IMP: Integrative Multi-species Prediction

Drosophila melanogaster

96 known processes

Tm1 (Dmel_CG4898)

Tropomyosin 1

(Aliases: TmH-33,2299,TMII,TmH-34,region 3,tmII,Tm,cTmII,cTm,l(3)02299,BcDNA:LD37158,BcDNA:GH09289,Dmel\CG4898,cTM,l(3)S130510,Dm TmH34,BcDNA:SD21996,1305/10,tm1,TnH-34,Dm TmH33,l(3)s2958,TmII,TnH-33,Dm Tm1,PmI,Tmr34,CG4898,tropomyosin,Tmr33,DmTm1,TmH33,mTmII,TmH34,TnH)

FLYBASE: FBgn0003721
Entrez: 41852
UniProtKB: P06754
UniProtKB: H1UUP7
UniProtKB: Q95TA3
UniProtKB: Q8IG84
UniProtKB: P49455
UniProtKB: Q8IGY1
UniProtKB: Q6NN28

Process Predictions
Disease Predictions

Tm1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
border follicle cell migration	GO:0007298	113	0.999
ovarian follicle cell migration	GO:0007297	121	0.997
localization of cell	GO:0051674	257	0.995	Rat
cell migration	GO:0016477	238	0.993	Rat
ameboidal type cell migration	GO:0001667	151	0.993
germ cell migration	GO:0008354	43	0.982
cell motility	GO:0048870	251	0.982	Rat
epithelial cell migration	GO:0010631	148	0.973
ovarian follicle cell development	GO:0030707	248	0.968
pole cell development	GO:0007277	26	0.952
epithelium migration	GO:0090132	148	0.936
epithelial cell development	GO:0002064	274	0.935
negative regulation of cellular metabolic process	GO:0031324	382	0.927
nucleus localization	GO:0051647	34	0.902
epithelial cell differentiation	GO:0030855	322	0.901
tissue migration	GO:0090130	155	0.893
pole plasm oskar mrna localization	GO:0045451	46	0.871
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.855
central nervous system development	GO:0007417	201	0.832	Rat
columnar cuboidal epithelial cell development	GO:0002066	249	0.785
pole plasm assembly	GO:0007315	61	0.735
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.693	Rat
chromosome organization	GO:0051276	360	0.682
cellular component assembly involved in morphogenesis	GO:0010927	151	0.618	Zebrafish
regionalization	GO:0003002	416	0.584
regulation of pole plasm oskar mrna localization	GO:0007317	27	0.584
intracellular mrna localization	GO:0008298	66	0.577
protein localization	GO:0008104	284	0.500
regulation of cellular amino acid metabolic process	GO:0006521	0	0.497
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.479
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.477
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.471
pole plasm mrna localization	GO:0019094	49	0.469
cell death	GO:0008219	279	0.465
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.448
negative regulation of rna biosynthetic process	GO:1902679	240	0.441
negative regulation of cellular biosynthetic process	GO:0031327	277	0.430
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.426
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.420
transcription from rna polymerase ii promoter	GO:0006366	368	0.409
cellular protein modification process	GO:0006464	438	0.405
organonitrogen compound metabolic process	GO:1901564	318	0.396	Rat
catabolic process	GO:0009056	409	0.388	Rat
brain development	GO:0007420	120	0.382	Rat
oocyte anterior posterior axis specification	GO:0007314	72	0.376
positive regulation of rna biosynthetic process	GO:1902680	266	0.372
death	GO:0016265	284	0.366
blastoderm segmentation	GO:0007350	159	0.362
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.361
axis specification	GO:0009798	167	0.336
maternal determination of anterior posterior axis embryo	GO:0008358	74	0.332
positive regulation of cellular biosynthetic process	GO:0031328	316	0.316
pole plasm rna localization	GO:0007316	52	0.313
negative regulation of gene expression	GO:0010629	387	0.313
regulation of oocyte development	GO:0060281	27	0.304
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.288
organelle localization	GO:0051640	148	0.274
regulation of embryonic development	GO:0045995	68	0.270
cellular macromolecule localization	GO:0070727	220	0.268
single organism behavior	GO:0044708	391	0.267
nucleotide metabolic process	GO:0009117	161	0.264	Rat
segmentation	GO:0035282	207	0.263
negative regulation of biosynthetic process	GO:0009890	277	0.261
nucleobase containing small molecule metabolic process	GO:0055086	174	0.261	Rat
regulation of embryonic pattern specification	GO:1902875	27	0.259
regulation of phosphate metabolic process	GO:0019220	210	0.253	Rat
positive regulation of rna metabolic process	GO:0051254	271	0.250
negative regulation of transcription dna templated	GO:0045892	237	0.248
programmed cell death	GO:0012501	257	0.244
regulation of multicellular organismal development	GO:2000026	414	0.239
apoptotic process	GO:0006915	159	0.238
negative regulation of cellular component organization	GO:0051129	108	0.233	Rat
ribonucleoside metabolic process	GO:0009119	127	0.231	Rat
respiratory system development	GO:0060541	213	0.209
oocyte construction	GO:0007308	112	0.206
regulation of cellular amine metabolic process	GO:0033238	3	0.203
pole cell formation	GO:0007279	19	0.197
cellular response to chemical stimulus	GO:0070887	199	0.196
cell maturation	GO:0048469	144	0.196
regulation of cellular ketone metabolic process	GO:0010565	3	0.190
head development	GO:0060322	135	0.188	Rat
developmental maturation	GO:0021700	172	0.180
chromatin organization	GO:0006325	207	0.179
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.175
oocyte development	GO:0048599	124	0.172
positive regulation of gene expression	GO:0010628	290	0.170
anterior posterior axis specification embryo	GO:0008595	103	0.169
anterior posterior pattern specification	GO:0009952	136	0.166
purine nucleoside catabolic process	GO:0006152	112	0.166	Rat
negative regulation of mitotic cell cycle	GO:0045930	109	0.164
pole plasm protein localization	GO:0007318	10	0.163
nuclear migration	GO:0007097	20	0.162
intracellular mrna localization involved in anterior posterior axis specification	GO:0060811	53	0.160
small molecule metabolic process	GO:0044281	305	0.160	Rat
innate immune response	GO:0045087	144	0.159
establishment of nucleus localization	GO:0040023	26	0.159
regulation of protein metabolic process	GO:0051246	256	0.157
positive regulation of macromolecule metabolic process	GO:0010604	405	0.157
establishment or maintenance of cytoskeleton polarity	GO:0030952	44	0.153
protein modification process	GO:0036211	438	0.150
carboxylic acid metabolic process	GO:0019752	92	0.142
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.141	Rat
cell division	GO:0051301	248	0.141
carbohydrate derivative metabolic process	GO:1901135	217	0.139	Rat
tripartite regional subdivision	GO:0007351	103	0.138
positive regulation of catalytic activity	GO:0043085	118	0.137	Rat
oocyte microtubule cytoskeleton polarization	GO:0008103	22	0.136
actin filament based movement	GO:0030048	26	0.132	Rat
positive regulation of cellular component organization	GO:0051130	156	0.132	Rat
intracellular transport	GO:0046907	228	0.129
organic substance catabolic process	GO:1901575	308	0.128	Rat
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.128	Rat
positive regulation of molecular function	GO:0044093	136	0.125	Rat
regulation of catalytic activity	GO:0050790	185	0.125	Rat
establishment of organelle localization	GO:0051656	122	0.123
embryonic pattern specification	GO:0009880	174	0.121
positive regulation of phosphate metabolic process	GO:0045937	139	0.119	Rat
digestive tract morphogenesis	GO:0048546	127	0.117
oocyte axis specification	GO:0007309	108	0.117
regulation of chromosome organization	GO:0033044	64	0.117
positive regulation of protein metabolic process	GO:0051247	128	0.117
establishment of localization in cell	GO:0051649	402	0.114
purine nucleotide metabolic process	GO:0006163	146	0.114	Rat
regulation of cellular component biogenesis	GO:0044087	201	0.113
cytoplasm organization	GO:0007028	64	0.113
purine ribonucleoside metabolic process	GO:0046128	127	0.112	Rat
ribonucleotide metabolic process	GO:0009259	145	0.112	Rat
regulation of localization	GO:0032879	275	0.112	Rat
biological adhesion	GO:0022610	138	0.108	Rat
anterior posterior axis specification	GO:0009948	109	0.107
axonogenesis	GO:0007409	290	0.106
chorion containing eggshell formation	GO:0007304	105	0.106
defense response	GO:0006952	300	0.104
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	41	0.102
nucleoside phosphate metabolic process	GO:0006753	162	0.102	Rat
cell cycle phase transition	GO:0044770	140	0.101
oocyte differentiation	GO:0009994	145	0.100
regulation of cellular protein metabolic process	GO:0032268	243	0.100
regulation of molecular function	GO:0065009	217	0.099	Rat
nucleotide catabolic process	GO:0009166	109	0.097	Rat
organic acid metabolic process	GO:0006082	103	0.096
response to abiotic stimulus	GO:0009628	341	0.095
cellular amine metabolic process	GO:0044106	12	0.092
rna localization	GO:0006403	115	0.091
neural precursor cell proliferation	GO:0061351	75	0.091
tissue morphogenesis	GO:0048729	297	0.089	Mouse
histone modification	GO:0016570	106	0.086
amine metabolic process	GO:0009308	12	0.086
positive regulation of cellular amine metabolic process	GO:0033240	0	0.086
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.086
purine ribonucleoside catabolic process	GO:0046130	112	0.085	Rat
single organism cell adhesion	GO:0098602	47	0.083
negative regulation of developmental process	GO:0051093	201	0.082
small gtpase mediated signal transduction	GO:0007264	88	0.082
positive regulation of biosynthetic process	GO:0009891	316	0.081
regulation of cell maturation	GO:1903429	27	0.079
response to radiation	GO:0009314	155	0.078
regulation of cellular catabolic process	GO:0031329	157	0.076	Rat
single organism cellular localization	GO:1902580	180	0.076
aromatic compound catabolic process	GO:0019439	166	0.074	Rat
cuticle development	GO:0042335	86	0.074
regulation of cell death	GO:0010941	173	0.073
morphogenesis of an epithelium	GO:0002009	276	0.073
positive regulation of cellular protein metabolic process	GO:0032270	118	0.072
nucleoside metabolic process	GO:0009116	127	0.071	Rat
cellular nitrogen compound catabolic process	GO:0044270	165	0.071	Rat
organelle fission	GO:0048285	340	0.070
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.070	Rat
stem cell differentiation	GO:0048863	117	0.069
regulation of cell differentiation	GO:0045595	302	0.068
positive regulation of reactive oxygen species metabolic process	GO:2000379	0	0.068
heterocycle catabolic process	GO:0046700	166	0.068	Rat
cellular response to dna damage stimulus	GO:0006974	223	0.067
cellularization	GO:0007349	90	0.066
purine ribonucleotide metabolic process	GO:0009150	145	0.065	Rat
regulation of hydrolase activity	GO:0051336	97	0.065	Rat
intracellular mrna localization involved in pattern specification process	GO:0060810	56	0.063
neurological system process	GO:0050877	358	0.062
dorsal appendage formation	GO:0046843	47	0.061
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	4	0.060
cell projection assembly	GO:0030031	94	0.059
chromosome segregation	GO:0007059	157	0.058
compound eye photoreceptor cell differentiation	GO:0001751	140	0.057
phenol containing compound metabolic process	GO:0018958	57	0.057
stem cell proliferation	GO:0072089	88	0.057
organophosphate catabolic process	GO:0046434	112	0.056	Rat
nucleoside catabolic process	GO:0009164	112	0.055	Rat
malpighian tubule morphogenesis	GO:0007443	44	0.055
ribonucleotide catabolic process	GO:0009261	109	0.054	Rat
regulation of nucleotide metabolic process	GO:0006140	62	0.054	Rat
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.053	Rat
instar larval development	GO:0002168	55	0.052
positive regulation of histone deacetylation	GO:0031065	2	0.052
negative regulation of rna metabolic process	GO:0051253	251	0.052
body morphogenesis	GO:0010171	2	0.052
regulation of organelle organization	GO:0033043	196	0.051	Rat
regulation of protein deacetylation	GO:0090311	2	0.051
meiotic cell cycle	GO:0051321	171	0.051
positive regulation of protein deacetylation	GO:0090312	2	0.049
cellular catabolic process	GO:0044248	372	0.049	Rat
positive regulation of transcription dna templated	GO:0045893	266	0.049
dna metabolic process	GO:0006259	227	0.048
regulation of multi organism process	GO:0043900	131	0.046
chemosensory behavior	GO:0007635	106	0.045
negative regulation of protein metabolic process	GO:0051248	85	0.045
negative regulation of cell death	GO:0060548	81	0.045
negative regulation of apoptotic process	GO:0043066	63	0.044
embryo development ending in birth or egg hatching	GO:0009792	152	0.044	Mouse
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.044
cellular response to organonitrogen compound	GO:0071417	36	0.043
regulation of protein complex assembly	GO:0043254	42	0.043	Rat
single organism catabolic process	GO:0044712	228	0.042	Rat
regulation of phosphorus metabolic process	GO:0051174	210	0.042	Rat
embryonic morphogenesis	GO:0048598	206	0.042
intracellular signal transduction	GO:0035556	300	0.041
molting cycle chitin based cuticle	GO:0007591	56	0.041
cellular response to organic substance	GO:0071310	132	0.040
microtubule organizing center organization	GO:0031023	168	0.040
regulation of protein modification process	GO:0031399	112	0.040
response to biotic stimulus	GO:0009607	294	0.039
purine nucleoside metabolic process	GO:0042278	127	0.039	Rat
negative regulation of cellular protein metabolic process	GO:0032269	85	0.039
photoreceptor cell development	GO:0042461	96	0.039
gastrulation	GO:0007369	70	0.039
embryonic axis specification	GO:0000578	107	0.039
carbohydrate derivative catabolic process	GO:1901136	118	0.038	Rat
stem cell development	GO:0048864	79	0.038
cellular ketone metabolic process	GO:0042180	24	0.038
phosphorylation	GO:0016310	294	0.038
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.037
cytoplasmic transport nurse cell to oocyte	GO:0007303	12	0.037
nuclear division	GO:0000280	332	0.036
regulation of cellular component movement	GO:0051270	42	0.036	Rat
cellular amino acid metabolic process	GO:0006520	61	0.036
response to light stimulus	GO:0009416	124	0.036
aggressive behavior	GO:0002118	63	0.036
organonitrogen compound catabolic process	GO:1901565	128	0.036	Rat
developmental growth involved in morphogenesis	GO:0060560	65	0.035
glycosyl compound metabolic process	GO:1901657	127	0.035	Rat
telencephalon development	GO:0021537	2	0.035
cardiovascular system development	GO:0072358	82	0.035	Zebrafish Mouse
meiotic cell cycle process	GO:1903046	132	0.035
ribose phosphate metabolic process	GO:0019693	145	0.034	Rat
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.034
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.034	Rat
multicellular organismal aging	GO:0010259	140	0.034
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.034	Rat
positive regulation of cellular component biogenesis	GO:0044089	80	0.034	Rat
mitotic cell cycle phase transition	GO:0044772	138	0.034
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.034
negative regulation of programmed cell death	GO:0043069	72	0.033
gastrulation involving germ band extension	GO:0010004	36	0.033
purine containing compound metabolic process	GO:0072521	155	0.033	Rat
regulation of endocytosis	GO:0030100	37	0.033
guanosine containing compound metabolic process	GO:1901068	74	0.033
chromatin modification	GO:0016568	147	0.033
organic substance transport	GO:0071702	257	0.032
cellular macromolecule catabolic process	GO:0044265	136	0.032
regulation of purine nucleotide metabolic process	GO:1900542	62	0.032	Rat
forebrain development	GO:0030900	2	0.032
immune system process	GO:0002376	347	0.032
immune response	GO:0006955	246	0.032
negative regulation of peptidyl tyrosine phosphorylation	GO:0050732	6	0.031
glial cell differentiation	GO:0010001	35	0.031
learning	GO:0007612	75	0.031
developmental cell growth	GO:0048588	52	0.031
vesicle mediated transport	GO:0016192	381	0.031
renal tubule development	GO:0061326	64	0.031
ribonucleoside catabolic process	GO:0042454	112	0.030	Rat
adult behavior	GO:0030534	137	0.030
regulation of protein localization	GO:0032880	76	0.030
regulation of peptidyl tyrosine phosphorylation	GO:0050730	10	0.029
neuroblast division	GO:0055057	35	0.029
nucleoside triphosphate catabolic process	GO:0009143	108	0.029	Rat
apical constriction	GO:0003383	18	0.029
nitrogen compound transport	GO:0071705	85	0.029
organophosphate metabolic process	GO:0019637	195	0.029	Rat
regulation of histone deacetylation	GO:0031063	2	0.029
purine containing compound catabolic process	GO:0072523	112	0.029	Rat
open tracheal system development	GO:0007424	204	0.029
rna processing	GO:0006396	147	0.028
developmental growth	GO:0048589	280	0.028
gtp catabolic process	GO:0006184	72	0.028
mitotic cell cycle checkpoint	GO:0007093	88	0.028
cell proliferation	GO:0008283	299	0.027
cellular response to organic cyclic compound	GO:0071407	32	0.027
connective tissue development	GO:0061448	3	0.027
negative regulation of cell cycle	GO:0045786	116	0.027
mushroom body development	GO:0016319	70	0.027
digestive tract development	GO:0048565	149	0.027
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.026	Rat
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.026	Rat
regulation of transport	GO:0051049	181	0.026
response to wounding	GO:0009611	94	0.026	Rat
cognition	GO:0050890	141	0.026
hindgut development	GO:0061525	58	0.026
regulation of growth	GO:0040008	233	0.026
compound eye development	GO:0048749	307	0.025
paracrine signaling	GO:0038001	7	0.025
single organismal cell cell adhesion	GO:0016337	45	0.025
establishment or maintenance of cell polarity	GO:0007163	167	0.025
protein targeting	GO:0006605	64	0.025
sex differentiation	GO:0007548	81	0.025
positive regulation of catabolic process	GO:0009896	105	0.025	Rat
centrosome cycle	GO:0007098	137	0.025
actin filament based process	GO:0030029	220	0.025	Zebrafish Rat
regulation of cell cycle	GO:0051726	291	0.024
cellular macromolecular complex assembly	GO:0034622	153	0.024	Rat
response to organonitrogen compound	GO:0010243	75	0.024
taxis	GO:0042330	304	0.024
negative regulation of phosphate metabolic process	GO:0045936	45	0.024
regulation of phosphorylation	GO:0042325	147	0.024
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.023
regulation of protein transport	GO:0051223	57	0.023
regulation of microtubule polymerization or depolymerization	GO:0031110	27	0.023
maintenance of location	GO:0051235	73	0.023
response to decreased oxygen levels	GO:0036293	58	0.023
nuclear import	GO:0051170	51	0.023
nucleoside monophosphate metabolic process	GO:0009123	52	0.023	Rat
regulation of catabolic process	GO:0009894	170	0.023	Rat
oxoacid metabolic process	GO:0043436	103	0.023
regulation of chromatin organization	GO:1902275	32	0.022
cytoplasmic transport	GO:0016482	130	0.022
negative regulation of microtubule depolymerization	GO:0007026	21	0.022
asymmetric stem cell division	GO:0098722	49	0.022
guanosine containing compound catabolic process	GO:1901069	74	0.022
organelle assembly	GO:0070925	198	0.022	Zebrafish
photoreceptor cell differentiation	GO:0046530	170	0.022
covalent chromatin modification	GO:0016569	106	0.022
macromolecule catabolic process	GO:0009057	161	0.022
circulatory system development	GO:0072359	82	0.022	Zebrafish Mouse
positive regulation of signaling	GO:0023056	243	0.022
positive regulation of cellular catabolic process	GO:0031331	95	0.021	Rat
positive regulation of organelle organization	GO:0010638	65	0.021	Rat
oocyte growth	GO:0001555	5	0.021
regulation of programmed cell death	GO:0043067	152	0.021
gastrulation with mouth forming first	GO:0001703	36	0.021
peptidyl tyrosine phosphorylation	GO:0018108	24	0.021
negative regulation of organelle organization	GO:0010639	56	0.021	Rat
cell fate determination	GO:0001709	91	0.021
germarium derived oocyte fate determination	GO:0007294	26	0.021
neuroblast proliferation	GO:0007405	74	0.021
positive regulation of phosphorus metabolic process	GO:0010562	139	0.021	Rat
actin mediated cell contraction	GO:0070252	21	0.021	Rat
peptidyl tyrosine modification	GO:0018212	24	0.021
dna repair	GO:0006281	54	0.020
proteolysis	GO:0006508	192	0.020
positive regulation of lipid metabolic process	GO:0045834	4	0.020
gtp metabolic process	GO:0046039	72	0.020
regulation of cell cycle phase transition	GO:1901987	130	0.020
protein import	GO:0017038	55	0.020
plasma membrane organization	GO:0007009	26	0.020
nephron development	GO:0072006	3	0.020
microtubule polymerization or depolymerization	GO:0031109	39	0.019
kidney development	GO:0001822	3	0.019
negative regulation of phosphorylation	GO:0042326	35	0.019
antimicrobial humoral response	GO:0019730	99	0.019
tube morphogenesis	GO:0035239	191	0.019
regulation of cell division	GO:0051302	72	0.019
regulation of cellular localization	GO:0060341	136	0.019
ventral cord development	GO:0007419	16	0.019
negative regulation of translation	GO:0017148	28	0.019
response to hypoxia	GO:0001666	53	0.019
carbohydrate metabolic process	GO:0005975	82	0.019
cellular response to ketone	GO:1901655	17	0.019
eggshell formation	GO:0030703	105	0.018
mitotic spindle organization	GO:0007052	220	0.018
regulation of nuclear division	GO:0051783	58	0.018
protein targeting to nucleus	GO:0044744	51	0.018
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.018	Rat
meiotic nuclear division	GO:0007126	151	0.018
regulation of apoptotic process	GO:0042981	130	0.018
ras protein signal transduction	GO:0007265	88	0.018
eye photoreceptor cell development	GO:0042462	81	0.018
cell cell junction organization	GO:0045216	55	0.018
negative regulation of cell cycle phase transition	GO:1901988	103	0.018
regulation of organ morphogenesis	GO:2000027	78	0.018
positive regulation of protein modification process	GO:0031401	58	0.018
purine ribonucleotide catabolic process	GO:0009154	109	0.018	Rat
positive regulation of cell communication	GO:0010647	250	0.018
positive regulation of multicellular organismal process	GO:0051240	143	0.018	Mouse
mesenchymal cell differentiation	GO:0048762	1	0.018
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.017	Rat
catechol containing compound metabolic process	GO:0009712	10	0.017
regulation of protein kinase activity	GO:0045859	51	0.017
spiracle morphogenesis open tracheal system	GO:0035277	22	0.017
macromolecular complex assembly	GO:0065003	256	0.017	Rat
nucleoside triphosphate metabolic process	GO:0009141	120	0.017	Rat
gland development	GO:0048732	191	0.017
eggshell chorion assembly	GO:0007306	66	0.017
regulation of epithelial cell proliferation	GO:0050678	4	0.017
hindbrain development	GO:0030902	2	0.017
renal tubule morphogenesis	GO:0061333	44	0.017
muscle organ morphogenesis	GO:0048644	7	0.017	Mouse
response to organic substance	GO:0010033	284	0.017
muscle system process	GO:0003012	21	0.017	Zebrafish Mouse Rat
oocyte nucleus localization involved in oocyte dorsal ventral axis specification	GO:0051663	12	0.017
regulation of protein tyrosine kinase activity	GO:0061097	9	0.017
positive regulation of nucleotide metabolic process	GO:0045981	55	0.017	Rat
regulation of cell cycle process	GO:0010564	181	0.017
neuron projection guidance	GO:0097485	241	0.016
establishment of protein localization to organelle	GO:0072594	62	0.016
protein import into nucleus	GO:0006606	51	0.016
tube formation	GO:0035148	21	0.016
negative regulation of protein tyrosine kinase activity	GO:0061099	5	0.016
pigmentation	GO:0043473	75	0.016
endosomal transport	GO:0016197	44	0.016
protein depolymerization	GO:0051261	31	0.016	Rat
asymmetric protein localization	GO:0008105	33	0.016
epithelial tube morphogenesis	GO:0060562	88	0.016
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.016
morphogenesis of embryonic epithelium	GO:0016331	94	0.016
molting cycle	GO:0042303	56	0.015
mucosal immune response	GO:0002385	10	0.015
response to extracellular stimulus	GO:0009991	116	0.015
regulation of protein phosphorylation	GO:0001932	64	0.015
negative regulation of cell differentiation	GO:0045596	143	0.015
positive regulation of developmental process	GO:0051094	143	0.015
multi organism behavior	GO:0051705	175	0.015
regulation of dna templated transcription in response to stress	GO:0043620	4	0.015
protein polymerization	GO:0051258	42	0.015	Rat
organonitrogen compound biosynthetic process	GO:1901566	117	0.015
glycosyl compound catabolic process	GO:1901658	112	0.015	Rat
salivary gland cell autophagic cell death	GO:0035071	83	0.015
meiosis i	GO:0007127	59	0.015
establishment or maintenance of apical basal cell polarity	GO:0035088	34	0.015
nucleoside phosphate catabolic process	GO:1901292	110	0.015	Rat
ribonucleoside monophosphate catabolic process	GO:0009158	39	0.015	Rat
phagocytosis	GO:0006909	215	0.015
cellular response to nitrogen compound	GO:1901699	51	0.014
mitotic dna integrity checkpoint	GO:0044774	75	0.014
regulation of locomotion	GO:0040012	42	0.014	Rat
posttranscriptional regulation of gene expression	GO:0010608	145	0.014
positive regulation of intracellular signal transduction	GO:1902533	116	0.014
centrosome organization	GO:0051297	163	0.014
defense response to other organism	GO:0098542	225	0.014
purine nucleotide catabolic process	GO:0006195	109	0.014	Rat
regulation of cell motility	GO:2000145	23	0.014	Rat
mitotic g2 m transition checkpoint	GO:0044818	70	0.014
somatic stem cell division	GO:0048103	37	0.014
chemotaxis	GO:0006935	249	0.014
positive regulation of hydrolase activity	GO:0051345	78	0.014	Rat
malpighian tubule development	GO:0072002	64	0.014
peptidyl amino acid modification	GO:0018193	105	0.014
regulation of response to stress	GO:0080134	200	0.014
positive regulation of ras gtpase activity	GO:0032320	36	0.014
myofibril assembly	GO:0030239	36	0.014	Zebrafish
muscle structure development	GO:0061061	224	0.014	Zebrafish Mouse
hindgut morphogenesis	GO:0007442	58	0.014
camera type eye development	GO:0043010	4	0.014
nucleobase containing compound transport	GO:0015931	56	0.014
protein phosphorylation	GO:0006468	169	0.014
organic cyclic compound catabolic process	GO:1901361	168	0.013	Rat
nucleus organization	GO:0006997	45	0.013
establishment or maintenance of bipolar cell polarity	GO:0061245	34	0.013
wound healing	GO:0042060	75	0.013	Rat
regulation of actin cytoskeleton organization	GO:0032956	42	0.013	Rat
regulation of neuroblast proliferation	GO:1902692	34	0.013
mitotic g2 dna damage checkpoint	GO:0007095	69	0.013
regulation of cell proliferation	GO:0042127	163	0.013
dephosphorylation	GO:0016311	51	0.013
g protein coupled receptor signaling pathway	GO:0007186	136	0.013
regulation of endopeptidase activity	GO:0052548	36	0.013
protein catabolic process	GO:0030163	101	0.013
protein localization to nucleus	GO:0034504	55	0.013
eye development	GO:0001654	323	0.013
regulation of innate immune response	GO:0045088	71	0.013
eye photoreceptor cell differentiation	GO:0001754	145	0.013
establishment of rna localization	GO:0051236	47	0.013
dna packaging	GO:0006323	91	0.013
single organism biosynthetic process	GO:0044711	206	0.013
negative regulation of cell cycle process	GO:0010948	109	0.013
chitin based cuticle development	GO:0040003	49	0.013
heart development	GO:0007507	82	0.013	Zebrafish Mouse
rna splicing via transesterification reactions	GO:0000375	73	0.013
response to organic cyclic compound	GO:0014070	89	0.013
carbohydrate derivative biosynthetic process	GO:1901137	85	0.012
kidney epithelium development	GO:0072073	3	0.012
golgi to plasma membrane protein transport	GO:0043001	8	0.012
drug transport	GO:0015893	2	0.012
pronuclear migration	GO:0035046	4	0.012
inter male aggressive behavior	GO:0002121	60	0.012
regulation of cell shape	GO:0008360	113	0.012
detection of external stimulus	GO:0009581	66	0.012
regulation of transferase activity	GO:0051338	58	0.012
regulation of nervous system development	GO:0051960	248	0.012
organic hydroxy compound metabolic process	GO:1901615	83	0.012
cellular response to oxygen containing compound	GO:1901701	79	0.012
regulation of cellular response to stress	GO:0080135	89	0.012

Tm1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.071
nervous system disease	DOID:863	0.022
gastrointestinal system disease	DOID:77	0.016
hepatobiliary disease	DOID:3118	0.016
biliary tract disease	DOID:9741	0.016
sensory system disease	DOID:0050155	0.013

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