IMP: Integrative Multi-species Prediction

Drosophila melanogaster

216 known processes

Dcr-2 (Dmel_CG6493)

Dicer-2

(Aliases: dicer,Dcr2,dcr2,DCR-2,DCR2,dicer2,Dmel\CG6493,dcr-2,Dicer,cg6493,DICER,CG6493)

Entrez: 36993
FLYBASE: FBgn0034246
UniProtKB: A1ZAW0

Process Predictions
Disease Predictions

Dcr-2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
defense response	GO:0006952	300	0.991
rhythmic process	GO:0048511	106	0.990
circadian rhythm	GO:0007623	105	0.987
locomotory behavior	GO:0007626	176	0.987
cognition	GO:0050890	141	0.983
epithelial cell differentiation	GO:0030855	322	0.978
immune system process	GO:0002376	347	0.972
single organism behavior	GO:0044708	391	0.954
regulation of anatomical structure morphogenesis	GO:0022603	242	0.949
actin filament based process	GO:0030029	220	0.898
circadian behavior	GO:0048512	76	0.897
autophagy	GO:0006914	108	0.886
imaginal disc derived wing morphogenesis	GO:0007476	337	0.885
epithelial cell development	GO:0002064	274	0.873
innate immune response	GO:0045087	144	0.868
cellular response to dna damage stimulus	GO:0006974	223	0.867
nuclear division	GO:0000280	332	0.855
catabolic process	GO:0009056	409	0.855
multi organism reproductive behavior	GO:0044705	121	0.854
macromolecule catabolic process	GO:0009057	161	0.853
muscle structure development	GO:0061061	224	0.850
negative regulation of signaling	GO:0023057	219	0.844
cellular catabolic process	GO:0044248	372	0.840
organelle fission	GO:0048285	340	0.830
positive regulation of cellular biosynthetic process	GO:0031328	316	0.829
regulation of cytoskeleton organization	GO:0051493	89	0.821
regulation of anatomical structure size	GO:0090066	163	0.813
synaptic transmission	GO:0007268	288	0.810
mitochondrion organization	GO:0007005	65	0.806
embryo development ending in birth or egg hatching	GO:0009792	152	0.806
response to bacterium	GO:0009617	198	0.801
regulation of cellular component size	GO:0032535	98	0.799
mating behavior	GO:0007617	106	0.796
regionalization	GO:0003002	416	0.792	Fly
response to organic cyclic compound	GO:0014070	89	0.753
actomyosin structure organization	GO:0031032	56	0.753
regulation of catabolic process	GO:0009894	170	0.723
immune response	GO:0006955	246	0.720
negative regulation of cell communication	GO:0010648	223	0.719
learning or memory	GO:0007611	141	0.718
cellular component assembly involved in morphogenesis	GO:0010927	151	0.709
regulation of organelle organization	GO:0033043	196	0.698
muscle cell differentiation	GO:0042692	103	0.666
somatic muscle development	GO:0007525	66	0.663
regulation of endopeptidase activity	GO:0052548	36	0.654
wing disc morphogenesis	GO:0007472	344	0.649
muscle cell development	GO:0055001	50	0.641
regulation of transport	GO:0051049	181	0.630
regulation of gene expression epigenetic	GO:0040029	128	0.602
neuromuscular synaptic transmission	GO:0007274	67	0.600
protein complex biogenesis	GO:0070271	201	0.599
meiotic cell cycle	GO:0051321	171	0.598
gene silencing	GO:0016458	138	0.593
aging	GO:0007568	143	0.588
regulation of cellular catabolic process	GO:0031329	157	0.584
regulation of protein metabolic process	GO:0051246	256	0.568
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	25	0.566
sleep	GO:0030431	49	0.565
negative regulation of cellular component organization	GO:0051129	108	0.560
secretion by cell	GO:0032940	101	0.555
secretion	GO:0046903	109	0.553
imaginal disc derived wing hair organization	GO:0035317	45	0.534
regulation of cellular localization	GO:0060341	136	0.531
response to inorganic substance	GO:0010035	44	0.526
regulation of response to stress	GO:0080134	200	0.524
negative regulation of response to stimulus	GO:0048585	258	0.524
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.520
negative regulation of gene expression	GO:0010629	387	0.516
embryonic development via the syncytial blastoderm	GO:0001700	148	0.503
response to oxidative stress	GO:0006979	86	0.498
meiotic nuclear division	GO:0007126	151	0.496
striated muscle cell differentiation	GO:0051146	90	0.495
short term memory	GO:0007614	19	0.495
regulation of behavior	GO:0050795	75	0.494
regulation of catalytic activity	GO:0050790	185	0.493
developmental growth	GO:0048589	280	0.488
neuron projection guidance	GO:0097485	241	0.487
negative regulation of signal transduction	GO:0009968	206	0.482
post embryonic appendage morphogenesis	GO:0035120	385	0.478
organic substance catabolic process	GO:1901575	308	0.478
positive regulation of catabolic process	GO:0009896	105	0.476
regulation of cellular component biogenesis	GO:0044087	201	0.471
cellular protein modification process	GO:0006464	438	0.468
intracellular signal transduction	GO:0035556	300	0.459
regulation of defense response to virus by host	GO:0050691	10	0.459
positive regulation of cellular catabolic process	GO:0031331	95	0.457
epithelial cell migration	GO:0010631	148	0.457
immune system development	GO:0002520	57	0.448
heterocycle catabolic process	GO:0046700	166	0.447
regulation of phosphate metabolic process	GO:0019220	210	0.439
hair cell differentiation	GO:0035315	47	0.435
ovarian follicle cell development	GO:0030707	248	0.435
myofibril assembly	GO:0030239	36	0.433
regulation of proteolysis	GO:0030162	87	0.432
male mating behavior	GO:0060179	70	0.418
negative regulation of programmed cell death	GO:0043069	72	0.415
circadian sleep wake cycle sleep	GO:0050802	23	0.414
actin cytoskeleton organization	GO:0030036	206	0.410
actin filament organization	GO:0007015	126	0.406
regulation of phosphorus metabolic process	GO:0051174	210	0.404
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.403
dna metabolic process	GO:0006259	227	0.399
posttranscriptional regulation of gene expression	GO:0010608	145	0.399
response to virus	GO:0009615	28	0.380
positive regulation of proteolysis	GO:0045862	52	0.380
regulation of secretion by cell	GO:1903530	39	0.376
cellular response to starvation	GO:0009267	61	0.376
response to organic substance	GO:0010033	284	0.373
single organism cellular localization	GO:1902580	180	0.371
protein localization	GO:0008104	284	0.364
regulation of actin filament length	GO:0030832	27	0.361
appendage morphogenesis	GO:0035107	397	0.350
regulation of secretion	GO:0051046	44	0.348
larval development	GO:0002164	104	0.345
axon development	GO:0061564	297	0.342
cellular macromolecule localization	GO:0070727	220	0.339
dendrite morphogenesis	GO:0048813	199	0.337	Fly
heart development	GO:0007507	82	0.336
sarcomere organization	GO:0045214	26	0.336
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.334
single organism catabolic process	GO:0044712	228	0.333
cation transport	GO:0006812	110	0.332
establishment of localization in cell	GO:0051649	402	0.329
regulation of cell differentiation	GO:0045595	302	0.327
regulation of molecular function	GO:0065009	217	0.322
regulation of ion transport	GO:0043269	39	0.320
cell motility	GO:0048870	251	0.320
response to nitrogen compound	GO:1901698	90	0.312
response to other organism	GO:0051707	293	0.307
wound healing	GO:0042060	75	0.307
multicellular organismal reproductive behavior	GO:0033057	110	0.304
defense response to other organism	GO:0098542	225	0.304
macroautophagy	GO:0016236	42	0.302
regulation of protein modification process	GO:0031399	112	0.301
regulation of peptidase activity	GO:0052547	39	0.298
hematopoietic or lymphoid organ development	GO:0048534	57	0.293
chemical homeostasis	GO:0048878	92	0.292
carbohydrate metabolic process	GO:0005975	82	0.290
morphogenesis of an epithelium	GO:0002009	276	0.289
chromosome segregation	GO:0007059	157	0.287
carbohydrate derivative metabolic process	GO:1901135	217	0.285
response to extracellular stimulus	GO:0009991	116	0.284	Fly
ion transmembrane transport	GO:0034220	122	0.282
nucleobase containing compound catabolic process	GO:0034655	165	0.281
response to nutrient levels	GO:0031667	114	0.279	Fly
locomotor rhythm	GO:0045475	56	0.278
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.278
defense response to bacterium	GO:0042742	178	0.276
protein modification process	GO:0036211	438	0.275
regulation of response to external stimulus	GO:0032101	115	0.270
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.267
carboxylic acid metabolic process	GO:0019752	92	0.266
hemopoiesis	GO:0030097	46	0.264
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.257
cardiovascular system development	GO:0072358	82	0.256
single organism carbohydrate metabolic process	GO:0044723	72	0.254
response to oxygen containing compound	GO:1901700	200	0.250
chemotaxis	GO:0006935	249	0.248
extracellular structure organization	GO:0043062	46	0.246
tube development	GO:0035295	244	0.236
endocytosis	GO:0006897	310	0.235
mitochondrial fission	GO:0000266	8	0.233
regulation of dendrite morphogenesis	GO:0048814	28	0.231
determination of adult lifespan	GO:0008340	137	0.227
cellular protein localization	GO:0034613	160	0.226
neuron maturation	GO:0042551	31	0.225
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.224
reproductive behavior	GO:0019098	122	0.224
columnar cuboidal epithelial cell development	GO:0002066	249	0.224
meiotic cell cycle process	GO:1903046	132	0.223
macromolecular complex assembly	GO:0065003	256	0.223
tissue morphogenesis	GO:0048729	297	0.223
positive regulation of developmental growth	GO:0048639	62	0.222
synapse organization	GO:0050808	196	0.219
regulation of cellular protein metabolic process	GO:0032268	243	0.217
adult behavior	GO:0030534	137	0.216
multicellular organismal aging	GO:0010259	140	0.214
protein localization to organelle	GO:0033365	82	0.211
muscle organ development	GO:0007517	127	0.209
positive regulation of response to stimulus	GO:0048584	323	0.206
positive regulation of signaling	GO:0023056	243	0.206
protein complex assembly	GO:0006461	200	0.205
regulation of actin filament based process	GO:0032970	42	0.205
regulation of cell death	GO:0010941	173	0.205
regulation of apoptotic process	GO:0042981	130	0.203
neurological system process	GO:0050877	358	0.202
spermatogenesis	GO:0007283	200	0.201
imaginal disc derived appendage development	GO:0048737	399	0.201
translation	GO:0006412	69	0.200
regulation of autophagy	GO:0010506	62	0.200
regulation of synaptic transmission	GO:0050804	69	0.197
cellular nitrogen compound catabolic process	GO:0044270	165	0.197
positive regulation of cell communication	GO:0010647	250	0.197
defense response to gram negative bacterium	GO:0050829	94	0.196
ribonucleoside catabolic process	GO:0042454	112	0.196
response to metal ion	GO:0010038	23	0.189
dephosphorylation	GO:0016311	51	0.185
spermatid development	GO:0007286	98	0.184
regulation of cysteine type endopeptidase activity	GO:2000116	27	0.183
regulation of innate immune response	GO:0045088	71	0.180
ribonucleotide catabolic process	GO:0009261	109	0.180
cellular protein complex assembly	GO:0043623	71	0.179
positive regulation of immune system process	GO:0002684	68	0.176
multi organism behavior	GO:0051705	175	0.175
response to radiation	GO:0009314	155	0.175
negative regulation of catalytic activity	GO:0043086	42	0.173
posttranscriptional gene silencing	GO:0016441	46	0.170
regulation of defense response	GO:0031347	102	0.169
organophosphate metabolic process	GO:0019637	195	0.169
nucleoside triphosphate catabolic process	GO:0009143	108	0.168
cellular response to organic substance	GO:0071310	132	0.165
reactive oxygen species metabolic process	GO:0072593	22	0.163
non sensory hair organization	GO:0035316	47	0.161
circulatory system development	GO:0072359	82	0.161
positive regulation of jun kinase activity	GO:0043507	4	0.160
rhythmic behavior	GO:0007622	76	0.159
eye development	GO:0001654	323	0.158
positive regulation of developmental process	GO:0051094	143	0.156
negative regulation of apoptotic process	GO:0043066	63	0.155
regulation of intracellular signal transduction	GO:1902531	236	0.155
dendrite development	GO:0016358	204	0.152	Fly
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.150
cellular response to nutrient levels	GO:0031669	62	0.148
sperm individualization	GO:0007291	48	0.144
homeostatic process	GO:0042592	199	0.143
defense response to virus	GO:0051607	23	0.141
purine containing compound catabolic process	GO:0072523	112	0.140
regulation of neurotransmitter levels	GO:0001505	38	0.137
negative regulation of cellular response to oxidative stress	GO:1900408	1	0.137
head involution	GO:0008258	35	0.136
actin filament polymerization	GO:0030041	27	0.132
regulation of synapse structural plasticity	GO:0051823	3	0.128
cortical cytoskeleton organization	GO:0030865	29	0.128
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.127
positive regulation of protein transport	GO:0051222	37	0.126
cellularization	GO:0007349	90	0.125	Fly
mating	GO:0007618	120	0.125
cation transmembrane transport	GO:0098655	88	0.124
purine ribonucleoside metabolic process	GO:0046128	127	0.122
immune effector process	GO:0002252	98	0.121
apical constriction involved in gastrulation	GO:0003384	7	0.121
signal transduction by phosphorylation	GO:0023014	107	0.121
epidermal cell differentiation	GO:0009913	51	0.119
ion transport	GO:0006811	145	0.118
regulation of neuron projection development	GO:0010975	69	0.118
apoptotic process	GO:0006915	159	0.116
positive regulation of biosynthetic process	GO:0009891	316	0.115
syncytium formation	GO:0006949	43	0.115
single organism biosynthetic process	GO:0044711	206	0.114
response to external biotic stimulus	GO:0043207	293	0.113
regulation of developmental growth	GO:0048638	174	0.112
establishment of tissue polarity	GO:0007164	87	0.111
protein phosphorylation	GO:0006468	169	0.111
female meiotic division	GO:0007143	70	0.110
positive regulation of hydrolase activity	GO:0051345	78	0.109
anatomical structure homeostasis	GO:0060249	97	0.105
positive regulation of peptidase activity	GO:0010952	29	0.104
myoblast fusion	GO:0007520	43	0.104
body morphogenesis	GO:0010171	2	0.103
transmembrane transport	GO:0055085	139	0.102
posttranscriptional gene silencing by rna	GO:0035194	45	0.102
organonitrogen compound metabolic process	GO:1901564	318	0.101
protein catabolic process	GO:0030163	101	0.099
organic substance transport	GO:0071702	257	0.098
positive regulation of multicellular organismal process	GO:0051240	143	0.098
regulation of reactive oxygen species metabolic process	GO:2000377	8	0.097
regulation of mitochondrion organization	GO:0010821	12	0.097
regulation of cell projection organization	GO:0031344	92	0.097
regulation of growth	GO:0040008	233	0.096
positive regulation of catalytic activity	GO:0043085	118	0.095
regulation of hemocyte proliferation	GO:0035206	37	0.094
regulation of organ morphogenesis	GO:2000027	78	0.092
positive regulation of molecular function	GO:0044093	136	0.092
regulation of programmed cell death	GO:0043067	152	0.092
transcription from rna polymerase ii promoter	GO:0006366	368	0.091
establishment of protein localization to organelle	GO:0072594	62	0.090
positive regulation of cellular component biogenesis	GO:0044089	80	0.089
negative regulation of cellular metabolic process	GO:0031324	382	0.088
response to wounding	GO:0009611	94	0.088
male gamete generation	GO:0048232	201	0.088
sensory perception	GO:0007600	196	0.088
regulation of neuron differentiation	GO:0045664	103	0.088
multi multicellular organism process	GO:0044706	123	0.088
positive regulation of protein phosphorylation	GO:0001934	34	0.087
organelle assembly	GO:0070925	198	0.086
negative regulation of molecular function	GO:0044092	51	0.086
localization of cell	GO:0051674	257	0.085
positive regulation of behavior	GO:0048520	19	0.084
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.082
positive regulation of phosphorus metabolic process	GO:0010562	139	0.082
regulation of synapse organization	GO:0050807	110	0.081
cellular response to oxygen containing compound	GO:1901701	79	0.080
cellular amino acid metabolic process	GO:0006520	61	0.079
peptidyl tyrosine modification	GO:0018212	24	0.079
positive regulation of protein metabolic process	GO:0051247	128	0.079
positive regulation of reactive oxygen species metabolic process	GO:2000379	0	0.079
response to osmotic stress	GO:0006970	14	0.078
appendage development	GO:0048736	401	0.078
spermatid differentiation	GO:0048515	114	0.078
positive regulation of gene expression	GO:0010628	290	0.078
nitrogen compound transport	GO:0071705	85	0.077
purine ribonucleotide catabolic process	GO:0009154	109	0.077
response to biotic stimulus	GO:0009607	294	0.077
mitochondrion degradation	GO:0000422	8	0.076
mapk cascade	GO:0000165	107	0.076
regulation of immune system process	GO:0002682	176	0.076
negative regulation of cellular protein metabolic process	GO:0032269	85	0.075
positive regulation of growth	GO:0045927	75	0.074
ribose phosphate metabolic process	GO:0019693	145	0.074
protein transport	GO:0015031	155	0.073
positive regulation of immune response	GO:0050778	63	0.073
cytokinetic process	GO:0032506	27	0.072
response to starvation	GO:0042594	97	0.071	Fly
regulation of cell shape	GO:0008360	113	0.070
regulation of protein localization to nucleus	GO:1900180	29	0.070
positive regulation of cellular protein metabolic process	GO:0032270	118	0.070
collateral sprouting	GO:0048668	3	0.069
skin development	GO:0043588	65	0.069
regulation of synapse structure and activity	GO:0050803	128	0.069
cell growth	GO:0016049	108	0.068
pigmentation	GO:0043473	75	0.068
eye morphogenesis	GO:0048592	260	0.068
neuromuscular junction development	GO:0007528	149	0.067
cell maturation	GO:0048469	144	0.066
purine nucleotide catabolic process	GO:0006195	109	0.066
negative regulation of gene expression epigenetic	GO:0045814	77	0.065
inositol lipid mediated signaling	GO:0048017	4	0.065
eggshell formation	GO:0030703	105	0.064
programmed cell death	GO:0012501	257	0.063
negative regulation of protein metabolic process	GO:0051248	85	0.063
growth	GO:0040007	359	0.062
gene silencing by rna	GO:0031047	57	0.062
regulation of phosphorylation	GO:0042325	147	0.062
cell division	GO:0051301	248	0.061	Fly
memory	GO:0007613	94	0.061
negative regulation of multicellular organismal process	GO:0051241	142	0.061
muscle attachment	GO:0016203	36	0.061
lipid metabolic process	GO:0006629	121	0.060
head development	GO:0060322	135	0.059
positive regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032436	19	0.059
negative regulation of neuron apoptotic process	GO:0043524	14	0.057
protein localization to nucleus	GO:0034504	55	0.057
learning	GO:0007612	75	0.056
cellular macromolecular complex assembly	GO:0034622	153	0.056
developmental cell growth	GO:0048588	52	0.056
epithelium migration	GO:0090132	148	0.056
adult locomotory behavior	GO:0008344	76	0.056
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.056
regulation of macroautophagy	GO:0016241	15	0.055
regulation of nervous system development	GO:0051960	248	0.055
chromatin organization	GO:0006325	207	0.055
compound eye morphogenesis	GO:0001745	249	0.054
regulation of phosphatidylinositol 3 kinase activity	GO:0043551	2	0.054
regulation of transferase activity	GO:0051338	58	0.054
actin polymerization or depolymerization	GO:0008154	31	0.054
mitochondrial fusion	GO:0008053	7	0.053
cellular response to metal ion	GO:0071248	6	0.053
cellular lipid metabolic process	GO:0044255	83	0.052
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.052
protein dephosphorylation	GO:0006470	27	0.051
regulation of apoptotic signaling pathway	GO:2001233	10	0.051
intracellular transport	GO:0046907	228	0.051
cellular response to extracellular stimulus	GO:0031668	64	0.050
cellular amine metabolic process	GO:0044106	12	0.050
digestive system development	GO:0055123	149	0.049
positive regulation of synapse assembly	GO:0051965	29	0.049
regulation of actin cytoskeleton organization	GO:0032956	42	0.049
aromatic compound catabolic process	GO:0019439	166	0.048
positive regulation of cellular component organization	GO:0051130	156	0.048
positive regulation of phosphate metabolic process	GO:0045937	139	0.048
cellular response to external stimulus	GO:0071496	66	0.048
telencephalon development	GO:0021537	2	0.047
morphogenesis of a branching structure	GO:0001763	45	0.047
behavioral response to ethanol	GO:0048149	49	0.047
negative regulation of cell death	GO:0060548	81	0.047
central nervous system development	GO:0007417	201	0.046
death	GO:0016265	284	0.046
oxoacid metabolic process	GO:0043436	103	0.046
meiotic cytokinesis	GO:0033206	33	0.045
gliogenesis	GO:0042063	80	0.045
molting cycle chitin based cuticle	GO:0007591	56	0.045
single organism membrane fusion	GO:0044801	42	0.045
neuron recognition	GO:0008038	101	0.045
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.044
single organism nuclear import	GO:1902593	51	0.044
humoral immune response	GO:0006959	117	0.044
cytokinetic cell separation	GO:0000920	1	0.043
positive regulation of intracellular signal transduction	GO:1902533	116	0.042
chromosome organization	GO:0051276	360	0.042
regulation of lipid kinase activity	GO:0043550	2	0.041
response to light stimulus	GO:0009416	124	0.041
camera type eye morphogenesis	GO:0048593	2	0.041
regulation of intracellular protein transport	GO:0033157	46	0.040
striated muscle cell development	GO:0055002	50	0.040
cell migration	GO:0016477	238	0.040
purine nucleotide metabolic process	GO:0006163	146	0.040
regulation of cell size	GO:0008361	63	0.040
activation of protein kinase activity	GO:0032147	12	0.039
positive regulation of nitric oxide biosynthetic process	GO:0045429	1	0.039
positive regulation of cell death	GO:0010942	69	0.038
positive regulation of lipid metabolic process	GO:0045834	4	0.038
positive regulation of macromolecule metabolic process	GO:0010604	405	0.038
muscle fiber development	GO:0048747	12	0.038
activation of innate immune response	GO:0002218	4	0.038
negative regulation of synaptic growth at neuromuscular junction	GO:0045886	39	0.038
purine ribonucleoside catabolic process	GO:0046130	112	0.037
germ line cyst formation	GO:0048134	44	0.037	Fly
skeletal muscle organ development	GO:0060538	48	0.037
semaphorin plexin signaling pathway	GO:0071526	4	0.037
signal release	GO:0023061	49	0.036
establishment of protein localization	GO:0045184	163	0.036
regulation of metal ion transport	GO:0010959	15	0.036
brain development	GO:0007420	120	0.036
nucleoside metabolic process	GO:0009116	127	0.036
negative regulation of organelle organization	GO:0010639	56	0.035
organophosphate catabolic process	GO:0046434	112	0.035
positive regulation of cysteine type endopeptidase activity	GO:2001056	24	0.035
actin mediated cell contraction	GO:0070252	21	0.035
regulation of hydrolase activity	GO:0051336	97	0.034
positive regulation of transport	GO:0051050	92	0.034
axon guidance	GO:0007411	233	0.034
vesicle mediated transport	GO:0016192	381	0.034
positive regulation of signal transduction	GO:0009967	223	0.033
regulation of kinase activity	GO:0043549	53	0.032
limb morphogenesis	GO:0035108	1	0.032
regulation of cell morphogenesis	GO:0022604	163	0.032
phagocytosis engulfment	GO:0006911	11	0.032
cell death	GO:0008219	279	0.032
purine containing compound metabolic process	GO:0072521	155	0.031
regulation of protein transport	GO:0051223	57	0.031
response to temperature stimulus	GO:0009266	106	0.031
ribonucleotide metabolic process	GO:0009259	145	0.031
regulation of cellular response to oxidative stress	GO:1900407	4	0.031
regulation of tube size	GO:0035150	46	0.031
synaptic transmission dopaminergic	GO:0001963	2	0.031
phosphorylation	GO:0016310	294	0.031
positive regulation of rna biosynthetic process	GO:1902680	266	0.031
actin filament depolymerization	GO:0030042	5	0.031
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.031
wnt signaling pathway planar cell polarity pathway	GO:0060071	6	0.031
negative regulation of neuromuscular synaptic transmission	GO:1900074	7	0.030
organic acid metabolic process	GO:0006082	103	0.030
cell recognition	GO:0008037	102	0.030
regulation of actin polymerization or depolymerization	GO:0008064	27	0.029
epidermis development	GO:0008544	65	0.029
nucleobase containing small molecule metabolic process	GO:0055086	174	0.029
signal transduction in response to dna damage	GO:0042770	3	0.029
response to abiotic stimulus	GO:0009628	341	0.028
chorion containing eggshell formation	GO:0007304	105	0.028
carbohydrate derivative biosynthetic process	GO:1901137	85	0.028
protein targeting to nucleus	GO:0044744	51	0.028
negative regulation of response to external stimulus	GO:0032102	22	0.028
positive regulation of synaptic growth at neuromuscular junction	GO:0045887	26	0.028
regulation of stress activated mapk cascade	GO:0032872	41	0.028
nucleoside phosphate metabolic process	GO:0006753	162	0.028
compound eye development	GO:0048749	307	0.028
cell type specific apoptotic process	GO:0097285	38	0.027
negative regulation of protein modification process	GO:0031400	29	0.027
nucleotide metabolic process	GO:0009117	161	0.027
regulation of protein kinase activity	GO:0045859	51	0.027
regulation of neurogenesis	GO:0050767	158	0.027
negative regulation of growth	GO:0045926	84	0.027
cellular response to chemical stimulus	GO:0070887	199	0.027
positive regulation of proteasomal protein catabolic process	GO:1901800	20	0.027
positive regulation of secretion by cell	GO:1903532	20	0.026
organic cyclic compound catabolic process	GO:1901361	168	0.026
regulation of multicellular organismal development	GO:2000026	414	0.026
stress activated mapk cascade	GO:0051403	52	0.026
sperm axoneme assembly	GO:0007288	13	0.026
male meiosis	GO:0007140	52	0.026
photoreceptor cell differentiation	GO:0046530	170	0.026
biological adhesion	GO:0022610	138	0.025
negative regulation of kinase activity	GO:0033673	16	0.025
lipid biosynthetic process	GO:0008610	46	0.025
actin filament bundle organization	GO:0061572	28	0.025
divalent inorganic cation homeostasis	GO:0072507	29	0.025
nucleocytoplasmic transport	GO:0006913	72	0.025
regulation of establishment of protein localization	GO:0070201	61	0.025
nucleoside phosphate catabolic process	GO:1901292	110	0.025
segmentation	GO:0035282	207	0.025	Fly
cellular response to organic cyclic compound	GO:0071407	32	0.025
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.025
response to endogenous stimulus	GO:0009719	119	0.024
single organism intracellular transport	GO:1902582	207	0.024
purine ribonucleoside monophosphate catabolic process	GO:0009169	38	0.024
sperm mitochondrion organization	GO:0030382	7	0.024
peripheral nervous system development	GO:0007422	52	0.024

Dcr-2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.208
cardiovascular system disease	DOID:1287	0.093
disease of metabolism	DOID:0014667	0.045
disease of cellular proliferation	DOID:14566	0.038
cancer	DOID:162	0.038
nervous system disease	DOID:863	0.025
neurodegenerative disease	DOID:1289	0.025
parkinson s disease	DOID:14330	0.025
central nervous system disease	DOID:331	0.025
synucleinopathy	DOID:0050890	0.025

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