IMP: Integrative Multi-species Prediction

Drosophila melanogaster

186 known processes

Lam (Dmel_CG6944)

Lamin

(Aliases: 2459,lamin Dm[[0]],misg,l(2)jf27,LamDm[[0]],nlam,Dm0,Dm1,Dm2,jf27,DmLamin,Dm,Lamin Dm[[0]],lamin,l(2)gdh-7,Dm[[0]],CG6944,l(2)04643,Lam(Dm0),Dm[[1]],lamDm0,Dm(0),Dmel\CG6944,lamDm[[0]],Lam[[Dm0]],Dm[[mit]],lam,l(2)gdh7,l(2)25Ec,Dm[[2]],Dmo,Lam Dm[[0]],74/76,LAM,DM[[O]],lamin Dm0,Dm[[o]],DmO,D5)

Entrez: 33782
FLYBASE: FBgn0002525
UniProtKB: M9NE89
UniProtKB: P08928

Process Predictions
Disease Predictions

Lam biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
pole plasm mrna localization	GO:0019094	49	1.000
oocyte development	GO:0048599	124	0.999
oocyte differentiation	GO:0009994	145	0.999
oocyte axis specification	GO:0007309	108	0.998
oocyte construction	GO:0007308	112	0.997
pole plasm rna localization	GO:0007316	52	0.994
pole plasm assembly	GO:0007315	61	0.991
pole plasm oskar mrna localization	GO:0045451	46	0.989
rna localization	GO:0006403	115	0.981
germarium derived female germ line cyst formation	GO:0030727	42	0.981
locomotory behavior	GO:0007626	176	0.979
rna processing	GO:0006396	147	0.970
oocyte anterior posterior axis specification	GO:0007314	72	0.960
regulation of cell differentiation	GO:0045595	302	0.958
single organism cellular localization	GO:1902580	180	0.946
protein localization to nucleus	GO:0034504	55	0.946
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.945	Mouse
rna splicing	GO:0008380	83	0.939
germarium derived egg chamber formation	GO:0007293	101	0.935
aging	GO:0007568	143	0.933
intracellular mrna localization involved in anterior posterior axis specification	GO:0060811	53	0.929
cellular macromolecule localization	GO:0070727	220	0.927
segmentation	GO:0035282	207	0.925
regulation of growth	GO:0040008	233	0.922	Worm
regionalization	GO:0003002	416	0.915
developmental maturation	GO:0021700	172	0.913
body morphogenesis	GO:0010171	2	0.912	Worm
embryonic pattern specification	GO:0009880	174	0.901
female germ line cyst formation	GO:0048135	42	0.896
circadian rhythm	GO:0007623	105	0.888
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.880	Mouse
developmental growth	GO:0048589	280	0.879	Worm
spermatogenesis	GO:0007283	200	0.866
transcription from rna polymerase ii promoter	GO:0006366	368	0.864
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.861
cell maturation	GO:0048469	144	0.853
regulation of developmental growth	GO:0048638	174	0.848	Worm
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.831
regulation of localization	GO:0032879	275	0.823	Mouse
maternal determination of anterior posterior axis embryo	GO:0008358	74	0.819
establishment of localization in cell	GO:0051649	402	0.800
nucleus organization	GO:0006997	45	0.780
growth	GO:0040007	359	0.779	Worm
microtubule organizing center organization	GO:0031023	168	0.756
negative regulation of cellular metabolic process	GO:0031324	382	0.753
negative regulation of rna biosynthetic process	GO:1902679	240	0.746
regulation of alternative mrna splicing via spliceosome	GO:0000381	60	0.742
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.740
protein localization	GO:0008104	284	0.726
multicellular organismal aging	GO:0010259	140	0.722	Worm
adult locomotory behavior	GO:0008344	76	0.716
cytoplasm organization	GO:0007028	64	0.707
germ line cyst formation	GO:0048134	44	0.700
regulation of rna splicing	GO:0043484	69	0.691
mitochondrion organization	GO:0007005	65	0.688	Mouse
lateral inhibition	GO:0046331	206	0.685
reproductive structure development	GO:0048608	74	0.684
organelle localization	GO:0051640	148	0.683
mrna metabolic process	GO:0016071	124	0.676
mrna splicing via spliceosome	GO:0000398	73	0.674
positive regulation of transcription dna templated	GO:0045893	266	0.673	Mouse
anterior posterior axis specification	GO:0009948	109	0.672
organ growth	GO:0035265	56	0.671
intracellular transport	GO:0046907	228	0.667	Mouse
regulation of cellular localization	GO:0060341	136	0.662	Mouse
anterior posterior pattern specification	GO:0009952	136	0.662
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.661	Mouse
regulation of apoptotic signaling pathway	GO:2001233	10	0.661	Mouse
adult behavior	GO:0030534	137	0.645
regulation of pole plasm oskar mrna localization	GO:0007317	27	0.644
establishment or maintenance of cytoskeleton polarity	GO:0030952	44	0.609	Mouse
organic substance catabolic process	GO:1901575	308	0.608	Worm
positive regulation of macromolecule metabolic process	GO:0010604	405	0.606	Mouse
microtubule based transport	GO:0010970	42	0.593
compound eye photoreceptor cell differentiation	GO:0001751	140	0.592
spermatid differentiation	GO:0048515	114	0.591
intracellular mrna localization involved in pattern specification process	GO:0060810	56	0.589
rna splicing via transesterification reactions	GO:0000375	73	0.587
negative regulation of gene expression	GO:0010629	387	0.586
oocyte microtubule cytoskeleton polarization	GO:0008103	22	0.585
spermatid development	GO:0007286	98	0.581
blastoderm segmentation	GO:0007350	159	0.578
dna templated transcription initiation	GO:0006352	25	0.576
embryonic axis specification	GO:0000578	107	0.573
regulation of transport	GO:0051049	181	0.568
imaginal disc derived appendage development	GO:0048737	399	0.566
sex differentiation	GO:0007548	81	0.563
dorsal ventral axis specification ovarian follicular epithelium	GO:0008069	13	0.561
taxis	GO:0042330	304	0.555
actin filament based process	GO:0030029	220	0.544	Worm Fly
determination of adult lifespan	GO:0008340	137	0.542	Worm
tube development	GO:0035295	244	0.537
establishment or maintenance of polarity of follicular epithelium	GO:0016334	26	0.535
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.534
photoreceptor cell differentiation	GO:0046530	170	0.531
axis specification	GO:0009798	167	0.524
regulation of multicellular organismal development	GO:2000026	414	0.520
embryo development ending in birth or egg hatching	GO:0009792	152	0.502	Worm
regulation of nervous system development	GO:0051960	248	0.494
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.494
rhythmic process	GO:0048511	106	0.480
cell death	GO:0008219	279	0.479	Mouse
negative regulation of transcription dna templated	GO:0045892	237	0.478
regulation of mrna metabolic process	GO:1903311	72	0.476
neuron projection guidance	GO:0097485	241	0.469
positive regulation of rna metabolic process	GO:0051254	271	0.457	Mouse
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.446
protein localization to organelle	GO:0033365	82	0.434
nuclear transport	GO:0051169	72	0.432	Mouse
anterior posterior axis specification embryo	GO:0008595	103	0.426
nuclear import	GO:0051170	51	0.425	Mouse
single organism behavior	GO:0044708	391	0.419
muscle structure development	GO:0061061	224	0.407	Human Mouse Worm Fly
endomembrane system organization	GO:0010256	119	0.398
negative regulation of cell differentiation	GO:0045596	143	0.390
negative regulation of developmental process	GO:0051093	201	0.387
axon guidance	GO:0007411	233	0.372
nuclear migration	GO:0007097	20	0.368
regulation of mitotic cell cycle	GO:0007346	190	0.364	Worm
axonogenesis	GO:0007409	290	0.363
regulation of mrna splicing via spliceosome	GO:0048024	64	0.362
respiratory system development	GO:0060541	213	0.353
gonad development	GO:0008406	50	0.352
response to organic substance	GO:0010033	284	0.351
regulation of cellular component biogenesis	GO:0044087	201	0.349	Fly
response to hormone	GO:0009725	45	0.347
germarium derived oocyte differentiation	GO:0030706	29	0.347
nitrogen compound transport	GO:0071705	85	0.344
protein targeting to nucleus	GO:0044744	51	0.343	Mouse
cellular response to hormone stimulus	GO:0032870	44	0.340
intracellular mrna localization	GO:0008298	66	0.337
single organism nuclear import	GO:1902593	51	0.335	Mouse
positive regulation of gene expression	GO:0010628	290	0.334	Mouse
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.333
positive regulation of cellular biosynthetic process	GO:0031328	316	0.324	Mouse
tripartite regional subdivision	GO:0007351	103	0.316
epithelial cell differentiation	GO:0030855	322	0.306
cytoplasmic transport nurse cell to oocyte	GO:0007303	12	0.305
chromatin organization	GO:0006325	207	0.300	Fly
death	GO:0016265	284	0.297	Mouse
cellularization	GO:0007349	90	0.296
regulation of oocyte development	GO:0060281	27	0.295
compound eye development	GO:0048749	307	0.293
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.291
posttranscriptional regulation of gene expression	GO:0010608	145	0.290
establishment or maintenance of cell polarity	GO:0007163	167	0.290	Mouse
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.287
branching involved in open tracheal system development	GO:0060446	45	0.284
response to nutrient levels	GO:0031667	114	0.284
germarium derived oocyte fate determination	GO:0007294	26	0.279
establishment of protein localization	GO:0045184	163	0.273	Mouse
cellular component assembly involved in morphogenesis	GO:0010927	151	0.268	Worm
regulation of intracellular transport	GO:0032386	64	0.258
transcription initiation from rna polymerase ii promoter	GO:0006367	25	0.254
regulation of cell division	GO:0051302	72	0.251
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.244
cell division	GO:0051301	248	0.241
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.241	Mouse
digestive tract development	GO:0048565	149	0.232
regulation of epithelial cell differentiation	GO:0030856	4	0.228
nucleocytoplasmic transport	GO:0006913	72	0.228	Mouse
establishment of organelle localization	GO:0051656	122	0.222
chromosome organization	GO:0051276	360	0.221	Fly
central nervous system development	GO:0007417	201	0.218
synaptic transmission	GO:0007268	288	0.214
regulation of response to stress	GO:0080134	200	0.211
protein transport	GO:0015031	155	0.211	Mouse
regulation of neurogenesis	GO:0050767	158	0.210
organelle fission	GO:0048285	340	0.205	Worm
chemotaxis	GO:0006935	249	0.203
cytokinesis	GO:0000910	90	0.202
mrna processing	GO:0006397	104	0.200
regulation of protein transport	GO:0051223	57	0.200
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.199
tissue morphogenesis	GO:0048729	297	0.198
homeostatic process	GO:0042592	199	0.198
cellular protein localization	GO:0034613	160	0.193
alternative mrna splicing via spliceosome	GO:0000380	60	0.184
morphogenesis of an epithelium	GO:0002009	276	0.179
epithelial cell migration	GO:0010631	148	0.176
stem cell maintenance	GO:0019827	67	0.176
regulation of embryonic pattern specification	GO:1902875	27	0.165
germ line stem cell maintenance	GO:0030718	50	0.162
spindle organization	GO:0007051	253	0.158
localization of cell	GO:0051674	257	0.155	Mouse
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	41	0.155	Mouse
regulation of cell development	GO:0060284	215	0.154
establishment of oocyte nucleus localization involved in oocyte dorsal ventral axis specification	GO:0030722	6	0.154
protein import	GO:0017038	55	0.153	Mouse
embryonic development via the syncytial blastoderm	GO:0001700	148	0.152
negative regulation of cell cycle process	GO:0010948	109	0.150
apoptotic signaling pathway	GO:0097190	27	0.149	Mouse
digestive system development	GO:0055123	149	0.143
response to hypoxia	GO:0001666	53	0.142	Human
larval development	GO:0002164	104	0.140	Worm
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	73	0.138
reproductive system development	GO:0061458	74	0.137
regulation of cell cycle	GO:0051726	291	0.136	Worm
cellular response to dna damage stimulus	GO:0006974	223	0.135
protein import into nucleus	GO:0006606	51	0.134	Mouse
regulation of mrna processing	GO:0050684	71	0.133
negative regulation of nervous system development	GO:0051961	92	0.129
negative regulation of programmed cell death	GO:0043069	72	0.129	Mouse
cellular macromolecular complex assembly	GO:0034622	153	0.128	Worm Fly
circulatory system development	GO:0072359	82	0.128	Mouse
regulation of nucleocytoplasmic transport	GO:0046822	35	0.128
nuclear envelope organization	GO:0006998	7	0.122
regulation of dendrite development	GO:0050773	37	0.122
organic substance transport	GO:0071702	257	0.120	Mouse
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.120	Mouse
amine metabolic process	GO:0009308	12	0.113
cell proliferation	GO:0008283	299	0.113	Worm
regulation of cell cycle process	GO:0010564	181	0.113
cellular response to endogenous stimulus	GO:0071495	80	0.111
macromolecule catabolic process	GO:0009057	161	0.111	Worm
protein phosphorylation	GO:0006468	169	0.109
lipid metabolic process	GO:0006629	121	0.108
mitotic cell cycle phase transition	GO:0044772	138	0.107
oocyte nucleus localization involved in oocyte dorsal ventral axis specification	GO:0051663	12	0.106
regulation of intracellular protein transport	GO:0033157	46	0.106
positive regulation of cell communication	GO:0010647	250	0.105
proteolysis	GO:0006508	192	0.105
cellular protein complex assembly	GO:0043623	71	0.104	Worm Fly
immune system process	GO:0002376	347	0.104
male gamete generation	GO:0048232	201	0.102
kidney development	GO:0001822	3	0.102
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.099
response to endogenous stimulus	GO:0009719	119	0.098
translation	GO:0006412	69	0.098
centrosome organization	GO:0051297	163	0.097
cilium morphogenesis	GO:0060271	39	0.097
telencephalon development	GO:0021537	2	0.096
epithelial tube morphogenesis	GO:0060562	88	0.095
positive regulation of biosynthetic process	GO:0009891	316	0.095	Mouse
negative regulation of mitotic cell cycle	GO:0045930	109	0.091
positive regulation of developmental process	GO:0051094	143	0.090	Human Worm
chromatin modification	GO:0016568	147	0.089
negative regulation of signal transduction	GO:0009968	206	0.089	Mouse
cell junction organization	GO:0034330	57	0.087
heart development	GO:0007507	82	0.087	Mouse
embryonic morphogenesis	GO:0048598	206	0.086
regulation of establishment of protein localization	GO:0070201	61	0.083
neurological system process	GO:0050877	358	0.083
covalent chromatin modification	GO:0016569	106	0.082
eye photoreceptor cell differentiation	GO:0001754	145	0.080
regulation of protein metabolic process	GO:0051246	256	0.079
regulation of cell growth	GO:0001558	43	0.079
negative regulation of signaling	GO:0023057	219	0.078	Mouse
neuromuscular junction development	GO:0007528	149	0.077
rna transport	GO:0050658	46	0.077
centrosome cycle	GO:0007098	137	0.076
autophagy	GO:0006914	108	0.075
compound eye morphogenesis	GO:0001745	249	0.074
wing disc morphogenesis	GO:0007472	344	0.074
synapse assembly	GO:0007416	143	0.073
apoptotic process	GO:0006915	159	0.071	Mouse
open tracheal system development	GO:0007424	204	0.070
positive regulation of protein metabolic process	GO:0051247	128	0.070
mapk cascade	GO:0000165	107	0.070
phosphorylation	GO:0016310	294	0.069
mitotic g2 dna damage checkpoint	GO:0007095	69	0.068
mitotic nuclear division	GO:0007067	213	0.067	Worm
regulation of neuron differentiation	GO:0045664	103	0.066
multicellular organismal homeostasis	GO:0048871	41	0.066
positive regulation of signal transduction	GO:0009967	223	0.066
cell cycle phase transition	GO:0044770	140	0.065
nucleus localization	GO:0051647	34	0.065
intracellular protein transport	GO:0006886	104	0.065	Mouse
positive regulation of response to stimulus	GO:0048584	323	0.065
protein targeting	GO:0006605	64	0.064	Mouse
chromosome segregation	GO:0007059	157	0.064	Worm
positive regulation of neurogenesis	GO:0050769	41	0.064
cystoblast division	GO:0007282	10	0.063
regulation of intracellular signal transduction	GO:1902531	236	0.063
regulation of protein localization	GO:0032880	76	0.063	Mouse
dorsal ventral pattern formation	GO:0009953	133	0.063
innate immune response	GO:0045087	144	0.062
nucleobase containing compound transport	GO:0015931	56	0.062
positive regulation of rna biosynthetic process	GO:1902680	266	0.061	Mouse
positive regulation of signaling	GO:0023056	243	0.061
ribonucleoprotein complex assembly	GO:0022618	23	0.061
dendrite development	GO:0016358	204	0.061
establishment of rna localization	GO:0051236	47	0.060
histone acetylation	GO:0016573	38	0.060
mitotic cytokinesis	GO:0000281	50	0.059
hemopoiesis	GO:0030097	46	0.059
cell cell junction organization	GO:0045216	55	0.059
response to lipid	GO:0033993	38	0.058
nuclear export	GO:0051168	24	0.057
regulation of cell death	GO:0010941	173	0.057	Mouse
regulation of cell cycle phase transition	GO:1901987	130	0.056
appendage development	GO:0048736	401	0.055
negative regulation of cell cycle phase transition	GO:1901988	103	0.054
negative regulation of growth	GO:0045926	84	0.054
tissue homeostasis	GO:0001894	36	0.054
myotube cell development	GO:0014904	3	0.053
actin cytoskeleton organization	GO:0030036	206	0.053	Worm Fly
sensory organ morphogenesis	GO:0090596	260	0.052
regulation of nurse cell apoptotic process	GO:0045477	9	0.051
regulation of organelle organization	GO:0033043	196	0.050	Mouse Fly
cell projection assembly	GO:0030031	94	0.050
lipid biosynthetic process	GO:0008610	46	0.049
heart morphogenesis	GO:0003007	32	0.049
appendage morphogenesis	GO:0035107	397	0.049
establishment of cell polarity	GO:0030010	40	0.048
regulation of cellular protein metabolic process	GO:0032268	243	0.048
regulation of protein complex assembly	GO:0043254	42	0.047	Fly
catabolic process	GO:0009056	409	0.047	Worm
stem cell differentiation	GO:0048863	117	0.047
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.046
secretion	GO:0046903	109	0.046
extrinsic apoptotic signaling pathway	GO:0097191	1	0.045	Mouse
peptidyl amino acid modification	GO:0018193	105	0.045
cellular protein modification process	GO:0006464	438	0.044
cellular lipid metabolic process	GO:0044255	83	0.044
branching morphogenesis of an epithelial tube	GO:0048754	45	0.044
dendrite morphogenesis	GO:0048813	199	0.044
organic hydroxy compound metabolic process	GO:1901615	83	0.044
genitalia development	GO:0048806	26	0.043	Worm
negative regulation of cellular biosynthetic process	GO:0031327	277	0.043
establishment of protein localization to organelle	GO:0072594	62	0.043	Mouse
regulation of embryonic development	GO:0045995	68	0.043
regulation of cellular ketone metabolic process	GO:0010565	3	0.043
regulation of cellular component size	GO:0032535	98	0.043	Fly
positive regulation of protein modification process	GO:0031401	58	0.042
establishment of nucleus localization	GO:0040023	26	0.042
negative regulation of cellular protein metabolic process	GO:0032269	85	0.041
positive regulation of transport	GO:0051050	92	0.041
meiotic cell cycle	GO:0051321	171	0.041	Worm
small gtpase mediated signal transduction	GO:0007264	88	0.041
negative regulation of apoptotic signaling pathway	GO:2001234	5	0.041	Mouse
negative regulation of cell proliferation	GO:0008285	69	0.041
cell fate determination	GO:0001709	91	0.040
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.040
epithelial cell development	GO:0002064	274	0.040
oocyte dorsal ventral axis specification	GO:0007310	34	0.040
compound eye photoreceptor development	GO:0042051	78	0.039
regulation of cytoskeleton organization	GO:0051493	89	0.039	Fly
mrna transport	GO:0051028	15	0.039
carboxylic acid metabolic process	GO:0019752	92	0.039
multicellular organism growth	GO:0035264	46	0.038	Worm
regulation of protein modification process	GO:0031399	112	0.038
cellular macromolecule catabolic process	GO:0044265	136	0.038
regulation of catabolic process	GO:0009894	170	0.037
cytoskeleton dependent intracellular transport	GO:0030705	44	0.037
organelle assembly	GO:0070925	198	0.036	Worm
ovarian follicle cell migration	GO:0007297	121	0.035
sperm individualization	GO:0007291	48	0.034
regulation of protein export from nucleus	GO:0046825	3	0.034
single organism carbohydrate metabolic process	GO:0044723	72	0.034
morphogenesis of follicular epithelium	GO:0016333	36	0.034
response to organic cyclic compound	GO:0014070	89	0.034
regulation of secretion	GO:0051046	44	0.033
positive regulation of cell differentiation	GO:0045597	64	0.033
response to bacterium	GO:0009617	198	0.033
dna templated transcriptional preinitiation complex assembly	GO:0070897	20	0.033
negative regulation of rna metabolic process	GO:0051253	251	0.033
regulation of cell cycle g1 s phase transition	GO:1902806	23	0.032
regulation of microtubule based process	GO:0032886	49	0.032
negative regulation of dendrite morphogenesis	GO:0050774	2	0.031
vesicle mediated transport	GO:0016192	381	0.031	Worm
biological adhesion	GO:0022610	138	0.031
regulation of cellular amino acid metabolic process	GO:0006521	0	0.031
positive regulation of organelle organization	GO:0010638	65	0.031
negative regulation of protein metabolic process	GO:0051248	85	0.031
regulation of actin filament based process	GO:0032970	42	0.031	Fly
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.030
intracellular signal transduction	GO:0035556	300	0.030
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.030
positive regulation of intracellular transport	GO:0032388	42	0.029
mitotic spindle organization	GO:0007052	220	0.029
cellular ketone metabolic process	GO:0042180	24	0.029
negative regulation of cell development	GO:0010721	62	0.029
regulation of phosphatase activity	GO:0010921	3	0.029
nuclear division	GO:0000280	332	0.029	Worm
response to nitrogen compound	GO:1901698	90	0.028
regulation of dendrite morphogenesis	GO:0048814	28	0.028
positive regulation of cellular protein metabolic process	GO:0032270	118	0.028
actomyosin structure organization	GO:0031032	56	0.027	Worm
cell fate specification	GO:0001708	71	0.027
response to alcohol	GO:0097305	95	0.027
stress activated mapk cascade	GO:0051403	52	0.026
histone modification	GO:0016570	106	0.026
organophosphate metabolic process	GO:0019637	195	0.026
regulation of dna templated transcription elongation	GO:0032784	17	0.026
macroautophagy	GO:0016236	42	0.026
signal transduction by phosphorylation	GO:0023014	107	0.026
regulation of phosphorylation	GO:0042325	147	0.026
negative regulation of biosynthetic process	GO:0009890	277	0.026
macromolecular complex assembly	GO:0065003	256	0.026	Worm Fly
defense response	GO:0006952	300	0.025
programmed cell death	GO:0012501	257	0.025	Mouse
negative regulation of cell communication	GO:0010648	223	0.025	Mouse
epidermis development	GO:0008544	65	0.025
maintenance of location	GO:0051235	73	0.025
establishment of spindle orientation	GO:0051294	18	0.025
positive regulation of intracellular signal transduction	GO:1902533	116	0.025
single organism catabolic process	GO:0044712	228	0.025
immune system development	GO:0002520	57	0.025
anatomical structure homeostasis	GO:0060249	97	0.024
response to biotic stimulus	GO:0009607	294	0.024
cellular response to organic substance	GO:0071310	132	0.023
regulation of cell projection organization	GO:0031344	92	0.023
protein catabolic process	GO:0030163	101	0.023	Worm
regulation of multi organism process	GO:0043900	131	0.023
regulation of protein stability	GO:0031647	43	0.023
cellular response to decreased oxygen levels	GO:0036294	30	0.023	Human
negative regulation of cell death	GO:0060548	81	0.023	Mouse
positive regulation of cell death	GO:0010942	69	0.023
response to decreased oxygen levels	GO:0036293	58	0.023	Human
imaginal disc derived wing morphogenesis	GO:0007476	337	0.022
protein complex biogenesis	GO:0070271	201	0.022	Worm Fly
vesicle organization	GO:0016050	44	0.022
small molecule biosynthetic process	GO:0044283	37	0.022
modification dependent protein catabolic process	GO:0019941	78	0.022
positive regulation of cellular component organization	GO:0051130	156	0.022
regulation of meiosis	GO:0040020	3	0.022
membrane disassembly	GO:0030397	4	0.022
negative regulation of multicellular organismal process	GO:0051241	142	0.022
regulation of actin cytoskeleton organization	GO:0032956	42	0.021	Fly
regulation of molecular function	GO:0065009	217	0.021
cellular response to external stimulus	GO:0071496	66	0.021
meiotic cell cycle process	GO:1903046	132	0.021
cell motility	GO:0048870	251	0.021	Mouse
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.020
rhabdomere development	GO:0042052	38	0.020
regulation of reproductive process	GO:2000241	54	0.020
fusome organization	GO:0045478	13	0.020
smad protein import into nucleus	GO:0007184	11	0.020
ribonucleoprotein complex biogenesis	GO:0022613	31	0.020
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.020
regulation of epidermal cell differentiation	GO:0045604	3	0.020
organic acid metabolic process	GO:0006082	103	0.020
gene silencing by mirna	GO:0035195	22	0.019
negative regulation of cell cycle	GO:0045786	116	0.019	Worm
dorsal ventral axis specification	GO:0009950	66	0.019
regulation of apoptotic process	GO:0042981	130	0.019	Mouse
posttranscriptional gene silencing	GO:0016441	46	0.019
posttranscriptional gene silencing by rna	GO:0035194	45	0.019
ribonucleoprotein complex subunit organization	GO:0071826	28	0.019
salivary gland morphogenesis	GO:0007435	145	0.019
rna polymerase ii transcriptional preinitiation complex assembly	GO:0051123	20	0.019
regulation of neuron projection development	GO:0010975	69	0.019
cellular response to organic cyclic compound	GO:0071407	32	0.018
secretion by cell	GO:0032940	101	0.018
oxoacid metabolic process	GO:0043436	103	0.018
peptidyl lysine acetylation	GO:0018394	39	0.018
regulation of circadian rhythm	GO:0042752	49	0.018
internal protein amino acid acetylation	GO:0006475	38	0.018
post embryonic appendage morphogenesis	GO:0035120	385	0.018
response to extracellular stimulus	GO:0009991	116	0.018
negative regulation of autophagy	GO:0010507	16	0.018
negative regulation of neurogenesis	GO:0050768	53	0.017
peptidyl lysine modification	GO:0018205	57	0.017
neuromuscular synaptic transmission	GO:0007274	67	0.017
embryonic organ development	GO:0048568	50	0.017
neuron migration	GO:0001764	5	0.017
jnk cascade	GO:0007254	50	0.016
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	4	0.016
establishment of mitotic spindle localization	GO:0040001	17	0.016
ovarian fusome organization	GO:0030723	11	0.016
cellular catabolic process	GO:0044248	372	0.016
negative regulation of apoptotic process	GO:0043066	63	0.016	Mouse
notch signaling pathway	GO:0007219	120	0.016
regulation of response to external stimulus	GO:0032101	115	0.016
cellular carbohydrate metabolic process	GO:0044262	22	0.016
nucleobase containing compound catabolic process	GO:0034655	165	0.016
border follicle cell migration	GO:0007298	113	0.016
regulation of macroautophagy	GO:0016241	15	0.016
regulation of synapse assembly	GO:0051963	94	0.016
response to oxygen containing compound	GO:1901700	200	0.015
mitotic cell cycle embryonic	GO:0045448	38	0.015
regulation of phosphorus metabolic process	GO:0051174	210	0.015
positive regulation of apoptotic process	GO:0043065	47	0.015
rna interference	GO:0016246	27	0.015
single organism membrane organization	GO:0044802	93	0.015
internal peptidyl lysine acetylation	GO:0018393	38	0.015
regulation of organ growth	GO:0046620	42	0.015
nucleic acid transport	GO:0050657	46	0.015
regulation of stress activated mapk cascade	GO:0032872	41	0.015
response to abiotic stimulus	GO:0009628	341	0.015	Human
cellular amine metabolic process	GO:0044106	12	0.015
oviposition	GO:0018991	19	0.015	Worm
membrane organization	GO:0061024	112	0.015
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.014	Mouse
positive regulation of protein transport	GO:0051222	37	0.014
ovarian follicle cell development	GO:0030707	248	0.014
positive regulation of phosphate metabolic process	GO:0045937	139	0.014
cellular response to oxygen levels	GO:0071453	30	0.014	Human
cellular response to organonitrogen compound	GO:0071417	36	0.014

Lam disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
muscular disease	DOID:0080000	0.165	Human
disease of anatomical entity	DOID:7	0.165	Human
musculoskeletal system disease	DOID:17	0.165	Human
muscle tissue disease	DOID:66	0.165	Human
myopathy	DOID:423	0.141	Human
central nervous system disease	DOID:331	0.064
neurodegenerative disease	DOID:1289	0.064
nervous system disease	DOID:863	0.064	Human
motor neuron disease	DOID:231	0.064

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network