Drosophila melanogaster

96 known processes

Hmgcr (Dmel_CG10367)

HMG Coenzyme A reductase

(Aliases: HMGCoAr,bs32f05.y1,CG10367,HMGCoARr,hmgcr,Dmel\CG10367,hmgrc,HMGCR_Dm,bro1,DmHMG-CoAr,Clb,hmgc,HMGCoAR,clb,HMGCR,BcDNA:LD15354,HmG-CoAR,Hmg,l(3)01152)

Hmgcr biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
negative regulation of cellular metabolic processGO:00313243820.558
Mouse
trachea morphogenesisGO:0060439220.442
rhythmic processGO:00485111060.441
cardiovascular system developmentGO:0072358820.432
immune system processGO:00023763470.393
negative regulation of rna metabolic processGO:00512532510.390
transmembrane transportGO:00550851390.335
homeostatic processGO:00425921990.320
sensory perceptionGO:00076001960.306
respiratory system developmentGO:00605412130.302
regionalizationGO:00030024160.291
immune responseGO:00069552460.282
germ cell migrationGO:0008354430.275
circadian rhythmGO:00076231050.274
positive regulation of rna biosynthetic processGO:19026802660.262
protein modification processGO:00362114380.259
Mouse
tissue morphogenesisGO:00487292970.253
negative regulation of nucleic acid templated transcriptionGO:19035072400.240
regulation of anatomical structure morphogenesisGO:00226032420.234
negative regulation of response to stimulusGO:00485852580.229
Mouse
establishment of localization in cellGO:00516494020.226
negative regulation of biosynthetic processGO:00098902770.219
negative regulation of nucleobase containing compound metabolic processGO:00459342610.214
negative regulation of transcription dna templatedGO:00458922370.213
digestive system developmentGO:00551231490.208
circulatory system developmentGO:0072359820.190
trachea developmentGO:0060438290.181
sensory perception of chemical stimulusGO:00076061160.178
negative regulation of apoptotic processGO:0043066630.174
regulation of epithelial cell migration open tracheal systemGO:2000274110.173
multi organism reproductive behaviorGO:00447051210.164
tube developmentGO:00352952440.160
negative regulation of nitrogen compound metabolic processGO:00511722650.158
developmental maturationGO:00217001720.154
Zebrafish
neurological system processGO:00508773580.154
Mouse
negative regulation of rna biosynthetic processGO:19026792400.147
deathGO:00162652840.147
response to organic substanceGO:00100332840.145
cation transmembrane transportGO:0098655880.144
ion transmembrane transportGO:00342201220.144
transcription from rna polymerase ii promoterGO:00063663680.138
negative regulation of cellular biosynthetic processGO:00313272770.137
organonitrogen compound biosynthetic processGO:19015661170.133
morphogenesis of an epitheliumGO:00020092760.130
detection of stimulus involved in sensory perceptionGO:0050906920.123
response to radiationGO:00093141550.121
Mouse
cardiocyte differentiationGO:0035051290.121
axon developmentGO:00615642970.121
epithelial cell migration open tracheal systemGO:0007427320.118
negative regulation of cell deathGO:0060548810.117
cell deathGO:00082192790.117
defense responseGO:00069523000.112
protein localizationGO:00081042840.112
regulation of localizationGO:00328792750.110
serotonin metabolic processGO:004242820.110
organelle fissionGO:00482853400.109
regulation of multicellular organism growthGO:0040014400.106
regulation of response to external stimulusGO:00321011150.103
organic substance transportGO:00717022570.101
negative regulation of macromolecule biosynthetic processGO:00105582700.101
male gamete generationGO:00482322010.100
head developmentGO:00603221350.098
negative regulation of gene expressionGO:00106293870.097
cellular response to abiotic stimulusGO:0071214580.097
rhythmic behaviorGO:0007622760.095
locomotory behaviorGO:00076261760.095
cell migrationGO:00164772380.094
open tracheal system developmentGO:00074242040.093
protein transportGO:00150311550.093
tissue migrationGO:00901301550.093
small molecule metabolic processGO:00442813050.092
Mouse
germline stem cell asymmetric divisionGO:0098728150.091
response to biotic stimulusGO:00096072940.091
regulation of immune system processGO:00026821760.090
blastoderm segmentationGO:00073501590.088
digestive tract developmentGO:00485651490.087
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.085
negative regulation of signalingGO:00230572190.085
Mouse
cell proliferationGO:00082832990.084
nuclear divisionGO:00002803320.084
positive regulation of molecular functionGO:00440931360.083
intracellular transportGO:00469072280.083
apical junction assemblyGO:0043297320.081
transition metal ion transportGO:0000041160.080
response to other organismGO:00517072930.079
regulation of epithelial cell proliferationGO:005067840.079
mesodermal cell differentiationGO:004833370.078
response to abiotic stimulusGO:00096283410.077
Mouse
sensory perception of mechanical stimulusGO:0050954720.076
response to light stimulusGO:00094161240.076
Mouse
regulation of transportGO:00510491810.076
regulation of multi organism processGO:00439001310.076
regulation of apoptotic processGO:00429811300.075
mesoderm developmentGO:0007498780.074
cell surface receptor signaling pathway involved in heart developmentGO:006131130.073
epithelial cell differentiationGO:00308553220.073
central nervous system developmentGO:00074172010.073
spermatogenesisGO:00072832000.072
heart morphogenesisGO:0003007320.072
Zebrafish
reproductive behaviorGO:00190981220.071
gonadal mesoderm developmentGO:000750680.071
regulation of cell deathGO:00109411730.070
ameboidal type cell migrationGO:00016671510.070
gastrulationGO:0007369700.070
mitochondrion organizationGO:0007005650.068
positive regulation of rna metabolic processGO:00512542710.068
innate immune responseGO:00450871440.068
regulation of developmental growthGO:00486381740.068
columnar cuboidal epithelial cell differentiationGO:00020652560.067
glial cell differentiationGO:0010001350.067
chemical homeostasisGO:0048878920.065
cellular macromolecule localizationGO:00707272200.065
positive regulation of developmental growthGO:0048639620.065
embryonic pattern specificationGO:00098801740.064
molting cycleGO:0042303560.064
regulation of transcription from rna polymerase ii promoterGO:00063573780.064
molting cycle chitin based cuticleGO:0007591560.063
cell migration involved in gastrulationGO:004207490.063
male courtship behaviorGO:0008049630.063
neuron projection guidanceGO:00974852410.062
developmental programmed cell deathGO:00106231380.062
gland morphogenesisGO:00226121450.061
single organism biosynthetic processGO:00447112060.061
Mouse
segmentationGO:00352822070.060
dendrite developmentGO:00163582040.060
vesicle mediated transportGO:00161923810.060
chromatin organizationGO:00063252070.060
negative regulation of signal transductionGO:00099682060.059
Mouse
oocyte differentiationGO:00099941450.059
single organism behaviorGO:00447083910.057
Mouse
neuronal stem cell divisionGO:0036445350.057
positive regulation of macromolecule metabolic processGO:00106044050.057
positive regulation of response to stimulusGO:00485843230.057
heart developmentGO:0007507820.056
defense response to gram positive bacteriumGO:0050830410.056
multi organism behaviorGO:00517051750.056
regulation of tube diameter open tracheal systemGO:0035158110.056
defense response to other organismGO:00985422250.056
regulation of programmed cell deathGO:00430671520.056
stem cell differentiationGO:00488631170.055
urogenital system developmentGO:0001655720.054
regulation of tube architecture open tracheal systemGO:0035152680.054
cation transportGO:00068121100.053
inorganic ion transmembrane transportGO:0098660730.053
negative regulation of transcription from rna polymerase ii promoterGO:00001221190.053
locomotor rhythmGO:0045475560.053
response to external biotic stimulusGO:00432072930.052
renal system developmentGO:0072001720.051
hindgut developmentGO:0061525580.050
cellular amide metabolic processGO:0043603800.050
mesodermal cell fate specificationGO:000750120.050
intracellular protein transportGO:00068861040.050
growthGO:00400073590.049
dendrite morphogenesisGO:00488131990.049
single organism intracellular transportGO:19025822070.049
regulation of protein metabolic processGO:00512462560.048
Mouse
positive regulation of transcription dna templatedGO:00458932660.047
mesoderm formationGO:0001707210.047
connective tissue developmentGO:006144830.047
circadian behaviorGO:0048512760.047
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.047
embryonic heart tube developmentGO:0035050220.047
cellular catabolic processGO:00442483720.047
regulation of dna templated transcription elongationGO:0032784170.047
terminal branching open tracheal systemGO:0007430170.046
organic hydroxy compound biosynthetic processGO:1901617210.046
Mouse
mesodermal cell migrationGO:000807870.046
synaptic vesicle localizationGO:0097479530.045
oocyte constructionGO:00073081120.045
regulation of notch signaling pathwayGO:00085931000.045
multicellular organismal reproductive behaviorGO:00330571100.045
oxoacid metabolic processGO:00434361030.044
gliogenesisGO:0042063800.044
negative regulation of programmed cell deathGO:0043069720.043
digestive tract morphogenesisGO:00485461270.043
embryonic morphogenesisGO:00485982060.043
cardioblast differentiationGO:0010002200.042
defense response to bacteriumGO:00427421780.042
limb morphogenesisGO:003510810.042
circadian sleep wake cycle sleepGO:0050802230.042
ion transportGO:00068111450.041
cellular response to organic substanceGO:00713101320.041
lipid metabolic processGO:00066291210.041
Mouse
branching involved in open tracheal system developmentGO:0060446450.040
apoptotic processGO:00069151590.040
oocyte developmentGO:00485991240.040
cell divisionGO:00513012480.040
establishment of protein localizationGO:00451841630.040
regulation of immune responseGO:00507761180.040
localization of cellGO:00516742570.039
mitotic nuclear divisionGO:00070672130.039
positive regulation of nucleic acid templated transcriptionGO:19035082660.039
organic acid metabolic processGO:00060821030.038
establishment of organelle localizationGO:00516561220.038
cellular response to chemical stimulusGO:00708871990.038
cellular amino acid metabolic processGO:0006520610.038
regulation of molecular functionGO:00650092170.037
Mouse
embryo development ending in birth or egg hatchingGO:00097921520.037
dorsal ventral pattern formationGO:00099531330.037
regulation of cellular localizationGO:00603411360.036
transition metal ion homeostasisGO:0055076170.036
regulation of multicellular organismal developmentGO:20000264140.036
regulation of neuron projection developmentGO:0010975690.036
regulation of membrane potentialGO:0042391350.036
neuroblast divisionGO:0055057350.036
regulation of transcription elongation from rna polymerase ii promoterGO:0034243150.036
programmed cell deathGO:00125012570.036
regulation of neurogenesisGO:00507671580.035
response to organophosphorusGO:004668320.035
columnar cuboidal epithelial cell developmentGO:00020662490.035
regulation of cellular response to stressGO:0080135890.035
cell motilityGO:00488702510.035
formation of primary germ layerGO:0001704240.035
stem cell divisionGO:0017145690.035
inorganic cation transmembrane transportGO:0098662610.035
organonitrogen compound metabolic processGO:19015643180.034
defense response to gram negative bacteriumGO:0050829940.034
cellular protein localizationGO:00346131600.034
positive regulation of multicellular organismal processGO:00512401430.033
regulation of anatomical structure sizeGO:00900661630.033
response to mechanical stimulusGO:0009612280.033
regulation of symbiosis encompassing mutualism through parasitismGO:0043903150.033
rna processingGO:00063961470.033
metal ion transportGO:0030001740.033
regulation of cell differentiationGO:00455953020.033
phosphorylationGO:00163102940.033
female meiotic divisionGO:0007143700.032
body morphogenesisGO:001017120.032
protein catabolic processGO:00301631010.032
cytoplasmic transportGO:00164821300.032
matingGO:00076181200.032
regulation of phosphorylationGO:00423251470.032
olfactory behaviorGO:0042048970.032
actin mediated cell contractionGO:0070252210.032
single organism cellular localizationGO:19025801800.031
limb developmentGO:006017310.031
regulation of cell morphogenesisGO:00226041630.031
neuromuscular synaptic transmissionGO:0007274670.031
ventral furrow formationGO:0007370170.031
endocytosisGO:00068973100.031
regulation of tube size open tracheal systemGO:0035151430.031
regulation of response to stressGO:00801342000.030
regulation of cell proliferationGO:00421271630.030
intracellular signal transductionGO:00355563000.030
response to alcoholGO:0097305950.029
dna templated transcription elongationGO:0006354180.029
regulation of gene silencingGO:0060968630.029
metal ion homeostasisGO:0055065440.029
epidermis developmentGO:0008544650.029
cardiac cell fate commitmentGO:0060911170.029
muscle tissue morphogenesisGO:006041520.029
positive regulation of immune system processGO:0002684680.029
outflow tract morphogenesisGO:000315140.028
cell maturationGO:00484691440.028
humoral immune responseGO:00069591170.028
chromosome organizationGO:00512763600.028
detection of stimulusGO:00516061560.027
tripartite regional subdivisionGO:00073511030.027
cranial nerve developmentGO:002154510.027
positive regulation of developmental pigmentationGO:004808750.027
skin developmentGO:0043588650.027
positive regulation of macromolecule biosynthetic processGO:00105572830.027
establishment of vesicle localizationGO:0051650510.027
positive regulation of gene expressionGO:00106282900.027
positive regulation of developmental processGO:00510941430.027
response to nutrient levelsGO:00316671140.026
developmental growthGO:00485892800.026
oocyte axis specificationGO:00073091080.026
chemotaxisGO:00069352490.026
regulation of embryonic developmentGO:0045995680.026
regulation of neuron deathGO:1901214260.026
neuronal action potentialGO:0019228100.026
vesicle localizationGO:0051648550.026
regulation of circadian rhythmGO:0042752490.026
reproductive structure developmentGO:0048608740.026
catecholamine biosynthetic processGO:004242330.026
glial cell migrationGO:0008347310.026
response to oxygen containing compoundGO:19017002000.026
negative regulation of cell divisionGO:0051782170.026
pigmentationGO:0043473750.025
phagocytosisGO:00069092150.025
tyrosine metabolic processGO:000657010.025
regulation of protein transportGO:0051223570.025
regulation of cell developmentGO:00602842150.025
cell fate determinationGO:0001709910.025
sleepGO:0030431490.025
positive regulation of growthGO:0045927750.025
protein complex biogenesisGO:00702712010.024
secretion by cellGO:00329401010.024
anterior posterior axis specification embryoGO:00085951030.024
dna repairGO:0006281540.024
morphogenesis of a polarized epitheliumGO:0001738930.024
cardioblast cell fate commitmentGO:0042684140.024
regulation of organelle organizationGO:00330431960.024
meiotic cell cycleGO:00513211710.024
larval developmentGO:00021641040.024
protein targetingGO:0006605640.024
cholesterol homeostasisGO:004263230.024
asymmetric stem cell divisionGO:0098722490.023
zygotic determination of anterior posterior axis embryoGO:0007354270.023
gene silencingGO:00164581380.023
meiotic nuclear divisionGO:00071261510.023
mesenchymal cell differentiationGO:004876210.023
pole plasm assemblyGO:0007315610.023
positive regulation of cellular biosynthetic processGO:00313283160.023
mesodermal cell fate commitmentGO:000171070.023
single organism nuclear importGO:1902593510.023
cuticle pigmentationGO:0048067220.023
regulation of nervous system developmentGO:00519602480.023
posttranscriptional gene silencing by rnaGO:0035194450.022
protein processingGO:0016485680.022
appendage developmentGO:00487364010.022
epithelial cell developmentGO:00020642740.022
morphogenesis of a branching epitheliumGO:0061138450.022
substrate dependent cell migrationGO:000692930.022
cuticle developmentGO:0042335860.022
reproductive system developmentGO:0061458740.022
positive regulation of stem cell differentiationGO:200073830.022
cellularizationGO:0007349900.022
oocyte maturationGO:000155630.022
nuclear importGO:0051170510.022
epithelial tube formationGO:007217570.022
regulation of tube length open tracheal systemGO:0035159240.021
g protein coupled receptor signaling pathwayGO:00071861360.021
determination of left right symmetryGO:000736890.021
protein maturationGO:0051604710.021
regulation of mitosisGO:0007088560.021
sensory perception of soundGO:0007605560.021
embryonic hemopoiesisGO:0035162260.021
proteolysisGO:00065081920.021
actin filament organizationGO:00070151260.021
synaptic transmissionGO:00072682880.021
regulation of behaviorGO:0050795750.021
aromatic amino acid family metabolic processGO:000907230.021
positive regulation of cellular component organizationGO:00511301560.021
cellular protein modification processGO:00064644380.021
Mouse
microtubule based movementGO:0007018510.021
establishment or maintenance of cell polarityGO:00071631670.021
secretionGO:00469031090.020
microtubule bundle formationGO:0001578270.020
regulation of response to extracellular stimulusGO:0032104180.020
cellular homeostasisGO:0019725800.020
regulation of cell cycleGO:00517262910.020
peptide metabolic processGO:0006518800.020
smoothened signaling pathwayGO:0007224490.020
regulation of phosphate metabolic processGO:00192202100.020
sex differentiationGO:0007548810.020
detection of abiotic stimulusGO:0009582660.020
female germ line stem cell asymmetric divisionGO:0048132140.020
axis elongationGO:000340130.020
catabolic processGO:00090564090.020
regulation of heart morphogenesisGO:200082630.020
anatomical structure homeostasisGO:0060249970.020
regulation of cell morphogenesis involved in differentiationGO:0010769610.020
protein targeting to nucleusGO:0044744510.019
mesenchymal cell developmentGO:001403110.019
protein localization to organelleGO:0033365820.019
regulation of protein phosphorylationGO:0001932640.019
Mouse
gastrulation with mouth forming firstGO:0001703360.019
embryonic axis specificationGO:00005781070.019
spindle organizationGO:00070512530.019
positive regulation of cellular amino acid metabolic processGO:004576400.019
embryonic epithelial tube formationGO:000183860.019
positive regulation of cell proliferationGO:0008284470.019
gastrulation involving germ band extensionGO:0010004360.019
negative regulation of epithelial cell proliferationGO:005068040.019
regulation of cell shapeGO:00083601130.019
forebrain developmentGO:003090020.018
cellular response to endogenous stimulusGO:0071495800.018
pole plasm mrna localizationGO:0019094490.018
immune system developmentGO:0002520570.018
maternal determination of anterior posterior axis embryoGO:0008358740.018
posttranscriptional regulation of gene expressionGO:00106081450.018
stem cell proliferationGO:0072089880.018
regulation of microtubule cytoskeleton organizationGO:0070507410.018
kidney developmentGO:000182230.018
neuroblast differentiationGO:0014016290.018
pole cell formationGO:0007279190.018
neutral lipid biosynthetic processGO:004646020.018
glandular epithelial cell differentiationGO:000206710.018
compound eye morphogenesisGO:00017452490.018
negative regulation of cell communicationGO:00106482230.018
Mouse
nitrogen compound transportGO:0071705850.018
organelle localizationGO:00516401480.018
sensory perception of smellGO:0007608800.018
meiosis iGO:0007127590.018
developmental pigmentationGO:0048066680.018
carboxylic acid metabolic processGO:0019752920.018
male mating behaviorGO:0060179700.017
action potentialGO:0001508130.017
monocarboxylic acid metabolic processGO:0032787290.017
intracellular protein transmembrane transportGO:006500240.017
cardioblast cell fate specificationGO:004268590.017
ovipositionGO:0018991190.017
cardiac cell fate specificationGO:0060912100.017
purine ribonucleoside triphosphate catabolic processGO:00092071080.017
regulation of steroid metabolic processGO:001921820.017
positive regulation of biosynthetic processGO:00098913160.017
epithelial cell migrationGO:00106311480.017
regulation of defense responseGO:00313471020.017
regulation of phosphorus metabolic processGO:00511742100.017
eggshell chorion assemblyGO:0007306660.017
tissue deathGO:00162711020.017
regulation of cellular catabolic processGO:00313291570.016
photoreceptor cell differentiationGO:00465301700.016
cell growthGO:00160491080.016
cation homeostasisGO:0055080510.016
regulation of organ formationGO:000315630.016
regulation of lipid metabolic processGO:0019216150.016
tube morphogenesisGO:00352391910.016
cellular ketone metabolic processGO:0042180240.016
imaginal disc growthGO:0007446370.016
oocyte dorsal ventral axis specificationGO:0007310340.016
mesoderm morphogenesisGO:0048332220.016
amine metabolic processGO:0009308120.016
centrosome organizationGO:00512971630.016
cell agingGO:000756920.016
anion homeostasisGO:005508130.016
multi multicellular organism processGO:00447061230.016
nuclear transportGO:0051169720.016
actin filament based processGO:00300292200.016
hemopoiesisGO:0030097460.016
regulation of extracellular matrix organizationGO:190305340.016
dna metabolic processGO:00062592270.016
regulation of cellular protein metabolic processGO:00322682430.016
Mouse
neuroblast proliferationGO:0007405740.016
regulation of response to nutrient levelsGO:0032107180.015
oocyte anterior posterior axis specificationGO:0007314720.015
primary amino compound metabolic processGO:190116020.015
ion homeostasisGO:0050801550.015
antimicrobial humoral responseGO:0019730990.015
regulation of epithelial cell differentiationGO:003085640.015
proteolysis involved in cellular protein catabolic processGO:0051603830.015
cholesterol transportGO:003030120.015
response to oxygen levelsGO:0070482590.015
nucleus organizationGO:0006997450.015
torso signaling pathwayGO:0008293210.015
enzyme linked receptor protein signaling pathwayGO:00071671790.015
regulation of response to dna damage stimulusGO:2001020230.015
regulation of proteolysisGO:0030162870.015
regulation of dna repairGO:000628250.015
axon guidanceGO:00074112330.015
protein importGO:0017038550.015
anion transportGO:0006820410.015
regulation of gene expression epigeneticGO:00400291280.015
axonogenesisGO:00074092900.015
establishment of glial blood brain barrierGO:0060857140.015
ribonucleotide catabolic processGO:00092611090.015
developmental inductionGO:003112830.015
regulation of cell divisionGO:0051302720.015
epithelial tube morphogenesisGO:0060562880.015
internal protein amino acid acetylationGO:0006475380.014
chorion containing eggshell formationGO:00073041050.014
anterior posterior axis specificationGO:00099481090.014
chitin based cuticle developmentGO:0040003490.014
formation of organ boundaryGO:0010160300.014
regulation of system processGO:0044057360.014
convergent extension involved in gastrulationGO:006002720.014
regulation of intracellular protein transportGO:0033157460.014
telencephalon developmentGO:002153720.014
organ formationGO:0048645390.014
hematopoietic or lymphoid organ developmentGO:0048534570.014
microtubule based transportGO:0010970420.014
negative regulation of hormone biosynthetic processGO:003235310.014
muscle tissue developmentGO:0060537300.014
negative regulation of smoothened signaling pathwayGO:0045879160.014
actin filament based movementGO:0030048260.014
cellular lipid metabolic processGO:0044255830.014
cellular amine metabolic processGO:0044106120.014
periodic partitioningGO:0007365290.014
regulation of intracellular signal transductionGO:19025312360.014
glial cell developmentGO:0021782270.014
regulation of glial cell differentiationGO:004568510.014
protein acetylationGO:0006473390.014
sterol homeostasisGO:005509240.014
modification dependent macromolecule catabolic processGO:0043632790.014
protein transmembrane transportGO:007180640.014
malpighian tubule morphogenesisGO:0007443440.014
immune effector processGO:0002252980.014

Hmgcr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
urinary system diseaseDOID:1800.059
disease of anatomical entityDOID:700.059
cardiovascular system diseaseDOID:128700.051
nervous system diseaseDOID:86300.038
cancerDOID:16200.030
disease of cellular proliferationDOID:1456600.030
organ system cancerDOID:005068600.030
sensory system diseaseDOID:005015500.025
eye and adnexa diseaseDOID:149200.019
eye diseaseDOID:561400.018
disease of metabolismDOID:001466700.018
connective tissue diseaseDOID:6500.018
musculoskeletal system diseaseDOID:1700.018
inherited metabolic disorderDOID:65500.017
kidney diseaseDOID:55700.015
acquired metabolic diseaseDOID:006015800.015