IMP: Integrative Multi-species Prediction

Drosophila melanogaster

0 known processes

CG12428 (Dmel_CG12428)

CG12428 gene product from transcript CG12428-RB

(Aliases: Dmel\CG12428)

Entrez: 43332
FLYBASE: FBgn0039543
UniProtKB: Q9VB02

Process Predictions
Disease Predictions

CG12428 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cellular lipid catabolic process	GO:0044242	16	0.874	Human
lipid modification	GO:0030258	24	0.616	Human
lipid catabolic process	GO:0016042	21	0.605	Human
acylglycerol catabolic process	GO:0046464	3	0.578
organic hydroxy compound metabolic process	GO:1901615	83	0.446	Yeast Mouse
fatty acid metabolic process	GO:0006631	20	0.415	Human Mouse
glycerolipid catabolic process	GO:0046503	3	0.404
lipid metabolic process	GO:0006629	121	0.382	Human Mouse
small molecule metabolic process	GO:0044281	305	0.373	Human Yeast Mouse
triglyceride catabolic process	GO:0019433	3	0.370
cholesterol homeostasis	GO:0042632	3	0.335
cellular lipid metabolic process	GO:0044255	83	0.294	Human Mouse
organic acid catabolic process	GO:0016054	16	0.266	Human
carboxylic acid metabolic process	GO:0019752	92	0.261	Human Yeast Mouse
fatty acid oxidation	GO:0019395	6	0.248	Human
oxoacid metabolic process	GO:0043436	103	0.222	Human Yeast Mouse
organelle fission	GO:0048285	340	0.211
neutral lipid catabolic process	GO:0046461	3	0.204
organic acid metabolic process	GO:0006082	103	0.198	Human Yeast Mouse
carboxylic acid catabolic process	GO:0046395	16	0.195	Human
neutral lipid metabolic process	GO:0006638	12	0.191
catabolic process	GO:0009056	409	0.186	Human
single organism biosynthetic process	GO:0044711	206	0.180	Fly
organic substance catabolic process	GO:1901575	308	0.167	Human
lateral inhibition	GO:0046331	206	0.167
monocarboxylic acid metabolic process	GO:0032787	29	0.166	Human Yeast Mouse
lipid homeostasis	GO:0055088	33	0.163
triglyceride metabolic process	GO:0006641	12	0.159
nuclear division	GO:0000280	332	0.154
acylglycerol metabolic process	GO:0006639	12	0.152
response to organic substance	GO:0010033	284	0.147	Rat
developmental growth	GO:0048589	280	0.141
organonitrogen compound metabolic process	GO:1901564	318	0.139	Mouse
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.137
very long chain fatty acid metabolic process	GO:0000038	4	0.130
lipid oxidation	GO:0034440	7	0.119	Human
cellular catabolic process	GO:0044248	372	0.113	Human
small molecule catabolic process	GO:0044282	21	0.110	Human
single organism catabolic process	GO:0044712	228	0.107	Human
sterol homeostasis	GO:0055092	4	0.104
monocarboxylic acid catabolic process	GO:0072329	10	0.098	Human
organic substance transport	GO:0071702	257	0.094	Mouse
single organism behavior	GO:0044708	391	0.093
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.092
fatty acid catabolic process	GO:0009062	9	0.090	Human
establishment of localization in cell	GO:0051649	402	0.088
ameboidal type cell migration	GO:0001667	151	0.079
lipid localization	GO:0010876	54	0.071	Mouse
positive regulation of lipid metabolic process	GO:0045834	4	0.071
protein localization	GO:0008104	284	0.068
open tracheal system development	GO:0007424	204	0.066
meiotic cell cycle	GO:0051321	171	0.066
lipid biosynthetic process	GO:0008610	46	0.066
columnar cuboidal epithelial cell development	GO:0002066	249	0.064
positive regulation of biosynthetic process	GO:0009891	316	0.064
fatty acid beta oxidation	GO:0006635	6	0.064	Human
regulation of cellular ketone metabolic process	GO:0010565	3	0.060
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.060
response to abiotic stimulus	GO:0009628	341	0.056
positive regulation of growth	GO:0045927	75	0.056
cellular ketone metabolic process	GO:0042180	24	0.055
protein transport	GO:0015031	155	0.055
regulation of cell cycle	GO:0051726	291	0.055
learning or memory	GO:0007611	141	0.053
amine metabolic process	GO:0009308	12	0.053
death	GO:0016265	284	0.052
cellular macromolecule localization	GO:0070727	220	0.052
thioester metabolic process	GO:0035383	3	0.052
neurotransmitter metabolic process	GO:0042133	2	0.051	Fly
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.049
positive regulation of rna biosynthetic process	GO:1902680	266	0.049
sulfur compound metabolic process	GO:0006790	59	0.048
cellular amino acid metabolic process	GO:0006520	61	0.048
post embryonic appendage morphogenesis	GO:0035120	385	0.047
maintenance of location	GO:0051235	73	0.047
appendage development	GO:0048736	401	0.046
acylglycerol biosynthetic process	GO:0046463	2	0.046
single organism intracellular transport	GO:1902582	207	0.045
response to nitrogen compound	GO:1901698	90	0.044	Rat
male gamete generation	GO:0048232	201	0.044
cellular protein modification process	GO:0006464	438	0.043
imaginal disc derived appendage development	GO:0048737	399	0.043
steroid metabolic process	GO:0008202	20	0.042
appendage morphogenesis	GO:0035107	397	0.042
regulation of developmental growth	GO:0048638	174	0.041
defense response to other organism	GO:0098542	225	0.041
regulation of cell morphogenesis	GO:0022604	163	0.040
glycerolipid metabolic process	GO:0046486	34	0.040
alcohol metabolic process	GO:0006066	25	0.039
cellular amine metabolic process	GO:0044106	12	0.039
epithelium migration	GO:0090132	148	0.039
wing disc morphogenesis	GO:0007472	344	0.038
imaginal disc derived wing morphogenesis	GO:0007476	337	0.038
negative regulation of cellular metabolic process	GO:0031324	382	0.037
negative regulation of cell communication	GO:0010648	223	0.037
cellular response to organic substance	GO:0071310	132	0.036
cell motility	GO:0048870	251	0.036
cell migration	GO:0016477	238	0.035
embryonic development via the syncytial blastoderm	GO:0001700	148	0.034
negative regulation of signal transduction	GO:0009968	206	0.034
regulation of cellular localization	GO:0060341	136	0.034
response to biotic stimulus	GO:0009607	294	0.034
negative regulation of signaling	GO:0023057	219	0.034
regulation of anatomical structure size	GO:0090066	163	0.033
spermatogenesis	GO:0007283	200	0.033
epithelial cell differentiation	GO:0030855	322	0.033
membrane organization	GO:0061024	112	0.033
regulation of mitotic cell cycle	GO:0007346	190	0.032
multicellular organismal aging	GO:0010259	140	0.032
nucleoside phosphate metabolic process	GO:0006753	162	0.031	Mouse
growth	GO:0040007	359	0.031
single organism membrane organization	GO:0044802	93	0.031
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.030
lipid storage	GO:0019915	38	0.030
protein modification process	GO:0036211	438	0.030
regulation of molecular function	GO:0065009	217	0.030
dna damage checkpoint	GO:0000077	78	0.030
ethanolamine containing compound metabolic process	GO:0042439	4	0.030
cellular response to endogenous stimulus	GO:0071495	80	0.029
positive regulation of gene expression	GO:0010628	290	0.029
defense response	GO:0006952	300	0.029
cognition	GO:0050890	141	0.029
mitotic g2 m transition checkpoint	GO:0044818	70	0.028
positive regulation of cellular biosynthetic process	GO:0031328	316	0.028
response to organonitrogen compound	GO:0010243	75	0.028	Rat
axonogenesis	GO:0007409	290	0.027
establishment of protein localization	GO:0045184	163	0.027
localization of cell	GO:0051674	257	0.027
chemical homeostasis	GO:0048878	92	0.027
neuromuscular synaptic transmission	GO:0007274	67	0.026	Fly
regulation of multicellular organismal development	GO:2000026	414	0.026
secretion	GO:0046903	109	0.026
regulation of cellular component biogenesis	GO:0044087	201	0.026
negative regulation of programmed cell death	GO:0043069	72	0.025
negative regulation of mitotic cell cycle	GO:0045930	109	0.025
negative regulation of response to stimulus	GO:0048585	258	0.025
exocrine system development	GO:0035272	162	0.025
ovarian follicle cell development	GO:0030707	248	0.025
ovarian follicle cell migration	GO:0007297	121	0.025
organelle fusion	GO:0048284	46	0.024
meiotic nuclear division	GO:0007126	151	0.024
regulation of lipid metabolic process	GO:0019216	15	0.024
body morphogenesis	GO:0010171	2	0.024
regulation of response to stress	GO:0080134	200	0.024
cell death	GO:0008219	279	0.024
negative regulation of cellular component organization	GO:0051129	108	0.023
acyl coa metabolic process	GO:0006637	3	0.023
organonitrogen compound biosynthetic process	GO:1901566	117	0.023
autophagy	GO:0006914	108	0.023
intracellular signal transduction	GO:0035556	300	0.023
regulation of cellular amine metabolic process	GO:0033238	3	0.023
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.023
gland development	GO:0048732	191	0.023
regulation of steroid metabolic process	GO:0019218	2	0.023
spermatid differentiation	GO:0048515	114	0.022
response to nutrient levels	GO:0031667	114	0.022
developmental programmed cell death	GO:0010623	138	0.022
response to copper ion	GO:0046688	4	0.022
histolysis	GO:0007559	102	0.022
protein import	GO:0017038	55	0.022
phenol containing compound metabolic process	GO:0018958	57	0.022
triglyceride biosynthetic process	GO:0019432	2	0.021
positive regulation of rna metabolic process	GO:0051254	271	0.021
connective tissue development	GO:0061448	3	0.021
positive regulation of macromolecule metabolic process	GO:0010604	405	0.021
regulation of anatomical structure morphogenesis	GO:0022603	242	0.021
membrane fusion	GO:0061025	42	0.021
response to starvation	GO:0042594	97	0.021
ion transport	GO:0006811	145	0.021	Mouse
programmed cell death	GO:0012501	257	0.021
regulation of secretion	GO:0051046	44	0.021
synaptic transmission	GO:0007268	288	0.021	Fly
epithelial cell development	GO:0002064	274	0.021
cell proliferation	GO:0008283	299	0.020
positive regulation of transcription dna templated	GO:0045893	266	0.020
regulation of cell cycle process	GO:0010564	181	0.020
dendrite development	GO:0016358	204	0.020
homeostatic process	GO:0042592	199	0.020
regulation of defense response	GO:0031347	102	0.020
regulation of catalytic activity	GO:0050790	185	0.020
peripheral nervous system development	GO:0007422	52	0.020
axon development	GO:0061564	297	0.019
neuron projection guidance	GO:0097485	241	0.019
organelle assembly	GO:0070925	198	0.019
establishment of protein localization to organelle	GO:0072594	62	0.019
positive regulation of transport	GO:0051050	92	0.019
negative regulation of cell cycle	GO:0045786	116	0.019
dna integrity checkpoint	GO:0031570	81	0.019
eggshell formation	GO:0030703	105	0.019
developmental pigmentation	GO:0048066	68	0.019
generation of precursor metabolites and energy	GO:0006091	42	0.019	Human
regulation of transport	GO:0051049	181	0.019
organophosphate metabolic process	GO:0019637	195	0.018	Mouse
axon guidance	GO:0007411	233	0.018
peptidyl amino acid modification	GO:0018193	105	0.018
regulation of cell substrate adhesion	GO:0010810	2	0.018
negative regulation of cell death	GO:0060548	81	0.018
positive regulation of lipid storage	GO:0010884	4	0.018
intracellular transport	GO:0046907	228	0.018
embryonic morphogenesis	GO:0048598	206	0.018
regulation of growth	GO:0040008	233	0.018
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.018
positive regulation of multicellular organismal process	GO:0051240	143	0.018
regulation of localization	GO:0032879	275	0.018
response to radiation	GO:0009314	155	0.018
regulation of catabolic process	GO:0009894	170	0.018
sterol metabolic process	GO:0016125	12	0.018
determination of adult lifespan	GO:0008340	137	0.017
renal tubule development	GO:0061326	64	0.017
g2 dna damage checkpoint	GO:0031572	69	0.017
cellular response to chemical stimulus	GO:0070887	199	0.017
pattern recognition receptor signaling pathway	GO:0002221	2	0.017
positive regulation of catabolic process	GO:0009896	105	0.017
positive regulation of developmental growth	GO:0048639	62	0.017
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.017
cellular response to oxygen containing compound	GO:1901701	79	0.016
regulation of lipid biosynthetic process	GO:0046890	6	0.016
male mating behavior	GO:0060179	70	0.016
long chain fatty acid metabolic process	GO:0001676	3	0.016
regulation of cell size	GO:0008361	63	0.016
sulfur compound biosynthetic process	GO:0044272	16	0.016
response to lipopolysaccharide	GO:0032496	4	0.016
regulation of cellular catabolic process	GO:0031329	157	0.016
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.016
cellular protein localization	GO:0034613	160	0.015
mitotic nuclear division	GO:0007067	213	0.015
eye pigmentation	GO:0048069	43	0.015
cellular response to lipopolysaccharide	GO:0071222	3	0.015
chemotaxis	GO:0006935	249	0.015
regulation of response to biotic stimulus	GO:0002831	63	0.015
cell adhesion	GO:0007155	136	0.015
tissue death	GO:0016271	102	0.015
phototaxis	GO:0042331	21	0.015
cell junction organization	GO:0034330	57	0.015
regulation of lipid storage	GO:0010883	22	0.015
immune response regulating signaling pathway	GO:0002764	2	0.014
response to external biotic stimulus	GO:0043207	293	0.014
neurological system process	GO:0050877	358	0.014
transcription from rna polymerase ii promoter	GO:0006366	368	0.014
mitotic g2 dna damage checkpoint	GO:0007095	69	0.014
cellular response to molecule of bacterial origin	GO:0071219	3	0.014
nephron tubule morphogenesis	GO:0072078	3	0.014
respiratory system development	GO:0060541	213	0.014
acetate ester metabolic process	GO:1900619	2	0.014	Fly
cellular component assembly involved in morphogenesis	GO:0010927	151	0.014
nitrogen compound transport	GO:0071705	85	0.014
steroid biosynthetic process	GO:0006694	16	0.014
chromosome segregation	GO:0007059	157	0.014
cellular response to organonitrogen compound	GO:0071417	36	0.014
olfactory behavior	GO:0042048	97	0.013
phagocytosis	GO:0006909	215	0.013
positive regulation of cell migration	GO:0030335	2	0.013
positive regulation of cellular catabolic process	GO:0031331	95	0.013
positive regulation of lipid biosynthetic process	GO:0046889	3	0.013
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.013
cation transport	GO:0006812	110	0.013
phosphatidylinositol mediated signaling	GO:0048015	4	0.013
oxidation reduction process	GO:0055114	123	0.013	Human
regulation of phosphate metabolic process	GO:0019220	210	0.013
endocytosis	GO:0006897	310	0.013
mating	GO:0007618	120	0.013
positive regulation of signal transduction	GO:0009967	223	0.013
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.013
single organism cellular localization	GO:1902580	180	0.013
proteolysis	GO:0006508	192	0.013
positive regulation of cell motility	GO:2000147	3	0.012
biological adhesion	GO:0022610	138	0.012
female meiotic division	GO:0007143	70	0.012
compound eye development	GO:0048749	307	0.012
choline metabolic process	GO:0019695	1	0.012
epithelial tube morphogenesis	GO:0060562	88	0.012
positive regulation of cell communication	GO:0010647	250	0.012
hormone metabolic process	GO:0042445	33	0.012
intracellular protein transmembrane transport	GO:0065002	4	0.012
forebrain development	GO:0030900	2	0.012
response to peptide	GO:1901652	29	0.012
intracellular protein transport	GO:0006886	104	0.012
response to wounding	GO:0009611	94	0.012
muscle structure development	GO:0061061	224	0.012
eye photoreceptor cell differentiation	GO:0001754	145	0.012
regulation of insulin receptor signaling pathway	GO:0046626	17	0.012
response to other organism	GO:0051707	293	0.012
response to peptide hormone	GO:0043434	29	0.012
skeletal muscle fiber development	GO:0048741	3	0.012
innate immune response	GO:0045087	144	0.012
macromolecular complex assembly	GO:0065003	256	0.012
regulation of cellular protein metabolic process	GO:0032268	243	0.011
immune system process	GO:0002376	347	0.011
macromolecule catabolic process	GO:0009057	161	0.011
protein acetylation	GO:0006473	39	0.011
regulation of apoptotic process	GO:0042981	130	0.011
small molecule biosynthetic process	GO:0044283	37	0.011
acetylcholine metabolic process	GO:0008291	2	0.011	Fly
response to oxygen containing compound	GO:1901700	200	0.011
response to light stimulus	GO:0009416	124	0.011
wound healing	GO:0042060	75	0.011
regulation of organelle organization	GO:0033043	196	0.011
regulation of cell adhesion	GO:0030155	27	0.011
regulation of establishment of protein localization	GO:0070201	61	0.011
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.011
negative regulation of multicellular organismal process	GO:0051241	142	0.011
pigmentation	GO:0043473	75	0.011
gland morphogenesis	GO:0022612	145	0.011
hindgut development	GO:0061525	58	0.011
negative regulation of biosynthetic process	GO:0009890	277	0.011
molting cycle chitin based cuticle	GO:0007591	56	0.011
regulation of phosphatidylinositol 3 kinase signaling	GO:0014066	4	0.011
response to oxidative stress	GO:0006979	86	0.011
cholesterol transport	GO:0030301	2	0.010
negative regulation of insulin receptor signaling pathway	GO:0046627	11	0.010
regulation of tube architecture open tracheal system	GO:0035152	68	0.010
positive regulation of secretion	GO:0051047	22	0.010
regulation of organ morphogenesis	GO:2000027	78	0.010
intracellular protein transmembrane import	GO:0044743	4	0.010
regulation of multicellular organism growth	GO:0040014	40	0.010
establishment of protein localization to peroxisome	GO:0072663	2	0.010

CG12428 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.026
disease of anatomical entity	DOID:7	0.021
integumentary system disease	DOID:16	0.016
hair disease	DOID:421	0.016
hypotrichosis	DOID:4535	0.016

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