IMP: Integrative Multi-species Prediction

Drosophila melanogaster

107 known processes

Cp190 (Dmel_CG6384)

Centrosomal protein 190kD

(Aliases: Rb188,Dmel\CG6384,CP-190,CEN190,Dmap190,Cen185,Map190,CP190,E(mod)4-1,Bx63,CG6384,DMAP190,AbS1-4,CP-60,dmap190,Cen190,DMAP-190)

FLYBASE: FBgn0000283
Entrez: 41848
UniProtKB: Q24478

Process Predictions
Disease Predictions

Cp190 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
chromosome organization	GO:0051276	360	0.992
positive regulation of cellular biosynthetic process	GO:0031328	316	0.987
regulation of cell cycle	GO:0051726	291	0.971
nuclear division	GO:0000280	332	0.970
organelle fission	GO:0048285	340	0.963
mitotic spindle organization	GO:0007052	220	0.952
positive regulation of transcription dna templated	GO:0045893	266	0.944
regulation of mitotic cell cycle	GO:0007346	190	0.938
protein complex biogenesis	GO:0070271	201	0.929
regulation of cell cycle phase transition	GO:1901987	130	0.925
regulation of cell cycle process	GO:0010564	181	0.881
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.869
mitotic nuclear division	GO:0007067	213	0.859
macromolecular complex assembly	GO:0065003	256	0.833
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.827
positive regulation of gene expression	GO:0010628	290	0.806
negative regulation of cell cycle	GO:0045786	116	0.805
positive regulation of rna biosynthetic process	GO:1902680	266	0.802
positive regulation of macromolecule metabolic process	GO:0010604	405	0.797
cell division	GO:0051301	248	0.792
protein complex assembly	GO:0006461	200	0.788
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.788
cell proliferation	GO:0008283	299	0.702
cell motility	GO:0048870	251	0.701
positive regulation of rna metabolic process	GO:0051254	271	0.693
vesicle mediated transport	GO:0016192	381	0.675
mitotic cell cycle phase transition	GO:0044772	138	0.665
transcription from rna polymerase ii promoter	GO:0006366	368	0.641
negative regulation of transcription dna templated	GO:0045892	237	0.635
positive regulation of biosynthetic process	GO:0009891	316	0.629
chromosome segregation	GO:0007059	157	0.620
negative regulation of rna metabolic process	GO:0051253	251	0.612
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.592
gonad development	GO:0008406	50	0.570
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.552
negative regulation of cell cycle phase transition	GO:1901988	103	0.521
cellular macromolecular complex assembly	GO:0034622	153	0.497
microtubule organizing center organization	GO:0031023	168	0.468
positive regulation of response to stimulus	GO:0048584	323	0.462
embryo development ending in birth or egg hatching	GO:0009792	152	0.437
development of primary sexual characteristics	GO:0045137	50	0.436
endomembrane system organization	GO:0010256	119	0.417
regulation of immune system process	GO:0002682	176	0.409
sister chromatid segregation	GO:0000819	92	0.408
negative regulation of rna biosynthetic process	GO:1902679	240	0.378
dna metabolic process	GO:0006259	227	0.365
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.358
establishment of organelle localization	GO:0051656	122	0.357
response to other organism	GO:0051707	293	0.353
negative regulation of mitotic cell cycle	GO:0045930	109	0.349
nuclear migration	GO:0007097	20	0.348
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.347
negative regulation of cellular metabolic process	GO:0031324	382	0.335
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.310
regulation of growth	GO:0040008	233	0.298
endocytosis	GO:0006897	310	0.297
dendrite development	GO:0016358	204	0.292
spindle organization	GO:0007051	253	0.282
developmental growth	GO:0048589	280	0.276
apoptotic process	GO:0006915	159	0.273
central nervous system development	GO:0007417	201	0.270
growth	GO:0040007	359	0.264
muscle structure development	GO:0061061	224	0.255
programmed cell death	GO:0012501	257	0.254
regulation of organelle organization	GO:0033043	196	0.247
positive regulation of signaling	GO:0023056	243	0.243
mitotic sister chromatid segregation	GO:0000070	87	0.241
cell cycle phase transition	GO:0044770	140	0.231
dendrite morphogenesis	GO:0048813	199	0.230
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.227
regulation of cellular protein metabolic process	GO:0032268	243	0.224
death	GO:0016265	284	0.223
stem cell proliferation	GO:0072089	88	0.220
regionalization	GO:0003002	416	0.220
stem cell differentiation	GO:0048863	117	0.219
negative regulation of cellular biosynthetic process	GO:0031327	277	0.216
negative regulation of biosynthetic process	GO:0009890	277	0.212
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.208
regulation of cell proliferation	GO:0042127	163	0.206
ameboidal type cell migration	GO:0001667	151	0.200
negative regulation of cell cycle process	GO:0010948	109	0.194
immune system process	GO:0002376	347	0.189
sex differentiation	GO:0007548	81	0.186
establishment of localization in cell	GO:0051649	402	0.186
negative regulation of cell death	GO:0060548	81	0.183
regulation of response to stress	GO:0080134	200	0.180
regulation of programmed cell death	GO:0043067	152	0.180
reproductive structure development	GO:0048608	74	0.176
positive regulation of signal transduction	GO:0009967	223	0.173
cell death	GO:0008219	279	0.170
regulation of protein localization	GO:0032880	76	0.166
meiotic nuclear division	GO:0007126	151	0.158
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.157
neuroblast proliferation	GO:0007405	74	0.151
regulation of dna metabolic process	GO:0051052	34	0.143
positive regulation of intracellular signal transduction	GO:1902533	116	0.143
regulation of intracellular protein transport	GO:0033157	46	0.142
cellular response to chemical stimulus	GO:0070887	199	0.137
positive regulation of cell cycle	GO:0045787	43	0.137
centriole replication	GO:0007099	24	0.137
reproductive system development	GO:0061458	74	0.135
single organism cellular localization	GO:1902580	180	0.134
muscle organ development	GO:0007517	127	0.133
regulation of cell morphogenesis	GO:0022604	163	0.127
regulation of nucleocytoplasmic transport	GO:0046822	35	0.117
regulation of cell division	GO:0051302	72	0.116
response to external biotic stimulus	GO:0043207	293	0.115
male gamete generation	GO:0048232	201	0.112
organelle localization	GO:0051640	148	0.112
eye development	GO:0001654	323	0.110
eye morphogenesis	GO:0048592	260	0.110
mesenchymal cell differentiation	GO:0048762	1	0.109
negative regulation of cell differentiation	GO:0045596	143	0.108
digestive tract development	GO:0048565	149	0.106
protein import into nucleus	GO:0006606	51	0.105
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.103
positive regulation of cell communication	GO:0010647	250	0.102
response to biotic stimulus	GO:0009607	294	0.102
regulation of g1 s transition of mitotic cell cycle	GO:2000045	23	0.102
cellular macromolecule localization	GO:0070727	220	0.100
regulation of protein transport	GO:0051223	57	0.099
spermatogenesis	GO:0007283	200	0.093
regulation of multicellular organismal development	GO:2000026	414	0.091
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.089
regulation of intracellular transport	GO:0032386	64	0.087
nucleus localization	GO:0051647	34	0.087
negative regulation of developmental process	GO:0051093	201	0.086
negative regulation of gene expression	GO:0010629	387	0.085
regulation of transport	GO:0051049	181	0.085
meiotic cell cycle process	GO:1903046	132	0.084
signal transduction by phosphorylation	GO:0023014	107	0.084
phosphorylation	GO:0016310	294	0.083
body morphogenesis	GO:0010171	2	0.082
regulation of protein metabolic process	GO:0051246	256	0.080
cell migration	GO:0016477	238	0.080
centrosome duplication	GO:0051298	121	0.079
positive regulation of protein import into nucleus	GO:0042307	21	0.078
histone modification	GO:0016570	106	0.077
localization of cell	GO:0051674	257	0.076
protein modification process	GO:0036211	438	0.076
meiotic cell cycle	GO:0051321	171	0.074
regulation of localization	GO:0032879	275	0.073
cell adhesion	GO:0007155	136	0.072
cardiovascular system development	GO:0072358	82	0.071
regulation of intracellular signal transduction	GO:1902531	236	0.070
centrosome cycle	GO:0007098	137	0.069
regulation of protein localization to nucleus	GO:1900180	29	0.068
genitalia development	GO:0048806	26	0.068
regulation of cytoplasmic transport	GO:1903649	47	0.066
organic substance transport	GO:0071702	257	0.065
chromatin modification	GO:0016568	147	0.065
digestive system development	GO:0055123	149	0.065
mitotic cell cycle checkpoint	GO:0007093	88	0.063
positive regulation of immune system process	GO:0002684	68	0.060
response to organic substance	GO:0010033	284	0.060
head development	GO:0060322	135	0.059
protein import	GO:0017038	55	0.058
cellular protein localization	GO:0034613	160	0.058
negative regulation of cell proliferation	GO:0008285	69	0.058
positive regulation of protein transport	GO:0051222	37	0.057
nuclear transport	GO:0051169	72	0.056
cellular protein modification process	GO:0006464	438	0.056
cell cycle g1 s phase transition	GO:0044843	31	0.052
regulation of anatomical structure morphogenesis	GO:0022603	242	0.051
centrosome organization	GO:0051297	163	0.050
regulation of cell death	GO:0010941	173	0.048
cell type specific apoptotic process	GO:0097285	38	0.047
cellular protein complex assembly	GO:0043623	71	0.047
intracellular transport	GO:0046907	228	0.045
regulation of developmental growth	GO:0048638	174	0.044
negative regulation of protein metabolic process	GO:0051248	85	0.044
determination of adult lifespan	GO:0008340	137	0.042
establishment of protein localization	GO:0045184	163	0.042
negative regulation of multicellular organismal process	GO:0051241	142	0.042
regulation of phosphorylation	GO:0042325	147	0.042
single organism intracellular transport	GO:1902582	207	0.041
chromosome separation	GO:0051304	42	0.040
regulation of cellular response to stress	GO:0080135	89	0.040
regulation of cellular localization	GO:0060341	136	0.040
oocyte differentiation	GO:0009994	145	0.040
regulation of cytoskeleton organization	GO:0051493	89	0.040
camera type eye development	GO:0043010	4	0.040
regulation of mitosis	GO:0007088	56	0.040
mrna metabolic process	GO:0016071	124	0.039
brain development	GO:0007420	120	0.039
cell maturation	GO:0048469	144	0.038
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	1	0.038
renal tubule development	GO:0061326	64	0.038
dorsal ventral pattern formation	GO:0009953	133	0.037
compound eye development	GO:0048749	307	0.037
negative regulation of protein secretion	GO:0050709	2	0.037
centriole assembly	GO:0098534	24	0.036
positive regulation of immune response	GO:0050778	63	0.035
neuron apoptotic process	GO:0051402	17	0.035
diterpenoid biosynthetic process	GO:0016102	1	0.035
developmental maturation	GO:0021700	172	0.034
positive regulation of nucleocytoplasmic transport	GO:0046824	24	0.034
regulation of cell differentiation	GO:0045595	302	0.033
regulation of immune response	GO:0050776	118	0.032
mitotic cell cycle embryonic	GO:0045448	38	0.032
golgi organization	GO:0007030	66	0.032
response to endogenous stimulus	GO:0009719	119	0.032
maternal determination of dorsal ventral axis ovarian follicular epithelium germ line encoded	GO:0008070	2	0.032
posttranscriptional regulation of gene expression	GO:0010608	145	0.032
regulation of nuclear division	GO:0051783	58	0.032
axon development	GO:0061564	297	0.032
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.032
cranial nerve development	GO:0021545	1	0.032
regulation of neuron apoptotic process	GO:0043523	16	0.031
asymmetric neuroblast division resulting in ganglion mother cell formation	GO:0055060	2	0.031
positive regulation of protein metabolic process	GO:0051247	128	0.031
intracellular signal transduction	GO:0035556	300	0.031
intracellular protein transport	GO:0006886	104	0.030
protein transport	GO:0015031	155	0.030
response to oxygen containing compound	GO:1901700	200	0.030
negative regulation of cellular protein metabolic process	GO:0032269	85	0.030
response to organic cyclic compound	GO:0014070	89	0.030
cytoplasmic microtubule organization	GO:0031122	22	0.030
meiotic chromosome segregation	GO:0045132	59	0.030
nitrogen compound transport	GO:0071705	85	0.029
epithelial cell migration	GO:0010631	148	0.029
positive regulation of mitotic cell cycle	GO:0045931	34	0.029
single organism nuclear import	GO:1902593	51	0.029
segmentation	GO:0035282	207	0.029
regulation of apoptotic process	GO:0042981	130	0.029
anterior posterior axis specification follicular epithelium	GO:0030714	2	0.029
ubiquitin dependent protein catabolic process	GO:0006511	78	0.029
protein targeting to nucleus	GO:0044744	51	0.028
proteolysis	GO:0006508	192	0.028
protein localization to nucleus	GO:0034504	55	0.028
positive regulation of transport	GO:0051050	92	0.028
tissue migration	GO:0090130	155	0.028
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.028
neural precursor cell proliferation	GO:0061351	75	0.028
protein modification by small protein conjugation or removal	GO:0070647	106	0.028
regulation of striated muscle contraction	GO:0006942	2	0.027
catabolic process	GO:0009056	409	0.027
sensory organ morphogenesis	GO:0090596	260	0.027
atp metabolic process	GO:0046034	49	0.026
defense response	GO:0006952	300	0.026
small molecule metabolic process	GO:0044281	305	0.026
protein phosphorylation	GO:0006468	169	0.026
biological adhesion	GO:0022610	138	0.026
negative regulation of gene expression epigenetic	GO:0045814	77	0.026
positive regulation of cell death	GO:0010942	69	0.026
regulation of microtubule based process	GO:0032886	49	0.025
single organism biosynthetic process	GO:0044711	206	0.025
positive regulation of cellular protein metabolic process	GO:0032270	118	0.025
carboxylic acid metabolic process	GO:0019752	92	0.025
regulation of microtubule cytoskeleton organization	GO:0070507	41	0.025
response to abiotic stimulus	GO:0009628	341	0.024
protein targeting	GO:0006605	64	0.024
positive regulation of phosphorylation	GO:0042327	87	0.024
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.024
embryonic morphogenesis	GO:0048598	206	0.024
cell cycle checkpoint	GO:0000075	95	0.023
phagocytosis	GO:0006909	215	0.023
pronuclear fusion	GO:0007344	4	0.023
nucleoside monophosphate metabolic process	GO:0009123	52	0.023
response to drug	GO:0042493	17	0.023
organonitrogen compound metabolic process	GO:1901564	318	0.023
organic acid metabolic process	GO:0006082	103	0.023
nuclear axial expansion	GO:0035191	3	0.022
axis specification	GO:0009798	167	0.022
mitochondrial membrane organization	GO:0007006	3	0.021
chromatin organization	GO:0006325	207	0.021
tube morphogenesis	GO:0035239	191	0.021
dna repair	GO:0006281	54	0.021
neuron projection guidance	GO:0097485	241	0.021
immune system development	GO:0002520	57	0.020
renal system development	GO:0072001	72	0.020
immune effector process	GO:0002252	98	0.020
negative regulation of programmed cell death	GO:0043069	72	0.020
cellular amine metabolic process	GO:0044106	12	0.019
response to radiation	GO:0009314	155	0.019
covalent chromatin modification	GO:0016569	106	0.019
response to hypoxia	GO:0001666	53	0.019
regulation of protein modification process	GO:0031399	112	0.019
regulation of nervous system development	GO:0051960	248	0.019
regulation of response to external stimulus	GO:0032101	115	0.019
dorsal closure leading edge cell differentiation	GO:0046663	2	0.018
meiosis i	GO:0007127	59	0.018
multicellular organismal aging	GO:0010259	140	0.018
modification dependent protein catabolic process	GO:0019941	78	0.018
cellular catabolic process	GO:0044248	372	0.018
cellular response to nutrient	GO:0031670	1	0.018
forebrain development	GO:0030900	2	0.017
negative regulation of apoptotic process	GO:0043066	63	0.017
microtubule polymerization or depolymerization	GO:0031109	39	0.017
positive regulation of developmental process	GO:0051094	143	0.017
nitric oxide metabolic process	GO:0046209	1	0.017
spermatid differentiation	GO:0048515	114	0.017
maintenance of location	GO:0051235	73	0.016
gland development	GO:0048732	191	0.016
stem cell development	GO:0048864	79	0.016
epithelium migration	GO:0090132	148	0.016
aging	GO:0007568	143	0.016
regulation of embryonic development	GO:0045995	68	0.016
telencephalon development	GO:0021537	2	0.016
positive regulation of cysteine type endopeptidase activity involved in execution phase of apoptosis	GO:2001272	4	0.016
oxoacid metabolic process	GO:0043436	103	0.016
regulation of establishment of protein localization	GO:0070201	61	0.016
positive regulation of epidermal growth factor activated receptor activity	GO:0045741	1	0.015
wnt signaling pathway	GO:0016055	98	0.015
regulation of mapk cascade	GO:0043408	92	0.015
protein localization	GO:0008104	284	0.015
protein localization to organelle	GO:0033365	82	0.015
meiotic chromosome movement towards spindle pole	GO:0016344	1	0.015
regulation of protein import into nucleus	GO:0042306	28	0.015
regulation of atp metabolic process	GO:1903578	6	0.015
regulation of multi organism process	GO:0043900	131	0.015
nucleocytoplasmic transport	GO:0006913	72	0.014
negative regulation of meiotic cell cycle phase transition	GO:1901994	1	0.014
morphogenesis of an epithelium	GO:0002009	276	0.014
neurological system process	GO:0050877	358	0.014
regulation of cellular component biogenesis	GO:0044087	201	0.014
regulation of protein targeting	GO:1903533	29	0.014
response to extracellular stimulus	GO:0009991	116	0.014
response to organonitrogen compound	GO:0010243	75	0.014
dorsal ventral axis specification	GO:0009950	66	0.014
cellular response to growth factor stimulus	GO:0071363	30	0.014
establishment of protein localization to organelle	GO:0072594	62	0.014
regulation of immune effector process	GO:0002697	52	0.014
chromatin remodeling	GO:0006338	72	0.014
regulation of protein phosphorylation	GO:0001932	64	0.014
regulation of molecular function	GO:0065009	217	0.014
neuron maturation	GO:0042551	31	0.014
hematopoietic progenitor cell differentiation	GO:0002244	1	0.013
immune response	GO:0006955	246	0.013
columnar cuboidal epithelial cell development	GO:0002066	249	0.013
cell cycle comprising mitosis without cytokinesis	GO:0033301	25	0.013
spindle assembly	GO:0051225	80	0.013
mesenchymal cell development	GO:0014031	1	0.013
nuclear pore organization	GO:0006999	1	0.013
response to growth factor	GO:0070848	31	0.013
macromolecule catabolic process	GO:0009057	161	0.013
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.013
positive regulation of intracellular transport	GO:0032388	42	0.013
oocyte morphogenesis	GO:0048601	3	0.012
negative regulation of nucleotide metabolic process	GO:0045980	4	0.012
regulation of neuron death	GO:1901214	26	0.012
regulation of atp catabolic process	GO:1903289	4	0.012
mapk cascade	GO:0000165	107	0.012
negative regulation of terminal cell fate specification open tracheal system	GO:0035155	2	0.012
circulatory system development	GO:0072359	82	0.012
taxis	GO:0042330	304	0.012
embryonic pattern specification	GO:0009880	174	0.012
regulation of cell development	GO:0060284	215	0.012
skeletal muscle tissue development	GO:0007519	13	0.012
regulation of cellular protein catabolic process	GO:1903362	44	0.012
oocyte fate commitment	GO:0048600	2	0.012
glial cell differentiation	GO:0010001	35	0.012
formation of a compartment boundary	GO:0060288	4	0.011
dna replication	GO:0006260	48	0.011
protein dna complex subunit organization	GO:0071824	86	0.011
amine metabolic process	GO:0009308	12	0.011
dendrite regeneration	GO:0031104	2	0.011
male meiosis	GO:0007140	52	0.011
rna polymerase ii transcriptional preinitiation complex assembly	GO:0051123	20	0.011
negative regulation of signal transduction	GO:0009968	206	0.011
g1 s transition of mitotic cell cycle	GO:0000082	31	0.011
hindbrain development	GO:0030902	2	0.011
regulation of cell proliferation involved in compound eye morphogenesis	GO:2000495	2	0.011
maternal determination of dorsal ventral axis ovarian follicular epithelium soma encoded	GO:0008071	1	0.011
defense response to other organism	GO:0098542	225	0.011
rna processing	GO:0006396	147	0.011
regulation of kinase activity	GO:0043549	53	0.010
proteasomal protein catabolic process	GO:0010498	59	0.010
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.010
chitin based larval cuticle pattern formation	GO:0035293	11	0.010

Cp190 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
connective tissue disease	DOID:65	0.069
bone disease	DOID:0080001	0.069
bone development disease	DOID:0080006	0.069
osteogenesis imperfecta	DOID:12347	0.069
disease of anatomical entity	DOID:7	0.069
osteochondrodysplasia	DOID:2256	0.069
musculoskeletal system disease	DOID:17	0.069
female reproductive organ cancer	DOID:120	0.012
organ system cancer	DOID:0050686	0.012
disease of cellular proliferation	DOID:14566	0.012
cancer	DOID:162	0.012
ovarian cancer	DOID:2394	0.012
reproductive organ cancer	DOID:193	0.012
nervous system benign neoplasm	DOID:0060115	0.011
neuroma	DOID:2001	0.011
organ system benign neoplasm	DOID:0060085	0.011
benign neoplasm	DOID:0060072	0.011

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