IMP: Integrative Multi-species Prediction

Drosophila melanogaster

45 known processes

Gdh (Dmel_CG5320)

Glutamate dehydrogenase

(Aliases: GLU-D,Dmel\CG5320,gdh,DHE3,GLUD pre-mRNA,GDH,GLUD,Glud,CG5320)

FLYBASE: FBgn0001098
Entrez: 42832
UniProtKB: Q8IMY1
UniProtKB: P54385

Process Predictions
Disease Predictions

Gdh biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
catabolic process	GO:0009056	409	0.592
single organism catabolic process	GO:0044712	228	0.378
organic acid metabolic process	GO:0006082	103	0.366
small molecule metabolic process	GO:0044281	305	0.330
nadh metabolic process	GO:0006734	1	0.314
organonitrogen compound metabolic process	GO:1901564	318	0.291
energy derivation by oxidation of organic compounds	GO:0015980	32	0.276
nad metabolic process	GO:0019674	1	0.272
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.271
oxidation reduction process	GO:0055114	123	0.232
carboxylic acid metabolic process	GO:0019752	92	0.230
oxidoreduction coenzyme metabolic process	GO:0006733	2	0.228
organic substance catabolic process	GO:1901575	308	0.210
oxoacid metabolic process	GO:0043436	103	0.198
nucleotide metabolic process	GO:0009117	161	0.149
nicotinamide nucleotide metabolic process	GO:0046496	2	0.147
centrosome organization	GO:0051297	163	0.137
alpha amino acid metabolic process	GO:1901605	20	0.114
lateral inhibition	GO:0046331	206	0.111
organophosphate metabolic process	GO:0019637	195	0.104
tricarboxylic acid metabolic process	GO:0072350	1	0.087
cellular catabolic process	GO:0044248	372	0.083
establishment of localization in cell	GO:0051649	402	0.074
organonitrogen compound catabolic process	GO:1901565	128	0.071
death	GO:0016265	284	0.065
defense response to other organism	GO:0098542	225	0.064
nucleoside phosphate metabolic process	GO:0006753	162	0.060
endocytosis	GO:0006897	310	0.060
nucleobase containing small molecule metabolic process	GO:0055086	174	0.059
vesicle mediated transport	GO:0016192	381	0.052
regulation of multicellular organismal development	GO:2000026	414	0.051
positive regulation of signaling	GO:0023056	243	0.051
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.049
purine containing compound catabolic process	GO:0072523	112	0.048
purine nucleoside metabolic process	GO:0042278	127	0.048
apoptotic process	GO:0006915	159	0.048
carbohydrate derivative catabolic process	GO:1901136	118	0.047
organonitrogen compound biosynthetic process	GO:1901566	117	0.047
ribonucleoside catabolic process	GO:0042454	112	0.046
regionalization	GO:0003002	416	0.045
cell death	GO:0008219	279	0.045
cellular respiration	GO:0045333	26	0.044
ribonucleotide metabolic process	GO:0009259	145	0.044
cellular carbohydrate catabolic process	GO:0044275	2	0.043
multicellular organismal reproductive behavior	GO:0033057	110	0.043
ribonucleoside monophosphate catabolic process	GO:0009158	39	0.043
immune system process	GO:0002376	347	0.043
purine ribonucleoside metabolic process	GO:0046128	127	0.042
body morphogenesis	GO:0010171	2	0.041
nucleoside metabolic process	GO:0009116	127	0.041
cellular nitrogen compound catabolic process	GO:0044270	165	0.041
positive regulation of macromolecule metabolic process	GO:0010604	405	0.041
purine ribonucleotide metabolic process	GO:0009150	145	0.040
ion transport	GO:0006811	145	0.038
growth	GO:0040007	359	0.038
programmed cell death	GO:0012501	257	0.038
purine nucleoside catabolic process	GO:0006152	112	0.037
nucleobase containing compound catabolic process	GO:0034655	165	0.036
inorganic cation transmembrane transport	GO:0098662	61	0.035
nucleoside triphosphate catabolic process	GO:0009143	108	0.034
phagocytosis	GO:0006909	215	0.034
epithelial cell differentiation	GO:0030855	322	0.034
pyridine containing compound metabolic process	GO:0072524	3	0.034
glycosyl compound metabolic process	GO:1901657	127	0.033
ribonucleoside metabolic process	GO:0009119	127	0.033
kidney development	GO:0001822	3	0.033
dorsal ventral pattern formation	GO:0009953	133	0.032
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.032
positive regulation of transport	GO:0051050	92	0.031
regulation of ion transport	GO:0043269	39	0.031
ribose phosphate metabolic process	GO:0019693	145	0.030
embryo development ending in birth or egg hatching	GO:0009792	152	0.030
positive regulation of cell communication	GO:0010647	250	0.029
cellular component assembly involved in morphogenesis	GO:0010927	151	0.029
developmental growth	GO:0048589	280	0.029
monovalent inorganic cation transport	GO:0015672	40	0.029
organophosphate catabolic process	GO:0046434	112	0.029
regulation of immune response	GO:0050776	118	0.029
nucleoside monophosphate metabolic process	GO:0009123	52	0.029
purine nucleoside biosynthetic process	GO:0042451	3	0.029
imaginal disc derived wing morphogenesis	GO:0007476	337	0.028
purine ribonucleoside catabolic process	GO:0046130	112	0.028
regulation of cellular ketone metabolic process	GO:0010565	3	0.028
glycosyl compound catabolic process	GO:1901658	112	0.028
negative regulation of cellular metabolic process	GO:0031324	382	0.028
regulation of growth	GO:0040008	233	0.027
heterocycle catabolic process	GO:0046700	166	0.027
actin cytoskeleton organization	GO:0030036	206	0.026
neuromuscular junction development	GO:0007528	149	0.026
atp metabolic process	GO:0046034	49	0.026
small molecule catabolic process	GO:0044282	21	0.026
nucleoside phosphate catabolic process	GO:1901292	110	0.026
intracellular transport	GO:0046907	228	0.026
defense response to gram negative bacterium	GO:0050829	94	0.025
regulation of response to stress	GO:0080134	200	0.025
purine ribonucleoside monophosphate biosynthetic process	GO:0009168	3	0.025
purine containing compound metabolic process	GO:0072521	155	0.025
purine ribonucleotide catabolic process	GO:0009154	109	0.025
nucleoside catabolic process	GO:0009164	112	0.025
regulation of localization	GO:0032879	275	0.025
carbohydrate derivative metabolic process	GO:1901135	217	0.025
aromatic compound catabolic process	GO:0019439	166	0.024
cation transport	GO:0006812	110	0.024
actin filament based process	GO:0030029	220	0.023
purine nucleotide metabolic process	GO:0006163	146	0.023
organic substance transport	GO:0071702	257	0.022
protein complex assembly	GO:0006461	200	0.022
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.022
carbohydrate metabolic process	GO:0005975	82	0.022
generation of precursor metabolites and energy	GO:0006091	42	0.021
ribonucleoside biosynthetic process	GO:0042455	3	0.021
organic cyclic compound catabolic process	GO:1901361	168	0.021
metal ion homeostasis	GO:0055065	44	0.021
regulation of transport	GO:0051049	181	0.020
central nervous system development	GO:0007417	201	0.020
localization of cell	GO:0051674	257	0.020
regulation of immune system process	GO:0002682	176	0.020
cellular amino acid metabolic process	GO:0006520	61	0.020
wing disc morphogenesis	GO:0007472	344	0.020
imaginal disc pattern formation	GO:0007447	91	0.019
multicellular organismal aging	GO:0010259	140	0.019
purine nucleotide catabolic process	GO:0006195	109	0.019
response to other organism	GO:0051707	293	0.019
single organism carbohydrate metabolic process	GO:0044723	72	0.019
response to oxygen containing compound	GO:1901700	200	0.019
larval development	GO:0002164	104	0.019
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.018
appendage morphogenesis	GO:0035107	397	0.018
synaptic transmission	GO:0007268	288	0.018
defense response	GO:0006952	300	0.018
negative regulation of biosynthetic process	GO:0009890	277	0.017
protein transport	GO:0015031	155	0.017
positive regulation of hydrolase activity	GO:0051345	78	0.017
microtubule organizing center organization	GO:0031023	168	0.017
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.017
head development	GO:0060322	135	0.016
regulation of cellular protein metabolic process	GO:0032268	243	0.016
sex differentiation	GO:0007548	81	0.016
post embryonic appendage morphogenesis	GO:0035120	385	0.016
protein complex biogenesis	GO:0070271	201	0.016
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.016
regulation of innate immune response	GO:0045088	71	0.016
behavioral response to ethanol	GO:0048149	49	0.015
endomembrane system organization	GO:0010256	119	0.015
appendage development	GO:0048736	401	0.015
nucleoside monophosphate catabolic process	GO:0009125	39	0.015
acyl coa metabolic process	GO:0006637	3	0.015
reproductive system development	GO:0061458	74	0.015
organelle assembly	GO:0070925	198	0.015
camera type eye development	GO:0043010	4	0.015
regulation of apoptotic process	GO:0042981	130	0.015
reproductive behavior	GO:0019098	122	0.015
digestive tract development	GO:0048565	149	0.015
purine ribonucleoside biosynthetic process	GO:0046129	3	0.015
cellular metal ion homeostasis	GO:0006875	31	0.014
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.014
determination of adult lifespan	GO:0008340	137	0.014
synapse organization	GO:0050808	196	0.014
adult behavior	GO:0030534	137	0.014
dorsal ventral pattern formation imaginal disc	GO:0007450	51	0.014
ribonucleotide catabolic process	GO:0009261	109	0.014
regulation of synapse organization	GO:0050807	110	0.014
protein modification process	GO:0036211	438	0.014
urogenital system development	GO:0001655	72	0.014
synapse assembly	GO:0007416	143	0.014
multi multicellular organism process	GO:0044706	123	0.014
nuclear import	GO:0051170	51	0.014
positive regulation of cellular biosynthetic process	GO:0031328	316	0.014
tube morphogenesis	GO:0035239	191	0.014
proteolysis	GO:0006508	192	0.014
regulation of cysteine type endopeptidase activity	GO:2000116	27	0.013
regulation of programmed cell death	GO:0043067	152	0.013
biological adhesion	GO:0022610	138	0.013
cellular macromolecule localization	GO:0070727	220	0.013
maintenance of location	GO:0051235	73	0.013
anatomical structure homeostasis	GO:0060249	97	0.013
regulation of molecular function	GO:0065009	217	0.013
protein processing	GO:0016485	68	0.013
negative regulation of neurogenesis	GO:0050768	53	0.013
chromosome segregation	GO:0007059	157	0.013
macromolecular complex assembly	GO:0065003	256	0.013
negative regulation of nervous system development	GO:0051961	92	0.013
positive regulation of multicellular organismal process	GO:0051240	143	0.013
phosphorylation	GO:0016310	294	0.013
eye development	GO:0001654	323	0.013
striated muscle cell differentiation	GO:0051146	90	0.012
negative regulation of signal transduction	GO:0009968	206	0.012
embryonic morphogenesis	GO:0048598	206	0.012
cytoplasmic transport	GO:0016482	130	0.012
regulation of cell proliferation	GO:0042127	163	0.012
muscle structure development	GO:0061061	224	0.012
regulation of cell differentiation	GO:0045595	302	0.012
negative regulation of cell development	GO:0010721	62	0.012
inorganic ion transmembrane transport	GO:0098660	73	0.012
reproductive structure development	GO:0048608	74	0.012
cation transmembrane transport	GO:0098655	88	0.012
digestive tract morphogenesis	GO:0048546	127	0.011
epithelial cell development	GO:0002064	274	0.011
myotube differentiation	GO:0014902	46	0.011
regulation of nervous system development	GO:0051960	248	0.011
citrate metabolic process	GO:0006101	0	0.011
regulation of anatomical structure size	GO:0090066	163	0.011
single organism cellular localization	GO:1902580	180	0.011
homeostatic process	GO:0042592	199	0.011
regulation of cell death	GO:0010941	173	0.011
cellular protein modification process	GO:0006464	438	0.011
nucleotide catabolic process	GO:0009166	109	0.011
wing disc dorsal ventral pattern formation	GO:0048190	47	0.011
negative regulation of cell cycle phase transition	GO:1901988	103	0.011
regulation of mitotic cell cycle	GO:0007346	190	0.011
cytoskeleton dependent cytokinesis	GO:0061640	81	0.011
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.011
multicellular organismal homeostasis	GO:0048871	41	0.011
single organism nuclear import	GO:1902593	51	0.011
striated muscle cell development	GO:0055002	50	0.011
defense response to bacterium	GO:0042742	178	0.011
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.011
mating	GO:0007618	120	0.011
glutamine family amino acid metabolic process	GO:0009064	12	0.011
secretion by cell	GO:0032940	101	0.011
cation homeostasis	GO:0055080	51	0.011
cell motility	GO:0048870	251	0.011
regulation of cellular localization	GO:0060341	136	0.011
cellular carbohydrate metabolic process	GO:0044262	22	0.011
purine nucleoside monophosphate catabolic process	GO:0009128	38	0.011
regulation of endopeptidase activity	GO:0052548	36	0.011
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.011
nucleoside triphosphate metabolic process	GO:0009141	120	0.011
regulation of developmental growth	GO:0048638	174	0.010
carboxylic acid catabolic process	GO:0046395	16	0.010
negative regulation of multicellular organismal process	GO:0051241	142	0.010
development of primary sexual characteristics	GO:0045137	50	0.010
brain development	GO:0007420	120	0.010
sensory organ morphogenesis	GO:0090596	260	0.010
regulation of hydrolase activity	GO:0051336	97	0.010
phosphate ion transport	GO:0006817	4	0.010

Gdh disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.102
nervous system disease	DOID:863	0.028
eye disease	DOID:5614	0.028
sensory system disease	DOID:0050155	0.028
eye and adnexa disease	DOID:1492	0.028
disease of metabolism	DOID:0014667	0.015
musculoskeletal system disease	DOID:17	0.013

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