IMP: Integrative Multi-species Prediction

Drosophila melanogaster

29 known processes

ref(2)P (Dmel_CG10360)

refractory to sigma P

(Aliases: Dmel\CG10360,ref(2)p,CG10360,ref(2)Pn,Ref(2)P,ref2p,ref(2)Po2,Ref2P,ref,Ref(2)p)

Entrez: 35246
FLYBASE: FBgn0003231
UniProtKB: P14199

Process Predictions
Disease Predictions

ref(2)P biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
mitochondrion morphogenesis	GO:0070584	8	0.935
mitochondrion organization	GO:0007005	65	0.783
spermatid development	GO:0007286	98	0.384
acylglycerol biosynthetic process	GO:0046463	2	0.369
response to starvation	GO:0042594	97	0.350
intracellular signal transduction	GO:0035556	300	0.312
cellular protein modification process	GO:0006464	438	0.312
positive regulation of mitochondrion organization	GO:0010822	8	0.263
mitochondrial fission	GO:0000266	8	0.259
regulation of organelle organization	GO:0033043	196	0.258
synaptic transmission	GO:0007268	288	0.215
localization of cell	GO:0051674	257	0.209
regulation of catabolic process	GO:0009894	170	0.208
post embryonic appendage morphogenesis	GO:0035120	385	0.193
regulation of mitochondrial fission	GO:0090140	7	0.175
negative regulation of response to stimulus	GO:0048585	258	0.169
negative regulation of programmed cell death	GO:0043069	72	0.166
apoptotic process	GO:0006915	159	0.166
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.161
appendage development	GO:0048736	401	0.154
positive regulation of lipid metabolic process	GO:0045834	4	0.154
protein modification process	GO:0036211	438	0.149
cell death	GO:0008219	279	0.148
regulation of cell death	GO:0010941	173	0.147
phosphorylation	GO:0016310	294	0.132
regulation of apoptotic process	GO:0042981	130	0.123
death	GO:0016265	284	0.120
regulation of multicellular organismal development	GO:2000026	414	0.108
regulation of programmed cell death	GO:0043067	152	0.107
imaginal disc derived appendage development	GO:0048737	399	0.106
negative regulation of cell death	GO:0060548	81	0.103
response to nutrient levels	GO:0031667	114	0.098
regulation of nervous system development	GO:0051960	248	0.095
small molecule metabolic process	GO:0044281	305	0.094
autophagy	GO:0006914	108	0.093
aging	GO:0007568	143	0.092
positive regulation of gene expression	GO:0010628	290	0.091
intracellular transport	GO:0046907	228	0.091
nuclear division	GO:0000280	332	0.090
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.089
programmed cell death	GO:0012501	257	0.088
negative regulation of apoptotic process	GO:0043066	63	0.086
organelle fission	GO:0048285	340	0.085
spermatogenesis	GO:0007283	200	0.084
single organism membrane fusion	GO:0044801	42	0.079
neurological system process	GO:0050877	358	0.079
organelle fusion	GO:0048284	46	0.078
ubiquitin dependent protein catabolic process	GO:0006511	78	0.075
single organism biosynthetic process	GO:0044711	206	0.072
microtubule polymerization or depolymerization	GO:0031109	39	0.071
developmental maturation	GO:0021700	172	0.071
cellular response to chemical stimulus	GO:0070887	199	0.067
oxoacid metabolic process	GO:0043436	103	0.067
cellular response to oxidative stress	GO:0034599	28	0.063
cytokinesis	GO:0000910	90	0.063
tissue migration	GO:0090130	155	0.062
regulation of protein phosphorylation	GO:0001932	64	0.062
regulation of protein complex disassembly	GO:0043244	29	0.061
negative regulation of cellular metabolic process	GO:0031324	382	0.061
organic substance transport	GO:0071702	257	0.059
positive regulation of organelle organization	GO:0010638	65	0.059
negative regulation of growth	GO:0045926	84	0.059
negative regulation of cellular component organization	GO:0051129	108	0.059
regulation of cellular amine metabolic process	GO:0033238	3	0.057
regulation of mitochondrion organization	GO:0010821	12	0.056
ribonucleoside monophosphate catabolic process	GO:0009158	39	0.055
protein transport	GO:0015031	155	0.054
lipid homeostasis	GO:0055088	33	0.054
regulation of cellular component biogenesis	GO:0044087	201	0.053
cell motility	GO:0048870	251	0.051
single organism behavior	GO:0044708	391	0.050
spermatid differentiation	GO:0048515	114	0.050
positive regulation of developmental process	GO:0051094	143	0.050
response to oxidative stress	GO:0006979	86	0.050
regulation of mitochondrial fusion	GO:0010635	5	0.049
triglyceride biosynthetic process	GO:0019432	2	0.049
actin filament organization	GO:0007015	126	0.048
metal ion transport	GO:0030001	74	0.047
positive regulation of signaling	GO:0023056	243	0.046
nucleotide metabolic process	GO:0009117	161	0.046
negative regulation of signal transduction	GO:0009968	206	0.045
cytoskeleton dependent cytokinesis	GO:0061640	81	0.045
regulation of cellular ketone metabolic process	GO:0010565	3	0.045
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.044
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.044
developmental growth	GO:0048589	280	0.044
organonitrogen compound metabolic process	GO:1901564	318	0.044
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.044
actin filament based process	GO:0030029	220	0.043
single organism cellular localization	GO:1902580	180	0.043
multicellular organismal aging	GO:0010259	140	0.042
establishment of localization in cell	GO:0051649	402	0.042
metal ion homeostasis	GO:0055065	44	0.042
positive regulation of rna biosynthetic process	GO:1902680	266	0.042
regulation of transport	GO:0051049	181	0.042
purine nucleotide catabolic process	GO:0006195	109	0.042
ion transmembrane transport	GO:0034220	122	0.042
negative regulation of signaling	GO:0023057	219	0.041
cell migration	GO:0016477	238	0.041
regulation of intracellular signal transduction	GO:1902531	236	0.041
forebrain development	GO:0030900	2	0.039
regulation of molecular function	GO:0065009	217	0.039
negative regulation of cytoskeleton organization	GO:0051494	30	0.039
positive regulation of macromolecule metabolic process	GO:0010604	405	0.039
regulation of protein metabolic process	GO:0051246	256	0.038
cellular catabolic process	GO:0044248	372	0.038
nucleoside monophosphate metabolic process	GO:0009123	52	0.038
mitochondrion distribution	GO:0048311	10	0.037
homeostatic process	GO:0042592	199	0.037
cytoplasmic transport	GO:0016482	130	0.037
response to inorganic substance	GO:0010035	44	0.037
cellular ketone metabolic process	GO:0042180	24	0.036
membrane organization	GO:0061024	112	0.036
regulation of cellular localization	GO:0060341	136	0.035
larval development	GO:0002164	104	0.035
telencephalon development	GO:0021537	2	0.035
er associated ubiquitin dependent protein catabolic process	GO:0030433	3	0.035
protein complex assembly	GO:0006461	200	0.034
tissue morphogenesis	GO:0048729	297	0.034
morphogenesis of an epithelium	GO:0002009	276	0.034
positive regulation of cellular biosynthetic process	GO:0031328	316	0.034
response to extracellular stimulus	GO:0009991	116	0.034
growth	GO:0040007	359	0.034
regulation of phosphorylation	GO:0042325	147	0.033
ion homeostasis	GO:0050801	55	0.033
regulation of mitotic cell cycle	GO:0007346	190	0.032
proteolysis	GO:0006508	192	0.032
imaginal disc derived wing morphogenesis	GO:0007476	337	0.032
muscle structure development	GO:0061061	224	0.032
chemical homeostasis	GO:0048878	92	0.032
protein complex disassembly	GO:0043241	36	0.031
positive regulation of cellular component organization	GO:0051130	156	0.031
regulation of cellular amino acid metabolic process	GO:0006521	0	0.031
regulation of protein modification process	GO:0031399	112	0.030
endoplasmic reticulum organization	GO:0007029	13	0.030
stress activated protein kinase signaling cascade	GO:0031098	55	0.030
catabolic process	GO:0009056	409	0.030
regulation of response to oxidative stress	GO:1902882	4	0.030
protein localization	GO:0008104	284	0.029
positive regulation of signal transduction	GO:0009967	223	0.028
response to alcohol	GO:0097305	95	0.028
single organism intracellular transport	GO:1902582	207	0.028
regulation of protein depolymerization	GO:1901879	27	0.028
regulation of localization	GO:0032879	275	0.028
non sensory hair organization	GO:0035316	47	0.027
negative regulation of intracellular signal transduction	GO:1902532	57	0.027
regulation of intracellular transport	GO:0032386	64	0.027
positive regulation of response to stimulus	GO:0048584	323	0.027
male gamete generation	GO:0048232	201	0.026
response to metal ion	GO:0010038	23	0.026
cell division	GO:0051301	248	0.026
cell proliferation	GO:0008283	299	0.026
nucleobase containing small molecule metabolic process	GO:0055086	174	0.026
organelle assembly	GO:0070925	198	0.026
macromolecular complex assembly	GO:0065003	256	0.026
epithelial cell migration	GO:0010631	148	0.025
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.025
mitochondrial fusion	GO:0008053	7	0.025
positive regulation of cellular catabolic process	GO:0031331	95	0.025
neutral lipid biosynthetic process	GO:0046460	2	0.025
protein modification by small protein conjugation or removal	GO:0070647	106	0.024
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.024
meiotic cell cycle	GO:0051321	171	0.024
organelle localization	GO:0051640	148	0.024
atp metabolic process	GO:0046034	49	0.024
response to oxygen containing compound	GO:1901700	200	0.024
neuron projection guidance	GO:0097485	241	0.024
positive regulation of cellular component biogenesis	GO:0044089	80	0.023
regulation of proteolysis	GO:0030162	87	0.023
ribose phosphate metabolic process	GO:0019693	145	0.023
cellular protein localization	GO:0034613	160	0.023
adult locomotory behavior	GO:0008344	76	0.023
regionalization	GO:0003002	416	0.022
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.022
purine nucleoside metabolic process	GO:0042278	127	0.022
negative regulation of organelle organization	GO:0010639	56	0.022
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.022
actin cytoskeleton organization	GO:0030036	206	0.022
regulation of cell proliferation	GO:0042127	163	0.022
modification dependent macromolecule catabolic process	GO:0043632	79	0.022
carboxylic acid metabolic process	GO:0019752	92	0.021
nuclear transport	GO:0051169	72	0.021
regulation of transferase activity	GO:0051338	58	0.021
meiotic cytokinesis	GO:0033206	33	0.021
sperm mitochondrion organization	GO:0030382	7	0.021
response to biotic stimulus	GO:0009607	294	0.021
nucleoside triphosphate catabolic process	GO:0009143	108	0.021
positive regulation of transcription dna templated	GO:0045893	266	0.021
response to abiotic stimulus	GO:0009628	341	0.021
negative regulation of rna biosynthetic process	GO:1902679	240	0.021
epithelium migration	GO:0090132	148	0.020
mitochondrion degradation	GO:0000422	8	0.020
ribonucleotide metabolic process	GO:0009259	145	0.020
organic acid metabolic process	GO:0006082	103	0.020
biological adhesion	GO:0022610	138	0.020
cell growth	GO:0016049	108	0.020
regulation of cellular catabolic process	GO:0031329	157	0.020
maintenance of location	GO:0051235	73	0.020
regulation of cell cycle	GO:0051726	291	0.020
regulation of steroid metabolic process	GO:0019218	2	0.020
axon guidance	GO:0007411	233	0.020
cellular divalent inorganic cation homeostasis	GO:0072503	23	0.020
cellular nitrogen compound catabolic process	GO:0044270	165	0.019
taxis	GO:0042330	304	0.019
protein catabolic process	GO:0030163	101	0.019
negative regulation of phosphatase activity	GO:0010923	3	0.019
positive regulation of phosphate metabolic process	GO:0045937	139	0.019
cellular response to dna damage stimulus	GO:0006974	223	0.019
secretion	GO:0046903	109	0.019
negative regulation of mitotic cell cycle	GO:0045930	109	0.019
cellular protein complex assembly	GO:0043623	71	0.018
positive regulation of cell differentiation	GO:0045597	64	0.018
peptidyl amino acid modification	GO:0018193	105	0.018
positive regulation of growth	GO:0045927	75	0.018
regulation of microtubule polymerization or depolymerization	GO:0031110	27	0.018
carbohydrate derivative metabolic process	GO:1901135	217	0.018
purine ribonucleoside metabolic process	GO:0046128	127	0.018
cellular amino acid metabolic process	GO:0006520	61	0.018
wing disc morphogenesis	GO:0007472	344	0.018
glycosyl compound catabolic process	GO:1901658	112	0.017
cellular macromolecule localization	GO:0070727	220	0.017
regulation of microtubule cytoskeleton organization	GO:0070507	41	0.017
positive regulation of programmed cell death	GO:0043068	62	0.017
protein modification by small protein removal	GO:0070646	28	0.017
protein complex biogenesis	GO:0070271	201	0.017
g2 dna damage checkpoint	GO:0031572	69	0.017
organic substance catabolic process	GO:1901575	308	0.017
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.017
tube morphogenesis	GO:0035239	191	0.017
connective tissue development	GO:0061448	3	0.017
lipid biosynthetic process	GO:0008610	46	0.016
dna metabolic process	GO:0006259	227	0.016
positive regulation of biosynthetic process	GO:0009891	316	0.016
positive regulation of cellular protein metabolic process	GO:0032270	118	0.016
lipid modification	GO:0030258	24	0.016
positive regulation of phosphorus metabolic process	GO:0010562	139	0.016
negative regulation of protein depolymerization	GO:1901880	23	0.016
ion transport	GO:0006811	145	0.016
transcription from rna polymerase ii promoter	GO:0006366	368	0.016
actin filament based movement	GO:0030048	26	0.016
cytokinetic process	GO:0032506	27	0.016
inorganic cation transmembrane transport	GO:0098662	61	0.015
protein k48 linked ubiquitination	GO:0070936	3	0.015
macroautophagy	GO:0016236	42	0.015
regulation of cell cycle process	GO:0010564	181	0.015
cellular response to oxygen levels	GO:0071453	30	0.015
adult behavior	GO:0030534	137	0.015
regulation of anatomical structure size	GO:0090066	163	0.015
cellular amine metabolic process	GO:0044106	12	0.015
positive regulation of rna metabolic process	GO:0051254	271	0.015
regulation of chromosome organization	GO:0033044	64	0.015
gliogenesis	GO:0042063	80	0.015
response to virus	GO:0009615	28	0.015
regulation of phosphorus metabolic process	GO:0051174	210	0.015
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.014
glycosyl compound metabolic process	GO:1901657	127	0.014
negative regulation of cell communication	GO:0010648	223	0.014
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.014
actin mediated cell contraction	GO:0070252	21	0.014
cellular homeostasis	GO:0019725	80	0.014
meiotic nuclear division	GO:0007126	151	0.014
mapk cascade	GO:0000165	107	0.014
cellular protein catabolic process	GO:0044257	83	0.014
protein localization to nucleus	GO:0034504	55	0.014
regulation of microtubule based process	GO:0032886	49	0.014
heterocycle catabolic process	GO:0046700	166	0.014
single organism catabolic process	GO:0044712	228	0.014
modification dependent protein catabolic process	GO:0019941	78	0.014
inorganic ion transmembrane transport	GO:0098660	73	0.014
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.014
purine ribonucleotide catabolic process	GO:0009154	109	0.013
positive regulation of phosphorylation	GO:0042327	87	0.013
regulation of kinase activity	GO:0043549	53	0.013
learning	GO:0007612	75	0.013
response to toxic substance	GO:0009636	22	0.013
establishment of protein localization to organelle	GO:0072594	62	0.013
appendage morphogenesis	GO:0035107	397	0.013
amine metabolic process	GO:0009308	12	0.013
negative regulation of cellular biosynthetic process	GO:0031327	277	0.013
muscle system process	GO:0003012	21	0.013
vesicle mediated transport	GO:0016192	381	0.013
purine containing compound metabolic process	GO:0072521	155	0.013
purine nucleotide metabolic process	GO:0006163	146	0.013
actin filament polymerization	GO:0030041	27	0.013
endosomal transport	GO:0016197	44	0.013
epithelial cell development	GO:0002064	274	0.013
posttranscriptional regulation of gene expression	GO:0010608	145	0.013
ribonucleoside catabolic process	GO:0042454	112	0.012
regulation of jnk cascade	GO:0046328	40	0.012
regulation of phosphate metabolic process	GO:0019220	210	0.012
neuromuscular synaptic transmission	GO:0007274	67	0.012
positive regulation of cell communication	GO:0010647	250	0.012
nucleocytoplasmic transport	GO:0006913	72	0.012
protein polymerization	GO:0051258	42	0.012
divalent inorganic cation homeostasis	GO:0072507	29	0.012
positive regulation of protein metabolic process	GO:0051247	128	0.012
nucleoside triphosphate metabolic process	GO:0009141	120	0.012
organic cyclic compound catabolic process	GO:1901361	168	0.012
embryo development ending in birth or egg hatching	GO:0009792	152	0.011
body morphogenesis	GO:0010171	2	0.011
reactive oxygen species metabolic process	GO:0072593	22	0.011
organophosphate metabolic process	GO:0019637	195	0.011
muscle organ development	GO:0007517	127	0.011
purine ribonucleotide metabolic process	GO:0009150	145	0.011
purine ribonucleoside monophosphate catabolic process	GO:0009169	38	0.011
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.011
stress activated mapk cascade	GO:0051403	52	0.011
protein localization to organelle	GO:0033365	82	0.011
cellular macromolecular complex assembly	GO:0034622	153	0.011
head development	GO:0060322	135	0.011
nucleoside metabolic process	GO:0009116	127	0.011
positive regulation of catabolic process	GO:0009896	105	0.011
nucleobase containing compound catabolic process	GO:0034655	165	0.011
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.011
atp catabolic process	GO:0006200	38	0.011
sodium ion transport	GO:0006814	22	0.010
regulation of catalytic activity	GO:0050790	185	0.010
nucleoside monophosphate catabolic process	GO:0009125	39	0.010
chemotaxis	GO:0006935	249	0.010
kidney development	GO:0001822	3	0.010
response to copper ion	GO:0046688	4	0.010
response to organic substance	GO:0010033	284	0.010
regulation of developmental growth	GO:0048638	174	0.010
immune system process	GO:0002376	347	0.010
cellular response to monosaccharide stimulus	GO:0071326	2	0.010

ref(2)P disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.042
synucleinopathy	DOID:0050890	0.020
central nervous system disease	DOID:331	0.020
nervous system disease	DOID:863	0.020
neurodegenerative disease	DOID:1289	0.020

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