248	0.417
biological adhesion	GO:0022610	138	0.417
oocyte maturation	GO:0001556	3	0.404
mushroom body development	GO:0016319	70	0.393
aging	GO:0007568	143	0.392
protein localization	GO:0008104	284	0.390	Yeast Rat
nucleoside phosphate metabolic process	GO:0006753	162	0.386
macromolecular complex assembly	GO:0065003	256	0.381
cell death	GO:0008219	279	0.375	Rat
negative regulation of protein modification process	GO:0031400	29	0.362
positive regulation of phosphate metabolic process	GO:0045937	139	0.359
negative regulation of cell death	GO:0060548	81	0.358
positive regulation of protein catabolic process	GO:0045732	34	0.349
organic substance catabolic process	GO:1901575	308	0.339
positive regulation of rna metabolic process	GO:0051254	271	0.337	Yeast
neural precursor cell proliferation	GO:0061351	75	0.326
actin filament based process	GO:0030029	220	0.326
appendage morphogenesis	GO:0035107	397	0.321
regulation of cytoskeleton organization	GO:0051493	89	0.310
regulation of phosphorylation	GO:0042325	147	0.294
chromatin organization	GO:0006325	207	0.289
vesicle mediated transport	GO:0016192	381	0.286
neuroblast proliferation	GO:0007405	74	0.285
negative regulation of cellular metabolic process	GO:0031324	382	0.284	Yeast
embryonic hindgut morphogenesis	GO:0048619	48	0.284
regulation of kinase activity	GO:0043549	53	0.279
negative regulation of biosynthetic process	GO:0009890	277	0.279
cellular macromolecule localization	GO:0070727	220	0.274	Yeast Rat
regionalization	GO:0003002	416	0.274
covalent chromatin modification	GO:0016569	106	0.269
meiotic nuclear division	GO:0007126	151	0.261
chromosome organization	GO:0051276	360	0.257
proteolysis	GO:0006508	192	0.252
urogenital system development	GO:0001655	72	0.251
peripheral nervous system development	GO:0007422	52	0.241
negative regulation of rna metabolic process	GO:0051253	251	0.239
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.237	Yeast
epithelial cell development	GO:0002064	274	0.234
cell maturation	GO:0048469	144	0.231
negative regulation of cell cycle	GO:0045786	116	0.231	Yeast
negative regulation of phosphate metabolic process	GO:0045936	45	0.223
regulation of membrane potential	GO:0042391	35	0.223
centrosome organization	GO:0051297	163	0.223
brain development	GO:0007420	120	0.219	Rat
positive regulation of biosynthetic process	GO:0009891	316	0.218	Yeast
developmental programmed cell death	GO:0010623	138	0.215
regulation of histone deacetylation	GO:0031063	2	0.205
embryo development ending in birth or egg hatching	GO:0009792	152	0.203
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.201
regulation of protein kinase activity	GO:0045859	51	0.200
ion transmembrane transport	GO:0034220	122	0.200
axon development	GO:0061564	297	0.195
negative regulation of cellular protein metabolic process	GO:0032269	85	0.190	Yeast
forebrain development	GO:0030900	2	0.190
protein import into nucleus	GO:0006606	51	0.189
cellular response to dna damage stimulus	GO:0006974	223	0.188
negative regulation of molecular function	GO:0044092	51	0.187
fertilization	GO:0009566	26	0.187
regulation of cell division	GO:0051302	72	0.183
immune system development	GO:0002520	57	0.182
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.180
male gamete generation	GO:0048232	201	0.179	Rat
germarium derived female germ line cyst formation	GO:0030727	42	0.176
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.176
negative regulation of cell cycle process	GO:0010948	109	0.174	Yeast
mating behavior	GO:0007617	106	0.173
learning or memory	GO:0007611	141	0.172
negative regulation of cell proliferation	GO:0008285	69	0.172
negative regulation of signal transduction	GO:0009968	206	0.170
apoptotic process	GO:0006915	159	0.168	Rat
protein localization to nucleus	GO:0034504	55	0.168	Yeast
regulation of epithelial cell proliferation	GO:0050678	4	0.165
protein targeting to nucleus	GO:0044744	51	0.165
positive regulation of cell cycle	GO:0045787	43	0.161	Yeast
meiotic chromosome segregation	GO:0045132	59	0.160
multicellular organismal reproductive behavior	GO:0033057	110	0.160	Worm
cellular response to carbon dioxide	GO:0071244	2	0.159
positive regulation of catalytic activity	GO:0043085	118	0.158
compound eye development	GO:0048749	307	0.157
cell adhesion	GO:0007155	136	0.155
positive regulation of molecular function	GO:0044093	136	0.153
head development	GO:0060322	135	0.152	Rat
establishment or maintenance of polarity of follicular epithelium	GO:0016334	26	0.151
regulation of transferase activity	GO:0051338	58	0.151
positive regulation of mitotic cell cycle	GO:0045931	34	0.147	Yeast
negative regulation of phosphorus metabolic process	GO:0010563	45	0.144
regulation of transmembrane transport	GO:0034762	27	0.141
organelle assembly	GO:0070925	198	0.140
somatic stem cell division	GO:0048103	37	0.138
regulation of anatomical structure morphogenesis	GO:0022603	242	0.138
regulation of stem cell differentiation	GO:2000736	14	0.137
cell migration	GO:0016477	238	0.137
chemical homeostasis	GO:0048878	92	0.137
nuclear division	GO:0000280	332	0.136
positive regulation of proteolysis	GO:0045862	52	0.135
female germ line cyst formation	GO:0048135	42	0.134
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.133
negative regulation of cell development	GO:0010721	62	0.132
secretion	GO:0046903	109	0.129
regulation of phosphorus metabolic process	GO:0051174	210	0.127	Rat
germ line cyst formation	GO:0048134	44	0.124
stem cell maintenance	GO:0019827	67	0.123
stem cell differentiation	GO:0048863	117	0.122
reproductive structure development	GO:0048608	74	0.121
glycosyl compound catabolic process	GO:1901658	112	0.120
positive regulation of cell cycle process	GO:0090068	28	0.118	Yeast
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.116
neuron death	GO:0070997	27	0.114	Rat
positive regulation of protein kinase activity	GO:0045860	25	0.113
energy derivation by oxidation of organic compounds	GO:0015980	32	0.112
endocytosis	GO:0006897	310	0.111
macromolecule catabolic process	GO:0009057	161	0.108
negative regulation of cellular biosynthetic process	GO:0031327	277	0.106
segmentation	GO:0035282	207	0.105
wnt signaling pathway	GO:0016055	98	0.105
lateral inhibition	GO:0046331	206	0.104
metal ion transport	GO:0030001	74	0.104
gland development	GO:0048732	191	0.103
organonitrogen compound metabolic process	GO:1901564	318	0.103
neurological system process	GO:0050877	358	0.100
negative regulation of multicellular organismal process	GO:0051241	142	0.100
small molecule metabolic process	GO:0044281	305	0.100
defense response	GO:0006952	300	0.099
intracellular transport	GO:0046907	228	0.098	Rat
regulation of developmental growth	GO:0048638	174	0.097
glycosyl compound metabolic process	GO:1901657	127	0.096
sensory organ morphogenesis	GO:0090596	260	0.095
positive regulation of programmed cell death	GO:0043068	62	0.093	Rat
cell motility	GO:0048870	251	0.092
positive regulation of transferase activity	GO:0051347	26	0.091
chemosensory behavior	GO:0007635	106	0.090
organ growth	GO:0035265	56	0.090
positive regulation of transcription dna templated	GO:0045893	266	0.088	Yeast
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.088
protein complex biogenesis	GO:0070271	201	0.087
glial cell development	GO:0021782	27	0.087
mitotic cell cycle embryonic	GO:0045448	38	0.087
regulation of mitotic cell cycle	GO:0007346	190	0.086
telencephalon development	GO:0021537	2	0.085
regulation of ion transport	GO:0043269	39	0.085
organelle localization	GO:0051640	148	0.085
positive regulation of phosphorus metabolic process	GO:0010562	139	0.085
vesicle localization	GO:0051648	55	0.084
olfactory behavior	GO:0042048	97	0.084
renal tubule morphogenesis	GO:0061333	44	0.084
spindle organization	GO:0007051	253	0.084	Worm
protein localization to organelle	GO:0033365	82	0.083	Yeast Rat
ubiquitin dependent protein catabolic process	GO:0006511	78	0.083
regulation of chromosome organization	GO:0033044	64	0.082
ion homeostasis	GO:0050801	55	0.080
modification dependent macromolecule catabolic process	GO:0043632	79	0.080
positive regulation of protein phosphorylation	GO:0001934	34	0.080
mitotic cell cycle phase transition	GO:0044772	138	0.080
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.080
hindbrain development	GO:0030902	2	0.080
eye morphogenesis	GO:0048592	260	0.079
positive regulation of rna biosynthetic process	GO:1902680	266	0.079	Yeast
positive regulation of cellular component organization	GO:0051130	156	0.078
membrane organization	GO:0061024	112	0.078
establishment of imaginal disc derived wing hair orientation	GO:0001737	24	0.077
homeostatic process	GO:0042592	199	0.076
dna metabolic process	GO:0006259	227	0.076
hair cell differentiation	GO:0035315	47	0.075
positive regulation of cell cycle g2 m phase transition	GO:1902751	2	0.075	Yeast
nuclear import	GO:0051170	51	0.074
regulation of programmed cell death	GO:0043067	152	0.074	Rat
regulation of localization	GO:0032879	275	0.074	Yeast
regulation of intracellular signal transduction	GO:1902531	236	0.074
protein ubiquitination	GO:0016567	70	0.073
epidermal cell differentiation	GO:0009913	51	0.073
regulation of microtubule cytoskeleton organization	GO:0070507	41	0.073
positive regulation of kinase activity	GO:0033674	25	0.072
compound eye retinal cell programmed cell death	GO:0046667	23	0.072
negative regulation of phosphorylation	GO:0042326	35	0.071
cellular component disassembly	GO:0022411	46	0.071
regulation of compound eye retinal cell programmed cell death	GO:0046669	18	0.070
positive regulation of response to stimulus	GO:0048584	323	0.070
negative regulation of catalytic activity	GO:0043086	42	0.070
response to light stimulus	GO:0009416	124	0.069
imaginal disc pattern formation	GO:0007447	91	0.069
regulation of proteolysis	GO:0030162	87	0.068
cation transmembrane transport	GO:0098655	88	0.067
neuron projection guidance	GO:0097485	241	0.066
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.066
cell type specific apoptotic process	GO:0097285	38	0.066	Rat
nucleobase containing small molecule metabolic process	GO:0055086	174	0.065
regulation of cellular catabolic process	GO:0031329	157	0.063
cellular macromolecule catabolic process	GO:0044265	136	0.062
positive regulation of growth	GO:0045927	75	0.062
phagocytosis	GO:0006909	215	0.062
positive regulation of cellular catabolic process	GO:0031331	95	0.061
digestive system development	GO:0055123	149	0.061
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.061	Yeast
muscle cell development	GO:0055001	50	0.061
positive regulation of developmental process	GO:0051094	143	0.060	Worm
juvenile hormone mediated signaling pathway	GO:0035626	3	0.060
embryonic development via the syncytial blastoderm	GO:0001700	148	0.060
circadian regulation of gene expression	GO:0032922	5	0.060
camera type eye development	GO:0043010	4	0.060
cellular response to organic substance	GO:0071310	132	0.059
cellular response to abiotic stimulus	GO:0071214	58	0.059
regulation of protein serine threonine kinase activity	GO:0071900	25	0.059
regulation of protein deacetylation	GO:0090311	2	0.059
circulatory system development	GO:0072359	82	0.059	Zebrafish
positive regulation of signaling	GO:0023056	243	0.058
skin development	GO:0043588	65	0.058
regulation of establishment of protein localization	GO:0070201	61	0.058
secretion by cell	GO:0032940	101	0.057
axonogenesis	GO:0007409	290	0.057
carbohydrate derivative metabolic process	GO:1901135	217	0.056
regulation of pathway restricted smad protein phosphorylation	GO:0060393	1	0.056
organophosphate metabolic process	GO:0019637	195	0.056
dendrite development	GO:0016358	204	0.055
organonitrogen compound catabolic process	GO:1901565	128	0.055
regulation of hydrolase activity	GO:0051336	97	0.055	Rat
regulation of apoptotic process	GO:0042981	130	0.055	Rat
myotube cell development	GO:0014904	3	0.054
sensory perception	GO:0007600	196	0.054
positive regulation of signal transduction	GO:0009967	223	0.053
chromatin mediated maintenance of transcription	GO:0048096	7	0.053
cellular catabolic process	GO:0044248	372	0.053
negative regulation of programmed cell death	GO:0043069	72	0.052
hematopoietic or lymphoid organ development	GO:0048534	57	0.052
negative regulation of protein phosphorylation	GO:0001933	17	0.051
axon ensheathment	GO:0008366	10	0.050
dna repair	GO:0006281	54	0.050
negative regulation of cell cycle phase transition	GO:1901988	103	0.050	Yeast
maintenance of protein location	GO:0045185	28	0.049
stem cell proliferation	GO:0072089	88	0.049
response to abiotic stimulus	GO:0009628	341	0.049
larval development	GO:0002164	104	0.049	Worm
compound eye photoreceptor cell differentiation	GO:0001751	140	0.048
muscle fiber development	GO:0048747	12	0.048
protein modification by small protein conjugation or removal	GO:0070647	106	0.048
establishment or maintenance of cell polarity	GO:0007163	167	0.048
mesenchymal cell development	GO:0014031	1	0.048
regulation of neurogenesis	GO:0050767	158	0.047
regulation of microtubule based process	GO:0032886	49	0.046
response to nutrient levels	GO:0031667	114	0.046
muscle structure development	GO:0061061	224	0.045
chemotaxis	GO:0006935	249	0.045
taxis	GO:0042330	304	0.045
regulation of protein catabolic process	GO:0042176	55	0.044
response to endogenous stimulus	GO:0009719	119	0.044
gonad development	GO:0008406	50	0.044
blood circulation	GO:0008015	26	0.044
regulation of neuronal synaptic plasticity	GO:0048168	8	0.044
eye photoreceptor cell differentiation	GO:0001754	145	0.044
positive regulation of protein modification process	GO:0031401	58	0.043
multicellular organismal signaling	GO:0035637	12	0.043
cellular protein complex assembly	GO:0043623	71	0.043
positive regulation of cell death	GO:0010942	69	0.042	Rat
circulatory system process	GO:0003013	37	0.042
cell junction organization	GO:0034330	57	0.042
centriole replication	GO:0007099	24	0.041
cellular response to organic cyclic compound	GO:0071407	32	0.041
positive regulation of organelle organization	GO:0010638	65	0.041
positive regulation of protein polymerization	GO:0032273	14	0.040
mesenchymal cell differentiation	GO:0048762	1	0.040
determination of adult lifespan	GO:0008340	137	0.040
circadian rhythm	GO:0007623	105	0.039
spindle assembly	GO:0051225	80	0.039
asymmetric protein localization involved in cell fate determination	GO:0045167	9	0.038
positive regulation of hydrolase activity	GO:0051345	78	0.038
immune system process	GO:0002376	347	0.038
positive regulation of protein complex assembly	GO:0031334	22	0.038
single organism nuclear import	GO:1902593	51	0.038
ribose phosphate metabolic process	GO:0019693	145	0.038
regulation of cellular localization	GO:0060341	136	0.038	Yeast
regulation of cellular component size	GO:0032535	98	0.038
cell cell junction organization	GO:0045216	55	0.037
negative regulation of response to stimulus	GO:0048585	258	0.037
stress activated mapk cascade	GO:0051403	52	0.037
asymmetric cell division	GO:0008356	37	0.037
organic acid metabolic process	GO:0006082	103	0.037
compound eye morphogenesis	GO:0001745	249	0.036
response to organic cyclic compound	GO:0014070	89	0.036
regulation of cell growth	GO:0001558	43	0.036
negative regulation of gene expression	GO:0010629	387	0.036	Yeast
synaptic growth at neuromuscular junction	GO:0051124	119	0.035
signal transduction by phosphorylation	GO:0023014	107	0.035
single organism cellular localization	GO:1902580	180	0.035	Rat
protein polymerization	GO:0051258	42	0.035
regulation of meiosis	GO:0040020	3	0.034
protein complex disassembly	GO:0043241	36	0.034
regulation of protein complex assembly	GO:0043254	42	0.034
negative regulation of signaling	GO:0023057	219	0.034
notch signaling pathway	GO:0007219	120	0.033
imaginal disc derived wing hair organization	GO:0035317	45	0.033
bmp signaling pathway involved in malpighian tubule cell chemotaxis	GO:0061353	3	0.033
posttranscriptional regulation of gene expression	GO:0010608	145	0.032
stem cell fate commitment	GO:0048865	25	0.032
positive regulation of cell motility	GO:2000147	3	0.032
organonitrogen compound biosynthetic process	GO:1901566	117	0.032
regulation of protein localization to plasma membrane	GO:1903076	7	0.032
negative regulation of neuroblast proliferation	GO:0007406	27	0.032
establishment of protein localization	GO:0045184	163	0.032	Rat
germarium derived egg chamber formation	GO:0007293	101	0.032
muscle cell fate commitment	GO:0042693	14	0.031
regulation of cell development	GO:0060284	215	0.031
response to hormone	GO:0009725	45	0.031
salivary gland morphogenesis	GO:0007435	145	0.031
actomyosin structure organization	GO:0031032	56	0.031
positive regulation of cell migration	GO:0030335	2	0.031
protein import	GO:0017038	55	0.031
regulation of purine nucleotide metabolic process	GO:1900542	62	0.031
nucleotide catabolic process	GO:0009166	109	0.030
regulation of neural precursor cell proliferation	GO:2000177	35	0.030
establishment of spindle localization	GO:0051293	22	0.030
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.030
cell fate commitment involved in pattern specification	GO:0060581	31	0.030
negative regulation of notch signaling pathway	GO:0045746	41	0.030
regulation of protein transport	GO:0051223	57	0.030
regulation of cellular amino acid metabolic process	GO:0006521	0	0.029
nuclear transport	GO:0051169	72	0.029
adult locomotory behavior	GO:0008344	76	0.029
endomembrane system organization	GO:0010256	119	0.029
hemopoiesis	GO:0030097	46	0.029
central nervous system development	GO:0007417	201	0.029	Rat
negative regulation of protein metabolic process	GO:0051248	85	0.028	Yeast
ribonucleotide catabolic process	GO:0009261	109	0.028
cell proliferation involved in imaginal disc derived wing morphogenesis	GO:0090255	2	0.028
negative regulation of kinase activity	GO:0033673	16	0.028
response to extracellular stimulus	GO:0009991	116	0.028
metal ion homeostasis	GO:0055065	44	0.028
regulation of immune system process	GO:0002682	176	0.028
response to alkaloid	GO:0043279	26	0.028
ras protein signal transduction	GO:0007265	88	0.027
regulation of cyclin dependent protein serine threonine kinase activity	GO:0000079	3	0.027
mapk cascade	GO:0000165	107	0.027
cell recognition	GO:0008037	102	0.027
locomotory behavior	GO:0007626	176	0.027
organic cyclic compound catabolic process	GO:1901361	168	0.027
inter male aggressive behavior	GO:0002121	60	0.027
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.027	Yeast
response to carbon dioxide	GO:0010037	4	0.026
ribonucleotide metabolic process	GO:0009259	145	0.026
cellular response to chemical stimulus	GO:0070887	199	0.026
retinal cell programmed cell death	GO:0046666	25	0.025
centrosome cycle	GO:0007098	137	0.025
gland morphogenesis	GO:0022612	145	0.025
centrosome duplication	GO:0051298	121	0.025
regulation of protein phosphorylation	GO:0001932	64	0.025
purine ribonucleotide metabolic process	GO:0009150	145	0.025
neuron recognition	GO:0008038	101	0.025
regulation of proteasomal protein catabolic process	GO:0061136	39	0.025
regulation of protein localization to nucleus	GO:1900180	29	0.024	Yeast
positive regulation of stem cell differentiation	GO:2000738	3	0.024
establishment of organelle localization	GO:0051656	122	0.024
nucleotide metabolic process	GO:0009117	161	0.024
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.024
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.024
purine nucleotide metabolic process	GO:0006163	146	0.024
establishment of protein localization to organelle	GO:0072594	62	0.024	Rat
skeletal muscle fiber development	GO:0048741	3	0.023
cellular response to nitrogen compound	GO:1901699	51	0.023
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.023	Yeast
neuron maturation	GO:0042551	31	0.023
midgut development	GO:0007494	23	0.023
positive regulation of cell cycle phase transition	GO:1901989	20	0.023	Yeast
regulation of intracellular protein transport	GO:0033157	46	0.023
positive regulation of phosphorylation	GO:0042327	87	0.023
negative regulation of transferase activity	GO:0051348	18	0.023
regulation of protein localization	GO:0032880	76	0.023	Yeast
positive regulation of cellular protein catabolic process	GO:1903364	24	0.023
tube development	GO:0035295	244	0.023	Zebrafish
ribonucleoside metabolic process	GO:0009119	127	0.022
purine ribonucleoside metabolic process	GO:0046128	127	0.022
cell elongation involved in imaginal disc derived wing morphogenesis	GO:0090254	5	0.022
mitotic cell cycle checkpoint	GO:0007093	88	0.022	Yeast
protein dephosphorylation	GO:0006470	27	0.022	Yeast
negative regulation of epithelial cell proliferation	GO:0050680	4	0.021
actin filament based movement	GO:0030048	26	0.021
nucleus localization	GO:0051647	34	0.021
epithelial cell migration	GO:0010631	148	0.021
body morphogenesis	GO:0010171	2	0.021
synaptic vesicle localization	GO:0097479	53	0.021
regulation of cellular component movement	GO:0051270	42	0.021
positive regulation of nucleotide metabolic process	GO:0045981	55	0.021
negative regulation of growth	GO:0045926	84	0.021
positive regulation of multicellular organismal process	GO:0051240	143	0.021	Worm
digestive tract development	GO:0048565	149	0.021
regulation of histone modification	GO:0031056	20	0.021
regulation of mitosis	GO:0007088	56	0.021
response to oxygen containing compound	GO:1901700	200	0.020
stem cell development	GO:0048864	79	0.020
centrosome separation	GO:0051299	20	0.020
positive regulation of intracellular protein transport	GO:0090316	30	0.020
ensheathment of neurons	GO:0007272	10	0.020
positive regulation of protein transport	GO:0051222	37	0.020
flight behavior	GO:0007629	26	0.020
single organism catabolic process	GO:0044712	228	0.020
cellular nitrogen compound catabolic process	GO:0044270	165	0.020
salivary gland development	GO:0007431	162	0.020
nephron epithelium development	GO:0072009	3	0.020
regulation of vesicle mediated transport	GO:0060627	59	0.019
regulation of nuclear division	GO:0051783	58	0.019
lipid homeostasis	GO:0055088	33	0.019
microtubule bundle formation	GO:0001578	27	0.019
purine containing compound metabolic process	GO:0072521	155	0.019
nephron tubule morphogenesis	GO:0072078	3	0.019
synapse organization	GO:0050808	196	0.019
regulation of glial cell proliferation	GO:0060251	11	0.019
regulation of heart contraction	GO:0008016	21	0.019
chitin based cuticle development	GO:0040003	49	0.019
mitochondrion distribution	GO:0048311	10	0.019
carboxylic acid metabolic process	GO:0019752	92	0.019
nf kappab import into nucleus	GO:0042348	1	0.018
non sensory hair organization	GO:0035316	47	0.018
germ line stem cell maintenance	GO:0030718	50	0.018
purine nucleotide catabolic process	GO:0006195	109	0.018
salivary gland cell autophagic cell death	GO:0035071	83	0.018
muscle cell differentiation	GO:0042692	103	0.018
multi organism reproductive behavior	GO:0044705	121	0.018	Worm
neuronal ion channel clustering	GO:0045161	2	0.018
membrane disassembly	GO:0030397	4	0.018

tws disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of metabolism	DOID:0014667	0	0.032

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